{"id":517438,"date":"2021-07-26T08:33:20","date_gmt":"2021-07-26T12:33:20","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/"},"modified":"2021-07-26T08:33:20","modified_gmt":"2021-07-26T12:33:20","slug":"cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/","title":{"rendered":"Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li style=\"text-align:left\">\n          <strong>SavaDx Detected Significant Changes in Plasma Levels of Altered Filamin A in Patients with Alzheimer\u2019s Disease Before and After Simufilam Treatment<\/p>\n<p><\/strong>\n        <\/li>\n<li>\n          <strong>Simufilam 100 mg and 50 mg Reduced Plasma Levels of Altered Filamin A in Alzheimer\u2019s Patients 48% (p=0.003) and 44% (p=0.02) Respectively <\/strong><\/p>\n<\/li>\n<li>\n          <strong>Plasma Results with SavaDx Track Plasma Results with p-Tau181<\/strong><\/p>\n<\/li>\n<li style=\"text-align:justify\">\n          <strong>Plasma Data Provide Evidence of Target Engagement <\/strong><\/p>\n<\/li>\n<li style=\"text-align:justify\">\n          <strong>Poster Presentation at AAIC Today<\/strong><br \/>\n          \n        <\/li>\n<\/ul>\n<p align=\"justify\">AUSTIN, Texas, July  26, 2021  (GLOBE NEWSWIRE) &#8212; Cassava Sciences, Inc. (Nasdaq: SAVA) today announced positive clinical data with SavaDx, an investigational diagnostic\/biomarker to detect Alzheimer\u2019s disease with a simple blood test. SavaDx was used to measure plasma levels of altered filamin A before and after simufilam treatment in patients with Alzheimer\u2019s disease. In this Phase 2b randomized, controlled trial sponsored by the National Institutes of Health (NIH), simufilam significantly reduced plasma levels of altered filamin A in Alzheimer\u2019s patients treated for 28 days. Plasma levels of p-tau181 also dropped significantly in these same patients.<\/p>\n<p align=\"justify\">Simufilam 100 mg and 50 mg reduced plasma levels of altered filamin A by 48% (p=0.003) and 44% (p=0.02) respectively, versus placebo. Additionally, simufilam 100 mg and 50 mg reduced plasma levels of p-tau181 by 17% (p=0.01) and 15% (p=0.02) respectively, versus placebo. Plasma p-tau181 is a biomarker that is known to be elevated in Alzheimer\u2019s disease.<\/p>\n<p align=\"justify\">\u201cWe believe altered filamin A is a major culprit in Alzheimer\u2019s disease,\u201d said Remi Barbier, President &amp; CEO. \u201cBefore simufilam treatment, SavaDx detected high plasma levels of altered filamin A in patients. After simufilam treatment, levels dropped significantly. We believe these data provide clear evidence that simufilam binds to and engages its intended target to produce treatment effects.\u201d<\/p>\n<p align=\"justify\">Treatment effects on CSF biomarkers for this Phase 2b study have been previously reported.<\/p>\n<p align=\"justify\">\n        <strong>About Today\u2019s <\/strong><br \/>\n        <strong>Poster Presentation at AAIC<\/strong><br \/>\n        <br \/>Scientists for Cassava Sciences will show a poster presentation titled, \u201c<em>SavaDx, a Novel Plasma Biomarker to Detect Alzheimer\u2019s Disease, Confirms Mechanism of Action of Simufilam<\/em>\u201d at the Alzheimer\u2019s Association International Conference (AAIC) in Denver, CO and virtually. Cassava Sciences\u2019 AAIC poster presentation with SavaDx can be accessed on the \u2018Investors\u2019 page of the Company\u2019s website: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=l6XWGZcpqBrxr34n1GF4KU4nnUB1VPLyxjn57Jbc7DeBRHeg5YKfwUcRubGG438SzSWjI7xheSkfROiaFIfRRN7MZdhT5-YFxEYiPy2xgEuNNydJfGxxLRf7WEb6aOEW\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.CassavaSciences.com<\/a><\/p>\n<p align=\"justify\">\n        <strong>About SavaDx<\/strong><br \/>\n        <br \/>SavaDx is Cassava Sciences\u2019 investigational diagnostic to detect Alzheimer\u2019s disease. The goal of SavaDx is to make the detection of Alzheimer\u2019s as simple as getting a blood test, possibly years before the appearance of any overt clinical symptoms. SavaDx was substantially funded by a peer-reviewed research grant award from the National Institutes of Health (NIH).<\/p>\n<p align=\"justify\">\n        <strong>About Simufilam<\/strong><br \/>\n        <br \/>Simufilam (sim-uh-FILL-am) is a proprietary, small molecule (oral) drug that restores the normal shape and function of altered filamin A (FLNA), a scaffolding protein, in the brain. Altered FLNA in the brain disrupts the normal function of neurons, leading to Alzheimer\u2019s pathology, neurodegeneration and neuroinflammation. The underlying science for simufilam is published in peer-reviewed journals, including <em>Journal of Neuroscience<\/em>, <em>Neurobiology of Aging<\/em>, <em>Journal of Biological Chemistry, Neuroimmunology and Neuroinflammation <\/em>and<em>\u00a0Journal of Prevention of Alzheimer\u2019s Disease. <\/em>Simufilam is substantially supported by peer-reviewed research grant awards from the National Institutes of Health (NIH).<\/p>\n<p align=\"justify\">\n        <strong>About Alzheimer\u2019s Disease<\/strong><br \/>\n        <br \/>Alzheimer\u2019s disease is a progressive brain disorder that destroys memory and thinking skills. As of 2020, there were approximately 50 million people worldwide living with dementia, a figure expected to increase to 150 million by 2050.<sup>1<\/sup> The annual global cost of dementia is now above $1 trillion, according to <em>Alzheimer\u2019s Disease International<\/em>, a charitable organization.<\/p>\n<p align=\"justify\">\n        <strong>About <\/strong><br \/>\n        <strong>Cassava Sciences, Inc.<\/strong><br \/>\n        <br \/>Cassava Sciences\u2019 mission is to discover and develop innovations for chronic, neurodegenerative conditions. Over the past 10 years, Cassava Sciences has combined state-of-the-art technology with new insights in neurobiology to develop novel solutions for Alzheimer\u2019s disease.<\/p>\n<p align=\"justify\">Simufilam and SavaDx were both developed in-house. Cassava Sciences owns worldwide development and commercial rights to its research programs in Alzheimer\u2019s disease, and related technologies, without royalty obligations to any third party.<\/p>\n<p align=\"justify\">For more information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=l6XWGZcpqBrxr34n1GF4KU4nnUB1VPLyxjn57Jbc7DfN0a9EPodjABy5JqX5b-__0_im7ITcQUjwgI4ICWuJ71FaDvJpIkCKwIKqnZCzBRU7E7AxIrarz2tVdo1nIEpK\" rel=\"nofollow noopener\" target=\"_blank\">https:\/\/www.CassavaSciences.com<\/a><\/p>\n<p align=\"justify\">\n        <strong>For More Information Contact: <\/strong><br \/>\n        <br \/>Eric Schoen, Chief Financial Officer<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=VWejhk2g4c_Qe-af2HpFyjjehV1UGCYymmpq2mmFwsxVeRltQzjYxd4GsQJKyp6_6MHCvEXC0q-5xll09PMtajOcso0H_Drgs7U9C1V2JdkLbBCfvluLcHicrXE-tXiB\" rel=\"nofollow noopener\" target=\"_blank\">eschoen@CassavaSciences.com<\/a><br \/>(512) 501-2450<\/p>\n<p align=\"center\">\n        <em>Cassava Sciences\u2019 open-label study of simufilam in Alzheimer\u2019s disease is funded by clinical research grant #AG065152 from the National Institutes of Health (NIH\/NIA).<\/em>\n      <\/p>\n<p align=\"center\">\n        <em>The content of this press release is solely the responsibility of Cassava Sciences and does not necessarily represent the official views of the NIH\/NIA. <\/em>\n      <\/p>\n<p align=\"justify\">\n        <strong><br \/>\n          <em>Cautionary Note Regarding Forward-Looking Statements:<\/em><br \/>\n        <\/strong><br \/>\n        <em> This news release contains forward-looking statements, including statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, relating to: <\/em><br \/>\n        <em>the treatment of Alzheimer\u2019s disease; <\/em><br \/>\n        <em>the interpretation of data with SavaDx from a randomized controlled Phase 2b study of simufilam; the interpretation of biomarker data from a Phase 2b study of simufilam; verbal commentaries made by our employees; and potential benefits, if any, of our product candidates<\/em><br \/>\n        <em>. <\/em><br \/>\n        <em>These statements may be identified by words such as \u201cmay,\u201d \u201canticipate,\u201d \u201cbelieve,\u201d \u201ccould,\u201d \u201cexpect,\u201d \u201cwould\u201d, \u201cforecast,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cpossible,\u201d \u201cpotential,\u201d and other words and terms of similar meaning. <\/em>\n      <\/p>\n<p align=\"justify\">\n        <em>Drug development involves a high degree of risk, and historically only a small number of research and development programs result in commercialization of a product. Clinical results from our earlier-stage clinical trials may not be indicative of full results or results from later-stage or larger scale clinical trials and do not ensure regulatory approval. You should not place undue reliance on these statements or any scientific data we present or publish.<\/em>\n      <\/p>\n<p align=\"justify\">\n        <em>Such statements are based largely on our current expectations and projections about future events. Such statements speak only as of the date of this news release and are subject to a number of risks, uncertainties and assumptions, including, but not limited to, those risks relating to the ability to conduct or complete clinical studies on expected timelines, to demonstrate the specificity, safety, efficacy or potential health benefits of our product candidates, the severity and duration of health care precautions given the COVID-19 pandemic, any unanticipated impacts of the pandemic on our business operations, and including those described in the section entitled \u201cRisk Factors\u201d in our Annual Report on Form 10-K for the year ended December 31, 2020 and future reports to be filed with the SEC. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from expectations in any forward-looking statement. In light of these risks, uncertainties and assumptions, the forward-looking statements and events discussed in this news release are inherently uncertain and may not occur, and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Accordingly, you should not rely upon forward-looking statements as predictions of future events. Except as required by law, we disclaim any intention or responsibility for updating or revising any forward-looking statements contained in this news release.<\/em>\n      <\/p>\n<p align=\"justify\">\n        <em>For further information regarding these and other risks related to our business, investors should consult our filings with the SEC, which are available on the SEC&#8217;s website at <\/em><br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Zf9FJIgKaySmCaQrJP5W2bFPVQv3tpMebjbUnxMW29G6ZbkcqJE_4EUWLlxsB76zt19CTXb9QeZ5z84tRku0wA==\" rel=\"nofollow noopener\" target=\"_blank\"><br \/>\n          <em><br \/>\n            <u>www.sec.gov<\/u><br \/>\n          <\/em><br \/>\n        <\/a><br \/>\n        <em>.<\/em>\n      <\/p>\n<p>\n        <sup>1<\/sup><br \/>\n        <em>Alzheimer&#8217;s Disease International, Dementia Statistics, <\/em>available on-line.<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODI4NjI5MiM0MzEzNjY3IzIwMjc4MTI=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/7cf4dcb8-ba91-461c-9d4a-a92d14ee9075\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>SavaDx Detected Significant Changes in Plasma Levels of Altered Filamin A in Patients with Alzheimer\u2019s Disease Before and After Simufilam Treatment Simufilam 100 mg and 50 mg Reduced Plasma Levels of Altered Filamin A in Alzheimer\u2019s Patients 48% (p=0.003) and 44% (p=0.02) Respectively Plasma Results with SavaDx Track Plasma Results with p-Tau181 Plasma Data Provide Evidence of Target Engagement Poster Presentation at AAIC Today AUSTIN, Texas, July 26, 2021 (GLOBE NEWSWIRE) &#8212; Cassava Sciences, Inc. (Nasdaq: SAVA) today announced positive clinical data with SavaDx, an investigational diagnostic\/biomarker to detect Alzheimer\u2019s disease with a simple blood test. SavaDx was used to measure plasma levels of altered filamin A before and after simufilam treatment in patients with Alzheimer\u2019s disease. In this Phase &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-517438","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"SavaDx Detected Significant Changes in Plasma Levels of Altered Filamin A in Patients with Alzheimer\u2019s Disease Before and After Simufilam Treatment Simufilam 100 mg and 50 mg Reduced Plasma Levels of Altered Filamin A in Alzheimer\u2019s Patients 48% (p=0.003) and 44% (p=0.02) Respectively Plasma Results with SavaDx Track Plasma Results with p-Tau181 Plasma Data Provide Evidence of Target Engagement Poster Presentation at AAIC Today AUSTIN, Texas, July 26, 2021 (GLOBE NEWSWIRE) &#8212; Cassava Sciences, Inc. (Nasdaq: SAVA) today announced positive clinical data with SavaDx, an investigational diagnostic\/biomarker to detect Alzheimer\u2019s disease with a simple blood test. SavaDx was used to measure plasma levels of altered filamin A before and after simufilam treatment in patients with Alzheimer\u2019s disease. In this Phase &hellip; Continue reading &quot;Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-26T12:33:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODI4NjI5MiM0MzEzNjY3IzIwMjc4MTI=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam\",\"datePublished\":\"2021-07-26T12:33:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/\"},\"wordCount\":1163,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODI4NjI5MiM0MzEzNjY3IzIwMjc4MTI=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\\\/\",\"name\":\"Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/cassava-sciences-announces-positive-data-with-savadx-from-a-randomized-controlled-phase-2b-study-of-simufilam\/","og_locale":"en_US","og_type":"article","og_title":"Cassava Sciences Announces Positive Data with SavaDx from a Randomized Controlled Phase 2b Study of Simufilam - Market Newsdesk","og_description":"SavaDx Detected Significant Changes in Plasma Levels of Altered Filamin A in Patients with Alzheimer\u2019s Disease Before and After Simufilam Treatment Simufilam 100 mg and 50 mg Reduced Plasma Levels of Altered Filamin A in Alzheimer\u2019s Patients 48% (p=0.003) and 44% (p=0.02) Respectively Plasma Results with SavaDx Track Plasma Results with p-Tau181 Plasma Data Provide Evidence of Target Engagement Poster Presentation at AAIC Today AUSTIN, Texas, July 26, 2021 (GLOBE NEWSWIRE) &#8212; Cassava Sciences, Inc. (Nasdaq: SAVA) today announced positive clinical data with SavaDx, an investigational diagnostic\/biomarker to detect Alzheimer\u2019s disease with a simple blood test. SavaDx was used to measure plasma levels of altered filamin A before and after simufilam treatment in patients with Alzheimer\u2019s disease. 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