Safety Run-In Portion of Confirmatory Trials of TAZVERIK\u00ae <\/sup>in ES and FL and Phase 2 Castration-Resistant Prostate Cancer Fully Enrolled; Initial Safety & Activity Data Expected in 2021<\/i><\/p>\n Strong Balance Sheet with Approximately $374 Million in Cash and Marketable Securities at Year-End 2020<\/i><\/p>\n Conference Call Today, February 23 at 8:00 a.m. ET<\/i><\/p>\n CAMBRIDGE, Mass.–(BUSINESS WIRE<\/a>)–Epizyme<\/a> (Nasdaq: EPZM), a fully integrated, commercial-stage biopharmaceutical company developing and delivering novel epigenetic therapies, today provided business and portfolio updates and reported fourth quarter and full year 2020 financial results.\n<\/p>\n \n\u201cEpizyme cemented its position as a leader in epigenetics in 2020, with back-to-back accelerated approvals for TAZVERIK, the first and only FDA-approved EZH2 inhibitor. Following the approvals, we quickly reached epithelioid sarcoma and follicular lymphoma patients in need, adapting our physician and patient outreach efforts to meet the unique challenges presented by the evolving COVID-19 pandemic,\u201d said Robert Bazemore, President and Chief Executive Officer of Epizyme. \u201cWhile the resurgence of COVID-19 cases in the fourth quarter extended many of these challenges, the adoption of TAZVERIK in both ES and FL continued to expand, with net revenue increasing 31% in the fourth quarter from the third quarter. Importantly, our sales and medical affairs teams continue to make progress reaching and educating physicians, reflected in the more than 50% increase in new accounts prescribing TAZVERIK during the fourth quarter. In addition to launch execution, we are encouraged by our clinical progress throughout 2020, during which we achieved all trial milestones on or ahead of schedule. Armed with sufficient capital to support our planned commercial and clinical execution, we believe Epizyme is well-positioned for success in 2021 and beyond.\u201d\n<\/p>\n Recent Progress<\/b><\/p>\n Fourth Quarter and Full Year 2020 Financial Results <\/b><\/p>\n 2021 Financial Guidance<\/b><\/p>\n Conference Call Information<\/b><\/p>\n \nEpizyme will host a conference call today, February 23, at 8:00 a.m. ET. To participate in the conference call, please dial (877) 844-6886 (domestic) or (970) 315-0315 (international) and refer to conference ID 3719819. A webcast, as well as supplemental slides to support the webcast, will be available in the investor section of the Company’s website at www.epizyme.com<\/a>, and will be archived for 60 days following the call.\n<\/p>\n About Non-GAAP Financial Measures<\/b><\/p>\n \nIn addition to financial information prepared in accordance with the U.S. generally accepted accounting principles (GAAP), this press release includes the following non-GAAP financial measures: total non-GAAP adjusted operating expenses on a historical and projected basis, non-GAAP adjusted R&D expenses on a historical basis and non-GAAP adjusted SG&A expenses on a historical basis. Epizyme derives these non-GAAP financial measures by excluding certain expenses and other items from the respective GAAP financial measure, that is most directly comparable to each non-GAAP financial measure. Specifically, the non-GAAP financial measures exclude stock-based compensation expense, depreciation and amortization of intangibles and milestone payments related to TAZVERIK that are payable under the company\u2019s collaboration agreement with Eisai Pharmaceuticals. The company\u2019s management believes that these non-GAAP financial measures are useful to both management and investors in analyzing its ongoing business and operating performance. Management does not intend the presentation of these non-GAAP financial measures to be considered in isolation or as a substitute for results prepared in accordance with GAAP, but as a complement to provide greater transparency. In addition, these non-GAAP financial measures may differ from similarly named measures used by other companies. A quantitative reconciliation of projected non-GAAP adjusted operating expenses to total operating expenses is not available without unreasonable effort primarily due to the company\u2019s inability to predict with reasonable certainty the amount of future stock-based compensation expense.\n<\/p>\n About TAZVERIK<\/b><\/p>\n \nTAZVERIK is a methyltransferase inhibitor indicated for the treatment of:\n<\/p>\n \nThese indications are approved under accelerated approval based on overall response rate and duration of response. Continued approval for these indications may be contingent upon verification and description of clinical benefit in confirmatory trials.\n<\/p>\n \nThe most common (\u226520%) adverse reactions in patients with epithelioid sarcoma are pain, fatigue, nausea, decreased appetite, vomiting and constipation. The most common (\u226520%) adverse reactions in patients with follicular lymphoma are fatigue, upper respiratory tract infection, musculoskeletal pain, nausea and abdominal pain.\n<\/p>\n \nView the U.S. Full Prescribing Information here: Epizyme.com<\/a><\/p>\n About Epizyme, Inc. <\/b><\/p>\n \nEpizyme, Inc. is a fully integrated, commercial-stage biopharmaceutical company committed to its mission of rewriting treatment for cancer and other serious diseases through novel epigenetic medicines. In addition to an active research and discovery pipeline, Epizyme has one U.S. FDA approved product, TAZVERIK\u00ae<\/sup> (tazemetostat), for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma (ES) who are not eligible for complete resection; adult patients with relapsed or refractory follicular lymphoma (FL) whose tumors are positive for an EZH2 mutation as detected by an FDA-approved test and who have received at least two prior systemic therapies; and adult patients with relapsed or refractory follicular lymphoma who have no satisfactory alternative treatment options. These indications are approved under accelerated approval based on overall response rate and duration of response. Continued approval for these indications may be contingent upon verification and description of clinical benefit in confirmatory trials. The Company is also exploring the treatment potential of tazemetostat in investigational clinical trials in other solid tumors and hematological malignancies, as a monotherapy and combination therapy in both relapsed and front-line disease settings. By focusing on the genetic drivers of disease, Epizyme seeks to match medicines with the patients who need them. For more information, visit www.epizyme.com<\/a>.\n<\/p>\n Cautionary Note on Forward-Looking Statements<\/b><\/p>\n \nAny statements in this press release about future expectations, plans and prospects for Epizyme, Inc. and other statements containing the words \u201canticipate,” \u201cbelieve,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cmay,\u201d \u201cplan,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201ctarget,\u201d \u201cpotential,\u201d \u201cwill,\u201d \u201cwould,\u201d \u201ccould,\u201d \u201cshould,\u201d \u201ccontinue,\u201d and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether commercial sales of TAZVERIK for epithelioid sarcoma and follicular lymphoma in the approved indications will be successful; whether tazemetostat will receive marketing approval for epithelioid sarcoma or follicular lymphoma in other jurisdictions, full approval in the United States or approval in any other indication; whether results from preclinical studies or earlier clinical studies will be predictive of the results of future trials, such as the ongoing confirmatory trials; whether results from clinical studies will warrant meetings with regulatory authorities, submissions for regulatory approval or review by governmental authorities under the accelerated approval process; whether the company will receive regulatory approvals, including accelerated approval, to conduct trials or to market products; the impact of the COVID-19 pandemic on the company\u2019s business, results of operations and financial condition; whether the company’s cash resources will be sufficient to fund the company\u2019s foreseeable and unforeseeable operating expenses and capital expenditure requirements; other matters that could affect the availability or commercial success of tazemetostat; and other factors discussed in the \u201cRisk Factors\u201d section of the company\u2019s most recent Form 10-K or Form 10-Q filed with the SEC and in the company’s other filings from time to time with the SEC. In addition, the forward-looking statements included in this press release represent the company\u2019s views as of the date hereof and should not be relied upon as representing the company\u2019s views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company\u2019s views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so.\n<\/p>\n \nTAZVERIK\u00ae<\/sup> is a registered trademark of Epizyme, Inc.\n<\/p>\n \n$\n<\/p>\n<\/td>\n \n168,215\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n139,482\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n205,391\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n241,605\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n47,002\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u2014\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n473,573\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n424,589\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n43,400\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n34,386\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n3,806\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n215,670\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n23,309\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 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\n(6,195\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(148\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(146\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(557\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(609\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(20,000\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n31,483\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n35,817\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n101,283\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n105,835\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n35,017\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n23,530\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n125,178\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n68,303\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(4,372\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(4,106\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(18,516\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(11,721\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(124\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(68\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(429\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(231\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n30,521\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n19,356\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n106,233\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n56,351\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n70,520\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n61,787\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n241,178\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n200,942\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(6,421\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(6,400\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(27,609\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(17,916\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(1,310\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(214\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(3,984\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(840\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(20,000\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n62,789\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n55,173\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n209,585\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n$\n<\/p>\n<\/td>\n \n162,186\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210223005109\/en\/<\/a><\/span><\/p>\n Media: Investors: KEYWORDS:<\/b> United States North America Massachusetts<\/p>\n INDUSTRY KEYWORDS:<\/b> Research Clinical Trials Other Health Biotechnology General Health Pharmaceutical Health Science Oncology Other Science<\/p>\n\n
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\n \u00a0<\/td>\n<\/tr>\n \n \n EPIZYME, INC<\/b><\/td>\n <\/tr>\n \n \n CONSOLIDATED BALANCE SHEET DATA (UNAUDITED)<\/b><\/td>\n <\/tr>\n \n \n (Amounts in thousands)<\/b><\/td>\n <\/tr>\n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n December 31,
2020<\/b><\/td>\n\n December 31,
2019<\/b><\/td>\n<\/tr>\n \n \n Consolidated Balance Sheet Data:<\/b><\/td>\n \n \n \n \n <\/tr>\n \n \n Cash and cash equivalents<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Marketable securities<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Intangible, net<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Total assets<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Total current liabilities<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Deferred revenue<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Related party long-term debt, net of debt discount<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Related party liability related to sale of future royalties<\/td>\n \n \n \n \n \n \n <\/tr>\n \n \n Total stockholders\u2019 equity<\/td>\n \n \n \n \n \n \n <\/tr>\n<\/table>\n \n
\n <\/tr>\n \n \n \n EPIZYME, INC.<\/b><\/td>\n \n <\/tr>\n \n \n \n CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)<\/b><\/td>\n \n <\/tr>\n \n \n \n (Amounts in thousands except per share data)<\/b><\/td>\n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n Three Months Ended<\/b><\/td>\n \n Twelve Months Ended<\/b><\/td>\n \n <\/tr>\n \n \n \n \n December 31<\/b><\/td>\n \n December 31<\/b><\/td>\n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Revenues<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Product revenue, net<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Collaboration revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Total revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Operating expenses<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Cost of product revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Research and development<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Selling, general and administrative<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Total operating expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Operating loss<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Other income, net:<\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Interest (expense) income, net<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Other expense, net<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Related party non-cash interest expense related to sale of future royalties<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Other (expense) income, net:<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Loss before income taxes<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Income provision<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Net loss<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Reconciliation of net loss to net loss attributable to common stockholders<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Net loss<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Accretion of convertible preferred stock<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Net loss attributable to common stockholders<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Net loss per share attributable to common stockholders – basic and diluted<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Weighted-average common shares outstanding used in net loss per share
attributable to common stockholders – basic and diluted<\/td>\n\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n<\/table>\n \n
\n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n EPIZYME, INC.<\/b><\/td>\n \n <\/tr>\n \n \n \n Reconciliation of Selected GAAP Measures to Non-GAAP Measures (UNAUDITED)<\/b><\/td>\n \n <\/tr>\n \n \n \n (Amounts in thousands)<\/b><\/td>\n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n Three Months Ended<\/b><\/td>\n \n Twelve Months Ended<\/b><\/td>\n \n <\/tr>\n \n \n \n \n December 31<\/b><\/td>\n \n December 31<\/b><\/td>\n \n <\/tr>\n \n \n \n Reconciliation of GAAP to Non-GAAP Cost of Product Revenue<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n GAAP Cost of Product Revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Depreciation and Amortization<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Non-GAAP Adjusted Cost of Product Revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Reconciliation of GAAP to Non-GAAP Research and Development<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n GAAP Research and Development<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Stock-Based Compensation Expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Depreciation and Amortization<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Eisai R&D Milestone Expense<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Non-GAAP Adjusted Research and Development<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Reconciliation of GAAP to Non-GAAP Selling, General and Administrative:<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n GAAP Selling, General and Administrative<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Stock-Based Compensation Expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Depreciation and Amortization<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Non-GAAP Adjusted Selling, General and Administrative<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n Reconciliation of GAAP to Non-GAAP Operating Expenses<\/b><\/td>\n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n GAAP Operating Expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Stock-Based Compensation Expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Depreciation and Amortization<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Less: Eisai R&D Milestone Expense<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n Non-GAAP Adjusted Operating Expenses<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n<\/table>\n <\/p>\n
\n<\/b>
Erin Graves, Epizyme, Inc.
\n
Media@epizyme.com
\n<\/a>
(617) 500-0615
\n<\/p>\n
\n<\/b>
Bill Slattery, Jr., W2O Group
\n
wslattery@w2ogroup.com<\/a><\/p>\n
![\"Logo\"](\"https:\/\/mms.businesswire.com\/media\/20210223005109\/en\/675037\/3\/Epizyme-Logo-Trademark.jpg\"){kind=logo}
<\/td>\n<\/tr>\n