{"id":441418,"date":"2021-02-23T01:33:06","date_gmt":"2021-02-23T06:33:06","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=441418"},"modified":"2021-02-23T01:33:06","modified_gmt":"2021-02-23T06:33:06","slug":"nicox-announces-the-publication-in-leading-scientific-journal-of-pre-clinical-efficacy-results-on-a-new-class-of-non-pga-no-donating-iop-lowering-compounds","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/nicox-announces-the-publication-in-leading-scientific-journal-of-pre-clinical-efficacy-results-on-a-new-class-of-non-pga-no-donating-iop-lowering-compounds\/","title":{"rendered":"Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering Compounds"},"content":{"rendered":"<div class=\"mw_release\">\n<table style=\"border-collapse: collapse;margin-left:9pt;width:472.7pt;border-collapse:collapse\">\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;vertical-align: top\">\n            <strong>Press Release<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;text-align: justify;vertical-align: middle;vertical-align: top\">Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering Compounds<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;vertical-align: top\">\n<ul type=\"disc\">\n<li>\n                <strong>New class works solely through nitric oxide (NO)-mediated activity<\/strong>\n              <\/li>\n<li>\n                <strong>Equivalent intraocular pressure (IOP) lowering and faster onset of activity demonstrated vs. the prostaglandin analog (PGA) travoprost<\/strong>\n              <\/li>\n<\/ul>\n<p>  February 23, 2021 \u2013 release at 7:30 am CET <br \/>Sophia Antipolis, France<\/p>\n<p><strong>Nicox SA<\/strong> (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today announced the publication of pre-clinical intraocular pressure (IOP)-lowering results on a new class of non-prostaglandin analog (PGA), nitric oxide (NO)-donating compounds, in the <em>Journal of Ocular Pharmacology and Therapeutics<sup>1<\/sup>. \u00a0<\/em>Increased IOP is one of the principal risk factors of open-angle glaucoma. \u00a0The NO-mediated IOP-lowering effect in this new class of compounds is enhanced by concomitant action of phosphodiesterase type-5 (PDE5) inhibition within the same molecule. <\/p>\n<p><strong>Michele Garufi, Chairman and CEO of Nicox, said <\/strong>\u201c<em>This new class of compounds, in which we optimized and enhanced the activity of nitric oxide, has been developed using the years of expertise and research in this area within Nicox. \u00a0We have shown with VYZULTA and our promising Phase 3 product candidate, NCX 470, that nitric oxide can bring additional efficacy on top of a prostaglandin analog.\u00a0 This new class of compounds enhance the nitric oxide-mediated intraocular pressure lowering effect with the concomitant action of phosphodiesterase type-5 inhibition.\u00a0 We identified product candidates in this class which could potentially be used as monotherapy, or in combination with prostaglandin analogs or other intraocular pressure lowering agents, to add efficacy to existing therapies.\u201d<\/em><\/p>\n<p> The published data on NCX 1741, an analog of Nicox\u2019s development candidate NCX 1728, compared its IOP lowering effect to that of travoprost in a non-human primate model of ocular hypertension<em>.\u00a0 <\/em>This publication reports that NCX 1741 reduced IOP to a similar extent to travoprost, with faster onset of activity. \u00a0Travoprost is a prostaglandin analog, a class of molecules which are considered standard of care for IOP lowering in humans.<\/p>\n<p> NCX 1728 is the first in this new class of compounds to be selected for development (See <a href=\"https:\/\/www.nicox.com\/assets\/files\/EN_NCX-1728-selection-PR_20201023_F..pdf\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>Press Release of October 23, 2020<\/u><\/a>). \u00a0Nicox will conduct a full characterization of the ophthalmic formulations of NCX 1728 prior to initiating non-clinical testing required for filing an IND application. \u00a0Nicox owns all exclusive worldwide rights to NCX 1728 and NCX 1741.<\/p>\n<p> The publication can be found at <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33595367\/\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>https:\/\/pubmed.ncbi.nlm.nih.gov\/33595367\/<\/u><\/a>.<\/p>\n<p><strong>NO-mediated IOP lowering agents<\/strong><\/p>\n<p> It has been established that NO plays a key role in the regulation of IOP. \u00a0An NO-donating moiety can be linked to other pharmaceutical agents to improve IOP-lowering efficacy, as is the case with our lead clinical development candidate NCX 470, a novel NO-donating prostaglandin analog, and our commercialized product with the same mechanism of action, VYZULTA<sup>\u00ae<\/sup> (latanoprostene bunod ophthalmic solution), 0.024%.\u00a0 VYZULTA<sup>\u00ae<\/sup>, indicated for the reduction of IOP in patients with open-angle glaucoma or ocular hypertension, is exclusively licensed worldwide to our partner Bausch + Lomb, who is commercializing it in the U.S., Canada, Argentina and Mexico. \u00a0The effect of NO on IOP lowering may be further increased and\/or prolonged by PDE5 inhibitors, which inhibit the degradation of cyclic guanosine monophosphate (cGMP), a key intracellular messenger that is produced as a result of stimulation by NO.<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;vertical-align: top\">\n            <strong>About Nicox<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;text-align: justify;vertical-align: middle;vertical-align: top\">Nicox S.A. is an international ophthalmology company developing innovative solutions to help maintain vision and improve ocular health.\u00a0 Nicox\u2019s lead program in clinical development is NCX 470, a novel nitric oxide-donating prostaglandin analog, for lowering intraocular pressure in patients with glaucoma.\u00a0 The company is also developing NCX 4251, a proprietary formulation of fluticasone, for acute exacerbations of blepharitis.\u00a0 Nicox generates revenue from VYZULTA<sup>\u00ae <\/sup>in glaucoma, licensed exclusively worldwide to Bausch + Lomb, and ZERVIATE<sup>\u00ae<\/sup> in allergic conjunctivitis, licensed in multiple geographies, including to Eyevance Pharmaceuticals, LLC, in the U.S. and Ocumension Therapeutics in the Chinese and in the majority of South East Asian markets.\u00a0 <\/p>\n<p> Nicox is headquartered in Sophia Antipolis, France, is listed on Euronext Paris (Compartment B: Mid Caps; Ticker symbol: COX) and is part of the CAC Healthcare, CAC Pharma &amp; Bio and Next 150 indexes. <\/p>\n<p> For more information on Nicox, its products or pipeline, please visit: <a href=\"http:\/\/www.nicox.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>www.nicox.com<\/u><\/a><u>.<\/u><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;vertical-align: top\">\n            <strong>Analyst coverage<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" style=\"width:336.54px;vertical-align: top\">\u00a0<\/p>\n<p> Bryan, Garnier &amp; Co \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Victor Floc\u2019h\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Paris, France<br \/>Cantor Fitzgerald\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Louise Chen\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 New York, U.S.<br \/>Edison Investment Research Pooya Hemami\u00a0\u00a0\u00a0\u00a0\u00a0 London, UK<br \/>H.C. Wainwright &amp; Co\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Yi Chen\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 New York, U.S.<br \/>Kepler Cheuvreux\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Damien Choplain Paris, France<\/p>\n<p><em>\u00a0<\/em><\/td>\n<td style=\"width:293.74px;vertical-align: middle;text-align: left;padding-left: 30.0px;vertical-align: top\">\u00a0<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;text-align: justify;vertical-align: middle;vertical-align: top\">\n            <em>The views expressed by analysts in their coverage of Nicox are those of the author and do not reflect the views of Nicox. Additionally, the information contained in their reports may not be correct or current. \u00a0Nicox disavows any obligation to correct or to update the information contained in analyst reports.<\/em>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;vertical-align: top\">\n            <strong>Contacts<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;vertical-align: top\">\n            <strong>Nicox<\/strong><br \/>\n            <br \/>Gavin Spencer<br \/>Executive Vice President, Chief Business Officer<br \/>&amp; Head of Corporate Development\u00a0 <br \/> T +33 (0)4 97 24 53 00<br \/><a href=\"mailto:communications@nicox.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>communications@nicox.com <\/u><\/a><\/td>\n<\/tr>\n<tr>\n<td style=\"width:313.6px;vertical-align: top\">Investors &amp; Media<br \/>United States &amp; Europe <br \/> LifeSci Advisors, LLC <br \/>Mary-Ann Chang <br \/>T +44 7483 284 853<br \/><a href=\"mailto:mchang@lifesciadvisors.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>mchang@lifesciadvisors.com<\/u><\/a><\/td>\n<td colspan=\"2\" style=\"width:316.67px;vertical-align: top\">Media<br \/>France<br \/>LifeSci Advisors, LLC<br \/>Sophie Baumont<br \/>M +33 (0)6 27 74 74 49 <br \/><a href=\"mailto:sophie@lifesciadvisors.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>sophie@lifesciadvisors.com<\/u><\/a><\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;border-bottom: solid black 1pt;vertical-align: top\">\n            <strong>Forward-Looking Statements<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;text-align: justify;vertical-align: middle;vertical-align: top\">The information contained in this document may be modified without prior notice. \u00a0This information includes forward-looking statements. Such forward-looking statements are not guarantees of future performance.\u00a0 These statements are based on current expectations or beliefs of the management of Nicox S.A. and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements.\u00a0 Nicox S.A. and its affiliates, directors, officers, employees, advisers or agents, do not undertake, nor do they have any obligation, to provide updates or to revise any forward-looking statements.<\/p>\n<p> Risks factors which are likely to have a material effect on Nicox\u2019s business are presented in the 3<sup>rd<\/sup> chapter of the \u2018<em>Document d\u2019enregistrement universel, rapport financier annuel et rapport de gestion 2019<\/em>\u2019 filed with the French <em>Autorit\u00e9 des March\u00e9s Financiers<\/em> (AMF) on March 6, 2020 which are available on Nicox\u2019s website (<a href=\"http:\/\/www.nicox.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>www.nicox.com<\/u><\/a>) and (ii) as restated in the 4<sup>th<\/sup> chapter of the half yearly financial report as of June 30, 2020, which is also available on Nicox\u2019s website.<\/td>\n<\/tr>\n<tr>\n<td colspan=\"3\" style=\"width:630.27px;vertical-align: top\">\n            <strong>Nicox S.A.<\/strong><br \/>\n            <br \/>Drakkar 2<br \/> B\u00e2t D, 2405 route des Dolines<br \/> CS 10313, Sophia Antipolis<br \/> 06560 Valbonne, France<br \/> T +33 (0)4 97 24 53 00<br \/> F +33 (0)4 97 24 53 99<\/td>\n<\/tr>\n<\/table>\n<p>\u00a0<\/p>\n<hr \/>\n<p>\n        <sup>1<\/sup> Bastia et al, Journal of Ocular Pharmacology and Therapeutics, 2021. doi: 10.1089\/jop.2020.0126. Epub ahead of print. PMID: 33595367.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p id=\"gnw_attachments_section-header\">\n        <strong>Attachment<\/strong>\n      <\/p>\n<ul id=\"gnw_attachments_section-items\">\n<li>\n          <a target=\"_blank\" href=\"https:\/\/ml-eu.globenewswire.com\/Resource\/Download\/f4af192a-0886-4347-bc6b-eabb6a709d6a\" rel=\"noopener noreferrer\">EN_NCX1741 JOPT PR_20210223_F<\/a>\n        <\/li>\n<\/ul>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMDQ1ODA4MiM0MDA4NzI4MjcjMTAxMTIzMQ==\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml-eu.globenewswire.com\/release\/track\/d9e5b78a-d4bf-4819-a0de-85c9102d89c6\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Press Release Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering Compounds New class works solely through nitric oxide (NO)-mediated activity Equivalent intraocular pressure (IOP) lowering and faster onset of activity demonstrated vs. the prostaglandin analog (PGA) travoprost February 23, 2021 \u2013 release at 7:30 am CET Sophia Antipolis, France Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today announced the publication of pre-clinical intraocular pressure (IOP)-lowering results on a new class of non-prostaglandin analog (PGA), nitric oxide (NO)-donating compounds, in the Journal of Ocular Pharmacology and Therapeutics1. \u00a0Increased IOP is one of the principal risk factors of open-angle glaucoma. \u00a0The NO-mediated IOP-lowering effect in this new &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/nicox-announces-the-publication-in-leading-scientific-journal-of-pre-clinical-efficacy-results-on-a-new-class-of-non-pga-no-donating-iop-lowering-compounds\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering Compounds&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-441418","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results 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solely through nitric oxide (NO)-mediated activity Equivalent intraocular pressure (IOP) lowering and faster onset of activity demonstrated vs. the prostaglandin analog (PGA) travoprost February 23, 2021 \u2013 release at 7:30 am CET Sophia Antipolis, France Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today announced the publication of pre-clinical intraocular pressure (IOP)-lowering results on a new class of non-prostaglandin analog (PGA), nitric oxide (NO)-donating compounds, in the Journal of Ocular Pharmacology and Therapeutics1. \u00a0Increased IOP is one of the principal risk factors of open-angle glaucoma. \u00a0The NO-mediated IOP-lowering effect in this new &hellip; Continue reading &quot;Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering Compounds&quot;\" \/>\n<meta property=\"og:url\" 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NO-donating IOP-Lowering Compounds New class works solely through nitric oxide (NO)-mediated activity Equivalent intraocular pressure (IOP) lowering and faster onset of activity demonstrated vs. the prostaglandin analog (PGA) travoprost February 23, 2021 \u2013 release at 7:30 am CET Sophia Antipolis, France Nicox SA (Euronext Paris: FR0013018124, COX), an international ophthalmology company, today announced the publication of pre-clinical intraocular pressure (IOP)-lowering results on a new class of non-prostaglandin analog (PGA), nitric oxide (NO)-donating compounds, in the Journal of Ocular Pharmacology and Therapeutics1. \u00a0Increased IOP is one of the principal risk factors of open-angle glaucoma. \u00a0The NO-mediated IOP-lowering effect in this new &hellip; Continue reading \"Nicox Announces the Publication in Leading Scientific Journal of Pre-Clinical Efficacy Results on a New Class of Non-PGA NO-donating IOP-Lowering 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