{"id":459949,"date":"2021-03-17T12:43:04","date_gmt":"2021-03-17T16:43:04","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=459949"},"modified":"2021-03-17T12:43:04","modified_gmt":"2021-03-17T16:43:04","slug":"valbiotis-releases-its-2020-annual-results","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/valbiotis-releases-its-2020-annual-results\/","title":{"rendered":"VALBIOTIS Releases Its 2020 Annual Results"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }\n.bwblockalignc { margin-left: auto; margin-right: auto }\n.bwcellpmargin { margin-bottom: 0px; margin-top: 0px }\n.bwleftsingle { border-left: solid black 1pt }\n.bwlistdisc { list-style-type: disc }\n.bwmarginl1 { margin-left: 30px }\n.bwpadl0 { padding-left: 0px }\n.bwpadr0 { padding-right: 0px }\n.bwrightsingle { border-right: solid black 1pt }\n.bwrowaltcolor0 { background-color: #cceeff }\n.bwsinglebottom { border-bottom: solid black 1pt }\n.bwtablemarginb { margin-bottom: 10px }\n.bwtopsingle { border-top: solid black 1pt }\n.bwvertalignb { vertical-align: bottom }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>VALBIOTIS Releases Its 2020 Annual Results<\/b><\/p>\n<p>LA ROCHELLE, France&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nRegulatory News:\n<\/p>\n<p><b>2020 highlights and results <\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nGlobal strategic partnership with Nestl\u00e9 Health Science for the development and marketing of TOTUM-63, a plant-based active substance with clinically proven metabolic health benefits in prediabetic subjects.<br \/>\n<\/li>\n<li>\nLaunch of REVERSE-IT, a global pivotal Phase II\/III clinical trial of TOTUM-63 for reducing Type 2 Diabetes risk factors.<br \/>\n<\/li>\n<li>\nNew milestones achieved with TOTUM-070, a plant-based active substance for lowering LDL-cholesterol, a risk factor for cardiovascular disease.<br \/>\n<\/li>\n<li>\n\u20ac14.6m in cash as at December 31, 2020.\n<\/li>\n<\/ul>\n<p><b>Post-balance sheet events and outlook <\/b><\/p>\n<ul class=\"bwlistdisc\">\n<li>\nImportant milestones are expected to be reached in the development of TOTUM-070 (reduction in blood LDL-cholesterol levels).<br \/>\n<\/li>\n<li>\nProgress within sight in the development of TOTUM-854, a plant-based active substance for lowering blood pressure, a risk factor for cardiovascular disease.\n<\/li>\n<\/ul>\n<p>\nVALBIOTIS (FR0013254851 \u2013 ALVAL, eligible for PEA \/ SME), a Research &amp; Development company committed to scientific innovation for preventing and combating metabolic diseases, releases its results for financial year 2020 and reports on recent progress.\n<\/p>\n<p><b>Main highlights in 2020 <\/b><\/p>\n<p>\nTOTUM-63\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nGlobal strategic partnership with Nestl\u00e9 Health Science\n<\/li>\n<\/ul>\n<p>\n2020 saw the announcement of a strategic partnership between Nestl\u00e9 Health Science and VALBIOTIS for the development and marketing of TOTUM-63 (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2020%2F02%2F2020-02-05-PR_VALBIOTIS_NHSc.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+February+5%2C+2020&amp;index=1&amp;md5=4410292fe21d86ee534af04c7235bdc0\">Press release of February 5, 2020<\/a>). Under the terms of this partnership, Nestl\u00e9 Health Science will market TOTUM-63 on a worldwide scale, possibly before the health claim is approved in some parts of the world. The agreement also paves the way for additional sources of revenue, as it provides for the future supply of TOTUM-63 by VALBIOTIS to Nestl\u00e9 Health Science, in addition to the milestone payments and progressive royalties on net sales agreed upon by the parties.\n<\/p>\n<p>\nVALBIOTIS has already received almost CHF 8m, comprising an upfront payment of CHF 5m in April and a second payment of CHF 3m in July at the FPFV (First Patient First Visit) in the REVERSE-IT trial. Under the agreement signed, the milestone payments could amount to up to CHF 66m.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nLaunch of the REVERSE-IT trial, final clinical development phase, and inclusion of the first patient\n<\/li>\n<\/ul>\n<p>\nFollowing its partnership with Nestl\u00e9 Health Science, and with the approval of the CPP (French Ethics Committee) and the ANSM (French National Agency for Medicines and Health Products Safety), VALBIOTIS announced the launch of REVERSE-IT, the final clinical development phase of TOTUM-63 (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2020%2F07%2F2020-07-08-PR_VALBIOTIS_AUTORISATION-REV_IT.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+July+8%2C+2020&amp;index=2&amp;md5=751a84d89bfdb0a1c7726cecb55e5c80\">Press release of July 8, 2020<\/a>).\n<\/p>\n<p>\nREVERSE-IT, which is funded entirely by Nestl\u00e9 Health Science, will include 600 subjects recruited in over 30 clinical centers worldwide. The main objective of the trial is to confirm the positive Phase II results obtained with TOTUM-63 on elevated fasting blood glucose, the main metabolic risk factor for Type 2 diabetes.\n<\/p>\n<p>\nThe COVID-19 health and economic crisis did not affect VALBIOTIS\u2019 plans to produce clinical batches for REVERSE-IT. Thus, the first visit of the first patient in the REVERSE-IT clinical trial took place, as announced, in mid-2020 (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2020%2F07%2F2020-07-15-PR_VALBIOTIS_FPFV_-REV_IT.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+July+15%2C+2020&amp;index=3&amp;md5=50525b255eaa6d0e18a3a7b213bb501f\">Press release of July 15, 2020<\/a>). Results from the trial are expected in the first half of 2022. If they confirm the efficacy of TOTUM-63, a health claim application will be filed with the American and European authorities.\n<\/p>\n<p>\nIn accordance with its research exploitation strategy, VALBIOTIS announced the results of the Phase II clinical trial of TOTUM-63 at the world\u2019s top two scientific conferences on diabetes: the annual scientific sessions of the American Diabetes Association (June 2020) and the annual meeting of the European Association for the Study of Diabetes (September 2020).\n<\/p>\n<p>\nTOTUM-070\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nAcquisition of American and European patents\n<\/li>\n<\/ul>\n<p>\nIn September 2020, VALBIOTIS was granted American and European patents for TOTUM-070 (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2020%2F09%2F2020-09-14-PR_VALBIOTIS_PATENT_TOTUM-070.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+September+14&amp;index=4&amp;md5=9c5bd48903f4bb7ae7ad220def89f5d2\">Press release of September 14<\/a>). TOTUM-070 is designed to reduce hypercholesterolemia, and the patents grant VALBIOTIS exclusive rights over the composition of the active substance for food and pharmaceutical applications. These patents are a key step in the ongoing development of TOTUM-070, the identification of commercial partners, and the approval of health claims in Europe and North America.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nStart of the Phase II clinical trial HEART\n<\/li>\n<\/ul>\n<p>\nIn October 2020, the Company initiated the launch of the Phase II clinical trial HEART.<br \/>\n<br \/>This multi-center, randomized, placebo-controlled, double-blind trial will include 120 subjects with untreated moderate hypercholesterolemia, with LDL-cholesterol levels ranging from 130 to 190 mg\/dL. The participants will be divided into 2 equal arms of 60 subjects, who will receive TOTUM-070 or placebo for 6 months. The primary endpoint of the trial will be to reduce blood LDL-cholesterol levels. There are also several secondary endpoints of interest. The results are expected at the start of 2022.\n<\/p>\n<p>\nOther highlights\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nA capital increase to strengthen VALBIOTIS\u2019 financial resources\n<\/li>\n<\/ul>\n<p>\nIn addition to the CHF 8m received through the partnership with Nestl\u00e9 Health Science to develop and market TOTUM-63, the Company has successfully increased its capital by securing a \u20ac2m private placement from AMIRAL GESTION (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2020%2F07%2F2020-07-17-PR_VALBIOTIS_PRIVATE_INVESTMENT-1.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+July+17%2C+2020&amp;index=5&amp;md5=cc2e77cffa131ad91ff69c04956ded2a\">Press release of July 17, 2020<\/a>). This placement was based on a share price of \u20ac4.50, representing a premium of 5.4% over the closing price on July 16, 2020. With the \u20ac2 million raised, the Company will have additional financial resources to support the development of the other active substances in its pipeline.\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nInclusion in the EnterNext<sup>\u00a9<\/sup> PEA-SME 150 index\n<\/li>\n<\/ul>\n<p>\nWith effect from the trading session of October 1, 2020, VALBIOTIS has joined the EnterNext<sup>\u00a9<\/sup> PEA-SME 150 index, a stock market index composed of French companies eligible for the PEA-SME equity savings plan. Broader than the CAC SME, the EnterNext<sup>\u00a9<\/sup> PEA-SME 150 is made up of 150 of the most liquid small and medium-sized shares.\n<\/p>\n<p>\nA well-controlled financial situation, and financial resources allocated to implementing the R&amp;D roadmap as a priority\n<\/p>\n<p>\nThe Company\u2019s 2020 financial statements, drawn up in accordance with IFRS, were approved by the Management Board on March 15, 2021. They were examined by the Statutory Auditor and are available on the VALBIOTIS website: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com%2Fen%2Finvestors&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=www.valbiotis.com%2Fen%2Finvestors&amp;index=6&amp;md5=eb31b9abd7b259f1a6811055e94175c8\">www.valbiotis.com\/en\/investors<\/a>.\n<\/p>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignc\">\n<tr>\n<td class=\"bwtopsingle bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Income statement &#8211; IFRS, in \u20acK, as at 31 December<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>2020<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>2019<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nOperating income<i> including<\/i><\/p>\n<\/td>\n<td rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n5,099\n<\/p>\n<\/td>\n<td class=\"bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n1,913\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwmarginl1\"><i>Turnover<\/i><\/p>\n<\/td>\n<td rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>3,092<\/i><\/p>\n<\/td>\n<td class=\"bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>91<\/i><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwmarginl1\"><i>Grants<\/i><\/p>\n<\/td>\n<td rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>750<\/i><\/p>\n<\/td>\n<td class=\"bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>602<\/i><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwmarginl1\"><i>Research Tax Credit<\/i><\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>1,257<\/i><\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><i>1,219<\/i><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nR&amp;D expenditure\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(5,411)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(3,974)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nSales and Marketing expenditure\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(1,031)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(1,473)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nOverhead expenditure\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(1,387)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(1,343)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Operating profit for the period <\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>(3,407)<\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>(5,157)<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nOperating profit\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(3,407)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(5,157)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nEarnings before tax\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(3,829)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(5,504)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Net profit<\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>(3,829)<\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>(5,504)<\/b><\/p>\n<\/td>\n<\/tr>\n<\/table>\n<table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignc\">\n<tr>\n<td class=\"bwtopsingle bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>IFRS in \u20acK<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>2020<\/b><\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwtopsingle bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\"><b>2019<\/b><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash flow from operating activities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n2,693\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(4,946)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash flow from investing activities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(332)\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n(290)\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\">\nCash flow from financing activities\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n4,191\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n5,850\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Variation in cash <\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n6,552\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n614\n<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"bwsinglebottom bwleftsingle bwpadl0\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin\"><b>Cash at end of period<\/b><\/p>\n<\/td>\n<td class=\"bwsinglebottom\" rowspan=\"1\" colspan=\"1\">\u00a0<\/td>\n<td class=\"bwsinglebottom bwrowaltcolor0 bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n14,585\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwalignc bwcellpmargin\">\n\u00a0\n<\/p>\n<\/td>\n<td class=\"bwsinglebottom bwrightsingle bwpadl0 bwpadr0 bwvertalignb bwalignc\" rowspan=\"1\" colspan=\"1\">\n<p class=\"bwcellpmargin bwalignc\">\n8,033\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n<p>\nIn 2020, VALBIOTIS generated a turnover of \u20ac3,092K, consisting mainly of the first milestone payment of CHF 3m (i.e. \u20ac2,821K) from Nestl\u00e9 following the launch of the Phase II\/III international clinical trial REVERSE-IT. This turnover also includes part of the initial payment of CHF 5m received by the Company in April 2020 and spread over the term of the licensing agreement (i.e. until October 2035). Of the CHF 5m paid upfront (i.e. \u20ac4,679K), only \u20ac271K have been recorded as turnover for the period.\n<\/p>\n<p>\nIn addition to turnover, operating income (\u20ac5,099K, up 166% compared to 2019) consists mainly of the Research Tax Credit received over the period (\u20ac1,257K) and grants (\u20ac750K), which were stable year on year.\n<\/p>\n<p>\nResearch and Development expenditure rose by 36% to \u20ac5,411K (compared to \u20ac3,974K in 2019). This fully expected increase reflects the continuation of preclinical research and the launch of two clinical trials during the year (final clinical development phase for TOTUM-63 in the REVERSE-IT trial, and the start of Phase II for TOTUM-070). Sales and marketing expenditure fell 30% to \u20ac1,031K (compared to \u20ac1,473K in 2019). This decline in business development expenditure is explained by the agreement of the strategic partnership with Nestl\u00e9 Health Science. Lastly, overhead expenditure remained constant at \u20ac1,387K compared to \u20ac1,343K in 2019. In all, net loss over the period amounted to \u20ac3,829K.\n<\/p>\n<p>\nOver the year, the cash flow from operating activities was positive at \u20ac2,693K (compared to (\u20ac4,946K) in 2019), due to the payments received under the agreement with Nestl\u00e9 Health Science. The cash flow from investing activities was negative at \u20ac332K, due to the purchase of new state-of-the-art equipment for the R&amp;D platform in Riom and the extension of international patents. The cash flow from financing activities was positive at \u20ac4,191K, due mainly to the \u20ac2 million capital increase from AMIRAL GESTION and a state-guaranteed loan totalling \u20ac3 million from Bpifrance, Soci\u00e9t\u00e9 G\u00e9n\u00e9rale and BNP Paribas.\n<\/p>\n<p>\nAs at December 31, 2020, VALBIOTIS had a cash position of \u20ac14,585K, up 81% versus the end of December 2019 (\u20ac8,033K).\n<\/p>\n<p>\nAt present, given:\n<\/p>\n<p class=\"bwmarginl1\">\n&#8211; its available cash flow at December 31, 2020 (i.e. \u20ac14,585K),\n<\/p>\n<p class=\"bwmarginl1\">\n&#8211; its operating expenditure related to its ongoing development plan,\n<\/p>\n<p class=\"bwmarginl1\">\n&#8211; its current debt repayment schedule,\n<\/p>\n<p>\nthe Company is in a strong financial position, enabling it to meet its operational requirements until the end of the first half of 2022. This cash outlook does not take account of any further milestone payments from Nestl\u00e9 Health Science, or any additional revenue from new strategic partners. It also excludes any unplanned expenditure arising from changes of direction in development programs.\n<\/p>\n<p><b>Review of post-balance sheet events and outlook <\/b><\/p>\n<p>\nIntensification of TOTUM-070 development efforts\n<\/p>\n<p>\nInitiated in October 2020, the Phase II clinical trial HEART was officially launched in February 2021 with the first visit of the first patient (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2021%2F02%2F2021-02-22-PR_VALBIOTIS_FPFV_-HEART.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+February+22%2C+2021&amp;index=7&amp;md5=bee19bef888a871fdb0324b9a52b9ff3\">Press release of February 22, 2021<\/a>).\n<\/p>\n<p>\nAt the same time, to improve and broaden its knowledge of TOTUM-070 and its effects on human lipid metabolism, VALBIOTIS decided to perform a complementary clinical trial with a small number of volunteers. The results are expected by the end of 2021.\n<\/p>\n<p>\nFinally, a series of preclinical experiments will also be launched and completed in 2021. These studies should provide further details on the impact of TOTUM-070 on lipid metabolism in a predictive model of human pathophysiology. The results will be submitted to the American Heart Association (AHA) annual conference in November 2021.\n<\/p>\n<p>\nGiven the potential of TOTUM-070, several clinical and preclinical studies will be conducted concurrently alongside the HEART Phase II trial and should provide a large amount of data by early next year, thus confirming TOTUM-070 as a major breakthrough in cardiovascular disease prevention.\n<\/p>\n<p>\nInternational recognition of TOTUM-854\n<\/p>\n<p>\nIn March 2021, VALBIOTIS announced that the preclinical results obtained with TOTUM-854 for arterial hypertension have been selected for presentation at the joint annual meeting of the European Society of Hypertension (ESH) and the International Society of Hypertension (ISH) (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.valbiotis.com%2Fapp%2Fuploads%2F2021%2F03%2F2021-03-08-PR_VALBIOTIS_ESH_CONGRESS.pdf&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=Press+release+of+March+8%2C+2021&amp;index=8&amp;md5=04ec6820b7938eacbbc8e4163a06629e\">Press release of March 8, 2021<\/a>). This meeting will take place in April 2021. TOTUM-854 will be the third active substance in VALBIOTIS\u2019 pipeline to enter the clinical development phase, in 2021.\n<\/p>\n<p>\nS\u00e9bastien PELTIER, CEO, Chairman of the Board of Directors at VALBIOTIS, says:<i> \u201cIn 2020 a global strategic partnership was agreed with Nestl\u00e9 Health Science, illustrating the strength of our business model and the efficiency of our R&amp;D platform, both of which have been set up in less than five years. This achievement is also a fitting reward for all the hard work done by our teams. The partnership guarantees that the final phases of development of our active substance TOTUM-63 will be completed, and the prospects for marketing it on a large scale are growing. But the adventure is far from over. Because we are in a stronger financial position, we are now ready to unlock the potential of the other active substances in our portfolio and bring them swiftly to market. This will be a key step towards fulfilling the mission that has driven our company from day one: to deliver solutions for the widespread prevention of cardiometabolic disease, which today affects the health and quality of life of millions of people worldwide.\u201d <\/i><\/p>\n<p>\nVALBIOTIS\u2019 annual financial report as at December 31, 2020 has been published and filed with the AMF. This document is available on the website: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com%2Fen%2Finvestors&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=www.valbiotis.com%2Fen%2Finvestors&amp;index=9&amp;md5=b9ab9c7a1ddc22e1c147b12703926460\">www.valbiotis.com\/en\/investors<\/a><\/p>\n<p>\nVALBIOTIS confirms that it meets the PEA-SME eligibility criteria set out in Article D.221-113-5 of implementing decree no. 2014-283 of March 4, 2014, namely:\n<\/p>\n<ul class=\"bwlistdisc\">\n<li>\nA total workforce of fewer than 5,000 employees;\n<\/li>\n<li>\nA turnover of less than \u20ac1.5 billion or a balance sheet total of less than \u20ac2 billion.\n<\/li>\n<\/ul>\n<p>\nAccordingly, VALBIOTIS\u2019 shares are still eligible for inclusion in PEA-SME accounts, which enjoy the same tax benefits as conventional equity savings plans (PEAs).\n<\/p>\n<p><b>ABOUT VALBIOTIS<br \/>\n<br \/><\/b>VALBIOTIS is a Research &amp; Development company committed to scientific innovation for preventing and combating metabolic diseases in response to unmet medical needs.<br \/>\n<br \/>VALBIOTIS has adopted an innovative approach, aiming to revolutionize healthcare by developing a new class of health nutrition products designed to reduce the risk of major metabolic diseases, based on a multi-target approach enabled by the use of plant-based ingredients.<br \/>\n<br \/>Its products are intended to be licensed to players in the health sector.<br \/>\n<br \/>Created at the beginning of 2014 in La Rochelle, the Company has forged numerous partnerships with leading academic centers. The Company has established three sites in France: P\u00e9rigny, La Rochelle (17) and Riom (63).<br \/>\n<br \/>Valbiotis is a member of the &#8220;BPI Excellence&#8221; network and has been recognized as an &#8220;Innovative Company&#8221; by the BPI label. Valbiotis has also been awarded &#8220;Young Innovative Company&#8221; status and has received major financial support from the European Union for its research programs via the European Regional Development Fund (ERDF). VALBIOTIS is a PEA-SME eligible company.<br \/>\n<br \/>For more information about VALBIOTIS, please visit: <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=www.valbiotis.com&amp;index=10&amp;md5=04cb0447bb0103d59ce148db90d1ced9\">www.valbiotis.com<\/a>.\n<\/p>\n<p class=\"bwalignc\">\nName: VALBIOTIS<br \/>\n<br \/>ISIN code: FR0013254851<br \/>\n<br \/>Mnemonic code: ALVAL<br \/>\n<br \/>EnterNext\u00a9 PEA-PME 150\n<\/p>\n<p><b>DISCLAIMER<br \/>\n<br \/><\/b>This press release contains forward-looking statements about VALBIOTIS&#8217; objectives. VALBIOTIS considers that these projections are based on rational hypotheses and the information available to the company at the present time. However, in no way does this constitute a guarantee of future performance, and these projections may be reconsidered based on changes in economic conditions and financial markets, as well as a certain number of risks and uncertainties, including those described in the VALBIOTIS registration document, filed with the French Financial Markets Regulator (AMF) on July 31, 2020 (application number R 20-018). This document is available on the Company&#8217;s website (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.valbiotis.com&amp;esheet=52397310&amp;newsitemid=20210317005491&amp;lan=en-US&amp;anchor=www.valbiotis.com&amp;index=11&amp;md5=42fff0f5a157e6bbd044ddde795f98ec\">www.valbiotis.com<\/a>).<br \/>\n<br \/>This press release, as well as the information contained herein, does not constitute an offer to sell or subscribe to, or a solicitation to purchase or subscribe to, VALBIOTIS&#8217; shares or securities in any country.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210317005491r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20210317005491\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20210317005491\/en\/<\/a><\/span><\/p>\n<p>\nVALBIOTIS \/ CORPORATE COMMUNICATION<br \/>\n<br \/>Carole Rocher \/ Marc Delaunay<br \/>\n<br \/>+33 5 46 28 62 58<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:media@valbiotis.com\">media@valbiotis.com<\/a><\/p>\n<p>\nACTIFIN \/ FINANCIAL COMMUNICATION<br \/>\n<br \/>St\u00e9phane Ruiz<br \/>\n<br \/>+33 1 56 88 11 14<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:sruiz@actifin.fr\">sruiz@actifin.fr<\/a><\/p>\n<p><b>KEYWORDS:<\/b> France Europe<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Science Other Science Biotechnology Research Pharmaceutical Health Clinical Trials Other Health<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20210317005491\/en\/682222\/3\/logo_valbiotis.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>VALBIOTIS Releases Its 2020 Annual Results LA ROCHELLE, France&#8211;(BUSINESS WIRE)&#8211; Regulatory News: 2020 highlights and results Global strategic partnership with Nestl\u00e9 Health Science for the development and marketing of TOTUM-63, a plant-based active substance with clinically proven metabolic health benefits in prediabetic subjects. Launch of REVERSE-IT, a global pivotal Phase II\/III clinical trial of TOTUM-63 for reducing Type 2 Diabetes risk factors. New milestones achieved with TOTUM-070, a plant-based active substance for lowering LDL-cholesterol, a risk factor for cardiovascular disease. \u20ac14.6m in cash as at December 31, 2020. Post-balance sheet events and outlook Important milestones are expected to be reached in the development of TOTUM-070 (reduction in blood LDL-cholesterol levels). Progress within sight in the development of TOTUM-854, a plant-based &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/valbiotis-releases-its-2020-annual-results\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;VALBIOTIS Releases Its 2020 Annual Results&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-459949","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>VALBIOTIS Releases Its 2020 Annual Results - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/valbiotis-releases-its-2020-annual-results\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"VALBIOTIS Releases Its 2020 Annual Results - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"VALBIOTIS Releases Its 2020 Annual Results LA ROCHELLE, France&#8211;(BUSINESS WIRE)&#8211; Regulatory News: 2020 highlights and results Global strategic partnership with Nestl\u00e9 Health Science for the development and marketing of TOTUM-63, a plant-based active substance with clinically proven metabolic health benefits in prediabetic subjects. Launch of REVERSE-IT, a global pivotal Phase II\/III clinical trial of TOTUM-63 for reducing Type 2 Diabetes risk factors. New milestones achieved with TOTUM-070, a plant-based active substance for lowering LDL-cholesterol, a risk factor for cardiovascular disease. \u20ac14.6m in cash as at December 31, 2020. Post-balance sheet events and outlook Important milestones are expected to be reached in the development of TOTUM-070 (reduction in blood LDL-cholesterol levels). 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Launch of REVERSE-IT, a global pivotal Phase II\/III clinical trial of TOTUM-63 for reducing Type 2 Diabetes risk factors. New milestones achieved with TOTUM-070, a plant-based active substance for lowering LDL-cholesterol, a risk factor for cardiovascular disease. \u20ac14.6m in cash as at December 31, 2020. Post-balance sheet events and outlook Important milestones are expected to be reached in the development of TOTUM-070 (reduction in blood LDL-cholesterol levels). 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