{"id":456582,"date":"2021-03-12T01:03:21","date_gmt":"2021-03-12T06:03:21","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=456582"},"modified":"2021-03-12T01:03:21","modified_gmt":"2021-03-12T06:03:21","slug":"altimmune-expands-adcovid-manufacturing-collaboration-with-lonza","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/","title":{"rendered":"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza"},"content":{"rendered":"

\nLonza to Commission a Dedicated Suite for Clinical and Commercial Supply of Altimmune\u2019s COVID-19 Vaccine Candidate at its Houston Facility
\n<\/h2>\n
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GAITHERSBURG, Md. and BASEL, Switzerland, March 12, 2021 (GLOBE NEWSWIRE) — Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that it has expanded its previously-announced AdCOVID manufacturing collaboration with Lonza. Under the expanded agreement, Lonza will commission a dedicated manufacturing suite for clinical and commercial production of AdCOVID, Altimmune\u2019s single-dose intranasal vaccine candidate for COVID-19, at its facility near Houston, Texas.\u00a0\u00a0<\/p>\n

\u201cManufacturing capacity for COVID-19 vaccines has been severely constrained, and this limitation has presented considerable challenges for vaccine developers,\u201d said Dr. Vyjayanthi Krishnan, Ph.D., Vice President of Product Development for Altimmune. \u201cBy expanding our Lonza collaboration and commissioning our own dedicated manufacturing suite, we are building extra capacity and redundancy into our manufacturing to support potential late-stage clinical trials with AdCOVID and potential future commercial supply. Lonza continues to be an outstanding partner in this mission, and we are pleased to have the opportunity to further our relationship with this world class team.\u201d<\/p>\n

Alberto Santagostino, SVP, Head of Cell and Gene Technologies for Lonza, commented, \u201cAltimmune\u2019s COVID-19 vaccine candidate could be a complete game-changer in the fight against COVID-19. Our reinforced commitment is to enable the team at Altimmune to scale-up production as needed and deliver vaccines at a global scale when ready.\u201d<\/p>\n

AdCOVID is a COVID-19 vaccine candidate that is administered via nasal spray. In preclinical studies, AdCOVID was shown to activate systemic immunity (neutralizing antibodies and T cell responses) and mucosal immunity in the respiratory tract. Activation of mucosal immunity may prevent both SARS-CoV-2 virus infection and transmission. In preclinical studies, AdCOVID stimulated a 29-fold increase in mucosal IgA, well above the level associated with protection in clinical studies of influenza.<\/p>\n

\u201cWe recently commenced our AdCOVID Phase 1 clinical trial and anticipate having a data readout in the second quarter of 2021,\u201d said Vipin K. Garg, Ph.D., President and Chief Executive Officer at Altimmune. \u201cIf the clinical data from our Phase 1 trial and subsequent clinical trials validate our preclinical observations, and AdCOVID is successfully commercialized, we believe that it could become an important new option for vaccination against COVID-19, offering the simplicity of nasal administration, potential ease of deployment and storage, and the potential to block viral transmission.\u201d<\/p>\n

Based on clinical experience with Altimmune\u2019s vaccine platform technology, Altimmune anticipates that AdCOVID could provide immunity of up to a year or more following a single dose with the potential for a favorable tolerability profile. Vaccine stability is critical for efficient vaccine deployment and based on data from Altimmune\u2019s other intranasal vaccine candidates, AdCOVID is expected to be shipped without cold chain logistics, permitting common refrigerated storage at community-based vaccination centers without the need for specialized freezer storage.<\/p>\n

\n About AdCOVID<\/strong>\n <\/p>\n

AdCOVID is a single-dose intranasal vaccine candidate for COVID-19. It is designed to stimulate a broad immune response including both systemic immunity (neutralizing antibody) and local immunity (mucosal IgA, resident memory T cells) in the nasal cavity and respiratory tract.<\/p>\n

In published preclinical studies (www.biorxiv.org\/content\/10.1101\/2020.10.10.331348v1<\/a>) conducted in collaboration with the University of Alabama at Birmingham, potent serum neutralizing antibody responses, T cell responses, and a robust induction in mucosal immunity were observed in mice following a single intranasal dose of AdCOVID. Mucosal immunity was characterized by IgA antibody and resident memory T cell responses in the respiratory tract, both of which are believed to be important in fighting infection, and importantly, transmission.<\/p>\n

Based on data from Altimmune\u2019s other intranasal platform vaccine candidates, AdCOVID is expected to have extended stability at room temperature that would allow for cold chain-free shipment of the vaccine. If demonstrated, AdCOVID could be stored in the common refrigerators found in community-based doctors\u2019 offices and pharmacies for two years or more. The Company believes that these simple and convenient handling requirements, together with the potential ability to block SARS-CoV-2 transmission, could position AdCOVID as a leading intranasal COVID-19 vaccine.<\/p>\n

\n About Lonza<\/strong>\n <\/p>\n

Lonza is the preferred global partner to the pharmaceutical, biotech and nutrition markets. We work to prevent illness and enable a healthier world by supporting our customers to deliver new and innovative medicines that help treat a wide range of diseases. We achieve this by combining technological insight with world-class manufacturing, scientific expertise and process excellence. These enable our customers to commercialize their discoveries and innovations in the healthcare sector.<\/p>\n

Founded in 1897 in the Swiss Alps, today Lonza operates across three continents. With approximately 14,000 full-time employees, we are built from high-performing teams and of individual talent who make a meaningful difference to our own business, as well as to the communities in which we operate. The company generated sales of CHF 4.5 billion in 2020 with a CORE EBITDA of CHF 1.4 billion. Find out more at www.lonza.com<\/a>.<\/p>\n

\n Follow @Lonza on <\/strong>
\n
\n LinkedIn<\/strong>
\n <\/a>
\n
\n Follow @LonzaGroup on <\/strong>
\n
\n Twitter<\/strong>
\n <\/a>\n <\/p>\n

\n About Altimmune<\/strong>\n <\/p>\n

Altimmune is a clinical stage biopharmaceutical company focused on developing intranasal vaccines, immune modulating therapies and treatments for liver disease. Our diverse pipeline includes proprietary intranasal vaccines for COVID-19 (AdCOVID\u2122), anthrax (NasoShield\u2122) and influenza (NasoVAX\u2122); an intranasal immune modulating therapeutic for COVID-19 (T-COVID\u2122); and next generation peptide therapeutics for NASH (ALT-801) and chronic hepatitis B (HepTcell\u2122). For more information on Altimmune, please visit www.altimmune.com<\/a>.<\/p>\n

\n Follow @Altimmune, Inc. on <\/strong>
\n
\n LinkedIn<\/strong>
\n <\/a>
\n
\n Follow @AltimmuneInc on <\/strong>
\n
\n Twitter<\/strong>
\n <\/a>\n <\/p>\n

\n Forward-Looking Statement for Altimmune<\/strong>\n <\/p>\n

Any statements made in this press release relating to future financial or business performance, conditions, plans, prospects, trends, or strategies and other financial and business matters, including without limitation, the timing of key milestones for our clinical assets, the timing of the data readout from the AdCOVID Phase 1 clinical trial in Q2 2021, the potential immunization effects of AdCOVID, the potential of AdCOVID to block SARS-CoV-2 transmission, the shipping and storage requirements for AdCOVID, and the prospects for regulatory approval, our ability to manufacture AdCOVID for our clinical trials and commercial needs, commercializing or selling any product or drug candidates, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. In addition, when or if used in this press release, the words \u201cmay,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cpredict\u201d and similar expressions and their variants, as they relate to Altimmune, Inc. (the \u201cCompany\u201d) may identify forward-looking statements. The Company cautions that these forward-looking statements are subject to numerous assumptions, risks, and uncertainties, which change over time. Important factors that may cause actual results to differ materially from the results discussed in the forward looking statements or historical experience include risks and uncertainties, including risks relating to: potential impacts due to the COVID-19 pandemic such as delays in regulatory review, manufacturing and supply chain interruptions, access to clinical sites, enrollment, adverse effects on healthcare systems and disruption of the global economy the reliability of the results of studies relating to human safety and possible adverse effects resulting from the administration of the Company\u2019s product candidates; the Company\u2019s ability to manufacture clinical trial materials and commercial supply on the timelines anticipated; the Company\u2019s ability to secure manufacturing approval from its SARS-CoV-2 cell licensor on the timelines anticipated; and the success of future product advancements, including the success of future clinical trials. Further information on the factors and risks that could affect the Company’s business, financial conditions and results of operations are contained in the Company\u2019s filings with the U.S. Securities and Exchange Commission, including under the heading \u201cRisk Factors\u201d in the Company\u2019s annual report on Form 10-K for the fiscal year ended December 31, 2020 filed with the SEC, which is available at www.sec.gov.<\/p>\n

\n Altimmune Investor & Media Contacts:<\/strong>\n <\/p>\n\n\n
Will Brown
Chief Financial Officer
Phone: 240-654-1450
wbrown@altimmune.com<\/a><\/td>\n		Stacey Jurchison
Sr. Dir, Investor Relations
Phone\u00a0: 410-474-8200\u00a0
sjurchison@altimmune.com<\/a>\u00a0<\/td>\n<\/tr>\n<\/table>\n

\n Additional Information and Disclaimer for Lonza<\/strong>\n <\/p>\n

Lonza Group Ltd has its headquarters in Basel, Switzerland, and is listed on the SIX Swiss Exchange. It has a secondary listing on the Singapore Exchange Securities Trading Limited (\u201cSGX-ST\u201d). Lonza Group Ltd is not subject to the SGX-ST\u2019s continuing listing requirements but remains subject to Rules 217 and 751 of the SGX-ST Listing Manual.<\/p>\n

Certain matters discussed in this news release may constitute forward-looking statements. These statements are based on current expectations and estimates of Lonza Group Ltd, although Lonza Group Ltd can give no assurance that these expectations and estimates will be achieved. Investors are cautioned that all forward-looking statements involve risks and uncertainty and are qualified in their entirety. The actual results may differ materially in the future from the forward-looking statements included in this news release due to various factors. Furthermore, except as otherwise required by law, Lonza Group Ltd disclaims any intention or obligation to update the statements contained in this news release.\u00a0\u00a0<\/p>\n

\n Lonza Contact Details:<\/strong>\n <\/p>\n

Victoria Morgan
Head of External Communications
Lonza Group Ltd
Tel +41 61 316 2283
victoria.morgan@lonza.com<\/p>\n

Dr. Martina Ribar Hestericov\u00e1
Trade Media Lead
Lonza Group Ltd
Tel +41 61 316 8982
martina.ribarhestericova@lonza.com<\/p>\n

Dirk Oehlers
Investor Relations
Lonza Group Ltd
Tel +41 61 316 8540
dirk.oehlers@lonza.com<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Lonza to Commission a Dedicated Suite for Clinical and Commercial Supply of Altimmune\u2019s COVID-19 Vaccine Candidate at its Houston Facility GAITHERSBURG, Md. and BASEL, Switzerland, March 12, 2021 (GLOBE NEWSWIRE) — Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that it has expanded its previously-announced AdCOVID manufacturing collaboration with Lonza. Under the expanded agreement, Lonza will commission a dedicated manufacturing suite for clinical and commercial production of AdCOVID, Altimmune\u2019s single-dose intranasal vaccine candidate for COVID-19, at its facility near Houston, Texas.\u00a0\u00a0 \u201cManufacturing capacity for COVID-19 vaccines has been severely constrained, and this limitation has presented considerable challenges for vaccine developers,\u201d said Dr. Vyjayanthi Krishnan, Ph.D., Vice President of Product Development for Altimmune. \u201cBy expanding our Lonza collaboration and … <\/p>\n

Continue reading “Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-456582","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nAltimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Lonza to Commission a Dedicated Suite for Clinical and Commercial Supply of Altimmune\u2019s COVID-19 Vaccine Candidate at its Houston Facility GAITHERSBURG, Md. and BASEL, Switzerland, March 12, 2021 (GLOBE NEWSWIRE) — Altimmune, Inc. (Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that it has expanded its previously-announced AdCOVID manufacturing collaboration with Lonza. Under the expanded agreement, Lonza will commission a dedicated manufacturing suite for clinical and commercial production of AdCOVID, Altimmune\u2019s single-dose intranasal vaccine candidate for COVID-19, at its facility near Houston, Texas.\u00a0\u00a0 \u201cManufacturing capacity for COVID-19 vaccines has been severely constrained, and this limitation has presented considerable challenges for vaccine developers,\u201d said Dr. Vyjayanthi Krishnan, Ph.D., Vice President of Product Development for Altimmune. \u201cBy expanding our Lonza collaboration and … Continue reading "Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-12T06:03:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE4ODY1NSM0MDYwMTU2IzIwMjYxNTY=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza\",\"datePublished\":\"2021-03-12T06:03:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/\"},\"wordCount\":1495,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODE4ODY1NSM0MDYwMTU2IzIwMjYxNTY=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\\\/\",\"name\":\"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza - 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(Nasdaq: ALT), a clinical-stage biopharmaceutical company, today announced that it has expanded its previously-announced AdCOVID manufacturing collaboration with Lonza. Under the expanded agreement, Lonza will commission a dedicated manufacturing suite for clinical and commercial production of AdCOVID, Altimmune\u2019s single-dose intranasal vaccine candidate for COVID-19, at its facility near Houston, Texas.\u00a0\u00a0 \u201cManufacturing capacity for COVID-19 vaccines has been severely constrained, and this limitation has presented considerable challenges for vaccine developers,\u201d said Dr. Vyjayanthi Krishnan, Ph.D., Vice President of Product Development for Altimmune. \u201cBy expanding our Lonza collaboration and … Continue reading \"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/","og_site_name":"Market Newsdesk","article_published_time":"2021-03-12T06:03:21+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE4ODY1NSM0MDYwMTU2IzIwMjYxNTY=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza","datePublished":"2021-03-12T06:03:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/"},"wordCount":1495,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE4ODY1NSM0MDYwMTU2IzIwMjYxNTY=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/altimmune-expands-adcovid-manufacturing-collaboration-with-lonza\/","name":"Altimmune Expands AdCOVID\u2122 Manufacturing Collaboration with Lonza - 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