{"id":439756,"date":"2021-02-19T07:03:20","date_gmt":"2021-02-19T12:03:20","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=439756"},"modified":"2021-02-19T07:03:20","modified_gmt":"2021-02-19T12:03:20","slug":"clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/","title":{"rendered":"Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021"},"content":{"rendered":"
\n

SALT LAKE CITY, Feb. 19, 2021 (GLOBE NEWSWIRE) — Clene Inc.<\/a> (NASDAQ: CLNN) (along with its subsidiaries, \u201cClene\u201d) and its wholly owned subsidiary Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced that it will present updated interim data from its REPAIR-MS study and updated blinded interim data from its VISIONARY-MS study in poster presentations at the Americas Committee for Treatment and Research in Multiple Sclerosis\u2019 ACTRIMS Forum 2021<\/a> (\u201cACTRIMS\u201d) taking place virtually from February 25-27, 2021.<\/p>\n

Details on the posters are shown below.<\/p>\n

\n
\n Title<\/u>
\n <\/strong>
\n :<\/strong> Effects of Nanocatalysis on CNS Bioenergetic Markers in Patients Treated with CNM-Au8: Interim Results from a Phase 2 31<\/sup>Phosphorous Magnetic Resonance Imaging Study in Relapsing MS
Presenter<\/u><\/strong>:<\/strong> Robert Glanzman, MD, FAAN, Chief Medical Officer of Clene<\/p>\n

\n
\n Title<\/u>
\n <\/strong>
\n :<\/strong> Update to a Phase 2 Clinical Trial of Catalytic Gold Nanocrystals, CNM-Au8, for the Treatment of Chronic Optic Neuropathy
Presenter<\/u><\/strong>:<\/strong> Robert Glanzman, MD, FAAN, Chief Medical Officer of Clene<\/p>\n

The posters will be available on demand via the conference portal beginning at 7:30 AM ET on February 25, 2021. Following their presentation at the conference, the posters will also be available on the \u201cEvents and Presentations<\/a>\u201d section of the Clene website.<\/p>\n

\n About VISIONARY-MS<\/strong>\n <\/p>\n

VISIONARY-MS is Phase 2, multi-center, double-blind, randomized, placebo-controlled trial evaluating the efficacy and safety of CNM-Au8 as a remyelinating and neuro-reparative treatment in stable relapsing MS patients with chronic visual impairment. The primary endpoint is improvement in low contrast letter acuity from baseline to Week-24. Key secondary endpoints include improvements from baseline to Week-24 in the remaining modified-Multiple Sclerosis Functional Composite subscales (symbol digit modalities test, 9-hole peg test, and timed 25-foot walk). Participants drink a 2 oz. (60 ml) dose of the nanocrystal suspension (or placebo) daily each morning. For more information see ClinicalTrials.gov Identifier: NCT03536559<\/a>.<\/p>\n

\n About REPAIR-MS<\/strong>\n <\/p>\n

REPAIR-MS is a Phase 2, single-center, open-label, sequential group study examining the brain metabolic effects, safety, pharmacokinetics and pharmacodynamics of CNM-Au8 in patients who have been diagnosed with MS within 15 years of screening. Investigators and participants are blinded to dose, which can consist of a 15 or 30 mg orally delivered dose of the nanocrystal suspension daily each morning for at least 12 weeks. Participants undergo\u00a031<\/sup>P-MRS brain imaging scans to semi-quantitatively compare bioenergetic brain metabolites prior to and after CNM-Au8 administration. The objective of this study is to demonstrate target engagement for CNM-Au8 on CNS biomarkers related to bioenergetics and neuronal metabolism in patients with MS. The study is taking place at the University of Texas Southwestern Medical Center with a team of internationally recognized experts in brain imaging and treatment of disorders of the CNS. For more information see ClinicalTrials.gov Identifier: NCT03993171<\/a>.<\/p>\n

\n About CNM-Au8<\/strong>\n <\/p>\n

CNM-Au8 is a concentrated, aqueous suspension of clean-surfaced faceted gold nanocrystals that act catalytically to support important intracellular biological reactions. CNM-Au8 consists solely of pure gold nanoparticles, composed of clean-surfaced, faceted, geometrical crystals held in stable aqueous suspension in pharmaceutical grade water. CNM-Au8 has demonstrated safety in Phase 1 studies in healthy volunteers and has shown both remyelination and neuroprotective effects in multiple preclinical (animal) models. Preclinical data, both published in peer-reviewed journals and presented at scientific congresses, demonstrate that treatment of neuronal cultures with CNM-Au8 improves survival of neurons, protects neurite networks, decreases intracellular levels of reactive oxygen species and improves mitochondrial capacity in response to cellular stresses induced by multiple disease-relevant neurotoxins. Oral treatment with CNM-Au8 improved functional behaviors in rodent models of ALS, MS and Parkinson\u2019s disease versus vehicle (placebo). CNM-Au8 is currently being tested in a Phase 2 clinical study for the treatment of chronic optic neuropathy in patients with stable relapsing MS, in addition to Phase 2 and Phase 3 clinical studies for disease progression in patients with ALS.<\/p>\n

\n About Clene<\/strong>\n <\/p>\n

Clene is a clinical-stage biopharmaceutical company focused on the development of unique therapeutics for neurodegenerative diseases. Clene has innovated a novel nanotechnology drug platform for the development of a new class of orally administered neurotherapeutic drugs. Clene has also advanced into the clinic an aqueous solution of ionic zinc and silver for anti-viral and anti-microbial uses. Founded in 2013, the company is based in Salt Lake City, Utah with R&D and manufacturing operations located in North East, Maryland. For more information, please visit www.clene.com<\/a>.<\/p>\n

\n Forward-Looking Statements <\/strong>\n <\/p>\n

This press release contains “forward-looking statements” within the meaning of the “safe harbor” provisions of the Private Securities Litigation Reform Act of 1995. Clene’s actual results may differ from its expectations, estimates and projections and consequently, you should not rely on these forward-looking statements as predictions of future events. Words such as “expect,” “estimate,” “project,” “budget,” “forecast,” “anticipate,” “intend,” “plan,” “may,” “will,” “could,” “should,” “believes,” “predicts,” “potential,” “might” and “continues,” and similar expressions are intended to identify such forward-looking statements. These forward-looking statements involve significant known and unknown risks and uncertainties, many of which are beyond Clene\u2019s control and could cause actual results to differ materially and adversely from expected results. Factors that may cause such differences include Clene\u2019s ability to demonstrate the efficacy and safety of its drug candidates; the clinical results for its drug candidates, which may not support further development or marketing approval; actions of regulatory agencies, which may affect the initiation, timing and progress of clinical trials and marketing approval; Clene\u2019s ability to achieve commercial success for its marketed products and drug candidates, if approved; Clene\u2019s ability to obtain and maintain protection of intellectual property for its technology and drugs; Clene\u2019s reliance on third parties to conduct drug development, manufacturing and other services; Clene\u2019s limited operating history and its ability to obtain additional funding for operations and to complete the licensing or development and commercialization of its drug candidates; the impact of the COVID-19 pandemic on Clene\u2019s clinical development, commercial and other operations, as well as those risks more fully discussed in the section entitled \u201cRisk Factors\u201d in Clene\u2019s recently filed registration statement on Form S-4, as well as discussions of potential risks, uncertainties, and other important factors in Clene\u2019s subsequent filings with the U.S. Securities and Exchange Commission. Clene undertakes no obligation to release publicly any updates or revisions to any forward-looking statements to reflect any change in its expectations or any change in events, conditions or circumstances on which any such statement is based, subject to applicable law. All information in this press release is as of the date of this press release. The information contained in any website referenced herein is not, and shall not be deemed to be, part of or incorporated into this press release.<\/p>\n

\n Media Contact<\/strong>
\n
Andrew Mielach
LifeSci Communications
(646) 876-5868
amielach@lifescicomms.com<\/p>\n

\n Investor Contact<\/strong>
\n
Bruce Mackle
LifeSci Advisors, LLC
(929) 469-3859
bmackle@lifesciadvisors.com<\/p>\n

Source: Clene Inc.<\/p>\n

\n
\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

SALT LAKE CITY, Feb. 19, 2021 (GLOBE NEWSWIRE) — Clene Inc. (NASDAQ: CLNN) (along with its subsidiaries, \u201cClene\u201d) and its wholly owned subsidiary Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced that it will present updated interim data from its REPAIR-MS study and updated blinded interim data from its VISIONARY-MS study in poster presentations at the Americas Committee for Treatment and Research in Multiple Sclerosis\u2019 ACTRIMS Forum 2021 (\u201cACTRIMS\u201d) taking place virtually from February 25-27, 2021. Details on the posters are shown below. Title : Effects of Nanocatalysis on CNS Bioenergetic Markers in Patients Treated with CNM-Au8: Interim Results from a Phase 2 31Phosphorous Magnetic Resonance Imaging Study in Relapsing MSPresenter: Robert Glanzman, MD, FAAN, Chief Medical Officer of … <\/p>\n

Continue reading “Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-439756","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nClene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"SALT LAKE CITY, Feb. 19, 2021 (GLOBE NEWSWIRE) — Clene Inc. (NASDAQ: CLNN) (along with its subsidiaries, \u201cClene\u201d) and its wholly owned subsidiary Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced that it will present updated interim data from its REPAIR-MS study and updated blinded interim data from its VISIONARY-MS study in poster presentations at the Americas Committee for Treatment and Research in Multiple Sclerosis\u2019 ACTRIMS Forum 2021 (\u201cACTRIMS\u201d) taking place virtually from February 25-27, 2021. Details on the posters are shown below. 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(NASDAQ: CLNN) (along with its subsidiaries, \u201cClene\u201d) and its wholly owned subsidiary Clene Nanomedicine, Inc., a clinical-stage biopharmaceutical company, today announced that it will present updated interim data from its REPAIR-MS study and updated blinded interim data from its VISIONARY-MS study in poster presentations at the Americas Committee for Treatment and Research in Multiple Sclerosis\u2019 ACTRIMS Forum 2021 (\u201cACTRIMS\u201d) taking place virtually from February 25-27, 2021. Details on the posters are shown below. Title : Effects of Nanocatalysis on CNS Bioenergetic Markers in Patients Treated with CNM-Au8: Interim Results from a Phase 2 31Phosphorous Magnetic Resonance Imaging Study in Relapsing MSPresenter: Robert Glanzman, MD, FAAN, Chief Medical Officer of … Continue reading \"Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/","og_site_name":"Market Newsdesk","article_published_time":"2021-02-19T12:03:20+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE1NTkwNSMzOTg0NTUzIzUwMDA3NjMxOA==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021","datePublished":"2021-02-19T12:03:20+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/"},"wordCount":1108,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE1NTkwNSMzOTg0NTUzIzUwMDA3NjMxOA==","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/clene-nanomedicine-to-present-updated-interim-data-from-phase-2-multiple-sclerosis-programs-at-actrims-forum-2021\/","name":"Clene Nanomedicine to Present Updated Interim Data from Phase 2 Multiple Sclerosis Programs at ACTRIMS Forum 2021 - 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