{"id":474027,"date":"2021-04-09T01:33:26","date_gmt":"2021-04-09T05:33:26","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=474027"},"modified":"2021-04-09T01:33:26","modified_gmt":"2021-04-09T05:33:26","slug":"transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/","title":{"rendered":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses"},"content":{"rendered":"<p>        <!--.bwlistdisc { list-style-type: disc }\n.bwuline { text-decoration: underline }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p><b>Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses<\/b><\/p>\n<p>\n&#8211; <i>Detailed results to be presented at AACR 2021 Annual Congress<br \/>\n<br \/><\/i>&#8211; <i>Intravenous administration could allow oncolytic viruses from Transgene\u2019s Invir.IO\u2122 platform to be used to treat a broad range of solid tumors<\/i><\/p>\n<p>STRASBOURG, France&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nRegulatory News:\n<\/p>\n<p><b>Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, today announces initial promising results from a Phase I study combining intravenous (IV) oncolytic virus TG6002 and oral 5-FC in patients with advanced gastrointestinal carcinomas. These data provide a clinical proof of concept for Transgene\u2019s double deleted VV<sub>cop<\/sub>TK<sup>&#8211;<\/sup>RR<sup>&#8211;<\/sup> patented virus backbone: after IV administration, TG6002 reached the tumor, multiplied within tumor cells, and induced the local expression of its payload (the <i>FCU1<\/i> gene). <\/b><\/p>\n<p><b>These results will be presented at the American Association for Cancer Research (AACR) virtual meeting taking place from April 10-15, 2021. <\/b><\/p>\n<p><b>DATA CONFIRM THAT THE CHEMOTHERAPY AGENT 5-FU IS PRODUCED IN PATIENTS\u2019 TUMORS AFTER INTRAVENOUS ADMINISTRATION<\/b><\/p>\n<p><b>TG6002 is a novel oncolytic virus that has been engineered to combine multiple mechanisms of action<\/b>. It has been designed to:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nselectively replicate within cancer cells. This is due to the deletion of the viral genes encoding TK and RR, which reduces the virus\u2019s ability to grow in normal cells. This selective viral replication leads to the breakdown of the infected tumor cells in a process called oncolysis,\n<\/li>\n<li>\nprime an immune response against the primary tumor and metastases,\n<\/li>\n<li>\nand to induce the local expression of a biologically active enzyme able to convert 5-FC into its active cytotoxic metabolite 5-FU, directly in the tumor.\n<\/li>\n<\/ul>\n<p><b>The data demonstrate that high concentration and continuous production of 5-FU chemotherapy can be obtained within the tumors through the local conversion of the pro-drug 5-FC<\/b> (administered orally). This mechanism of action is based on the in-tumor expression of the proprietary <i>FCU1<\/i> gene that has been integrated within the genome of TG6002.\n<\/p>\n<p><b>In this study, extensive analyses are being performed<\/b> including metastasis biopsy with synchronous blood sampling, assessment of virus presence, quantification of 5-FC and 5-FU and assessment of neutralizing antibody titers.\n<\/p>\n<p>\nThese analyses have allowed Transgene to document TG6002\u2019s pharmacokinetics (PK) and biodistribution, and the functioning of the <i>FCU1<\/i> gene when given by IV administration.\n<\/p>\n<p><b>Detailed results:<\/b><\/p>\n<p>\n\u2714 TG6002 infects tumors after intravenous administration, remains active and effectively express <i>FCU1<\/i> gene selectively in tumor tissue;<br \/>\n<br \/>\u2714 Absence of widespread virus distribution in the body and association of FCU1 activity with high virus concentration in tumor tissue suggest that the replication of TG6002 is concentrated in tumor cells;<br \/>\n<br \/>\u2714 None of the patients presented clinical signs of extra-tumoral dissemination of the virus suggesting a high tumor specificity of the viral replication;<br \/>\n<br \/>\u2714 The study is continuing with escalating dosing of TG6002.\n<\/p>\n<p><b>CLINICAL PROOF OF CONCEPT OF THE FEASIBILITY OF THE IV ADMINISTRATION OF TRANSGENE\u2019S PROPRIETARY ONCOLYTIC VIRUS <\/b><\/p>\n<p><b>To-date, the only oncolytic virus that has received regulatory approval is only approved for intra-tumoral administration, restricting its use to superficial lesions.<\/b><\/p>\n<p><b>Transgene aims to enlarge the number of solid tumors, such as gastro-intestinal tumors, that could be addressed by an oncolytic virus, by developing oncolytics that can be administered intravenously. <\/b><\/p>\n<p>\nThe findings that will be presented at AACR demonstrate the relevance of intravenous administration of Transgene\u2019s next generation oncolytic viruses including TG6002.\n<\/p>\n<p><b>These data also suggest that candidates derived from Transgene\u2019s unique Invir.IO\u2122 platform could also be given intravenously, extending the use of these therapies to a broad range of solid tumors.<\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li><b>Title of the poster: <\/b>\u201cOncolytic virus TG6002 locates to tumors after intravenous infusion and induces tumor-specific expression of a functional pro-drug activating enzyme in patients with advanced gastrointestinal carcinomas\u201d\n<\/li>\n<li><b>Authors<\/b>: Kaidre Bendjama, Philippe Cassier, Victor Moreno, Bernard Doger, Emiliano Calvo, Maria De Miguel, Christiane Jungels, Philippe Erbs, Damien Carpentier, Alain Sadoun.\n<\/li>\n<li><b>Abstract\/Poster Number<\/b>: LB179\n<\/li>\n<li><b>Session<\/b>: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.abstractsonline.com%2Fpp8%2F%23%21%2F9325%2Fsession%2F699&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=PO.IM02.11+-+Vaccines&amp;index=1&amp;md5=be84199ecdfeb68e1ecf67c0bc636b9f\">PO.IM02.11 &#8211; Vaccines<\/a><\/li>\n<\/ul>\n<p>\nThe e-poster presentation will be available on the AACR website beginning at 8:30 am US EDT on Saturday, April 10, until Monday, June 21. The text of this abstract will be posted at 12:01 am US EDT on Friday, April 9 on the AACR website.\n<\/p>\n<p><b><i>About the trial (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fclinicaltrials.gov%2Fct2%2Fshow%2FNCT03724071&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=NCT03724071&amp;index=2&amp;md5=56b1ac095c366ee882dc5fd738e973da\">NCT03724071<\/a>)<br \/>\n<br \/><\/i><\/b>This trial is a single-arm open-label Phase I\/II trial evaluating the safety and tolerability of multiple ascending doses of TG6002 administered intravenously in combination with oral 5-FC, a non-cytotoxic pro-drug that can be converted in 5-FU, its active metabolite. Based on the safety profile of TG6002, several dose levels have been added to the initial Phase I clinical protocol. At the end of this Phase I part, Phase II patients will receive the recommended dose of TG6002. The trial has safety as primary endpoint for the Phase I part and efficacy for the Phase II part. The trial also evaluates pharmacokinetic properties and biodistribution of TG6002, along with immune modulation of the tumor micro-environment. This European study will enroll up to 40 patients suffering from advanced gastrointestinal carcinomas who have failed and\/or are intolerant to standard therapeutic options in the Phase I part. Patients with colon cancer and liver metastases will be enrolled in the Phase II part.\n<\/p>\n<p>\nDr. Philippe Cassier, M.D., PhD, head of the early-phase trials unit at Centre L\u00e9on B\u00e9rard (Lyon, France) is the principal investigator of the trial.\n<\/p>\n<p><b><i>About TG6002<br \/>\n<br \/><\/i><\/b>TG6002 has been engineered to directly kill cancer cells (oncolysis), to enable the production of a chemotherapy agent (5-FU) within the tumor, and to elicit an immune response by the body against the tumor cells. In preclinical experiments, TG6002 has been shown to induce the shrinkage of the primary tumor as well as the regression of distant metastases (Foloppe, et al., <i>Molecular Therapy Oncolytics<\/i>, <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.omto.2019.03.005&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=https%3A%2F%2Fdoi.org%2F10.1016%2Fj.omto.2019.03.005&amp;index=3&amp;md5=104c91a41b3f8576f841b1e759982e87\">https:\/\/doi.org\/10.1016\/j.omto.2019.03.005<\/a>).\n<\/p>\n<p>\nThe production of 5-FU directly in the tumor aims to achieve a better anti-tumoral effect with limited chemotherapy-induced side effects.\n<\/p>\n<p>\nTG6002 induces the production of 5-FU in the cancer cells it has infected, by enabling the local conversion of the pro-drug 5-FC (administered orally) into 5-FU. 5-FU is a common chemotherapy agent for patients with gastro-intestinal cancers. This mechanism of action is based on the in-tumor expression of the proprietary FCU1 gene that has been encoded in the genome of TG6002, taking advantage of the virus selective replication in the tumor cells.\n<\/p>\n<p>\nWhen administered systemically, 5-FU is associated with side effects that can lead to treatment discontinuation. With TG6002, 5-FU is produced within the tumor where it is expected to be present at a high concentration level in contrast to the very low levels anticipated in the rest of the patient\u2019s body.\n<\/p>\n<p><b><i>About Transgene<br \/>\n<br \/><\/i><\/b>Transgene (Euronext: TNG) is a biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. Transgene\u2019s programs utilize viral vector technology with the goal of indirectly or directly killing cancer cells.<br \/>\n<br \/>The Company\u2019s clinical-stage programs consist of two therapeutic vaccines (TG4001 for the treatment of HPV-positive cancers, and TG4050, the first individualized therapeutic vaccine based on the <i>myvac<\/i>\u00ae platform) as well as two oncolytic viruses (TG6002 for the treatment of solid tumors, and BT-001, the first oncolytic virus based on the Invir.IO\u2122 platform).<br \/>\n<br \/>With Transgene\u2019s <i>myvac<\/i>\u00ae platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The <i>myvac<\/i>\u00ae approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.<br \/>\n<br \/>With its proprietary platform Invir.IO\u2122, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses. Transgene has an ongoing Invir.IO\u2122 collaboration with AstraZeneca.<br \/>\n<br \/>Additional information about Transgene is available at: <span class=\"bwuline\"><a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.transgene.fr&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=www.transgene.fr&amp;index=4&amp;md5=70727cc5c2678f7396e95fc6ebb3a5ed\">www.transgene.fr<br \/>\n<\/a><br \/><\/span>Follow us on Twitter: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2Ftransgenesa&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=%40TransgeneSA&amp;index=5&amp;md5=3a6c297198c9eeee12d3acf2c78eeaad\">@TransgeneSA<\/a><\/p>\n<p><b><i>Disclaimer<br \/>\n<br \/><\/i><\/b><i>This press release contains forward-looking statements, which are subject to numerous risks and uncertainties, which could cause actual results to differ materially from those anticipated. The occurrence of any of these risks could have a significant negative outcome for the Company\u2019s activities, perspectives, financial situation, results, regulatory authorities\u2019 agreement with development phases, and development. The Company\u2019s ability to commercialize its products depends on but is not limited to the following factors: positive pre-clinical data may not be predictive of human clinical results, the success of clinical studies, the ability to obtain financing and\/or partnerships for product manufacturing, development and commercialization, and marketing approval by government regulatory authorities. For a discussion of risks and uncertainties which could cause the Company\u2019s actual results, financial condition, performance or achievements to differ from those contained in the forward-looking statements, please refer to the Risk Factors (\u201cFacteurs de Risque\u201d) section of the Universal Registration Document, available on the AMF website (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.amf-france.org&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=http%3A%2F%2Fwww.amf-france.org&amp;index=6&amp;md5=376f67fffb3be0a6d1a92bfc2df57201\">http:\/\/www.amf-france.org<\/a>) or on Transgene\u2019s website (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.transgene.fr&amp;esheet=52408761&amp;newsitemid=20210408005698&amp;lan=en-US&amp;anchor=www.transgene.fr&amp;index=7&amp;md5=b0888e0a4b04a75fa93746149c90cd44\">www.transgene.fr<\/a>). Forward-looking statements speak only as of the date on which they are made, and Transgene undertakes no obligation to update these forward-looking statements, even if new information becomes available in the future.<\/i><\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20210408005698\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20210408005698\/en\/<\/a><\/span><\/p>\n<p><b>Transgene:<br \/>\n<\/b><br \/><b>Lucie Larguier<br \/>\n<\/b><br \/>Director Corporate Communications &amp; IR<br \/>\n<br \/>+33 (0)3 88 27 91 04<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investorrelations@transgene.fr\">investorrelations@transgene.fr<\/a><\/p>\n<p><b>Media: Citigate Dewe Rogerson<br \/>\n<\/b><br \/><b>David Dible\/Sylvie Berrebi<br \/>\n<\/b><br \/>+ 44 (0)20 7638 9571<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:transgene@citigatedewerogerson.com\">transgene@citigatedewerogerson.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> Europe United States North America France<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Research Genetics Clinical Trials Stem Cells Other Health Biotechnology Pharmaceutical Health Science Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\" \/>\n","protected":false},"excerpt":{"rendered":"<p>Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses &#8211; Detailed results to be presented at AACR 2021 Annual Congress &#8211; Intravenous administration could allow oncolytic viruses from Transgene\u2019s Invir.IO\u2122 platform to be used to treat a broad range of solid tumors STRASBOURG, France&#8211;(BUSINESS WIRE)&#8211; Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, today announces initial promising results from a Phase I study combining intravenous (IV) oncolytic virus TG6002 and oral 5-FC in patients with advanced gastrointestinal carcinomas. These data provide a clinical proof of concept for Transgene\u2019s double deleted VVcopTK&#8211;RR&#8211; patented virus backbone: after IV administration, TG6002 reached the &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-474027","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses &#8211; Detailed results to be presented at AACR 2021 Annual Congress &#8211; Intravenous administration could allow oncolytic viruses from Transgene\u2019s Invir.IO\u2122 platform to be used to treat a broad range of solid tumors STRASBOURG, France&#8211;(BUSINESS WIRE)&#8211; Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, today announces initial promising results from a Phase I study combining intravenous (IV) oncolytic virus TG6002 and oral 5-FC in patients with advanced gastrointestinal carcinomas. These data provide a clinical proof of concept for Transgene\u2019s double deleted VVcopTK&#8211;RR&#8211; patented virus backbone: after IV administration, TG6002 reached the &hellip; Continue reading &quot;Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-04-09T05:33:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses\",\"datePublished\":\"2021-04-09T05:33:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/\"},\"wordCount\":1566,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/\",\"name\":\"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"datePublished\":\"2021-04-09T05:33:26+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#primaryimage\",\"url\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"contentUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#website\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/\",\"name\":\"Market Newsdesk\",\"description\":\"Latest Business News in Real Time\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\",\"name\":\"Newsdesk\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g\",\"caption\":\"Newsdesk\"},\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/author\\\/newsdesk\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/","og_locale":"en_US","og_type":"article","og_title":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk","og_description":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses &#8211; Detailed results to be presented at AACR 2021 Annual Congress &#8211; Intravenous administration could allow oncolytic viruses from Transgene\u2019s Invir.IO\u2122 platform to be used to treat a broad range of solid tumors STRASBOURG, France&#8211;(BUSINESS WIRE)&#8211; Regulatory News: Transgene (Paris:TNG) (Euronext Paris: TNG), a biotech company that designs and develops virus-based immunotherapeutics against cancer, today announces initial promising results from a Phase I study combining intravenous (IV) oncolytic virus TG6002 and oral 5-FC in patients with advanced gastrointestinal carcinomas. These data provide a clinical proof of concept for Transgene\u2019s double deleted VVcopTK&#8211;RR&#8211; patented virus backbone: after IV administration, TG6002 reached the &hellip; Continue reading \"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/","og_site_name":"Market Newsdesk","article_published_time":"2021-04-09T05:33:26+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses","datePublished":"2021-04-09T05:33:26+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/"},"wordCount":1566,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/","name":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses - Market Newsdesk","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#primaryimage"},"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","datePublished":"2021-04-09T05:33:26+00:00","author":{"@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"breadcrumb":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#primaryimage","url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","contentUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210408005698r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en"},{"@type":"BreadcrumbList","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/transgene-presents-initial-phase-i-data-of-tg6002-highlighting-the-potential-of-the-intravenous-administration-of-its-oncolytic-viruses\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.marketnewsdesk.com\/"},{"@type":"ListItem","position":2,"name":"Transgene Presents Initial Phase I Data of TG6002, Highlighting the Potential of the Intravenous Administration of Its Oncolytic Viruses"}]},{"@type":"WebSite","@id":"https:\/\/www.marketnewsdesk.com\/#website","url":"https:\/\/www.marketnewsdesk.com\/","name":"Market Newsdesk","description":"Latest Business News in Real Time","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.marketnewsdesk.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979","name":"Newsdesk","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a0d0bd5b0f0ca12a265a459b13169dac35f33776d8501eda5e68844a366f2f46?s=96&d=mm&r=g","caption":"Newsdesk"},"url":"https:\/\/www.marketnewsdesk.com\/index.php\/author\/newsdesk\/"}]}},"_links":{"self":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/474027","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/comments?post=474027"}],"version-history":[{"count":0,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/posts\/474027\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/media?parent=474027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/categories?post=474027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.marketnewsdesk.com\/index.php\/wp-json\/wp\/v2\/tags?post=474027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}