{"id":524050,"date":"2021-08-05T08:05:06","date_gmt":"2021-08-05T12:05:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\/"},"modified":"2021-08-05T08:05:06","modified_gmt":"2021-08-05T12:05:06","slug":"immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\/","title":{"rendered":"Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003"},"content":{"rendered":"<div class=\"mw_release\">\n<p>Sydney, Aug.  05, 2021  (GLOBE NEWSWIRE) &#8212; Immutep Limited (ASX: IMM; NASDAQ: IMMP) (\u201c<b>Immutep<\/b>\u201d or the \u201c<b>Company<\/b>\u201d), a biotechnology company developing novel LAG-3 related immunotherapy treatments for cancer and autoimmune disease, is pleased to announce that the first patient has been enrolled and safely dosed in INSIGHT-003. This patient with metastatic non-small cell lung carcinoma received pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) combined with Immutep\u2019s lead product candidate eftilagimod alpha (efti or IMP321).<\/p>\n<p align=\"justify\">INSIGHT-003 is evaluating a triple combination therapy consisting of efti in conjunction with an existing approved standard of care combination of chemotherapy and anti-PD-1 therapy. The study will continue to recruit up to 20 patients with various solid tumours and first results are expected in calendar year 2022.<\/p>\n<p align=\"justify\">\n        <b>CSO and CMO Dr. Fr\u00e9d\u00e9ric Triebel said: <\/b>\u201cINSIGHT-003 is the first time a triple combination therapy consisting of efti plus anti-PD-1 plus chemo is administered. We are evaluating how efti might boost an approved chemotherapy and anti-PD-1 combination therapy, looking at safety and initial activity. Dosing the first patient in this trial is a significant milestone and it sets the wheels in motion for reporting first data which are currently anticipated in 2022.\u201d <\/p>\n<p align=\"justify\">\n        <b>About INSIGHT-003<\/b><br \/>\n        <br \/>INSIGHT-003 is an investigator-initiated trial conducted by the Institute of Clinical Cancer Research IKF at Krankenhaus Nordwest in Frankfurt. It is being run as the third arm (Stratum C) of the ongoing phase 1 INSIGHT trial with Prof. Dr. Salah-Eddin Al-Batran as lead investigator.<\/p>\n<p align=\"justify\">Up to 20 patients with solid tumours will be recruited to participate in the trial. Patients will receive 30 mg subcutaneous doses of efti every two weeks in conjunction with standard of care chemotherapy plus anti-PD-1 therapy. The trial will assess the safety, tolerability and initial efficacy of the combination.<\/p>\n<p align=\"justify\">\n        <b>About Immutep <\/b>\n      <\/p>\n<p align=\"justify\">Further information can be found on the Company\u2019s website www.immutep.com or by contacting:<\/p>\n<p align=\"justify\">\n        <b>Australian Investors\/Media:<\/b><br \/>\n        <br \/>Catherine Strong, Citadel-MAGNUS<br \/>+61 (0)406 759 268; cstrong@citadelmagnus.com<\/p>\n<p align=\"justify\">\n        <b>U.S. Media:<\/b><br \/>\n        <br \/>Tim McCarthy, LifeSci Advisors<br \/>+1 (212) 915.2564;\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=aeyyGBS3PhOiaSPwUFT7K3M86zC1ZKe_KBdNOQJqWxWcGqsaCbpcRhgeUdoVFmt8qOFTHmrxfrfo8JWWPRSlSonAnKhXEJhcTf5rgbp3WWU=\" rel=\"nofollow noopener\" target=\"_blank\">tim@lifesciadvisors.com<\/a><\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwMzI5NCM0MzQyNzg2IzIwMTk4MzM=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/93f24122-bc21-46bb-bdac-c51aad00bad2\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sydney, Aug. 05, 2021 (GLOBE NEWSWIRE) &#8212; Immutep Limited (ASX: IMM; NASDAQ: IMMP) (\u201cImmutep\u201d or the \u201cCompany\u201d), a biotechnology company developing novel LAG-3 related immunotherapy treatments for cancer and autoimmune disease, is pleased to announce that the first patient has been enrolled and safely dosed in INSIGHT-003. This patient with metastatic non-small cell lung carcinoma received pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) combined with Immutep\u2019s lead product candidate eftilagimod alpha (efti or IMP321). INSIGHT-003 is evaluating a triple combination therapy consisting of efti in conjunction with an existing approved standard of care combination of chemotherapy and anti-PD-1 therapy. The study will continue to recruit up to 20 patients with various solid tumours and first results are expected in calendar &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-524050","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Sydney, Aug. 05, 2021 (GLOBE NEWSWIRE) &#8212; Immutep Limited (ASX: IMM; NASDAQ: IMMP) (\u201cImmutep\u201d or the \u201cCompany\u201d), a biotechnology company developing novel LAG-3 related immunotherapy treatments for cancer and autoimmune disease, is pleased to announce that the first patient has been enrolled and safely dosed in INSIGHT-003. This patient with metastatic non-small cell lung carcinoma received pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) combined with Immutep\u2019s lead product candidate eftilagimod alpha (efti or IMP321). INSIGHT-003 is evaluating a triple combination therapy consisting of efti in conjunction with an existing approved standard of care combination of chemotherapy and anti-PD-1 therapy. The study will continue to recruit up to 20 patients with various solid tumours and first results are expected in calendar &hellip; Continue reading &quot;Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-08-05T12:05:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODMwMzI5NCM0MzQyNzg2IzIwMTk4MzM=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003\",\"datePublished\":\"2021-08-05T12:05:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/\"},\"wordCount\":337,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODMwMzI5NCM0MzQyNzg2IzIwMTk4MzM=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immutep-reports-dosing-of-first-patient-for-triple-combination-efti-anti-pd-1-chemo-in-insight-003\\\/\",\"name\":\"Immutep Reports Dosing of First Patient for Triple Combination (efti + anti-PD-1 + chemo) in INSIGHT-003 - 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This patient with metastatic non-small cell lung carcinoma received pembrolizumab plus doublet chemotherapy (carboplatin and pemetrexed) combined with Immutep\u2019s lead product candidate eftilagimod alpha (efti or IMP321). INSIGHT-003 is evaluating a triple combination therapy consisting of efti in conjunction with an existing approved standard of care combination of chemotherapy and anti-PD-1 therapy. 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