{"id":498990,"date":"2021-05-26T09:05:01","date_gmt":"2021-05-26T13:05:01","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/"},"modified":"2021-05-26T09:05:01","modified_gmt":"2021-05-26T13:05:01","slug":"glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/","title":{"rendered":"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation<\/b><\/p>\n<p class=\"bwalignc\"><i>Clinicians at Washington University in St. Louis Enroll Trial\u2019s First Patient at Siteman Cancer Center<\/i><\/p>\n<p>ROCKVILLE, Md.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nGlycoMimetics, Inc. (Nasdaq: GLYC) announced today that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial (IST) evaluating uproleselan as a prophylactic agent to reduce gastrointestinal (GI) toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation (auto-HCT) for multiple myeloma (MM). Dr. Keith Stockerl-Goldstein, M.D., Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine, is the clinical trial\u2019s principal investigator.\n<\/p>\n<p>\n\u201cGI side effects are the dose-limiting toxicities of high-dose melphalan in autologous hematopoietic stem-cell transplantation. Preclinical data have demonstrated a protective effect of uproleselan against mucosal damage and, in the GlycoMimetics Phase 2 trial reported at the American Society of Hematology (ASH) meeting in 2018, uproleselan demonstrated the potential to mitigate severe mucositis in relapsed and refractory acute myeloid leukemia (AML) patients undergoing intensive chemotherapy,\u201d said Eric J. Feldman, M.D., GlycoMimetics\u2019 Chief Medical Officer. \u201cWith this background, Washington University clinicians at Siteman Cancer Center will be the first to look closely at the potential of uproleselan to attenuate GI toxicities in multiple myeloma patients undergoing transplant. If this placebo-controlled study demonstrates positive improvements, we believe it will underscore the unique properties of our compound and the potential safety benefits of adding uproleselan to a range of other standard blood cancer therapies where toxicity and durability of response are concerns.\u201d\n<\/p>\n<p><b>About the Phase 2 Study<\/b><\/p>\n<p>\nThe study led by Washington University is a Phase 2, single-center, randomized, double-blind, and placebo-controlled IST designed to evaluate whether prophylactic uproleselan plus standard of care (SOC) compared to placebo plus SOC can reduce diarrhea severity in patients receiving high-dose melphalan conditioning in preparation for auto-HCT in MM. Clinicians will observe for oral mucositis severity and other GI toxicities as secondary endpoints. Exploratory endpoints will also assess minimal residual disease at 100 days post-HCT; soluble E-selectin levels at pre-dose and post-conditioning time points; progression free survival; and overall survival.\n<\/p>\n<p>\nEligible patients undergoing first auto-HCT with melphalan conditioning (200mg\/m<sup>2<\/sup>) for MM will be randomized in a 1:1 allocation to receive either prophylactic uproleselan plus SOC or placebo plus SOC. Randomization will be stratified by age \u226565 years and &lt;65 years, due to increased frequency of GI toxicity in elderly populations. GlycoMimetics anticipates a data readout from the trial in mid-2022.\n<\/p>\n<p>\nSiteman Cancer Center, based at Barnes-Jewish Hospital and Washington University School of Medicine, is a top-ranked National Cancer Institute (NCI)-designated Comprehensive Cancer Center and recently received the NCI\u2019s highest possible rating of \u201cExceptional\u201d for its research programs.\n<\/p>\n<p><b>About Uproleselan <\/b><\/p>\n<p>\nDiscovered and developed by GlycoMimetics, uproleselan is an investigational, first-in-class, targeted antagonist of E-selectin. Uproleselan (yoo\u2019 pro le\u2019 sel an), currently in a comprehensive Phase 3 development program in AML, has received Breakthrough Therapy designation from the U.S. Food and Drug Administration and the Chinese Health authority for the treatment of adult AML patients with relapsed or refractory disease. Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance\n<\/p>\n<p><b>About GlycoMimetics, Inc.<\/b><\/p>\n<p>\nGlycoMimetics is a clinical-stage biotechnology company discovering and developing glycobiology-based therapies for cancers, including acute myeloid leukemia (AML) and breast cancer, and inflammatory diseases with high unmet need. Our science is based on an understanding of the role that carbohydrates play on the surface of every living cell and applying our specialized chemistry platform to discover small molecule drugs, known as glycomimetics, that alter these carbohydrate-mediated pathways in a variety of disease states, including signaling in cancer and inflammation. As a leader in this space, we are leveraging this unique targeted approach to advance our pipeline of wholly owned drug candidates, with the goal of developing transformative therapies for serious diseases. Our leading drug candidate, uproleselan, has received Breakthrough Therapy Designation in the U.S. and China and is undergoing evaluation across a range of patient populations, including a Phase 3 trial in relapsed\/refractory AML. GlycoMimetics is located in Rockville, MD in the BioHealth Capital Region. Learn more at <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.glycomimetics.com&amp;esheet=52435434&amp;newsitemid=20210526005159&amp;lan=en-US&amp;anchor=www.glycomimetics.com&amp;index=1&amp;md5=2c8e7f60cbe4d8a93b1e6c977bdafa7e\">www.glycomimetics.com<\/a>.\n<\/p>\n<p><b>Forward-Looking Statements <\/b><\/p>\n<p>\nThis press release contains forward-looking statements. These forward-looking statements include those relating to the planned or potential clinical development of the Company\u2019s product candidates, as well as the presentation of data from preclinical studies and clinical trials and the potential benefits and impact of the Company\u2019s drug candidates. Actual results may differ materially from those described in these forward-looking statements. For a further description of the risks associated with these statements, as well as other risks facing GlycoMimetics, please see the risk factors described in the Company\u2019s annual report on Form 10-K filed with the U.S. Securities and Exchange Commission (SEC) on February 28, 2021, and other filings GlycoMimetics makes with the SEC from time to time. Forward-looking statements speak only as of the date of this release, and GlycoMimetics undertakes no obligation to update or revise these statements, except as may be required by law.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210526005159r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20210526005159\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20210526005159\/en\/<\/a><\/span><\/p>\n<p>\nInvestor Contact:<br \/>\n<br \/>Shari Annes<br \/>\n<br \/>Phone: 650-888-0902<br \/>\n<br \/>Email: <a rel=\"nofollow\" href=\"mailto:sannes@annesassociates.com\">sannes@annesassociates.com<\/a><\/p>\n<p>\nMedia Contact:<br \/>\n<br \/>Jamie Lacey-Moreira<br \/>\n<br \/>Phone: 410-299-3310<br \/>\n<br \/>Email: <a rel=\"nofollow\" href=\"mailto:jamielacey@presscommpr.com\">jamielacey@presscommpr.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> Missouri Maryland United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Oncology Health Stem Cells Clinical Trials Pharmaceutical Biotechnology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20210526005159\/en\/881002\/3\/Glyco-logo.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation Clinicians at Washington University in St. Louis Enroll Trial\u2019s First Patient at Siteman Cancer Center ROCKVILLE, Md.&#8211;(BUSINESS WIRE)&#8211; GlycoMimetics, Inc. (Nasdaq: GLYC) announced today that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial (IST) evaluating uproleselan as a prophylactic agent to reduce gastrointestinal (GI) toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation (auto-HCT) for multiple myeloma (MM). Dr. Keith Stockerl-Goldstein, M.D., Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine, is the clinical trial\u2019s principal investigator. \u201cGI side effects are the &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-498990","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation Clinicians at Washington University in St. Louis Enroll Trial\u2019s First Patient at Siteman Cancer Center ROCKVILLE, Md.&#8211;(BUSINESS WIRE)&#8211; GlycoMimetics, Inc. (Nasdaq: GLYC) announced today that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial (IST) evaluating uproleselan as a prophylactic agent to reduce gastrointestinal (GI) toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation (auto-HCT) for multiple myeloma (MM). Dr. Keith Stockerl-Goldstein, M.D., Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine, is the clinical trial\u2019s principal investigator. \u201cGI side effects are the &hellip; Continue reading &quot;GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-26T13:05:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210526005159r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation\",\"datePublished\":\"2021-05-26T13:05:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/\"},\"wordCount\":938,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210526005159r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\\\/\",\"name\":\"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/","og_locale":"en_US","og_type":"article","og_title":"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation - Market Newsdesk","og_description":"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation Clinicians at Washington University in St. Louis Enroll Trial\u2019s First Patient at Siteman Cancer Center ROCKVILLE, Md.&#8211;(BUSINESS WIRE)&#8211; GlycoMimetics, Inc. (Nasdaq: GLYC) announced today that clinicians at Washington University School of Medicine in St. Louis have dosed the first patient in an investigator-sponsored trial (IST) evaluating uproleselan as a prophylactic agent to reduce gastrointestinal (GI) toxicities associated with high-dose melphalan in autologous hematopoietic cell transplantation (auto-HCT) for multiple myeloma (MM). Dr. Keith Stockerl-Goldstein, M.D., Professor of Medicine, Division of Oncology, Section of Bone Marrow Transplantation, Washington University School of Medicine, is the clinical trial\u2019s principal investigator. \u201cGI side effects are the &hellip; Continue reading \"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/","og_site_name":"Market Newsdesk","article_published_time":"2021-05-26T13:05:01+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210526005159r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation","datePublished":"2021-05-26T13:05:01+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/"},"wordCount":938,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210526005159r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/glycomimetics-announces-investigator-sponsored-phase-2-clinical-trial-evaluating-uproleselan-for-prevention-of-gastro-intestinal-toxicity-in-autologous-hematopoietic-cell-transplantation\/","name":"GlycoMimetics Announces Investigator-Sponsored Phase 2 Clinical Trial Evaluating Uproleselan for Prevention of Gastro-Intestinal Toxicity in Autologous Hematopoietic Cell Transplantation - 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