{"id":464650,"date":"2021-03-24T17:03:22","date_gmt":"2021-03-24T21:03:22","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=464650"},"modified":"2021-03-24T17:03:22","modified_gmt":"2021-03-24T21:03:22","slug":"genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\/","title":{"rendered":"Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China"},"content":{"rendered":"

<\/p>\n

Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China<\/b><\/p>\n

HCCscreenTM<\/sup> achieved 88% sensitivity and 93% specificity, compared with 71% and 95%, respectively, by ultrasound plus AFP.<\/i><\/p>\n

In early-stage patients, the sensitivities of HCCscreenTM<\/sup> are 85% (tumor size of <3cm) and 96% (3-5 cm).<\/i><\/p>\n

The Company plans to initiate an NMPA registrational trial in China in Q2 2021.<\/i><\/p>\n

Management team will discuss the data at the upcoming March 25, 2021 earnings conference call.<\/i><\/p>\n

BEIJING–(BUSINESS WIRE<\/a>)–
\nGenetron Holdings Limited (\u201cGenetron Health\u201d or the \u201cCompany\u201d, NASDAQ:GTH), a leading precision oncology platform company in China that specializes in molecular profiling tests, early cancer screening products and companion diagnostics development, today presented new data and results for HCCscreenTM<\/sup>, a blood-based early screening test for hepatocellular carcinoma (\u201cHCC\u201d).\n<\/p>\n

\nThis multi-center prospective study, named the \u201cH<\/b>CCscreenTM<\/sup>I<\/b>nvestigational St<\/b>udy\u201d (HIT<\/b>), is a collaboration between Genetron Health and the National Cancer Center China that started in 2019. Among a total of 1,615 HBsAg+ individuals that completed the follow-up phase by February 2021, the primary outcome showed that HCCscreenTM<\/sup> achieved 88% sensitivity and 93% specificity, compared with 71% sensitivity and 95% specificity, respectively, by ultrasound plus alpha-fetoprotein (AFP) combined. HCCscreenTM<\/sup> also achieved 40.9% positive predictive value (PPV) and 99.3% negative predictive value (NPV). The study results are summarized in the following tables:\n<\/p>\n

\nTable 1. HIT Results: Genetron HCCscreenTM<\/sup> Final Analysis (N=1615)\n<\/p>\n\n\n\n\n\n\n\n
\n

HCCscreenTM<\/sup> Test<\/b><\/p>\n<\/td>\n

\n\n

HCC<\/b><\/p>\n<\/td>\n

\n\n

Non-HCC<\/b><\/p>\n<\/td>\n

\n\n

Total<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Positive\n<\/p>\n<\/td>\n

\n\n

\n76\n<\/p>\n<\/td>\n

\n\n

\n110\n<\/p>\n<\/td>\n

\n\n

\n186\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Negative\n<\/p>\n<\/td>\n

\n\n

\n10\n<\/p>\n<\/td>\n

\n\n

\n1,419\n<\/p>\n<\/td>\n

\n\n

\n1,429\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTotal\n<\/p>\n<\/td>\n

\n\n

\n86\n<\/p>\n<\/td>\n

\n\n

\n1,529\n<\/p>\n<\/td>\n

\n\n

\n1,615\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSensitivity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n88% (80%, 94%)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSpecificity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n93% (91%, 94%)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\nTable 2. HIT Results: Ultrasound + AFP Final Analysis (N=1615)\n<\/p>\n\n\n\n\n\n\n\n
\n

Ultrasound + AFP<\/b><\/p>\n<\/td>\n

\n\n

HCC<\/b><\/p>\n<\/td>\n

\n\n

Non-HCC<\/b><\/p>\n<\/td>\n

\n\n

Total<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Positive\n<\/p>\n<\/td>\n

\n\n

\n61\n<\/p>\n<\/td>\n

\n\n

\n83\n<\/p>\n<\/td>\n

\n\n

\n144\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Negative\n<\/p>\n<\/td>\n

\n\n

\n25\n<\/p>\n<\/td>\n

\n\n

\n1,446\n<\/p>\n<\/td>\n

\n\n

\n1471\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTotal\n<\/p>\n<\/td>\n

\n\n

\n86\n<\/p>\n<\/td>\n

\n\n

\n1,529\n<\/p>\n<\/td>\n

\n\n

\n1615\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSensitivity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n71% (60%, 80%)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSpecificity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n95% (93%, 96%)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\nFurthermore, stratified by tumor size, 49% (28\/57) of the cases identified by HCCscreenTM<\/sup> were in early stage, i.e. <3cm. These patients are expected to have much better prognosis than advanced stage ones. Additionally, HCCscreenTM<\/sup> achieved sensitivities of 85% for tumor sizes of <3cm, 96% for 3-5cm, and 88% for >5cm. The results are summarized in the following table:\n<\/p>\n

\nTable 3. HIT Results: Genetron HCCscreenTM <\/sup>Sensitivities by Tumor Size\n<\/p>\n\n\n\n\n\n\n\n
\n\n\n

Tumor Size (N=64)<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

HCCscreenTM<\/sup> Test<\/b><\/p>\n<\/td>\n

\n\n

<3cm<\/b><\/p>\n<\/td>\n

\n\n

3-5cm<\/b><\/p>\n<\/td>\n

\n\n

>5cm<\/b><\/p>\n<\/td>\n

\n\n

Total<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\nTest Positive\n<\/p>\n<\/td>\n

\n\n

\n28\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n22\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n7\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n57\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTest Negative\n<\/p>\n<\/td>\n

\n\n

\n5\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n1\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n1\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n7\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTotal\n<\/p>\n<\/td>\n

\n\n

\n33\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n23\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n8\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n64\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSensitivity\n<\/p>\n<\/td>\n

\n\n

\n85%\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n96%\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n88%\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\nPreviously, Genetron Health reported preliminary analysis results from the first 297 patients enrolled in the study. Compared with the preliminary results, the confidence interval of sensitivity had improved from 62%-100% to 80%-94%, and the confidence interval of specificity had improved from 89%-96% to 91%-94%. The preliminary study results are summarized in the following table:\n<\/p>\n

\nTable 4. HIT Results: Genetron HCCscreenTM <\/sup>Preliminary Data (N=297)\n<\/p>\n\n\n\n\n\n\n\n
\n

HCCscreenTM<\/sup> Test<\/b><\/p>\n<\/td>\n

\n\n

HCC<\/b><\/p>\n<\/td>\n

\n\n

Non-HCC<\/b><\/p>\n<\/td>\n

\n\n

Total<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Positive\n<\/p>\n<\/td>\n

\n\n

\n11\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n20\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n31\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTest – Negative\n<\/p>\n<\/td>\n

\n\n

\n1\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n265\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n266\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nTotal\n<\/p>\n<\/td>\n

\n\n

\n12\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n285\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n297\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSensitivity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n92% (62%, 100%)\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

\nSpecificity (95% CI)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n93% (89%, 96%)\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\n\u201cWe are very pleased with the new HCCscreenTM<\/sup> data from this large, prospective cohort study, which showed overall better sensitivity data, and comparable specificity data versus the standard of care. These additional validation updates gave us more confidence about our assay\u2019s performance, and we will move forward to initiate an NMPA registrational study in the second quarter of this year,\u201d said Mr. Sizhen Wang, co-founder and CEO of Genetron Health. \u201cOverall, HCCscreenTM<\/sup> continues to be a leading liquid-biopsy early detection assay in hepatocellular carcinoma. We are delighted with our clinical and commercial progress to bring this product to more patients, and address an unmet, significant medical need in China.\u201d\n<\/p>\n

About HCCscreenTM <\/sup>and Liver Cancer<\/b><\/p>\n

\nIn September 2020, Genetron Health received the U.S. Food and Drug Administration (\u201cFDA\u201d)\u2019s Breakthrough Device designation for HCCscreenTM<\/sup>, and the product has been commercialized recently as a lab developed test (\u201cLDT\u201d) in China.\n<\/p>\n

\nGlobally, liver cancer is the fourth most common cause of cancer-related death and the sixth in terms of incidence1<\/sup>. China represents the largest market, accounting for almost half of the global incidences. New incidence in China was estimated to be around 393,000 per year, with 369,000 deaths2<\/sup>. Market data by Frost and Sullivan estimated that as of 2019, among the 120 million high risk liver cancer population in China, around 74 million were HBV carriers.\n<\/p>\n

\nHCCscreenTM<\/sup> is powered by Genetron Health\u2019s innovative and proprietary Mutation CapsuleTM<\/sup> technology, which enables detection of multiple methylation alterations in parallel with mutations in cell-free DNA from peripheral blood specimens.\n<\/p>\n

\nReferences:\n<\/p>\n

    \n
  1. \nVillanueva, A. Hepatocellular Carcinoma. N. Engl. J. Med. 2019, 380, 1450\u20131462.\n<\/li>\n
  2. \nGlobocan 2018. https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a>. Information on this website is not incorporated into this update and should not be considered part of this update. We have included any website as an inactive textual reference only.\n<\/li>\n<\/ol>\n

    About Genetron Holdings Limited<\/b><\/p>\n

    \nGenetron Holdings Limited (\u201cGenetron Health\u201d or the \u201cCompany\u201d) (Nasdaq:GTH) is a leading precision oncology platform company in China that specializes in cancer molecular profiling and harnesses advanced technologies in molecular biology and data science to transform cancer treatment. The Company has developed a comprehensive oncology portfolio that covers the entire spectrum of cancer management, addressing needs and challenges from early screening, diagnosis and treatment recommendations, as well as continuous disease monitoring and care. Genetron Health also partners with global biopharmaceutical companies and offers customized services and products. For more information, please visit ir.genetronhealth.com.\n<\/p>\n

    Safe Harbor Statement <\/b><\/p>\n

    \nThis press release contains forward-looking statements. These statements are made under the \u201csafe harbor\u201d provisions of the U.S. Private Securities Litigation Reform Act of 1995. Statements that are not historical facts, including statements about the Company\u2019s beliefs and expectations and prospectus of and plans for commercializing HCCscreenTM<\/sup> in China, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties, and a number of factors could cause actual results to differ materially from those contained in any forward-looking statement. In some cases, forward-looking statements can be identified by words or phrases such as \u201cmay\u201d, \u201cwill,\u201d \u201cexpect,\u201d \u201canticipate,\u201d \u201ctarget,\u201d \u201caim,\u201d \u201cestimate,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cbelieve,\u201d \u201cpotential,\u201d \u201ccontinue,\u201d \u201cis\/are likely to\u201d or other similar expressions. Further information regarding these and other risks, uncertainties or factors is included in the Company\u2019s filings with the SEC. All information provided in this press release is as of the date of this press release, and the Company does not undertake any duty to update such information, except as required under applicable law.\n<\/p>\n

    \"\"<\/p>\n

    View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210324005932\/en\/<\/a><\/span><\/p>\n

    Investor Relations Contact
    \n<\/strong>
    US:
    \n<\/span>
    Hoki Luk
    \n
    Head of Investor Relations
    \n
    Email:     hoki.luk@genetronhealth.com
    \n<\/a>
    Phone: +1 (408) 891-9255\n<\/p>\n

    \nDavid Deuchler, CFA
    \n
    Managing Director | Gilmartin Group
    \n
    ir@genetronhealth.com<\/a><\/p>\n

    Media Relations Contact
    \n<\/strong>
    Yanrong Zhao
    \n
    Genetron Health
    \n
    yanrong.zhao@genetronhealth.com<\/a><\/p>\n

    \nEdmond Lococo
    \n
    ICR
    \n
    Edmond.Lococo@icrinc.com
    \n<\/a>
    Mobile: +86 138-1079-1408
    \n
    genetron.pr@icrinc.com<\/a><\/p>\n

    KEYWORDS:<\/b> China Asia Pacific<\/p>\n

    INDUSTRY KEYWORDS:<\/b> Biotechnology Health Oncology Medical Devices<\/p>\n

    MEDIA:<\/b><\/p>\n\n","protected":false},"excerpt":{"rendered":"

    Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China HCCscreenTM achieved 88% sensitivity and 93% specificity, compared with 71% and 95%, respectively, by ultrasound plus AFP. In early-stage patients, the sensitivities of HCCscreenTM are 85% (tumor size of <3cm) and 96% (3-5 cm). The Company plans to initiate an NMPA registrational trial in China in Q2 2021. Management team will discuss the data at the upcoming March 25, 2021 earnings conference call. BEIJING–(BUSINESS WIRE)– Genetron Holdings Limited (\u201cGenetron Health\u201d or the \u201cCompany\u201d, NASDAQ:GTH), a leading precision oncology platform company in China that specializes in molecular profiling tests, early cancer screening products and companion diagnostics development, today presented new data and results for HCCscreenTM, a … <\/p>\n

    Continue reading “Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-464650","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nGenetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China HCCscreenTM achieved 88% sensitivity and 93% specificity, compared with 71% and 95%, respectively, by ultrasound plus AFP. In early-stage patients, the sensitivities of HCCscreenTM are 85% (tumor size of <3cm) and 96% (3-5 cm). The Company plans to initiate an NMPA registrational trial in China in Q2 2021. Management team will discuss the data at the upcoming March 25, 2021 earnings conference call. BEIJING–(BUSINESS WIRE)– Genetron Holdings Limited (\u201cGenetron Health\u201d or the \u201cCompany\u201d, NASDAQ:GTH), a leading precision oncology platform company in China that specializes in molecular profiling tests, early cancer screening products and companion diagnostics development, today presented new data and results for HCCscreenTM, a … Continue reading "Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-24T21:03:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&sty=20210324005932r1&sid=flmnd&distro=nx&lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China\",\"datePublished\":\"2021-03-24T21:03:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/\"},\"wordCount\":1076,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&sty=20210324005932r1&sid=flmnd&distro=nx&lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/genetron-health-releases-new-data-results-of-hccscreen-for-liver-cancer-early-screening-in-china\\\/\",\"name\":\"Genetron Health Releases New Data Results of HCCscreen\u2122 for Liver Cancer Early Screening in China - 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In early-stage patients, the sensitivities of HCCscreenTM are 85% (tumor size of <3cm) and 96% (3-5 cm). The Company plans to initiate an NMPA registrational trial in China in Q2 2021. Management team will discuss the data at the upcoming March 25, 2021 earnings conference call. 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