{"id":434954,"date":"2021-02-12T07:33:32","date_gmt":"2021-02-12T12:33:32","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=434954"},"modified":"2021-02-12T07:33:32","modified_gmt":"2021-02-12T12:33:32","slug":"denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\/","title":{"rendered":"Denali Therapeutics Reports Positive Three-Month Data from Phase 1\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II)"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li>\n          <strong>Sustained normalization and further decreased levels of CSF glycosaminoglycan heparan sulfate, a key CNS disease biomarker, observed after three months of intravenous dosing <\/strong><\/p>\n<\/li>\n<li>\n          <strong>Reductions in exploratory CSF biomarkers consistent with improved lysosomal function\u00a0<\/strong><\/p>\n<\/li>\n<li>\n          <strong>Reductions in levels of urine\u00a0glycosaminoglycans\u00a0following\u00a0a switch from\u00a0idursulfase support potential for improved peripheral effects relative to standard of care<\/strong><\/p>\n<\/li>\n<li>\n          <strong>Generally well tolerated with\u00a0safety profile consistent with\u00a0other\u00a0enzyme replacement\u00a0therapies; most frequently observed adverse events of mild or moderate infusion-related reactions\u00a0<\/strong><\/p>\n<\/li>\n<li>\n          <strong>Management will host a webinar\u00a0for analysts\u00a0at 8:00 a.m. Eastern\u00a0Time\u00a0today\u00a0<\/strong><br \/>\n          \n        <\/li>\n<\/ul>\n<p>SOUTH SAN FRANCISCO, Calif., Feb.  12, 2021  (GLOBE NEWSWIRE) &#8212; Denali Therapeutics Inc. (NASDAQ: DNLI), a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases, today announced\u00a0additional positive\u00a0interim results from the ongoing Phase 1\/2\u00a0study evaluating\u00a0ETV:IDS\u00a0(DNL310)\u00a0as a potential brain-penetrant enzyme replacement therapy for treating both central nervous system (CNS) and peripheral manifestations of\u00a0Hunter syndrome (MPS II).\u00a0The data will be presented later today during a late-breaker session at\u00a0WORLD<em>Symposium<\/em>\u2122. Denali management will host an analyst webinar today\u00a0beginning\u00a0at 8:00 a.m. Eastern Time\u00a0to discuss both interim clinical and new preclinical data\u00a0that will be presented at the\u00a0conference.\u00a0\u00a0<\/p>\n<p>An interim analysis included data on a total of five patients enrolled in Cohort A in the Phase 1\/2 study, who all received three months of weekly intravenous doses of DNL310 after switching from idursulfase enzyme replacement therapy on Day 1 of the study. Key results included:<\/p>\n<ul type=\"disc\">\n<li>Normal levels of heparan sulfate, a glycosaminoglycan (GAG), in cerebrospinal fluid (CSF) that were seen after four weeks of dosing in four of five patients were sustained after three months of dosing (mean 85% reduction across Cohort A; p&lt;0.001); heparan sulfate levels were further significantly reduced and approached normal levels in the fifth patient (from 25% to 73% reduction from one to three months, respectively).<\/li>\n<li>Reductions in downstream exploratory CSF biomarkers, GM3 and BMP (lysosomal lipids),\u00a0of 39%\u00a0and 15%, respectively, were observed after eight weeks of dosing with DNL310, consistent with improvement in lysosomal function.<\/li>\n<li>Reductions in urine\u00a0heparan sulfate\u00a0and\u00a0dermatan sulfate following a switch from idursulfase, of 76%\u00a0and\u00a082%, respectively,\u00a0were observed after\u00a0eight\u00a0weeks of dosing\u00a0of DNL310, supporting potential for improved peripheral effects relative to standard of care.<\/li>\n<li>DNL310 was generally well tolerated with no dose reductions and all five patients continue in the study. The\u00a0most frequently observed adverse events were mild or moderate infusion-related reactions in three of five patients, which is consistent with\u00a0other\u00a0enzyme replacement\u00a0therapies (ERTs).\u00a0\u00a0<\/li>\n<li>Based on three-month clinical data, doses of DNL310 from 3 mg\/kg to 30 mg\/kg are generally well tolerated and provide flexibility for dose selection in clinical studies.<\/li>\n<\/ul>\n<p>\u201cWe are encouraged by these new Phase 1\/2 data, which continue to support the overall safety profile and biomarker effects of DNL310 as an investigational treatment in Hunter syndrome,\u201d said Carole Ho, M.D., Denali\u2019s Chief Medical Officer. \u201cImportantly, at dose levels resulting in robust and durable biomarker response, DNL310 appears\u00a0generally well tolerated and\u00a0consistent with standard\u00a0of\u00a0care ERT.\u00a0We are pleased to observe that early biomarker effects\u00a0initially seen after four weeks of treatment with DNL310\u00a0were\u00a0sustained after three months of dosing.\u00a0We are also encouraged by the findings related to exploratory\u00a0lipid\u00a0biomarkers which indicate, for the first time, improvement in lysosomal function.\u00a0Taken together, these data\u00a0support our previously announced decision to expand and\u00a0advance\u00a0clinical studies with DNL310 as a potential treatment for both body and brain in patients with Hunter syndrome.\u201d\u00a0<\/p>\n<p>Denali also presented preclinical research at WORLD<em>Symposium<\/em>\u2122 on a mouse model of Hunter syndrome showing that ETV:IDS treatment reduces CSF GAGs and that these reductions are correlated with GAG reductions in the brain. Furthermore, reduction in CSF GAG levels was associated with subsequent improvements in lysosomal function, neurodegeneration biomarkers, neurobehavioral outcomes and\u00a0correction of\u00a0skeletal disease manifestations in the mouse model.<\/p>\n<p>\u201cThe magnitude and durability of biomarker response and tolerability seen with DNL310 provide strong support for the potential application of our Transport Vehicle (TV) technology to deliver enzymes and other therapeutic modalities to the brain,\u201d said Ryan Watts, Ph.D., Denali\u2019s Chief Executive Officer. \u201cCompared to other investigational BBB transport technologies, we have engineered specific molecular properties into our TV technology for better brain uptake and biodistribution of the therapeutic cargo to relevant cell types. The DNL310 Phase 1\/2 results also support the potential for systemic administration of TV-enabled therapeutics to address peripheral disease. Taken together, these data increase our confidence that DNL310 may ultimately prove to be an impactful therapy for Hunter syndrome patients and their families and that we can apply our TV technology more broadly to defeat degeneration and address other diseases with brain manifestations.\u201d<\/p>\n<p>\n        <strong>About the DNL310 Development Program for the Potential Treatment of Hunter syndrome (MPS II)<\/strong><br \/>\n        <br \/>Hunter syndrome (MPS II) is a rare neurodegenerative lysosomal storage disorder caused by a mutation in the gene that encodes for the enzyme iduronate-2-sulfatase (IDS). The resultant reduction or loss of IDS enzyme activity leads to accumulation of GAGs, which causes lysosomal dysfunction and neurodegeneration as well as progressive damage to multiple organs including bone, cartilage, heart and lung. Current standard of care enzyme replacement treatment does not address neuronopathic manifestations of the disease as it does not sufficiently cross the BBB. DNL310 is a fusion protein composed of IDS fused to Denali\u2019s proprietary Enzyme Transport Vehicle (ETV), which is engineered to cross the BBB via receptor-mediated transcytosis into the brain. Denali previously announced human biomarker proof-of-concept for its TV technology from Cohort A (n=5) of an ongoing Phase 1\/2 study of DNL310 in patients with Hunter syndrome. The study is currently enrolling Cohort B, and a Cohort C is planned to further explore clinical endpoints. DNL310 is an investigational drug and is not approved by any health authority.<\/p>\n<p>\n        <strong>About Denali\u2019s TV\u00a0Platform<\/strong>\u00a0<br \/>The BBB is essential in maintaining the brain\u2019s microenvironment and protecting it from harmful substances and pathogens circulating in the bloodstream. Historically, the BBB has posed significant challenges to drug development for CNS diseases by preventing most drugs from reaching the brain in therapeutically relevant concentrations.\u00a0Denali\u2019s TV platform is a proprietary technology designed to effectively deliver large therapeutic molecules such as antibodies, enzymes, proteins, and oligonucleotides across the BBB after intravenous administration. The TV technology is based on engineered Fc fragments that bind to specific natural transport receptors, such as transferrin receptor, which are expressed at the BBB and are delivered to the brain through receptor-mediated transcytosis. Denali research has shown that in animal models, antibodies and enzymes engineered with the TV technology have demonstrated more than 10- to 30-fold greater brain exposure than similar antibodies and enzymes without this technology. Improved exposure and broad distribution in the brain may increase therapeutic efficacy by enabling widespread achievement of therapeutically relevant concentrations of product candidates.\u00a0ETV:IDS\u00a0(DNL310) is Denali\u2019s lead TV-enabled program in Phase 1\/2 development for the potential treatment of Hunter syndrome (MPS II).\u00a0\u00a0<\/p>\n<p>\n        <strong>Webinar Information<\/strong>\u00a0<br \/>Denali will host a webinar today,\u00a0Friday,\u00a0February 12, at 8:00 a.m. Eastern Time to discuss the DNL310 Phase 1\/2\u00a0data. A registration link will be available on the Events page under the Investor section of Denali\u2019s website at <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=6_R8omS_p0UMSM9-Bl7wxgU_h0UOpByfoRZJzJvtQVzWYev84wsLymCO8GRkwH6805oDajhdWmn2KI2aunUTOhZQ3NWs1J-6nUTr4hkD9nFWUqSllgJ82wE4j5fkK4KN2FRCbz6_NEh5PqwOXNYDtU6Es70BBgeJH7WJJ0mrgrM=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">https:\/\/www.denalitherapeutics.com\/investors\/events<\/a> or by clicking <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=_MBcYU4NGcuDaEbiSgrRi5aNW0ILysH8VMk-_dLmazb1b-ApXX5tj6w8RF8e2zgfxOP6pWlDPmC7pgRjA1hu-kHlshfmdq93U8xZPGG8-c8UUdRU8HCKHR6IADfG9xt-\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">here<\/a>. An archived replay of the webinar will be available for at least 30 days following the event.<\/p>\n<p>\n        <strong>About Denali Therapeutics<\/strong>\u00a0<br \/>Denali Therapeutics is a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases. Denali pursues new treatments by rigorously assessing genetically validated targets, engineering delivery across the BBB and guiding development through biomarkers that demonstrate target and pathway engagement. Denali is based in South San Francisco. For additional information, please visit www.denalitherapeutics.com.\u00a0\u00a0<\/p>\n<p>\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p>This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements expressed or implied in this press release include, but are not limited to, statements regarding Denali&#8217;s progress and business plans; plans, timelines and expectations related to DNL310, the DNL310 development program, Denali\u2019s TV technology platform, other programs enabled by Denali\u2019s TV platform, and the ongoing Phase 1\/2 study, and planned future studies, of DNL310; the therapeutic potential of DNL310 and Denali\u2019s TV platform; and statements made by Denali\u2019s Chief Medical Officer and Chief Executive Officer.\u00a0<\/p>\n<p>Actual results are subject to risks and uncertainties and may differ materially from those indicated by these forward-looking statements as a result of these risks and uncertainties, including but not limited to, risks related to: any and all risks to Denali\u2019s business and operations caused directly or indirectly by the evolving COVID-19 pandemic; risk of the occurrence of any event, change or other circumstance that could give rise to the termination of Denali\u2019s agreements with its partners; Denali\u2019s early stages of clinical drug development; Denali\u2019s and its partners\u2019 ability to complete the development and, if approved, commercialization of its product candidates; Denali\u2019s and its partners\u2019 ability to enroll patients in its ongoing and future clinical trials; Denali\u2019s reliance on third parties for the manufacture and supply of its product candidates for clinical trials; Denali\u2019s dependence on successful development of its blood-brain barrier platform technology and TV-enabled product candidates; Denali\u2019s and its partners&#8217; ability to conduct or complete clinical trials on expected timelines; the potential for clinical trial results of DNL310 to differ from preclinical, preliminary or expected results, the risk that Denali will be able to continue dose escalation in the Phase 1\/2 study, whether DNL310 will cause any serious adverse events, whether DNL310 will impact downstream biomarkers of neurodegeneration, and that DNL310 may not receive regulatory approval as a treatment of Hunter syndrome necessary to be commercialized; risk of the occurrence of any event, change or other circumstance that could give rise to the termination of Denali\u2019s agreements with its partners; Denali\u2019s ability to continue to create a pipeline of product candidates or develop commercially successful products; Denali\u2019s ability to obtain, maintain, or protect intellectual property rights related to its product candidates; implementation of Denali\u2019s strategic plans for its business, product candidates and blood-brain barrier platform technology; and other risks. In light of these risks, uncertainties and assumptions, the forward-looking statements in this press release are inherently uncertain and may not occur, and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Accordingly, you should not rely upon forward-looking statements as predictions of future events. Information regarding additional risks and uncertainties may be found in Denali\u2019s Annual and Quarterly Reports filed on Forms 10-K and 10-Q filed with the Securities and Exchange Commission (SEC) on February 27, 2020, and November 5, 2020, respectively, and Denali\u2019s future reports to be filed with the SEC. Denali does not undertake any obligation to update or revise any forward-looking statements, to conform these statements to actual results or to make changes in Denali\u2019s expectations, except as required by law.\u00a0<\/p>\n<p>\n        <strong>Investor Relations Contact:<\/strong>\u00a0<br \/><strong>\u00a0<\/strong>\u00a0<br \/>Laura Hansen, Ph.D.\u00a0<br \/>Vice President, Investor Relations\u00a0<br \/>(650) 452-2747\u00a0<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=S0jXfRdvvg3ywrKQkHxoS24Ps_ylRU6GM44Gaqx0b35P7NwUwxMVELsaQwlDUt6AGJq9eU2EWkVHsTM96jwWcg==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">hansen@dnli.com<\/a><\/u>\u00a0<\/p>\n<p><strong>Media Contacts:<\/strong>\u00a0<br \/>\u00a0\u00a0<br \/>Lizzie Hyland\u00a0<br \/>(646) 495-2706\u00a0<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=S5dVYLMR30-5gp1YUrRFuroPmqfNhhom7CtX-z7wSSQIxZuP2ihfTXvMj23u5WexOY2ZFVYWAklosYN4RwWLZg==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">lhyland@gpg.com<\/a><\/u>\u00a0<br \/>\u00a0\u00a0<br \/>or\u00a0<br \/>\u00a0\u00a0<br \/>Morgan Warners\u00a0<br \/>(202) 295-0124\u00a0<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=jUTUbbBsRj3fLGuXYizy0CWAzg89oG7isvfW11McoKtQ7MC69adEloWhfsyX9Zfbl1PyEKLNSN1pGYQZvcW9aA==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">mwarners@gpg.com<\/a><\/u>\u00a0<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE1MjA3OCMzOTczODQ4IzIwOTM0Njg=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/979cb8f1-065b-434c-b69e-19e0809f17c3\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sustained normalization and further decreased levels of CSF glycosaminoglycan heparan sulfate, a key CNS disease biomarker, observed after three months of intravenous dosing Reductions in exploratory CSF biomarkers consistent with improved lysosomal function\u00a0 Reductions in levels of urine\u00a0glycosaminoglycans\u00a0following\u00a0a switch from\u00a0idursulfase support potential for improved peripheral effects relative to standard of care Generally well tolerated with\u00a0safety profile consistent with\u00a0other\u00a0enzyme replacement\u00a0therapies; most frequently observed adverse events of mild or moderate infusion-related reactions\u00a0 Management will host a webinar\u00a0for analysts\u00a0at 8:00 a.m. Eastern\u00a0Time\u00a0today\u00a0 SOUTH SAN FRANCISCO, Calif., Feb. 12, 2021 (GLOBE NEWSWIRE) &#8212; Denali Therapeutics Inc. (NASDAQ: DNLI), a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases, today announced\u00a0additional positive\u00a0interim results from the &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Denali Therapeutics Reports Positive Three-Month Data from Phase 1\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-434954","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Denali Therapeutics Reports Positive Three-Month Data from Phase 1\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II) - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Denali Therapeutics Reports Positive Three-Month Data from Phase 1\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II) - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Sustained normalization and further decreased levels of CSF glycosaminoglycan heparan sulfate, a key CNS disease biomarker, observed after three months of intravenous dosing Reductions in exploratory CSF biomarkers consistent with improved lysosomal function\u00a0 Reductions in levels of urine\u00a0glycosaminoglycans\u00a0following\u00a0a switch from\u00a0idursulfase support potential for improved peripheral effects relative to standard of care Generally well tolerated with\u00a0safety profile consistent with\u00a0other\u00a0enzyme replacement\u00a0therapies; most frequently observed adverse events of mild or moderate infusion-related reactions\u00a0 Management will host a webinar\u00a0for analysts\u00a0at 8:00 a.m. Eastern\u00a0Time\u00a0today\u00a0 SOUTH SAN FRANCISCO, Calif., Feb. 12, 2021 (GLOBE NEWSWIRE) &#8212; Denali Therapeutics Inc. (NASDAQ: DNLI), a biopharmaceutical company developing a broad portfolio of product candidates engineered to cross the blood-brain barrier (BBB) for neurodegenerative diseases, today announced\u00a0additional positive\u00a0interim results from the &hellip; Continue reading &quot;Denali Therapeutics Reports Positive Three-Month Data from Phase 1\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II)&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-12T12:33:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE1MjA3OCMzOTczODQ4IzIwOTM0Njg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Denali Therapeutics Reports Positive Three-Month Data from Phase 1\\\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II)\",\"datePublished\":\"2021-02-12T12:33:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/\"},\"wordCount\":1891,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODE1MjA3OCMzOTczODQ4IzIwOTM0Njg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/denali-therapeutics-reports-positive-three-month-data-from-phase-1-2-study-with-etvids-dnl310-in-patients-with-hunter-syndrome-mps-ii\\\/\",\"name\":\"Denali Therapeutics Reports Positive Three-Month Data from Phase 1\\\/2 Study with ETV:IDS (DNL310) in Patients with Hunter Syndrome (MPS II) - 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