{"id":517303,"date":"2021-07-26T07:03:36","date_gmt":"2021-07-26T11:03:36","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/"},"modified":"2021-07-26T07:03:36","modified_gmt":"2021-07-26T11:03:36","slug":"trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/","title":{"rendered":"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19"},"content":{"rendered":"

\nTRV027 will be dosed in ~300 patients in nationwide trial led by Vanderbilt University Medical Center (VUMC)
\n<\/h2>\n
\n

CHESTERBROOK, Pa., July 26, 2021 (GLOBE NEWSWIRE) — Trevena, Inc. (Nasdaq: TRVN)<\/strong>, a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that the first COVID-19 patient has been enrolled in the NIH-funded ACTIV-4 Host Tissue (Accelerating COVID-19 Therapeutic Interventions and Vaccines) trial.<\/p>\n

\u201cThere is no one solution to end COVID-19, and we are honored to play a role in the global effort to overcome this pandemic and mitigate its long-term impact on our communities,\u201d said Carrie Bourdow, President and CEO of Trevena. \u201cI am excited that patients are now being enrolled in this study and that TRV027 is the one of the first active treatment arms available for patient randomization.\u201d<\/p>\n

The trial, known as ACTIV-4 Host Tissue, is testing four investigational agents that combat dysregulation of the renin-angiotensin-aldosterone system (RAAS) and the immune system caused by a COVID-19 infection. TRV027 is a novel AT1<\/sub> receptor selective agonist that specifically binds to and rebalances AT1<\/sub> receptor activation within the RAAS, blocking the damaging pathway that leads to acute lung damage and abnormal blood clotting, while activating the cellular pathway that selectively targets reparative actions that improve lung function and promote anti-inflammatory effects.<\/p>\n

The trial is enrolling approximately 1,600 patients at over 50 sites in the U.S. TRV027 is part of the initial trial launch, and additional study arms will be added to the trial over time. The study is evaluating the impact of each intervention on recovery, supplemental oxygen use, need for mechanical ventilation, organ failure, and mortality.<\/p>\n

\u201cAs the COVID-19 pandemic continues to evolve, the development of interventions that can combat the vascular, fibrotic, and inflammatory damage done by the coronavirus remains a top priority,\u201d said Sean Collins, M.D., M.Sci., Principal Investigator of the ACTIV-4 Host Tissue trial, Co-Director of the Vanderbilt Coordinating Center and Professor of Emergency Medicine, Vanderbilt University Medical Center. \u201cI am very pleased that we have enrolled our first patient in the ACTIV-4 Host Tissue trial, and I look forward to investigating the potential of TRV027 to modulate the RAAS and improve outcomes for patients hospitalized with COVID-19.\u201d<\/p>\n

\n About ACTIV-4 Host Tissue<\/strong>\n <\/p>\n

This is a multi-site, randomized, placebo-controlled, clinical trial with multiple treatment arms, each enrolling approximately 300-400 COVID-19 patients \u2265 18 years old. Four trial arms are testing investigational agents, including TRV027, that target the RAAS or the immune system through distinct mechanisms of action. The objective of the trial is to determine whether modulation of these systems is an effective strategy for preventing progression to critical illness, multiorgan failure, or mortality in hospitalized COVID-19 patients.<\/p>\n

The trial is funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the NIH.<\/p>\n

\n About the NIH ACTIV Initiative<\/strong>\n <\/p>\n

On April 17, 2020, the National Institutes of Health (NIH) announced the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) public-private partnership to develop a coordinated research strategy for prioritizing and speeding development of the most promising treatments and vaccines.<\/p>\n

Coordinated by the Foundation for the National Institutes of Health (FNIH), ACTIV brings NIH together with its sibling agencies in the Department of Health and Human Services, including the Biomedical Advanced Research and Development Authority (BARDA), Centers for Disease Control and Prevention (CDC), and the U.S. Food and Drug Administration (FDA); other government agencies including the Department of Defense (DOD) and Department of Veterans Affairs (VA); The Operation; the European Medicines Agency (EMA); and representatives from academia, philanthropic organizations, and numerous biopharmaceutical companies.<\/p>\n

For more information about the ACTIV therapeutic trials, including ACTIV-4 Host Tissue, visit the ACTIV website: https:\/\/www.nih.gov\/research-training\/medical-research-initiatives\/activ<\/a>.<\/p>\n

\n About TRV027<\/strong>\n <\/p>\n

TRV027 is a novel AT1<\/sub> receptor selective agonist that is currently being investigated by multiple institutions as a potential treatment for acute lung injury contributing to ARDS and abnormal blood clotting in COVID-19 patients. It has previously been studied in 691 individuals, has a well-characterized pharmacokinetic profile, and has demonstrated efficacy, potency, and selectivity at the AT1<\/sub> receptor in nonclinical studies. In previous clinical trials, there was a low dropout rate associated with TRV027, and no significant safety issues were reported. TRV027 is currently being evaluated in the REMAP-CAP COVID-19 ACE2 RAS Modulation Domain, an international, multi-site, randomized, Phase 2 \/ 3 adaptive clinical trial in hospitalized COVID-19 patients. In April 2021, the Company filed a non-provisional patent application and PCT application with the United States Patent and Trademark Office covering the use of TRV027 to treat ARDS and the prevention or treatment of abnormal clotting in COVID-19 patients.<\/p>\n

\n About Trevena<\/strong>\n <\/p>\n

Trevena, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative medicines for patients with CNS disorders. The Company has one approved product in the United States, OLINVYK\u00ae<\/sup> (oliceridine) injection, indicated in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. The Company\u2019s novel pipeline is based on Nobel Prize winning research and includes four differentiated investigational drug candidates: TRV250 for the acute treatment of migraine, TRV734 for maintenance treatment of opioid use disorder, TRV045 for diabetic neuropathic pain and epilepsy, and TRV027 for acute respiratory distress syndrome and abnormal blood clotting in COVID-19 patients.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

Any statements in this press release about future expectations, plans and prospects for the Company, including statements about the Company\u2019s strategy, future operations, clinical development and trials of its therapeutic candidates, plans for potential future product candidates and other statements containing the words \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201csuggest,\u201d \u201ctarget,\u201d \u201cpotential,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201ccontinue,\u201d and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the status, timing, costs, results and interpretation of the Company\u2019s clinical trials or any future trials of any of the Company\u2019s investigational drug candidates; the uncertainties inherent in conducting clinical trials; expectations for regulatory interactions, submissions and approvals, including the Company\u2019s assessment of the discussions with FDA, the timing of FDA\u2019s decision on the oliceridine NDA; available funding ; uncertainties related to the Company\u2019s intellectual property; uncertainties related to the ongoing COVID-19 pandemic, other matters that could affect the availability or commercial potential of the Company\u2019s therapeutic candidates; and other factors discussed in the Risk Factors set forth in the Company\u2019s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings the Company makes with the SEC from time to time. In addition, the forward-looking statements included in this press release represent the Company\u2019s views only as of the date hereof. The Company anticipates that subsequent events and developments may cause the Company\u2019s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, except as may be required by law.<\/p>\n

\n For more information, please contact:<\/strong><\/p>\n

Investor Contact:<\/strong>
\n
Dan Ferry
Managing Director
LifeSci Advisors, LLC
daniel@lifesciadvisors.com<\/u><\/a>
(617) 430-7576<\/p>\n

\n PR & Media Contact:<\/strong>
\n
Sasha Bennett
Associate Vice President
Clyde Group
Sasha.Bennett@clydegroup.com<\/u><\/a>
(239) 248-3409<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

TRV027 will be dosed in ~300 patients in nationwide trial led by Vanderbilt University Medical Center (VUMC) CHESTERBROOK, Pa., July 26, 2021 (GLOBE NEWSWIRE) — Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that the first COVID-19 patient has been enrolled in the NIH-funded ACTIV-4 Host Tissue (Accelerating COVID-19 Therapeutic Interventions and Vaccines) trial. \u201cThere is no one solution to end COVID-19, and we are honored to play a role in the global effort to overcome this pandemic and mitigate its long-term impact on our communities,\u201d said Carrie Bourdow, President and CEO of Trevena. \u201cI am excited that patients are now being … <\/p>\n

Continue reading “Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-517303","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nTrevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"TRV027 will be dosed in ~300 patients in nationwide trial led by Vanderbilt University Medical Center (VUMC) CHESTERBROOK, Pa., July 26, 2021 (GLOBE NEWSWIRE) — Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that the first COVID-19 patient has been enrolled in the NIH-funded ACTIV-4 Host Tissue (Accelerating COVID-19 Therapeutic Interventions and Vaccines) trial. \u201cThere is no one solution to end COVID-19, and we are honored to play a role in the global effort to overcome this pandemic and mitigate its long-term impact on our communities,\u201d said Carrie Bourdow, President and CEO of Trevena. \u201cI am excited that patients are now being … Continue reading "Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-07-26T11:03:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODI4NjI4NCM0MzEzNjMxIzIwMDUwMzQ=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19\",\"datePublished\":\"2021-07-26T11:03:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/\"},\"wordCount\":1227,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODI4NjI4NCM0MzEzNjMxIzIwMDUwMzQ=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\\\/\",\"name\":\"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19 - 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(Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that the first COVID-19 patient has been enrolled in the NIH-funded ACTIV-4 Host Tissue (Accelerating COVID-19 Therapeutic Interventions and Vaccines) trial. \u201cThere is no one solution to end COVID-19, and we are honored to play a role in the global effort to overcome this pandemic and mitigate its long-term impact on our communities,\u201d said Carrie Bourdow, President and CEO of Trevena. \u201cI am excited that patients are now being … Continue reading \"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/","og_site_name":"Market Newsdesk","article_published_time":"2021-07-26T11:03:36+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODI4NjI4NCM0MzEzNjMxIzIwMDUwMzQ=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19","datePublished":"2021-07-26T11:03:36+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/"},"wordCount":1227,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODI4NjI4NCM0MzEzNjMxIzIwMDUwMzQ=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/trevena-announces-first-patient-enrolled-in-nih-funded-activ-4-host-tissue-trial-of-trv027-for-covid-19\/","name":"Trevena Announces First Patient Enrolled in NIH-Funded ACTIV-4 Host Tissue Trial of TRV027 for COVID-19 - 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