{"id":521529,"date":"2021-08-02T16:09:44","date_gmt":"2021-08-02T20:09:44","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-inc-publishes-new-data-demonstrating-a-novel-composite-biomarker-neops-for-predicting-response-to-cancer-immunotherapy-in-late-stage-melanoma-patients\/"},"modified":"2021-08-02T16:09:44","modified_gmt":"2021-08-02T20:09:44","slug":"personalis-inc-publishes-new-data-demonstrating-a-novel-composite-biomarker-neops-for-predicting-response-to-cancer-immunotherapy-in-late-stage-melanoma-patients","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-inc-publishes-new-data-demonstrating-a-novel-composite-biomarker-neops-for-predicting-response-to-cancer-immunotherapy-in-late-stage-melanoma-patients\/","title":{"rendered":"Personalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients"},"content":{"rendered":"

<\/p>\n

\nPersonalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients\n<\/p>\n

MENLO PARK, Calif.–(BUSINESS WIRE<\/a>)–
\nPersonalis, Inc. (Nasdaq: PSNL), a leader in advanced translational genomics and diagnostics for cancer, today announced the publication of its study “Prediction of immunotherapy response in melanoma through combined modeling of neoantigen burden and immune-related resistance mechanisms<\/a><\/i><\/span>,”(1) <\/sup>in Clinical Cancer Research<\/i>, a journal published by the American Association for Cancer Research.\n<\/p>\n

\nThe study details the development of the Personalis Neoantigen Presentation Score (NEOPS\u2122), a novel composite biomarker for predicting response to cancer immunotherapy. Enabled by comprehensive tumor immunogenomic profiling from the Personalis NeXT Platform, NEOPS simultaneously models both neoantigen burden and immune-related resistance mechanisms to better predict immunotherapy response in a cohort of late-stage melanoma patients. In this study, NEOPS was more strongly predictive of therapy response than other standard single analyte and investigational biomarkers tested, including tumor mutational burden. Performance of this composite biomarker was initially tested on a cohort of late-stage melanoma patients receiving immune checkpoint blockade therapies and later validated on an independent dataset of similarly treated late-stage melanoma patients.\n<\/p>\n

\n\u201cGiven the varied response to immunotherapy as well as the potential toxicities associated with treatment, there is a need for improved biomarker approaches to better predict which patients will respond to therapy,\u201d said Richard Chen, MD, Personalis CMO. \u201cOur findings suggest that integrative, multi-omic biomarkers like NEOPS can be stronger predictors of response than simpler, single-analyte approaches, especially in the setting of new cancer therapies where the underlying biological mechanisms governing response are highly complex. We feel that NEOPS and other composite biomarkers will be important, sharper tools for enabling precision oncology.\u201d\n<\/p>\n

\nNEOPS utilizes technology that Personalis has been developing since 2015 to better predict neoantigens and identify associated escape mechanisms such as HLA LOH. Our ImmunoID NeXT, and clinical NeXT Dx tests make this advanced capability, including NEOPS, available to pharmaceutical researchers and clinicians for clinical trials and investigational use, and additional clinical studies with other tumor types are planned.\n<\/p>\n

About Personalis, Inc.<\/b><\/p>\n

\nPersonalis, Inc. is a leader in advanced cancer genomics for enabling the next generation of precision cancer therapies and diagnostics. The Personalis NeXT Platform<\/a>\u2122 is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers and clinicians with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. In population sequencing, Personalis operates one of the largest sequencing laboratories globally and is currently the sole sequencing provider to the VA MVP. To enable cancer and population sequencing, The Personalis Clinical Laboratory<\/a> is built with a focus on clinical accuracy, quality, big data, scale, and efficiency. The laboratory is GxP aligned as well as CLIA\u201988-certified and CAP-accredited. For more information, please visit www.personalis.com<\/a> and follow Personalis on Twitter (@PersonalisInc<\/a>).\n<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nAll statements in this press release that are not historical are \u201cforward-looking statements\u201d within the meaning of U.S. securities laws, including statements relating to attributes or advantages of NEOPS or the Personalis NeXT Platform, Personalis\u2019 business opportunities, leadership, plans, vision or growth, or other future events. Such forward-looking statements involve risks and uncertainties, including those related to the COVID-19 pandemic, that could cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements. Factors that could materially affect actual results can be found in Personalis\u2019 filings with the U.S. Securities and Exchange Commission, including Personalis\u2019 most recent reports on Forms 8-K, 10-K and 10-Q, and include those listed under the caption \u201cRisk Factors.\u201d Personalis disclaims any obligation to update such forward-looking statements.\n<\/p>\n

(1)<\/sup> Clin Cancer Res August 1 2021 (27) (15) 4265-4276; DOI:<\/b> 10.1158\/1078-0432.CCR-20-4314\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210802005694\/en\/<\/a><\/span><\/p>\n

Investor Relations Contact for Personalis:
\n<\/strong>
Caroline Corner
\n
investors@personalis.com
\n<\/a>
415-202-5678\n<\/p>\n

Media Contact for Personalis:
\n<\/strong>
Jennifer Havlek
\n
pr@personalis.com
\n<\/a>
www.personalis.com
\n<\/a>
650-752-1300\n<\/p>\n

KEYWORDS:<\/b> North America United States Europe Australia Australia\/Oceania California<\/p>\n

INDUSTRY KEYWORDS:<\/b> Biotechnology Pharmaceutical Health Oncology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Personalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients MENLO PARK, Calif.–(BUSINESS WIRE)– Personalis, Inc. (Nasdaq: PSNL), a leader in advanced translational genomics and diagnostics for cancer, today announced the publication of its study “Prediction of immunotherapy response in melanoma through combined modeling of neoantigen burden and immune-related resistance mechanisms,”(1) in Clinical Cancer Research, a journal published by the American Association for Cancer Research. The study details the development of the Personalis Neoantigen Presentation Score (NEOPS\u2122), a novel composite biomarker for predicting response to cancer immunotherapy. Enabled by comprehensive tumor immunogenomic profiling from the Personalis NeXT Platform, NEOPS simultaneously models both neoantigen burden and immune-related resistance mechanisms to … <\/p>\n

Continue reading “Personalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-521529","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nPersonalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-inc-publishes-new-data-demonstrating-a-novel-composite-biomarker-neops-for-predicting-response-to-cancer-immunotherapy-in-late-stage-melanoma-patients\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Personalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Personalis, Inc. Publishes New Data Demonstrating a Novel Composite Biomarker NEOPS\u2122 for Predicting Response to Cancer Immunotherapy in Late-Stage Melanoma Patients MENLO PARK, Calif.–(BUSINESS WIRE)– Personalis, Inc. (Nasdaq: PSNL), a leader in advanced translational genomics and diagnostics for cancer, today announced the publication of its study “Prediction of immunotherapy response in melanoma through combined modeling of neoantigen burden and immune-related resistance mechanisms,”(1) in Clinical Cancer Research, a journal published by the American Association for Cancer Research. The study details the development of the Personalis Neoantigen Presentation Score (NEOPS\u2122), a novel composite biomarker for predicting response to cancer immunotherapy. Enabled by comprehensive tumor immunogenomic profiling from the Personalis NeXT Platform, NEOPS simultaneously models both neoantigen burden and immune-related resistance mechanisms to … Continue reading "Personalis, Inc. 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