{"id":461072,"date":"2021-03-18T16:08:13","date_gmt":"2021-03-18T20:08:13","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=461072"},"modified":"2021-03-18T16:08:13","modified_gmt":"2021-03-18T20:08:13","slug":"sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\/","title":{"rendered":"Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights"},"content":{"rendered":"
\n

CAMBRIDGE, Mass., March 18, 2021 (GLOBE NEWSWIRE) — Sigilon Therapeutics, Inc. (NASDAQ:SGTX), a biotechnology company that seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics\u2122 platform, today reported financial results for the fourth quarter and full year ended December 31, 2020 as well as certain other business highlights.<\/p>\n

\u201c2020 was a transformational period for Sigilon marked by the achievement of numerous key regulatory, clinical, and financial milestones, which we believe have positioned us to deliver on our commitments over the next several years,\u201d commented Rogerio Vivaldi, M.D., Chief Executive Officer of Sigilon. \u201cThe modularity of our Shielded Living Therapeutics\u2122 platform has enabled us to build a robust pipeline spanning a diverse range of chronic disorders, including rare blood, lysosomal and endocrine diseases. Notably, in 2020, our lead product candidate SIG-001 received IND and CTA clearance and we dosed the first patients in our Phase 1 \/2 safety and dose-ranging study in severe to moderate-severe hemophilia A\u2014a significant milestone for both our platform technology and the hemophilia community.\u201d<\/p>\n

Continued Dr. Vivaldi: \u201cWhile our immediate priority is developing SIG-001, looking ahead, we are also leveraging our platform to advance several additional candidates\u2014including SIG-005 for MPS-1, SIG-007 for Fabry disease and SIG-002 for Type 1 Diabetes\u2014into the clinic over the next two years. Having successfully completed an upsized Initial Public Offering in December, which attracted a breadth of healthcare specialists and long-term focused shareholders, we are well-positioned to execute across each of these initiatives as we work to provide functional cures for patients.\u201d<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n Recent Program Highlights<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\nIn the fourth quarter, the Company dosed the first two patients in its Phase 1\/2 safety and dose-ranging study with SIG-001 in severe to moderate-severe hemophilia A. No serious adverse events have been reported. At the initial dose levels for this study, tested in the first two patients, the Company has observed FVIII activity levels in the low- to mid-single digits.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\nAs dose levels increase, Sigilon initiated planned manufacturing changes in the first quarter of 2021 designed to, among other things, increase cell potency and enhance cell function. The Company has filed amendments to its CTA and IND for SIG-001 with the MHRA and FDA, respectively, to incorporate these changes.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\nIn December 2020, the FDA granted Orphan Drug designation to SIG-005 for the treatment of mucopolysaccharidosis type I (MPS-1), a chronic, progressive lysosomal disease.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\nFour scientific abstracts outlining several ongoing preclinical studies in a range of lysosomal diseases were selected for presentation \u2013 including an oral presentation on mucopolysaccharidosis type II (MPS-2) \u2013 at the 17th<\/sup> Annual WORLDSymposium<\/em>\u2122. In all these preclinical studies, platform cells produced high levels of biochemically active enzyme having characteristics nearly identical to the enzyme replacement therapies. Significant reduction in substrates across tissues were observed.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\nIn March 2021, the FDA granted Orphan Drug designation for SIG-007 for the treatment of Fabry disease, which is also a progressive, life-threatening lysosomal disease.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Corporate Updates<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022\u00a0<\/td>\nIn December 2020, the Company raised $144.9 million in gross proceeds from an initial public offering of 8,050,000 shares of common stock at a public offering price of $18.00 per share.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022\u00a0<\/td>\nDevyn Smith, Ph.D., will step down as Chief Operating Officer of Sigilon, effective on April 26, 2021, to assume a CEO role within the biotech industry.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Anticipated Milestones<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022\u00a0<\/td>\nThe Company is planning to file a CTA and\/or IND for MPS-1 in the second quarter of 2021 and anticipates additional regulatory filings before the end of 2022.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022\u00a0<\/td>\nPhase 1\/2 safety and dose-ranging study of SIG-001 in severe to moderate-severe hemophilia:<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2022<\/td>\nSigilon expects to disclose up to 9 months of follow up data for 3-4 patients in the third quarter of 2021; and<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2022<\/td>\nSigilon expects to complete enrollment of the study in the second half of 2021.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Financial Results<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\n\n Cash Position: <\/strong>Cash was $202.2 million as of December 31, 2020.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\n\n R&D Expenses:<\/strong> Research and development expenses were $14.3 million for the fourth quarter of 2020 compared to $15.0 million for the fourth quarter of 2019. For the full year of 2020, research and development expenses were $53.5 million compared to $48.1 million for the same period in 2019. The increase in research and development expenses as compared to the prior year period was related to increased costs associated with Sigilon\u2019s lead programs, increased costs associated with platform and pipeline development, an increase in personnel expenses costs due to headcount additions and an increase in stock-based compensation associated with stock option\u00a0grants.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\n\n G&A Expenses:<\/strong> General and administrative expenses were $3.5 million for the fourth quarter of 2020 compared to $2.9 million for the fourth quarter of 2019. For the full year of 2020, general and administrative expenses were $12.5 million compared to $10.2 million for the same period in 2019. The increase in general and administrative expenses as compared to the prior year period was primarily driven by an increase in professional fees and insurance costs that are primarily due to the costs of operating as a public company, an increase in personnel related costs due to increased headcount and an increase in stock-based compensation associated with stock option\u00a0grants.<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u2022<\/td>\n\n Net Loss:<\/strong> Net loss was $15.2 million for the quarter ended December 31, 2020 compared to $14.7 million for the same period of 2019. For the full year 2020, Sigilon reported a net loss of $54.6\u00a0million, compared to a net loss of $43.9 million for the full year 2019.<\/td>\n<\/tr>\n<\/table>\n

\n About Sigilon Therapeutics<\/strong>
\n \n <\/p>\n

Sigilon Therapeutics seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics\u2122 platform. Sigilon\u2019s product candidates are non-viral engineered cell-based therapies designed to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, lysosomal disorders and diabetes. The engineered cells are protected by Sigilon\u2019s Afibromer\u2122 biomaterials matrix, which shields them from immune rejection and fibrosis. Sigilon was founded by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

This press release includes forward-looking statements. These forward-looking statements generally can be identified by the use of words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201ccould,\u201d \u201cmay,\u201d \u201cwill,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cforecast,\u201d \u201cgoal,\u201d \u201cproject,\u201d and other words of similar meaning. These forward-looking statements address various matters, including the effect of manufacturing changes on cell potency and cell function, the timing for the submission of INDs or CTAs for MPS-1 and other product candidates and the timing for patient enrollment and dosing, disclosure of data and the completion of our Phase 1\/2 clinical study of SIG-001 in Hemophilia A. Each forward-looking statement contained in this press release is subject to risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statement. Applicable risks and uncertainties include, among others, those related to our clinical and preclinical research, product candidates, the enrollment and timeline for our clinical trials and the regulatory filings related thereto, and the risks identified under the heading \u201cRisk Factors\u201d in our Prospectus filed with the Securities and Exchange Commission on December 7, 2020, as well as the other information we file with the SEC. We caution investors not to place considerable reliance on the forward-looking statements contained in this press release. You are encouraged to read our filings with the SEC, available at www.sec.gov<\/a>, for a discussion of these and other risks and uncertainties. The forward-looking statements in this press release speak only as of the date of this document, and we undertake no obligation to update or revise any of these statements.\u00a0 Our business is subject to substantial risks and uncertainties, including those referenced above. Investors, potential investors, and others should give careful consideration to these risks and uncertainties.<\/p>\n

\n
\n
\n <\/strong>\n <\/p>\n

\n Sigilon Therapeutics, Inc.<\/strong>
\n
\n Condensed Consolidated Balance Sheets<\/strong>
\n
\n (in thousands, except share and per share amounts)<\/strong>
\n
\n (Unaudited)<\/strong>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/td>\n\n December\u00a031,\u00a0<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n\u00a0\u00a0\u00a0\u00a0<\/td>\n\n 2019<\/strong>\n <\/td>\n<\/tr>\n
\n Assets<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Current assets:<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Cash<\/td>\n$<\/td>\n202,229<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n76,069<\/td>\n\u00a0<\/td>\n<\/tr>\n
Accounts receivable<\/td>\n\u00a0<\/td>\n177<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n136<\/td>\n\u00a0<\/td>\n<\/tr>\n
Prepaid expenses and other current assets<\/td>\n\u00a0<\/td>\n1,729<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n732<\/td>\n\u00a0<\/td>\n<\/tr>\n
Restricted cash\u2014current<\/td>\n\u00a0<\/td>\n75<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n<\/tr>\n
Total current assets<\/td>\n\u00a0<\/td>\n204,210<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n76,937<\/td>\n\u00a0<\/td>\n<\/tr>\n
Deferred offering costs<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n65<\/td>\n\u00a0<\/td>\n<\/tr>\n
Property and equipment, net<\/td>\n\u00a0<\/td>\n2,991<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n2,949<\/td>\n\u00a0<\/td>\n<\/tr>\n
Right\u2011of\u2011use assets<\/td>\n\u00a0<\/td>\n16,731<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n9,851<\/td>\n\u00a0<\/td>\n<\/tr>\n
Restricted cash<\/td>\n\u00a0<\/td>\n1,118<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n576<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Total assets<\/strong>\n <\/td>\n$<\/td>\n225,050<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n90,378<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Liabilities, convertible preferred stock and stockholders\u2019 equity (deficit)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Current liabilities:<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Accounts payable<\/td>\n$<\/td>\n1,988<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n2,005<\/td>\n\u00a0<\/td>\n<\/tr>\n
Accrued expenses and other current liabilities<\/td>\n\u00a0<\/td>\n7,892<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n5,852<\/td>\n\u00a0<\/td>\n<\/tr>\n
Lease liabilities, current portion<\/td>\n\u00a0<\/td>\n5,361<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n3,378<\/td>\n\u00a0<\/td>\n<\/tr>\n
Deferred revenue from related party, current portion<\/td>\n\u00a0<\/td>\n31,777<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n29,140<\/td>\n\u00a0<\/td>\n<\/tr>\n
Total current liabilities<\/td>\n\u00a0<\/td>\n47,018<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n40,375<\/td>\n\u00a0<\/td>\n<\/tr>\n
Deferred revenue from related party, net of current portion<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n15,550<\/td>\n\u00a0<\/td>\n<\/tr>\n
Lease liability, net of current portion<\/td>\n\u00a0<\/td>\n11,893<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n6,808<\/td>\n\u00a0<\/td>\n<\/tr>\n
Long\u2011term debt, net of discount<\/td>\n\u00a0<\/td>\n19,807<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n14,868<\/td>\n\u00a0<\/td>\n<\/tr>\n
Preferred stock warrant liability<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n333<\/td>\n\u00a0<\/td>\n<\/tr>\n
Other liabilities<\/td>\n\u00a0<\/td>\n176<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Total liabilities<\/strong>\n <\/td>\n$<\/td>\n78,894<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n77,934<\/td>\n\u00a0<\/td>\n<\/tr>\n
Commitments and contingencies<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Preferred stock, par value $0.001 per share; 25,000,000 and no shares authorized at December\u00a031,\u00a02020 and 2019, respectively; no shares issued and outstanding at December\u00a031,\u00a02020 and\u00a02019<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n<\/tr>\n
Convertible preferred stock (Series A, A\u20111, A\u20113 and B), par value $0.001 per share; no and 35,536,001 shares authorized at December\u00a031,\u00a02020 and 2019, respectively; no and 31,836,001 issued and outstanding at December\u00a031,\u00a02020 and\u00a02019, respectively; liquidation preference of $0 and $90,461 at December\u00a031,\u00a02020 and 2019, respectively<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n90,206<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Stockholders\u2019 equity (deficit)<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Common stock, par value $0.001 per share; 175,000,000 and 60,000,000 shares authorized at December\u00a031,\u00a02020 and December\u00a031,\u00a02019, respectively; 31,464,989 and 5,221,628 shares issued and outstanding at December\u00a031,\u00a02020 and December\u00a031,\u00a02019, respectively<\/td>\n\u00a0<\/td>\n31<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n5<\/td>\n\u00a0<\/td>\n<\/tr>\n
Additional paid\u2011in capital<\/td>\n\u00a0<\/td>\n282,053<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n3,553<\/td>\n\u00a0<\/td>\n<\/tr>\n
Accumulated deficit<\/td>\n\u00a0<\/td>\n(135,928<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(81,320<\/td>\n)<\/td>\n<\/tr>\n
Total stockholders\u2019 equity (deficit)<\/td>\n\u00a0<\/td>\n146,156<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(77,762<\/td>\n)<\/td>\n<\/tr>\n
\n Total liabilities, convertible preferred stock and stockholders\u2019 equity (deficit)<\/strong>\n <\/td>\n$<\/td>\n225,050<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n90,378<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

\n
\n
\n <\/strong>\n <\/p>\n

\n Sigilon Therapeutics, Inc.<\/strong>
\n
\n Condensed Consolidated Statements of Operations and Comprehensive Loss <\/strong>
\n
\n (in thousands, except share and per share amounts)<\/strong>
\n
\n (Unaudited)<\/strong>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/td>\n\n Three Months Ended December\u00a031,\u00a0<\/strong>\n <\/td>\n\u00a0<\/td>\n\n Year Ended December\u00a031,\u00a0<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n\n \u00a0\u00a0\u00a0\u00a0<\/strong>\n <\/td>\n\n 2019<\/strong>\n <\/td>\n\n \u00a0\u00a0\u00a0\u00a0<\/strong>\n <\/td>\n\n 2020<\/strong>\n <\/td>\n\n \u00a0\u00a0\u00a0\u00a0<\/strong>\n <\/td>\n\n 2019<\/strong>\n <\/td>\n<\/tr>\n
Revenue<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Collaboration revenue<\/td>\n$<\/td>\n3,756<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n3,098<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n13,374<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n14,155<\/td>\n\u00a0<\/td>\n<\/tr>\n
Operating expenses:<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Research and development<\/td>\n\u00a0<\/td>\n14,337<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n15,014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n53,488<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n48,108<\/td>\n\u00a0<\/td>\n<\/tr>\n
General and administrative<\/td>\n\u00a0<\/td>\n3,505<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n2,900<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n12,528<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n10,170<\/td>\n\u00a0<\/td>\n<\/tr>\n
Total operating expenses<\/td>\n\u00a0<\/td>\n17,842<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n17,914<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n66,016<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n58,278<\/td>\n\u00a0<\/td>\n<\/tr>\n
Loss from operations<\/td>\n\u00a0<\/td>\n(14,086<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(14,816<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(52,642<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(44,123<\/td>\n)<\/td>\n<\/tr>\n
Other income (expense), net:<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Interest income<\/td>\n\u00a0<\/td>\n44<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n277<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n312<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n1,058<\/td>\n\u00a0<\/td>\n<\/tr>\n
Interest expense<\/td>\n\u00a0<\/td>\n(505<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(188<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(1,202<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(650<\/td>\n)<\/td>\n<\/tr>\n
Other expense<\/td>\n\u00a0<\/td>\n(42<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(89<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(6<\/td>\n)<\/td>\n<\/tr>\n
Change in fair value of preferred stock warrant liability<\/td>\n\u00a0<\/td>\n(600<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(2<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(644<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(204<\/td>\n)<\/td>\n<\/tr>\n
Loss on extinguishment of debt<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(343<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n<\/tr>\n
Total other income (expense), net<\/td>\n\u00a0<\/td>\n(1,103<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n87<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(1,966<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n198<\/td>\n\u00a0<\/td>\n<\/tr>\n
Net loss and comprehensive loss<\/td>\n$<\/td>\n(15,189<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(14,729<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(54,608<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(43,925<\/td>\n)<\/td>\n<\/tr>\n
Net loss per share attributable to common stockholders\u2014basic and diluted<\/td>\n$<\/td>\n(1.15<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(3.17<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(7.55<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(10.74<\/td>\n)<\/td>\n<\/tr>\n
Weighted average common stock outstanding\u2014basic and diluted<\/td>\n\u00a0<\/td>\n13,230,224<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n4,642,290<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n7,229,626<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n4,090,691<\/td>\n\u00a0<\/td>\n<\/tr>\n<\/table>\n

\n
\n
\n <\/strong>\n <\/p>\n

\n Sigilon Therapeutics, Inc.<\/strong>
\n
\n Condensed Consolidated Statements of Cash Flows<\/strong>
\n
\n (in thousands)<\/strong>
\n
\n (Unaudited)<\/strong>\n <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u00a0<\/td>\n\n Year\u00a0Ended\u00a0December\u00a031,\u00a0<\/strong>\n <\/td>\n<\/tr>\n
\u00a0<\/td>\n\n 2020<\/strong>\n <\/td>\n\n \u00a0\u00a0\u00a0\u00a0\u00a0<\/strong>\n <\/td>\n\n 2019<\/strong>
\n \n <\/td>\n<\/tr>\n
\n Cash flows from operating activities:<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Net loss<\/td>\n$<\/td>\n(54,608<\/td>\n)<\/td>\n\u00a0<\/td>\n$<\/td>\n(43,925<\/td>\n)<\/td>\n<\/tr>\n
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Stock-based compensation expense<\/td>\n\u00a0<\/td>\n3,127<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n2,073<\/td>\n\u00a0<\/td>\n<\/tr>\n
Deferred revenue<\/td>\n\u00a0<\/td>\n(12,913<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(13,172<\/td>\n)<\/td>\n<\/tr>\n
Other non-cash expenses, net<\/td>\n\u00a0<\/td>\n5,293<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n2,668<\/td>\n\u00a0<\/td>\n<\/tr>\n
Other changes in assets and liabilities<\/td>\n\u00a0<\/td>\n(2,547<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n2,282<\/td>\n\u00a0<\/td>\n<\/tr>\n
Net cash used in operating activities<\/td>\n\u00a0<\/td>\n(61,648<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(50,074<\/td>\n)<\/td>\n<\/tr>\n
\n Cash flows from investing activities:<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Purchase of property and equipment<\/td>\n\u00a0<\/td>\n(972<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(1,209<\/td>\n)<\/td>\n<\/tr>\n
Net cash used in investing activities<\/td>\n\u00a0<\/td>\n(972<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(1,209<\/td>\n)<\/td>\n<\/tr>\n
\n Cash flows from financing activities:<\/strong>\n <\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0\u00a0<\/td>\n<\/tr>\n
Proceeds from issuance of common stock in connection with the initial public offering, net of underwriting discounts and commissions<\/td>\n\u00a0<\/td>\n132,527<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(65<\/td>\n)<\/td>\n<\/tr>\n
Proceeds from issuance of convertible preferred stock, including deemed dividend, net of issuance costs<\/td>\n\u00a0<\/td>\n51,723<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n53,136<\/td>\n\u00a0<\/td>\n<\/tr>\n
Repayment of debt<\/td>\n\u00a0<\/td>\n(15,000<\/td>\n)<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n(1,000<\/td>\n)<\/td>\n<\/tr>\n
Proceeds from long term debt<\/td>\n\u00a0<\/td>\n19,788<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n11,000<\/td>\n\u00a0<\/td>\n<\/tr>\n
Other financing activities, net<\/td>\n\u00a0<\/td>\n359<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n171<\/td>\n\u00a0<\/td>\n<\/tr>\n
Net cash provided by financing activities<\/td>\n\u00a0<\/td>\n189,397<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n63,242<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Net increase in cash and restricted cash<\/strong>\n <\/td>\n\u00a0<\/td>\n126,777<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n11,959<\/td>\n\u00a0<\/td>\n<\/tr>\n
Cash and restricted cash at beginning of period<\/td>\n\u00a0<\/td>\n76,645<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n64,686<\/td>\n\u00a0<\/td>\n<\/tr>\n
Cash and restricted cash at end of period<\/td>\n$<\/td>\n203,422<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n76,645<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n<\/tr>\n
Cash<\/td>\n$<\/td>\n202,229<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n76,069<\/td>\n\u00a0<\/td>\n<\/tr>\n
Restricted cash-current<\/td>\n\u00a0<\/td>\n75<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u2014<\/td>\n\u00a0<\/td>\n<\/tr>\n
Restricted cash-non-current<\/td>\n\u00a0<\/td>\n1,118<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n576<\/td>\n\u00a0<\/td>\n<\/tr>\n
\n Total cash and restricted cash<\/strong>\n <\/td>\n$<\/td>\n203,422<\/td>\n\u00a0<\/td>\n\u00a0<\/td>\n$<\/td>\n76,645<\/td>\n\u00a0<\/td>\n<\/tr>\n
\u00a0<\/td>\n<\/tr>\n<\/table>\n

\n SOURCE: Sigilon Therapeutics, Inc.<\/strong>\n <\/p>\n

\n Investor Contacts<\/strong>
\n
Glenn Reicin
Sigilon Therapeutics, Chief Financial Officer
glenn.reicin@sigilon.com
646-696-4344<\/p>\n

Jennifer Porcelli
Solebury Trout
jporcelli@soleburytrout.com
646-378-2962<\/p>\n

\n Media Contact<\/strong>
\n
Amy Bonanno
Solebury Trout
abonanno@soleburytrout.com
914-450-0349<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

CAMBRIDGE, Mass., March 18, 2021 (GLOBE NEWSWIRE) — Sigilon Therapeutics, Inc. (NASDAQ:SGTX), a biotechnology company that seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics\u2122 platform, today reported financial results for the fourth quarter and full year ended December 31, 2020 as well as certain other business highlights. \u201c2020 was a transformational period for Sigilon marked by the achievement of numerous key regulatory, clinical, and financial milestones, which we believe have positioned us to deliver on our commitments over the next several years,\u201d commented Rogerio Vivaldi, M.D., Chief Executive Officer of Sigilon. \u201cThe modularity of our Shielded Living Therapeutics\u2122 platform has enabled us to build a robust pipeline spanning a diverse range of chronic disorders, including … <\/p>\n

Continue reading “Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-461072","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"CAMBRIDGE, Mass., March 18, 2021 (GLOBE NEWSWIRE) — Sigilon Therapeutics, Inc. (NASDAQ:SGTX), a biotechnology company that seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics\u2122 platform, today reported financial results for the fourth quarter and full year ended December 31, 2020 as well as certain other business highlights. \u201c2020 was a transformational period for Sigilon marked by the achievement of numerous key regulatory, clinical, and financial milestones, which we believe have positioned us to deliver on our commitments over the next several years,\u201d commented Rogerio Vivaldi, M.D., Chief Executive Officer of Sigilon. \u201cThe modularity of our Shielded Living Therapeutics\u2122 platform has enabled us to build a robust pipeline spanning a diverse range of chronic disorders, including … Continue reading "Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-18T20:08:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE5MjgwOSM0MDcxNTg0IzIxODExMTk=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights\",\"datePublished\":\"2021-03-18T20:08:13+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/\"},\"wordCount\":1754,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODE5MjgwOSM0MDcxNTg0IzIxODExMTk=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/sigilon-therapeutics-reports-fourth-quarter-and-full-year-2020-financial-results-and-business-highlights\\\/\",\"name\":\"Sigilon Therapeutics Reports Fourth Quarter and\u00a0Full Year 2020 Financial Results and Business Highlights - 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