{"id":505545,"date":"2021-06-22T09:58:09","date_gmt":"2021-06-22T13:58:09","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/adc-therapeutics-announces-encouraging-interim-results-from-pivotal-phase-2-clinical-trial-of-camidanlumab-tesirine-cami-presented-at-the-16th-annual-international-conference-on-malignant-lymphoma\/"},"modified":"2021-06-22T09:58:09","modified_gmt":"2021-06-22T13:58:09","slug":"adc-therapeutics-announces-encouraging-interim-results-from-pivotal-phase-2-clinical-trial-of-camidanlumab-tesirine-cami-presented-at-the-16th-annual-international-conference-on-malignant-lymphoma","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/adc-therapeutics-announces-encouraging-interim-results-from-pivotal-phase-2-clinical-trial-of-camidanlumab-tesirine-cami-presented-at-the-16th-annual-international-conference-on-malignant-lymphoma\/","title":{"rendered":"ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }\n.bwlistdisc { list-style-type: disc }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16<sup>th<\/sup> Annual International Conference on Malignant Lymphoma<\/b><\/p>\n<p class=\"bwalignc\"><i>Phase 2 dosing schedule results in encouraging overall response rate and long-lasting treatment effects in heavily pre-treated patients with relapsed or refractory Hodgkin lymphoma<\/i><\/p>\n<p class=\"bwalignc\"><i>Phase 2 safety profile, including incidence of GBS, consistent with Phase 1<\/i><\/p>\n<p>LAUSANNE, Switzerland&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nADC Therapeutics SA (NYSE: ADCT), a commercial-stage biotechnology company leading the development of novel antibody drug conjugates (ADCs) to treat hematological malignancies and solid tumors, announced today that updated interim results from the ongoing pivotal Phase 2 clinical trial of camidanlumab tesirine (Cami) in patients with relapsed or refractory Hodgkin lymphoma were presented in an oral presentation (Abstract 075) at the 16<sup>th<\/sup> Annual International Conference on Malignant Lymphoma (ICML). The pivotal Phase 2 study is intended to support the submission of a Biologics License Application.\n<\/p>\n<p>\n\u201cThe interim results from our ongoing pivotal Phase 2 trial of Cami as a single agent for patients with relapsed or refractory Hodgkin lymphoma demonstrate that a significant number of patients experience long-lasting treatment effects,\u201d said Jay Feingold, MD, PhD, Senior Vice President and Chief Medical Officer of ADC Therapeutics. \u201cIn Phase 2, we used the optimal Phase 1 dosing schedule based on activity and tolerability, and we are encouraged by the interim data that show the median duration of response has not been reached. We also note that the incidence of GBS in Phase 2 is consistent with Phase 1. We look forward to providing future updates on this pivotal program as the overall response rate and duration of response data continue to mature.\u201d\n<\/p>\n<p>\nCami is being evaluated in a multicenter, open-label, single-arm Phase 2 clinical trial in 117 patients with relapsed or refractory Hodgkin lymphoma who have received \u22653 prior lines of treatment (\u22652 lines if ineligible for hematopoietic stem cell transplantation, HSCT), including prior treatment with brentuximab vedotin and a checkpoint inhibitor. The interim data cut includes 101 evaluable patients who had been in the study a median of 5.1 months. Patients were heavily pretreated with a median of 6 prior lines of systemic therapy.\n<\/p>\n<p>\nKey data presented at ICML by Pier Luigi Zinzani, MD, PhD, IRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia &#8220;Ser\u00e0gnoli&#8221;, and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Universit\u00e0 di Bologna, Bologna, Italy, include:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nOverall response rate (ORR) was 66.3% (67\/101 patients) with a complete response rate (CRR) of 27.7% and partial response rate (PRR) of 38.6%\n<\/li>\n<li>\nMedian duration of response has not been reached\n<\/li>\n<li>\nNo new safety signals have been identified and the most common grade \u22653 treatment-emergent adverse events in \u22655% of patients were hypophosphatemia (7.7%), maculopapular rash (6.8%), thrombocytopenia (6.8%), anemia (6.0%) and lymphopenia (6.0%)\n<\/li>\n<li>\nTo date, nine patients (7.7%) were able to proceed to HSCT following Cami treatment\n<\/li>\n<li>\n7\/117 patients (6.0%) developed Guillain-Barre syndrome\/Polyradiculopathy (consistent with the incidence in the Phase 1 Hodgkin lymphoma patients)\n<\/li>\n<\/ul>\n<p>\n\u201cPatients with relapsed or refractory Hodgkin lymphoma who have failed several lines of previous therapy such as brentuximab vedotin and PD-1 blockade have limited treatment options,\u201d said Dr. Zinzani. \u201cThe antitumor activity and safety profile of Cami continues to demonstrate that this novel CD25-targeted ADC has the potential to address the unmet need in heavily pre-treated patients.\u201d\n<\/p>\n<p><b>About Camidanlumab Tesirine (Cami)<\/b><\/p>\n<p>\nCamidanlumab tesirine (Cami, formerly ADCT-301) is an antibody drug conjugate (ADC) comprised of a monoclonal antibody that binds to CD25 (HuMax<sup>\u00ae<\/sup>-TAC, licensed from Genmab A\/S), conjugated to the pyrrolobenzodiazepine (PBD) dimer payload, tesirine. Once bound to a CD25-expressing cell, Cami is internalized into the cell where enzymes release the PBD-based payload, killing the cell. This applies to CD25-expressing tumor cells and also to CD25-expressing Tregs. The intra-tumoral release of its PBD payload may also cause bystander killing of neighboring tumor cells, and PBDs have also been shown to induce immunogenic cell death. All of these properties of Cami may enhance immune-mediated anti-tumor activity.\n<\/p>\n<p>\nCami is being evaluated in a pivotal Phase 2 clinical trial in patients with relapsed or refractory Hodgkin lymphoma and a Phase 1b clinical trial as monotherapy and in combination with pembrolizumab in solid tumors.\n<\/p>\n<p><b>About ADC Therapeutics<\/b><\/p>\n<p>\nADC Therapeutics (NYSE: ADCT) is a commercial-stage biotechnology company improving the lives of cancer patients with its next-generation, targeted antibody drug conjugates (ADCs). The Company is advancing its proprietary PBD-based ADC technology to transform the treatment paradigm for patients with hematologic malignancies and solid tumors.\n<\/p>\n<p>\nADC Therapeutics\u2019 CD19-directed ADC ZYNLONTA\u2122 (loncastuximab tesirine-lpyl) is approved by the FDA for the treatment of relapsed or refractory diffuse large B-cell lymphoma after two or more lines of systemic therapy. ZYNLONTA is also in late-stage clinical trials in combination with other agents. Cami (camidanlumab tesirine) is being evaluated in a late-stage clinical trial for relapsed or refractory Hodgkin lymphoma and in a Phase 1b clinical trial for various advanced solid tumors. In addition to ZYNLONTA and Cami, the Company has multiple PBD-based ADCs in ongoing clinical and preclinical development.\n<\/p>\n<p>\nADC Therapeutics is based in Lausanne (Biop\u00f4le), Switzerland and has operations in London, the San Francisco Bay Area and New Jersey. For more information, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fadctherapeutics.com%2F&amp;esheet=52449140&amp;newsitemid=20210622005355&amp;lan=en-US&amp;anchor=https%3A%2F%2Fadctherapeutics.com%2F&amp;index=1&amp;md5=e4febf05bef8d0e8f578734bdab90f2e\">https:\/\/adctherapeutics.com\/<\/a> and follow the Company on <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2Fadctherapeutics&amp;esheet=52449140&amp;newsitemid=20210622005355&amp;lan=en-US&amp;anchor=Twitter&amp;index=2&amp;md5=21dc9dbae5c7040066bbe06a8d125aef\">Twitter<\/a> and <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fadc-therapeutics%2F&amp;esheet=52449140&amp;newsitemid=20210622005355&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=3&amp;md5=d1a20dd452f9379b8e0368d0fa8cc861\">LinkedIn<\/a>.\n<\/p>\n<p>\nZYNLONTA\u2122 is a trademark of ADC Therapeutics SA.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210622005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20210622005355\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20210622005355\/en\/<\/a><\/span><\/p>\n<p><strong>Investors<br \/>\n<\/strong><br \/>Eugenia Litz<br \/>\n<br \/>ADC Therapeutics<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:Eugenia.Litz@adctherapeutics.com\">Eugenia.Litz@adctherapeutics.com<br \/>\n<\/a><br \/>+44 7879 627205\n<\/p>\n<p>\nAmanda Hamilton<br \/>\n<br \/>ADC Therapeutics<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:amanda.hamilton@adctherapeutics.com\">amanda.hamilton@adctherapeutics.com<br \/>\n<\/a><br \/>+1 917-288-7023\n<\/p>\n<p><strong>EU Media<br \/>\n<\/strong><br \/>Alexandre M\u00fcller<br \/>\n<br \/>Dynamics Group<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:amu@dynamicsgroup.ch\">amu@dynamicsgroup.ch<br \/>\n<\/a><br \/>+41 (0) 43 268 3231\n<\/p>\n<p><strong>USA Media<br \/>\n<\/strong><br \/>Annie Starr<br \/>\n<br \/>6 Degrees<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:astarr@6degreespr.com\">astarr@6degreespr.com<br \/>\n<\/a><br \/>+1 973-768-2170\n<\/p>\n<p><b>KEYWORDS:<\/b> Europe Switzerland United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Science Biotechnology Research Pharmaceutical Oncology General Health Health Clinical Trials<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20210622005355\/en\/886761\/3\/ADCT_4C_TM.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma Phase 2 dosing schedule results in encouraging overall response rate and long-lasting treatment effects in heavily pre-treated patients with relapsed or refractory Hodgkin lymphoma Phase 2 safety profile, including incidence of GBS, consistent with Phase 1 LAUSANNE, Switzerland&#8211;(BUSINESS WIRE)&#8211; ADC Therapeutics SA (NYSE: ADCT), a commercial-stage biotechnology company leading the development of novel antibody drug conjugates (ADCs) to treat hematological malignancies and solid tumors, announced today that updated interim results from the ongoing pivotal Phase 2 clinical trial of camidanlumab tesirine (Cami) in patients with relapsed or refractory Hodgkin lymphoma were presented in an &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/adc-therapeutics-announces-encouraging-interim-results-from-pivotal-phase-2-clinical-trial-of-camidanlumab-tesirine-cami-presented-at-the-16th-annual-international-conference-on-malignant-lymphoma\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-505545","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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patients with relapsed or refractory Hodgkin lymphoma Phase 2 safety profile, including incidence of GBS, consistent with Phase 1 LAUSANNE, Switzerland&#8211;(BUSINESS WIRE)&#8211; ADC Therapeutics SA (NYSE: ADCT), a commercial-stage biotechnology company leading the development of novel antibody drug conjugates (ADCs) to treat hematological malignancies and solid tumors, announced today that updated interim results from the ongoing pivotal Phase 2 clinical trial of camidanlumab tesirine (Cami) in patients with relapsed or refractory Hodgkin lymphoma were presented in an &hellip; Continue reading &quot;ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma&quot;\" \/>\n<meta property=\"og:url\" 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Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma Phase 2 dosing schedule results in encouraging overall response rate and long-lasting treatment effects in heavily pre-treated patients with relapsed or refractory Hodgkin lymphoma Phase 2 safety profile, including incidence of GBS, consistent with Phase 1 LAUSANNE, Switzerland&#8211;(BUSINESS WIRE)&#8211; ADC Therapeutics SA (NYSE: ADCT), a commercial-stage biotechnology company leading the development of novel antibody drug conjugates (ADCs) to treat hematological malignancies and solid tumors, announced today that updated interim results from the ongoing pivotal Phase 2 clinical trial of camidanlumab tesirine (Cami) in patients with relapsed or refractory Hodgkin lymphoma were presented in an &hellip; Continue reading \"ADC Therapeutics Announces Encouraging Interim Results from Pivotal Phase 2 Clinical Trial of Camidanlumab Tesirine (Cami) Presented at the 16th Annual International Conference on Malignant Lymphoma\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/adc-therapeutics-announces-encouraging-interim-results-from-pivotal-phase-2-clinical-trial-of-camidanlumab-tesirine-cami-presented-at-the-16th-annual-international-conference-on-malignant-lymphoma\/","og_site_name":"Market Newsdesk","article_published_time":"2021-06-22T13:58:09+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210622005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 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