\nBicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle\u00ae<\/i>) technology, today announced that for the first time, preclinical work describing the discovery of BT7480, a novel Nectin-4\/CD137 tumor-targeted immune cell agonist (TICATM<\/sup>), will be presented virtually in a \u201cNew Drugs on the Horizon\u201d session at the American Association for Cancer Research (AACR) Annual Meeting, taking place April 10-15, 2021. Additional work covering TICAs and Bicycle<\/i> Toxin Conjugates\u00ae (BTCs), will also be covered in a late-breaking mini-symposium, as well as in five e-posters.\n<\/p>\n
\n\u201cOur TICA platform has made significant progress, and we are thrilled to present information about the discovery of BT7480, as well as preclinical data across multiple programs in our immuno-oncology pipeline,\u201d said Nicholas Keen, Ph.D., Chief Scientific Officer of Bicycle Therapeutics. \u201cThese presentations highlight the potential utility of Bicycle<\/i>-based therapeutic candidates for treating multiple tumor types via diverse mechanisms as we pursue our goal of improving the treatment paradigm for patients with cancer.\u201d\n<\/p>\n
Bicycle <\/i>TICAs are potent, fully synthetic compounds that represent an immuno-oncology approach engineered to overcome the limitations of other immunomodulatory mechanisms. Bicycles <\/i>are small, structurally constrained peptides discovered via phage display and optimized using structure-driven design and medicinal chemistry approaches. Bicycle has applied this disruptive technology by identifying CD137 Bicycles<\/i> and chemically linking these to tumor antigen binding Bicycles<\/i> to generate multifunctional molecules that induce tumor antigen-dependent, tumor-localized agonism of CD137. Bicycle expects BT7480 to enter the clinic in the second half of 2021.\n<\/p>\n
\nDetails on Bicycle\u2019s presentations and posters at AACR are as follows:\n<\/p>\n
Poster Title:<\/b> Molecular-based enrichment strategy for Nectin-4 targeted Bicycle<\/i> toxin conjugate BT8009
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Abstract #:<\/b> 391
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Session, Date and Time<\/b>: Biomarkers Predictive of Therapeutic Benefit, April 10, 8:30 AM\n<\/p>\n
Poster Title:<\/b> Nectin-4-dependent immune cell stimulation and anti-tumor efficacy by BT7480, a Nectin-4\/CD137 Bicycle<\/i>\u00ae tumor-targeted immune cell agonist (TICA\u2122)
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Poster #:<\/b> 1728
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Session, Date and Time:<\/b> Immunomodulatory Agents and Interventions, April 10, 8:30 AM\n<\/p>\n
Poster Title:<\/b> Microinjection of Nectin-4\/CD137 tumor-targeted immune cell agonist (TICA\u2122) activates the local tumor microenvironment
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Poster #:<\/b> 1724
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Session, Date and Time:<\/b> Immunomodulatory Agents and Interventions, April 10, 8:30 AM\n<\/p>\n
Poster Title:<\/b> A multi tumor survey of Nectin-4 expression to guide BT8009 indication selection
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Poster #:<\/b> 1197
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Session, Date and Time:<\/b> Molecular Classification of Tumors for Diagnostics, Prognostics, and Therapeutic Outcomes, April 10, 8:30 AM\n<\/p>\n
Poster Title:<\/b> Rapid Accumulation of Cytotoxic Payload in Tumor Tissue Drives BT5528 Activity in Tumor Models
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Poster #:<\/b> 1319
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Session, Date and Time:<\/b> Novel Drug Delivery Systems, April 10, 8:30 AM\n<\/p>\n
Presentation Title:<\/b> BT7480, a novel Nectin-4 dependent agonist of the immune cell costimulatory receptor CD137
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Session, Date and Time:<\/b> New Drugs on the Horizon: Part 1, April 10, 1:30 \u2013 3:15 OM, Channel 1\n<\/p>\n
Presentation Title:<\/b> Integrative surfaceome profiling identifies immunotherapeutic targets in osteosarcoma and preclinical testing of BT1769, an MT1-MMP-targeted Bicycle<\/i>\u00ae toxin conjugate, in osteosarcoma by the Pediatric Preclinical Testing Consortium (PPTC)
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Session, Date and Time:<\/b> Late-Breaking Mini-symposium 2, April 12, 1:35 \u2013 1:45 OM, Channel 7\n<\/p>\n
\nThe posters will be available on the Publications section of bicycletherapeutics.com<\/span> following each session.\n<\/p>\n About Bicycle Therapeutics<\/b><\/p>\n \nBicycle Therapeutics (NASDAQ: BCYC) is a clinical-stage biopharmaceutical company developing a novel class of medicines, referred to as Bicycles, for diseases that are underserved by existing therapeutics. Bicycles are fully synthetic short peptides constrained with small molecule scaffolds to form two loops that stabilize their structural geometry. This constraint facilitates target binding with high affinity and selectivity, making Bicycles attractive candidates for drug development. Bicycle\u2019s lead product candidate, BT1718, a Bicycle<\/i> Toxin Conjugate (BTC) that targets MT1-MMP, is being investigated in an ongoing Phase I\/IIa clinical trial in collaboration with the Centre for Drug Development of Cancer Research UK. Bicycle is also evaluating BT5528, a second-generation BTC targeting EphA2, in a company-sponsored Phase I\/II trial. BT8009 is a BTC targeting Nectin-4, a well-validated tumor antigen, and is also currently being evaluated in a Company-sponsored Phase I\/II trial. Bicycle is headquartered in Cambridge, UK with many key functions and members of its leadership team located in Lexington, MA. For more information, visit bicycletherapeutics.com.\n<\/p>\n Forward-Looking Statements<\/b><\/p>\n \nThis press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as \u201caims,\u201d \u201canticipates,\u201d \u201cbelieves,\u201d \u201ccould,\u201d \u201cestimates,\u201d \u201cexpects,\u201d \u201cforecasts,\u201d \u201cgoal,\u201d \u201cintends,\u201d \u201cmay,\u201d \u201cplans,\u201d \u201cpossible,\u201d \u201cpotential,\u201d \u201cseeks,\u201d \u201cwill\u201d and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements regarding Bicycle\u2019s anticipated initiation of a clinical trial of BT7480 and the therapeutic potential of Bicycle\u2019s pre-clinical targets and product candidates. Bicycle may not actually achieve the plans, intentions or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: risks to Bicycle\u2019s and its collaboration partners\u2019 abilities to meet anticipated deadlines and milestones presented by the ongoing COVID-19 pandemic; uncertainties inherent in the initiation and completion of preclinical studies and clinical trials and clinical development of Bicycle\u2019s product candidates by Bicycle or its collaboration partners; the risk that Bicycle or its collaboration partners may not realize the intended benefits of Bicycle\u2019s technology; availability and timing of results from preclinical studies and clinical trials; whether the outcomes of preclinical studies will be predictive of clinical trial results; whether initial or interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; the risk that studies and trials may be delayed and may not have satisfactory outcomes; potential adverse effects arising from the testing or use of Bicycle\u2019s product candidates; risks related to Bicycle\u2019s ability to maintain existing collaborations and realize the benefits thereof; expectations for regulatory approvals to conduct trials or to market products; and other important factors, any of which could cause Bicycle\u2019s actual results to differ from those contained in the forward-looking statements, and which are described in greater detail in the section entitled \u201cRisk Factors\u201d in Bicycle\u2019s Annual Report on Form 10-K filed with the Securities and Exchange Commission (SEC) on March 11, 2021, as well as in other filings Bicycle may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Bicycle expressly disclaims any obligation to update any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise, except as otherwise required by law.\n<\/p>\n View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210410005015\/en\/<\/a><\/span><\/p>\n<\/p>\n