{"id":451761,"date":"2021-03-05T08:55:29","date_gmt":"2021-03-05T13:55:29","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=451761"},"modified":"2021-03-05T08:55:29","modified_gmt":"2021-03-05T13:55:29","slug":"eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/","title":{"rendered":"Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data"},"content":{"rendered":"<div class=\"xn-newslines\">\n<h2 class=\"xn-hedline\">&#8211;       Oral presentations and posters highlighting Eisai&#8217;s investigational novel therapies and immunoassay system being studied for Alzheimer&#8217;s disease and its clinical symptoms<\/h2>\n<h2 class=\"xn-hedline\">&#8211;       Preliminary analyses evaluating brain amyloid beta reduction with lecanemab to be featured in oral presentation<\/h2>\n<h2 class=\"xn-hedline\">&#8211;       Virtual symposium: The Science Behind the A\u03b2 Pathway in Alzheimer&#8217;s Disease<\/h2>\n<p class=\"xn-distributor\">PR Newswire<\/p>\n<\/p><\/div>\n<div class=\"xn-content\">\n<p>\n        <span class=\"xn-location\">WOODCLIFF LAKE, N.J.<\/span>, <span class=\"xn-chron\">March 5, 2021<\/span> \/PRNewswire\/ &#8212;\u00a0Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today the presentation of data and information from the company&#8217;s robust Alzheimer&#8217;s disease (AD) pipeline, including lecanemab (BAN2401). Jointly developed by Eisai and Biogen Inc., lecanemab is an investigational humanized monoclonal antibody that binds to neutralize and eliminate soluble, toxic amyloid beta (A\u03b2) aggregates (protofibrils) that are thought to contribute to the neurodegenerative process in AD. This data will be among Eisai&#8217;s many presentations at AD\/PD\u2122 2021 Virtual Conference, the 15<sup>th<\/sup> International Conference on Alzheimer&#8217;s and Parkinson&#8217;s Diseases, <span class=\"xn-chron\">March 9 &#8211; 14, 2021<\/span>.<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p>\n          <a href=\"https:\/\/mma.prnewswire.com\/media\/378839\/Eisai_Logo.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><br \/>\n            <img decoding=\"async\" src=\"https:\/\/mma.prnewswire.com\/media\/378839\/Eisai_Logo.jpg\" title=\"Eisai logo\" alt=\"Eisai logo\" \/><br \/>\n          <\/a>\n        <\/p>\n<\/p><\/div>\n<p>&#8220;Alzheimer&#8217;s disease is a progressively debilitating and devastating neurodegenerative disease. The focus on Alzheimer&#8217;s disease has historically been on alleviating cognitive and behavioral symptoms, but there has been significant progress in understanding the biological mechanisms of the disease through the science of biomarkers. We look forward to sharing data and discussing the scientific rationale that the amyloid beta pathway plays a key role in the pathophysiology of Alzheimer&#8217;s disease,&#8221; said Harald\u00a0Hampel, M.D., Ph.D., Vice President, Chief Medical Officer, Neurology Business Group, Eisai Inc., who was recently named one of the world&#8217;s top five Alzheimer&#8217;s disease experts by Expertscape based on objective ranking of his contribution and impact on the Alzheimer&#8217;s field through scientific publications.\u00a0<\/p>\n<p>\n        <b>Eisai and Biogen Joint Investigational Assets<\/b>\n      <\/p>\n<p>Eisai Oral Presentation for Lecanemab:<\/p>\n<ul type=\"disc\">\n<li>Preliminary findings for lecanemab, a humanized lgG1 that selectively binds to A\u03b2 protofibrils, to evaluate the longitudinal amyloid positron emission tomography (PET) findings across the Core, GAP period between end of Core and Open-Label Extension (OLE) baseline and OLE in subjects who participated in the Core and OLE amyloid imaging subgroups. These results will be presented on <span class=\"xn-chron\">March 13<\/span>.<\/li>\n<\/ul>\n<p>Biogen Oral Presentations for Aducanumab:<\/p>\n<ul type=\"disc\">\n<li>Cerebrospinal Fluid (CSF) Biomarker Concordance with Amyloid PET in EMERGE\/ENGAGE, Phase 3 Studies of Aducanumab in Patients with Early Alzheimer&#8217;s Disease. These results will be presented on <span class=\"xn-chron\">March 10<\/span>. <\/li>\n<li>Evaluation of Aducanumab Efficacy in Early Alzheimer&#8217;s Disease. These results will be presented on <span class=\"xn-chron\">March 13<\/span>. <\/li>\n<li>Evaluation of Aducanumab Safety in Early Alzheimer&#8217;s Disease. These results will be presented on <span class=\"xn-chron\">March 13<\/span>.<\/li>\n<\/ul>\n<p>\n        <b>Select Eisai-Only Presentations<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li>The effects of E2027 on cognitive impairment in a mouse model of AD. Eisai is developing E2027, a selective phosphodiesterase (PDE) 9 inhibitor, as a potential treatment for dementia with Lewy bodies. Inhibiting PDE9 increases cGMP, which is involved in synaptic plasticity and cognitive function, and it is believed to be a target for memory improvement. <\/li>\n<li>Additional studies using electronic health records from the U.S. Veterans&#8217; Affairs (USVA) health care system explore: <\/li>\n<ul type=\"circle\">\n<li>Epidemiology of mild cognitive impairment, AD and AD-related dementia over the past 20 years; <\/li>\n<li>USVA health care system&#8217;s capacity and readiness for AD disease-modifying therapies; <\/li>\n<li>Association of selected long-term medication use on the risk of occurrence of possible AD<\/li>\n<\/ul>\n<\/ul>\n<p>\n        <b>Eisai and Sysmex Presentation<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li>A Fully Automated Plasma A\u03b2 Assay Incorporating APOE4 Status Shows High Performance to Predict Amyloid Positivity Determined by Centiloids of Amyloid PET. These results will be presented on <span class=\"xn-chron\">March 12<\/span>.<\/li>\n<\/ul>\n<p>\n        <b>Virtual Symposium: The Science Behind the <\/b><br \/>\n        <b>A\u03b2 <\/b><br \/>\n        <b>Pathway in AD<\/b>\n      <\/p>\n<p>Eisai and Biogen are hosting a symposium focusing on the central role of the A\u03b2 pathway in the pathophysiology of AD. Expert faculty provide a comprehensive overview of the cross-disciplinary evidence supporting the loss of A\u03b2 homeostasis as an early pathophysiological event within the AD biological-clinical continuum. There will also be a short state-of-the-art presentation of the in vivo biomarkers of A\u03b2. Featured speakers will include:<\/p>\n<ul type=\"disc\">\n<li>\n          <span class=\"xn-person\">Jeffrey Cummings<\/span>, M.D. <\/li>\n<li>\n          <span class=\"xn-person\">John Hardy<\/span>, Ph.D. <\/li>\n<li>\n          <span class=\"xn-person\">Colin Masters<\/span>, M.D. <\/li>\n<li>\n          <span class=\"xn-person\">Philip Scheltens<\/span>, M.D., Ph.D.<\/li>\n<\/ul>\n<p>&#8220;With Eisai&#8217;s and Biogen&#8217;s joint asset, aducanumab, under regulatory review in the U.S., European Union and <span class=\"xn-location\">Japan<\/span>, the companies&#8217; joint asset, lecanemab, in Phase 3 Clarity-AD and AHEAD 3-45 clinical studies and the data presented at this year&#8217;s ADPD, it is an incredibly exciting time for Eisai&#8217;s growing Alzheimer&#8217;s disease franchise,&#8221;\u00a0said <span class=\"xn-person\">Ivan Cheung<\/span>, Chairman, Eisai Inc. and Global President, Neurology Business Group, Eisai Co., Ltd. &#8220;Eisai is dedicated to advancing our\u00a0robust pipeline of novel investigational therapies targeting the disease pathophysiology as well as its clinical symptoms.&#8221;<\/p>\n<p>The full list of virtual presentations is included below. All presentations will be available to registered participants via the <a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=3087977-1&amp;h=3305562202&amp;u=https%3A%2F%2Fadpd.kenes.com%2Fscientific-program%2F&amp;a=AD%2FPD%E2%84%A2%C2%A02021\" rel=\"nofollow noopener noreferrer\">AD\/PD\u2122<sup>\u00a0<\/sup>2021<\/a><b>\u00a0<\/b><b>virtual platform<\/b><b>\u00a0<\/b>the start of the meeting and for three months afterward.<\/p>\n<div>\n<table cellspacing=\"0\" cellpadding=\"0\" border=\"1\" class=\"prntblns\">\n<tr>\n<td colspan=\"2\" nowrap=\"nowrap\" class=\"prngen2\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>AD\/PD\u2122<\/b><br \/>\n                  <b>\u00a02021 Presentations <\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen3\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Topic, Session, Time (CET)<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen4\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Title, Presenter<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecanemab (BAN2401)<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: A\u03b2\u00a0Targeting Therapies in AD 2<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Saturday, March 13<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 13:30<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 13:15 &#8211; 13:30<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:30 &#8211; 18:00<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Preliminary Amyloid PET Analysis in BAN2401 Phase 2 Open-Label Extension <br \/>in Subjects who Participated in the Core Imaging Subgroup<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Presenter: Chad J. Swanson <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">E2027<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Poster: P153 \/ #535 <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Effect of E2027, A Novel Phosphodiesterase-9 Inhibitor, on Cognitive Function <br \/>and Hippocampal Cyclic GMP in TG2576 Mouse Model of Alzheimer&#8217;s Disease<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Authors: Y Goto et al<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Immunoassay system, in partnership with Sysmex<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Friday, March 12<\/span>\n              <\/p>\n<p>Session Name: Amyloid, Tau and\u00a0Synapse PET Imaging<br \/>Session Time: 10:00 &#8211; 12:00Lecture Time: 11:15 &#8211; 11:30<br \/>Live Discussion: 16:30 &#8211; 17:00<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">A Fully Automated Plasma A\u03b2 Assay Incorporating APOE4 Status Shows High <br \/>Performance to Predict Amyloid Positivity Determined by Centiloids of Amyloid PET<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Presenter: Kazuto Yamashita (Sysmex)<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">General AD<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: Epidemiology and Genetics of <br \/>Neurodegeneration <\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Saturday, March 13<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 14:00\u00a0 <\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 12:00 &#8211; 12:15<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:30 &#8211; 18:00<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Epidemiology of Mild Cognitive Impairment, Alzheimer&#8217;s Disease, and Related <br \/>Dementia in U.S. Veteran Patients<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Presenter: Donald R. Miller<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">General AD<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Poster: P704 \/ #1636 <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Modeling the Association of Selected Medications on the Occurrence of Possible <br \/>Alzheimer&#8217;s Disease: Atorvastatin and Lisinopril Outperform Simvastatin<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Authors: Y Wang et al<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">General AD<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Poster: P696 \/ #1644 <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Health System Preparedness for Alzheimer&#8217;s Disease Treatment: Veterans <br \/>Health Administration<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Authors: D Miller et al<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Elenbecestat<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: A\u03b2\u00a0Targeting Therapies in AD 1<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Wednesday, March 10<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 13:15<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 12:30 &#8211; 12:45<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:00 &#8211; 17:30<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Efficacy and Safety of Elenbecestat in Subjects with Early Alzheimer&#8217;s Disease: <br \/>Results from the MissionAD Phase 3 Program<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Presenter: Michelle Gee<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Elenbecestat<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Poster: P220 \/ #1487 <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Performance of CSF AD Biomarkers in Predicting Amyloid PET Positivity in Early AD: <br \/>Data from Eisai&#8217;s MissionAD Program<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Authors: J Kaplow et al<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" nowrap=\"nowrap\" class=\"prngen2\">\n              \n            <\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" nowrap=\"nowrap\" class=\"prngen2\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Eisai and Biogen Virtual Symposium<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen3\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Topic, Session, Time (CET)<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen4\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Title, Presenter<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Virtual Symposium\/On Demand Viewing: <br \/>Saturday, March 13, 14:00 &#8211; 15:30 CET and <br \/>90 days following ADPD<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">The Science Behind the A\u03b2 Pathway in Alzheimer&#8217;s Disease<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" nowrap=\"nowrap\" class=\"prngen2\">\n              \n            <\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" nowrap=\"nowrap\" class=\"prngen2\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Biogen Presentations for Aducanumab<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen3\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Topic, Session, Time (CET)<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen4\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\"><br \/>\n                  <b>Title, Presenter<\/b><br \/>\n                <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: A\u03b2\u00a0Targeting Therapies in AD 1<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Wednesday, March 10<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 13:15<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 12:45 &#8211; 13:00<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:00 &#8211; 17:30<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Cerebrospinal Fluid Biomarker Concordance with Amyloid PET in EMERGE\/ENGAGE, <br \/>Phase 3 Studies of Aducanumab in Patients with Early Alzheimer&#8217;s Disease<\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: A\u03b2 Targeting Therapies in AD 2<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Saturday, March 13<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 13:30<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 12:45 &#8211; 13:00<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:30 &#8211; 18:00<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Evaluation of Aducanumab Efficacy in Early Alzheimer&#8217;s Disease. <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<tr>\n<td nowrap=\"nowrap\" class=\"prngen5\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session: A\u03b2 Targeting Therapies in AD 2<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Saturday, March 13<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Session Time: 12:00 &#8211; 13:30<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Lecture Time: 13:00 &#8211; 13:15<\/span>\n              <\/p>\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Live Discussion: 17:30 &#8211; 18:00\u00a0<\/span>\n              <\/p>\n<\/td>\n<td nowrap=\"nowrap\" class=\"prngen6\">\n<p class=\"prnews_p\">\n                <span class=\"prnews_span\">Evaluation of Aducanumab Safety in Early Alzheimer&#8217;s Disease. <\/span>\n              <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n<p>This release discusses investigational uses of agents in development and is not intended to convey conclusions about efficacy or safety. There is no guarantee that such investigational agents will successfully complete clinical development or gain health authority approval. <\/p>\n<p>[Notes to editors]<\/p>\n<ol type=\"1\">\n<li>\n          <b>About Lecanemab (BAN2401)<br \/><\/b>Lecanemab is an investigational humanized monoclonal antibody for Alzheimer&#8217;s disease that is the result of a strategic research alliance between Eisai and BioArctic. Lecanemab selectively binds to neutralize and eliminate soluble, toxic A\u03b2 aggregates (protofibril) that are thought to contribute to the neurodegenerative process in AD. As such, lecanemab may have the potential to have an effect on disease pathology and to slow down the progression of the disease. Eisai obtained the global rights to study, develop, manufacture and market lecanemab for the treatment of AD pursuant to an agreement concluded with BioArctic in <span class=\"xn-chron\">December 2007<\/span>. In <span class=\"xn-chron\">March 2014<\/span>, Eisai and Biogen entered into a joint development and commercialization agreement for lecanemab and the parties amended that agreement in <span class=\"xn-chron\">October 2017<\/span>.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <br \/>Currently, lecanemab\u00a0is being studied in a pivotal Phase 3 clinical study in symptomatic early AD (Clarity-AD), following the outcome of the Phase II clinical study (Study 201). In July of 2020, the Phase III clinical study \uff08AHEAD 3-45) for individuals with preclinical AD, meaning they are clinically normal and have intermediate or elevated levels of amyloid in their brains, was initiated. AHEAD 3-45 is conducted as a public-private partnership between the Alzheimer&#8217;s Clinical Trial Consortium, funded by the National Institute on Aging, part of the National Institutes of Health, and Eisai.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/li>\n<li>\n          <b>About the Joint Development between Eisai and Biogen for <\/b><br \/>\n          <b>Alzheimer&#8217;s Disease<br \/><\/b>Eisai and Biogen are collaborating on the joint development and commercialization of AD treatments. Biogen serves as the lead in the co-development of aducanumab and Eisai serves as the lead in the co-development of lecanemab, anti-amyloid beta (A\u03b2) protofibril antibodies, and the companies plan to pursue marketing authorizations for aducanumab and lecanemab worldwide. If approved, the companies will also co-promote aducanumab and lecanemab in major markets, such as <span class=\"xn-location\">the United States<\/span>, the European Union and <span class=\"xn-location\">Japan<\/span>. Both companies will equally split overall costs, including research and development expenses. Eisai will book all sales for lecanemab following marketing approval and launch, and profits will be equally shared between the companies.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/li>\n<li>\n          <b>About the Collaboration between Eisai and BioArctic for Alzheimer&#8217;s Disease <br \/><\/b>Since 2005, BioArctic has had a long-term collaboration with Eisai regarding the development and commercialization of drugs for the treatment of AD. The commercialization agreement on the lecanemab antibody was signed in <span class=\"xn-chron\">December 2007<\/span>, and the development and commercialization agreement on the antibody lecanemab back-up for AD, which was signed in <span class=\"xn-chron\">May 2015<\/span>. Eisai is responsible for the clinical development, application for market approval and commercialization of the products for AD. BioArctic has no development costs for lecanemab in AD.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/li>\n<li>\n          <b>About E2027<br \/><\/b>Discovered by Eisai, E2027 is a selective phosphodiesterase (PDE) 9 inhibitor. Inhibiting PDE9 reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain. Eisai is currently developing E2027 as a new treatment for dementia with Lewy bodies.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/li>\n<li>\n          <b>About the Collaboration between Eisai and Sysmex<br \/><\/b>Eisai and Sysmex have entered into a comprehensive non-exclusive collaboration agreement aimed at the creation of new diagnostics in the field of dementia in <span class=\"xn-chron\">February 2016<\/span>. Leveraging each other&#8217;s technologies and knowledge, the two companies aim to discover next-generation diagnostics that will enable early diagnosis, selection of treatment options and the regular monitoring of the effects of treatment for dementia.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/li>\n<li>\n          <b>About Eisai Inc.<br \/><\/b>At Eisai Inc.,\u00a0<i>human health care (hhc)<\/i>\u00a0is our goal. We give our first thoughts to patients and their families, and helping to increase the benefits health care provides. As the U.S. pharmaceutical subsidiary of\u00a0Tokyo-based Eisai Co., Ltd., we have a passionate commitment to patient care that is the driving force behind our efforts to discover and develop innovative therapies to help address unmet medical needs. Eisai is a fully integrated pharmaceutical business that operates in two global business groups: oncology and neurology (dementia-related diseases and neurodegenerative diseases). Our U.S. headquarters, commercial and clinical development organizations are located in\u00a0New Jersey; our discovery labs are in\u00a0Massachusetts\u00a0and\u00a0Pennsylvania; and our global demand chain organization resides in\u00a0Maryland\u00a0and\u00a0North Carolina. To learn more about Eisai Inc., please visit us at\u00a0<a target=\"_blank\" href=\"blank\" rel=\"nofollow noopener noreferrer\">www.eisai.com\/US<\/a>\u00a0and follow us on\u00a0<a target=\"_blank\" href=\"blank\" rel=\"nofollow noopener noreferrer\">Twitter<\/a>\u00a0and\u00a0<a target=\"_blank\" href=\"blank\" rel=\"nofollow noopener noreferrer\">LinkedIn<\/a>.<\/li>\n<\/ol>\n<p>\n        <b>Contact:<br \/><\/b><br \/>\n        <b>Eisai Inc. <br \/><\/b><br \/>\n        <span class=\"xn-person\">Libby Holman<\/span><br \/>\n        <br \/>201-753-1945 <br \/><a target=\"_blank\" href=\"mailto:libby_holman@eisai.com\" rel=\"nofollow noopener noreferrer\">libby_holman@eisai.com<\/a>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\"><\/div>\n<p id=\"PURL\">\n        <img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=NY00434&amp;sd=2021-03-05\" \/> View original content to download multimedia:<a id=\"PRNURL\" rel=\"nofollow\" href=\"http:\/\/www.prnewswire.com\/news-releases\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-adpd-2021-including-lecanemab-ban2401-data-301241517.html\">http:\/\/www.prnewswire.com\/news-releases\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-adpd-2021-including-lecanemab-ban2401-data-301241517.html<\/a><\/p>\n<p>SOURCE  Eisai Inc.<\/p>\n<\/p><\/div>\n<p>    <img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=NY00434&amp;Transmission_Id=202103050852PR_NEWS_USPR_____NY00434&amp;DateId=20210305\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8211; Oral presentations and posters highlighting Eisai&#8217;s investigational novel therapies and immunoassay system being studied for Alzheimer&#8217;s disease and its clinical symptoms &#8211; Preliminary analyses evaluating brain amyloid beta reduction with lecanemab to be featured in oral presentation &#8211; Virtual symposium: The Science Behind the A\u03b2 Pathway in Alzheimer&#8217;s Disease PR Newswire WOODCLIFF LAKE, N.J., March 5, 2021 \/PRNewswire\/ &#8212;\u00a0Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today the presentation of data and information from the company&#8217;s robust Alzheimer&#8217;s disease (AD) pipeline, including lecanemab (BAN2401). Jointly developed by Eisai and Biogen Inc., lecanemab is an investigational humanized monoclonal antibody that binds to neutralize and eliminate soluble, toxic amyloid beta (A\u03b2) aggregates (protofibrils) that are thought to contribute &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-451761","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Eisai Alzheimer&#039;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Eisai Alzheimer&#039;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"&#8211; Oral presentations and posters highlighting Eisai&#8217;s investigational novel therapies and immunoassay system being studied for Alzheimer&#8217;s disease and its clinical symptoms &#8211; Preliminary analyses evaluating brain amyloid beta reduction with lecanemab to be featured in oral presentation &#8211; Virtual symposium: The Science Behind the A\u03b2 Pathway in Alzheimer&#8217;s Disease PR Newswire WOODCLIFF LAKE, N.J., March 5, 2021 \/PRNewswire\/ &#8212;\u00a0Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today the presentation of data and information from the company&#8217;s robust Alzheimer&#8217;s disease (AD) pipeline, including lecanemab (BAN2401). Jointly developed by Eisai and Biogen Inc., lecanemab is an investigational humanized monoclonal antibody that binds to neutralize and eliminate soluble, toxic amyloid beta (A\u03b2) aggregates (protofibrils) that are thought to contribute &hellip; Continue reading &quot;Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-03-05T13:55:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnewswire.com\/media\/378839\/Eisai_Logo.jpg\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\\\/PD\u2122 2021, Including Lecanemab (BAN2401) Data\",\"datePublished\":\"2021-03-05T13:55:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/\"},\"wordCount\":1938,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mma.prnewswire.com\\\/media\\\/378839\\\/Eisai_Logo.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\\\/\",\"name\":\"Eisai Alzheimer's Disease Pipeline Research to be Presented at Virtual AD\\\/PD\u2122 2021, Including Lecanemab (BAN2401) Data - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/","og_locale":"en_US","og_type":"article","og_title":"Eisai Alzheimer's Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data - Market Newsdesk","og_description":"&#8211; Oral presentations and posters highlighting Eisai&#8217;s investigational novel therapies and immunoassay system being studied for Alzheimer&#8217;s disease and its clinical symptoms &#8211; Preliminary analyses evaluating brain amyloid beta reduction with lecanemab to be featured in oral presentation &#8211; Virtual symposium: The Science Behind the A\u03b2 Pathway in Alzheimer&#8217;s Disease PR Newswire WOODCLIFF LAKE, N.J., March 5, 2021 \/PRNewswire\/ &#8212;\u00a0Eisai Inc., the U.S. pharmaceutical subsidiary of Eisai Co., Ltd., announced today the presentation of data and information from the company&#8217;s robust Alzheimer&#8217;s disease (AD) pipeline, including lecanemab (BAN2401). Jointly developed by Eisai and Biogen Inc., lecanemab is an investigational humanized monoclonal antibody that binds to neutralize and eliminate soluble, toxic amyloid beta (A\u03b2) aggregates (protofibrils) that are thought to contribute &hellip; Continue reading \"Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/","og_site_name":"Market Newsdesk","article_published_time":"2021-03-05T13:55:29+00:00","og_image":[{"url":"https:\/\/mma.prnewswire.com\/media\/378839\/Eisai_Logo.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"10 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Eisai Alzheimer&#8217;s Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data","datePublished":"2021-03-05T13:55:29+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/"},"wordCount":1938,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/#primaryimage"},"thumbnailUrl":"https:\/\/mma.prnewswire.com\/media\/378839\/Eisai_Logo.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/eisai-alzheimers-disease-pipeline-research-to-be-presented-at-virtual-ad-pd-2021-including-lecanemab-ban2401-data\/","name":"Eisai Alzheimer's Disease Pipeline Research to be Presented at Virtual AD\/PD\u2122 2021, Including Lecanemab (BAN2401) Data - 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