{"id":439873,"date":"2021-02-19T08:33:14","date_gmt":"2021-02-19T13:33:14","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=439873"},"modified":"2021-02-19T08:33:14","modified_gmt":"2021-02-19T13:33:14","slug":"tff-pharmaceuticals-announces-positive-preclinical-results-with-two-biodefense-countermeasures-for-the-united-states-army-medical-research-institute-of-infectious-diseases-usamriid","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/tff-pharmaceuticals-announces-positive-preclinical-results-with-two-biodefense-countermeasures-for-the-united-states-army-medical-research-institute-of-infectious-diseases-usamriid\/","title":{"rendered":"TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID)"},"content":{"rendered":"

<\/p>\n

TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID)<\/b><\/p>\n

Company\u2019s Thin Film Freezing maintained efficacy for two different biodefense countermeasures against Alphaviruses and Filoviruses <\/i><\/p>\n

AUSTIN, Texas–(BUSINESS WIRE<\/a>)–
\nTFF Pharmaceuticals, Inc. (NASDAQ: TFFP), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented thin-film freeze-drying (TFFD) technology platform, today announced that, in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), the Company obtained positive preclinical in vitro<\/i> efficacy data from TFF formulated biodefense countermeasures.\n<\/p>\n

\nIn April of 2020, TFF Pharmaceuticals and USAMRIID, part of the U.S. Army Medical Research and Development Command, the U.S. Army\u2019s premier institution and facility for defensive research into countermeasures against biological warfare, entered into a 3-year Cooperative Research and Development Agreement (CRADA) to investigate TFFD of various biodefense countermeasures to demonstrate the use of these formulations as needle-free, inhaled treatments that are temperature-insensitive. The first two countermeasures, a monoclonal antibody (mAbs) against Ebolavirus Zaire (EBOV) and a recombinant vesicular stomatitis virus (rVSV) vaccine candidate against Venezuelan equine encephalitis virus (VEEV), were TFFD formulated and tested for efficacy in a well-established in vitro<\/i> neutralization assay. Data showed that the activity of the mAbs and rVSV vaccines were preserved after TFFD. Formulation optimization and long-term stability testing are ongoing. Next steps will be in vivo<\/i> testing in appropriate animal models.\n<\/p>\n

\n\u201cThis data utilizing our TFFD technology to reformulate currently developed and characterized medical countermeasures against EBOV and VEEV is an important milestone,\u201d said Glenn Mattes, CEO of TFF Pharmaceuticals. \u201cMost countermeasures are parenterally delivered, require trained personnel for administration and are temperature sensitive. There is an urgent need to develop technologies to improve biodefense countermeasures to better protect the warfighter.\u201d\n<\/p>\n

\n\u201cGreat strides have been made to develop licensed countermeasures against Department of Defense (DoD) select agents of interest, such as Ebolavirus Zaire (EBOV) and Venezuelan equine encephalitis (VEEV),\u201d said John M. Dye, Jr., Viral Immunology branch chief, USAMRIID. \u201cAn alternate route of administration that bypasses the need for cold chain control and administration by specialized personnel could be critical in the protection of our defense forces in biologically hostile environments around the globe.\u201d\n<\/p>\n

\nTFF continues to engage and collaborate with various government and defense contracting agencies in an effort to utilize the Company\u2019s TFFD technology platform to formulate dry powder vaccines and therapeutics for delivery via reconstitution, or for lung or nasal inhalation.\n<\/p>\n

About the U.S. Army Medical Research Institute of Infectious Diseases:<\/b><\/p>\n

\nFor over 50 years, USAMRIID has provided leading edge medical capabilities to deter and defend against current and emerging biological threat agents. The Institute is the only laboratory in the Department of Defense equipped to safely study highly hazardous viruses requiring maximum containment at Biosafety Level 4. Research conducted at USAMRIID leads to medical solutions \u2013 vaccines, drugs, diagnostics, information, and training programs \u2013 that benefit both military personnel and civilians. Established in 1969, the Institute plays a key role as the lead military medical research laboratory for the Defense Threat Reduction Agency\u2019s Joint Science and Technology Office for Chemical and Biological Defense. USAMRIID is a subordinate laboratory of the U.S. Army Medical Research and Development Command. For more information, visit www.usamriid.army.mil<\/a>. The information contained in this press release does not necessarily reflect the position or the policy of the Government and no official endorsement should be inferred.\n<\/p>\n

About TFF Pharmaceuticals\u2019 Thin Film Freezing technology platform<\/b><\/p>\n

\nTFF Pharmaceuticals\u2019 Thin Film Freezing (TFF) platform was designed to improve the solubility and absorption of poorly water-soluble drugs and is particularly suited to generate dry powder particles with properties targeted for inhalation delivery, especially to the deep lung, an area of extreme interest in respiratory medicine. The TFF process results in a \u201cBrittle Matrix Particle,\u201d which possesses low bulk density, high surface area, and typically an amorphous morphology, allowing the particles to supersaturate when contacting the target site, such as lung tissue. Based upon laboratory experiments, the aerodynamic properties of the particles are such that the portion of a drug deposited to the deep lung has the potential to reach as high as 75 percent.\n<\/p>\n

About TFF Pharmaceuticals<\/b><\/p>\n

\nTFF Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented Thin Film Freezing, or TFF, technology platform. Early testing confirms that the TFF platform can significantly improve the solubility and absorption of poorly water-soluble drugs, a class of drugs that comprises approximately one-third of the major pharmaceuticals worldwide, thereby improving their pharmacokinetics. TFF Pharmaceuticals has two lead drug candidates: Voriconazole Inhalation Powder and Tacrolimus Inhalation Powder. The Company plans to add to this pipeline by collaborating with large pharmaceutical partners. The TFF Platform is protected by 42 patents issued or pending in the US and internationally. To learn more about TFF Pharmaceuticals and its product candidates, visit the Company\u2019s website at https:\/\/tffpharma.com<\/a><\/p>\n

SAFE HARBOR<\/b><\/p>\n

\nThis press release contains forward-looking statements regarding TFF Pharmaceuticals, Inc., including the benefits of the Company\u2019s TFFD platform and its dry powder versions of voriconazole and the Company\u2019s plans to add to its existing pipeline of product candidates. Those forward-looking statements involve known and unknown risks, uncertainties and other factors that could cause actual results to differ materially. Among those factors are: (i) the risk that the Company may not be able to successfully conclude preclinical testing of its EBOV mAbs or rVSV vaccine or obtain pre-market approval of either product candidate, (ii) no drug product incorporating the TFFD platform has received FDA pre-market approval or otherwise been incorporated into a commercial drug product, (iii) the Company has no current agreements or understandings with any large pharmaceutical companies for the development of a drug product incorporating the TFFD Platform, (iv) the risk that the Company will not be able to conclude a long-term commercial agreement with any third-party, and (v) those other risks disclosed in the section \u201cRisk Factors\u201d included in the Company\u2019s prospectus supplement filed with the SEC on December 8, 2020. TFF Pharmaceuticals cautions readers not to place undue reliance on any forward-looking statements. TFF Pharmaceuticals does not undertake, and specifically disclaims, any obligation to update or revise such statements to reflect new circumstances or unanticipated events as they occur, except as required by law.\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20210219005285\/en\/<\/a><\/span><\/p>\n

Company:
\n<\/b>
Glenn Mattes
\n
President and CEO
\n
TFF Pharmaceuticals, Inc.
\n
gmattes@tffpharma.com
\n<\/a>
737-802-1973<\/p>\n

Kirk Coleman
\n
Chief Financial Officer
\n
TFF Pharmaceuticals, Inc.
\n
kcoleman@tffpharma.com
\n<\/a>
817-989-6358<\/p>\n

Investor Relations and Media:
\n<\/b>
Paul Sagan
\n
LaVoieHealthScience
\n
psagan@lavoiehealthscience.com
\n<\/a>
617-953-4779\n<\/p>\n

KEYWORDS:<\/b> Texas United States North America<\/p>\n

INDUSTRY KEYWORDS:<\/b> Medical Devices Other Defense Infectious Diseases Clinical Trials Biotechnology Health Pharmaceutical General Health Defense<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) Company\u2019s Thin Film Freezing maintained efficacy for two different biodefense countermeasures against Alphaviruses and Filoviruses AUSTIN, Texas–(BUSINESS WIRE)– TFF Pharmaceuticals, Inc. (NASDAQ: TFFP), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented thin-film freeze-drying (TFFD) technology platform, today announced that, in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), the Company obtained positive preclinical in vitro efficacy data from TFF formulated biodefense countermeasures. In April of 2020, TFF Pharmaceuticals and USAMRIID, part of the U.S. Army Medical Research and Development Command, the U.S. Army\u2019s premier institution … <\/p>\n

Continue reading “TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID)”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-439873","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nTFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/tff-pharmaceuticals-announces-positive-preclinical-results-with-two-biodefense-countermeasures-for-the-united-states-army-medical-research-institute-of-infectious-diseases-usamriid\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"TFF Pharmaceuticals Announces Positive Preclinical Results with Two Biodefense Countermeasures for the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) Company\u2019s Thin Film Freezing maintained efficacy for two different biodefense countermeasures against Alphaviruses and Filoviruses AUSTIN, Texas–(BUSINESS WIRE)– TFF Pharmaceuticals, Inc. (NASDAQ: TFFP), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented thin-film freeze-drying (TFFD) technology platform, today announced that, in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), the Company obtained positive preclinical in vitro efficacy data from TFF formulated biodefense countermeasures. 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(NASDAQ: TFFP), a clinical-stage biopharmaceutical company focused on developing and commercializing innovative drug products based on its patented thin-film freeze-drying (TFFD) technology platform, today announced that, in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID), the Company obtained positive preclinical in vitro efficacy data from TFF formulated biodefense countermeasures. 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