{"id":419881,"date":"2021-01-25T01:33:03","date_gmt":"2021-01-25T06:33:03","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=419881"},"modified":"2021-01-25T01:33:03","modified_gmt":"2021-01-25T06:33:03","slug":"ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\/","title":{"rendered":"OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li>\n          <strong>Milestone as part of the collaborative program named EFFIMab marks continued clinical progress<\/strong>\n        <\/li>\n<li>\n          <strong>Interleukin-7 receptor antagonist (IL-7R) OSE-127\/S95011 is currently in a Phase 2 clinical trial in ulcerative colitis, sponsored by OSE<\/strong>\n        <\/li>\n<\/ul>\n<p align=\"justify\">NANTES, France, Jan.  25, 2021  (GLOBE NEWSWIRE) &#8212; <strong>OSE Immunotherapeutics<\/strong> (ISIN: FR0012127173; Mnemo: OSE) today announced it received a milestone payment of \u20ac1.3 million from Bpifrance related to the Company\u2019s collaborative program, EFFIMab, focused on evaluating interleukin-7 receptor antagonist OSE-127\/S95011, partnered with Servier<sup>1<\/sup>.<\/p>\n<p align=\"justify\">This new milestone payment of \u20ac1.3 million was triggered by achieving several key steps in the development of OSE-127\/S95011 including reinforcement of preclinical and translational data in ulcerative colitis (UC), completion of the Phase 1 clinical trial, obtaining the Phase 2 regulatory authorization as well as specific manufacturing steps.<\/p>\n<p align=\"justify\">Alexis Peyroles, Chief Executive Officer of OSE Immunotherapeutics, commented: <em>\u201cThis new milestone payment reflects the significant progress made with OSE-127\/S95011, which is now in\u00a0<\/em><em>Phase 2 under OSE\u2019s sponsorship in ulcerative colitis, a disabling chronic inflammatory bowel disease affecting 3.3 million people in the U.S., Europe and Japan. With 70-75% of ulcerative colitis patients<\/em><sup>2<\/sup><em> either not responding or losing response to current treatments, ulcerative colitis represents a substantial medical need. There is a large potential market in ulcerative colitis for OSE-127\/S95011 as it is the only full-antagonist of IL-7R, with a novel and differentiated mechanism of action. We look forward to confirming the product\u2019s efficacy in both ulcerative colitis and Sj\u00f6gren\u2019s syndrome, another debilitating autoimmune disease, with a trial launching soon and conducted by our partner Servier.\u201d<\/em><\/p>\n<p align=\"justify\">\n        <strong>OSE-127\/S95011 Phase 2 in ulcerative colitis<\/strong><br \/>\n        <br \/>The Phase 2 clinical trial with OSE-127\/S95011 in UC started in December 2020 under OSE Immunotherapeutics\u2019 sponsorship. This study aims to assess the efficacy and safety of OSE-127\/S95011 versus placebo in patients with moderate to severe active UC who have previously failed or lost response or are intolerant to previous treatment(s). In parallel to the trial being conducted in UC, an independent Phase 2 clinical study is planned to start shortly in Sj\u00f6gren\u2019s syndrome under Servier\u2019s sponsorship. Under the terms of the license option agreement, OSE is eligible to receive a \u20ac5 million milestone payment from Servier upon enrollment of the first patient in this Phase 2. OSE-127\/S95011 is being developed in partnership with Servier under an option agreement up to the completion of both Phase 2 clinical studies.<\/p>\n<p align=\"justify\">\n        <strong>Ulcerative colitis background<\/strong><br \/>\n        <br \/>UC is a debilitating inflammatory bowel disease that affects 3.3 million patients in the U.S., Europe and Japan. Despite multiple approved therapeutic options, remission rates are 25-30%<sup>2<\/sup>, leaving most patients in therapeutic failure and in need of alternative new therapies. The current standard of care is largely comprised of two main therapeutic classes (5-ASAs and TNF\u03b1) with a total market size of $6.3 billion<sup>3<\/sup>.<\/p>\n<p align=\"justify\">\n        <sup>1<\/sup> Servier is a global independent pharmaceutical group, governed by a non-profit foundation, with headquarters based in France.<br \/><sup>2<\/sup> Drugs Context. 2019; 8: 212572 \u2013 doi: 10.7573\/dic.212572<br \/><sup>3<\/sup> EvaluatePharma<\/p>\n<p align=\"justify\">\n        <strong>ABOUT THE EFFIMab PROGRAM<br \/><\/strong>This collaborative program is headed by OSE Immunotherapeutics as the leader of the consortium to develop OSE-127\/S95011, a monoclonal immunomodulatory antibody targeting the CD127 receptor, the alpha chain of the interleukin-7 receptor (IL-7R). The funding from Bpifrance is planned to cover the product\u2019s development until the Phase 2 clinical stage. The total amount of the OSE-127\/S95011 program, being developed by OSE Immunotherapeutics in collaboration with INSERM and Nantes University Hospital, is \u20ac20 million with \u20ac9.1 million allotted by Bpifrance.<\/p>\n<p align=\"justify\">\n        <strong>ABOUT OSE Immunotherapeutics<br \/><\/strong>OSE Immunotherapeutics is an integrated biotechnology company focused on developing and partnering therapies to control the immune system for immuno-oncology and autoimmune diseases. The company\u2019s immunology research and development platform is focused on three areas: T-cell-based vaccination, Immuno-Oncology (focus on myeloid targets), Auto-immunity &amp; Inflammation. Its balanced first-in-class clinical and preclinical portfolio has a diversified risk profile:<\/p>\n<p align=\"justify\">\n        <strong>Vaccine platform<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <strong>Tedopi<sup>\u00ae<\/sup><\/strong> (innovative combination of neoepitopes): the company\u2019s most advanced product; positive results for Step-1 of the Phase 3 trial (Atalante 1) in Non-Small Cell Lung Cancer post checkpoint inhibitor failure.<br \/>In Phase 2 in pancreatic cancer (TEDOPaM, sponsor GERCOR) in combination.<\/li>\n<li style=\"text-align:justify\">\n          <strong>CoVepiT<\/strong>: a prophylactic vaccine against COVID-19, developed using SARS-CoV-2 optimized neo-epitopes. Positive preclinical and human ex vivo results in August 2020, clinical trial expected to start in Q1 2021.<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>Immuno-oncology platform<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <strong>BI 765063<\/strong> (OSE-172, anti-SIRP\u03b1 mAb on SIRP\u03b1\/CD47 pathway): developed in partnership with Boehringer Ingelheim; myeloid checkpoint inhibitor in Phase 1 in advanced solid tumors.<\/li>\n<li style=\"text-align:justify\">\n          <strong>CLEC-1 <\/strong>(novel myeloid checkpoint target): identification of mAb antagonists of CLEC-1 blocking the \u201cDon\u2019t Eat Me\u201d signal that increase both tumor cell phagocytosis by macrophages and antigen capture by dendritic cells.<\/li>\n<li style=\"text-align:justify\">\n          <strong>BiCKI<sup>\u00ae<\/sup><\/strong>: bispecific fusion protein platform built on the key backbone component anti-PD-1 (OSE-279) combined with new immunotherapy targets; 2<sup>nd<\/sup> generation of PD-(L)1 inhibitors to increase antitumor efficacity.<\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>Auto-immunity and inflammation platform<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li style=\"text-align:justify\">\n          <strong>FR104 <\/strong>(anti-CD28 monoclonal antibody): positive Phase 1 results; ongoing Phase 1\/2 in renal transplant, Phase 2-ready asset in a niche indication in autoimmune diseases.<\/li>\n<li style=\"text-align:justify\">\n          <strong>OSE-127\/S95011<\/strong> (humanized monoclonal antibody targeting IL-7 receptor): developed in partnership with Servier; positive Phase 1 results; in Phase 2 in ulcerative colitis (OSE sponsor) and an independent Phase 2 planned in Sj\u00f6gren\u2019s syndrome (Servier sponsor).<\/li>\n<li style=\"text-align:justify\">\n          <strong>OSE-230 <\/strong>(ChemR23 agonist mAb): first-in-class therapeutic agent with the potential to resolve chronic inflammation by driving affected tissues to tissue integrity.<br \/><em>Due to the COVID-19 crisis, accrual of new patients in the clinical trial TEDOPaM is temporarily suspended and initiation timelines for both Phase 2 trials of OSE-127\/S95011 could be impacted during the coming months.<\/em><\/li>\n<\/ul>\n<p>For more information: <br \/>Click and follow us on Twitter and LinkedIn<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=xopzAv2IxnTvZgoQBaB_3hjdakuc2NkgsTFjQ4AIDvvvZSEXigKV54RF6_vYaEWky7GqcF0uxo4twHY6O_wIwkXC4qfSYCySwaE896T0B5XcLR70otlpoz8EJ1Nzl5GF\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">https:\/\/twitter.com\/OSEIMMUNO<\/a><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=cQhHtIYB6T55yCcJO5kMe9tXbxKgelRI8acyyO_b_VZ73Ar1RfJenIyd3IKydsYGfVwSeRZA7p9Y2PU0Rz-Xzw==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><br \/><\/a><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=xopzAv2IxnTvZgoQBaB_3nSFDX5BFEaHqUzy-gNtzY8aeTwl24CNO7_8MNYK2Q_Obwe6x9HqldcaY0RN3rkJcwtii_bAO1OiK6TZnRIGL1_NsRvi_Cl3Ek0kb63BfqGzgb8BqvV5nLtp7w9QDW7MiA==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">https:\/\/www.linkedin.com\/company\/10929673<\/a><\/p>\n<p>\n        <strong>Contacts<\/strong>\n      <\/p>\n<table style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td style=\"max-width:50%;width:50%;min-width:50%;text-align: left;vertical-align: middle;vertical-align: top\">\n            <strong>OSE Immunotherapeutics<\/strong><br \/>\n            <br \/>Sylvie D\u00e9try<br \/><a href=\"mailto:Sylvie.detry@ose-immuno.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Sylvie.detry@ose-immuno.com<\/a><br \/>+33\u00a0153\u00a0198 757<\/p>\n<p><strong>French Media: FP2COM<\/strong><br \/>Florence Portejoie<br \/><a href=\"mailto:fportejoie@fp2com.fr\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">fportejoie@fp2com.fr<\/a><br \/>+33\u00a0607\u00a0768\u00a0283<\/p>\n<p><strong>Bpifrance<\/strong><br \/>Sophie Santandrea<br \/><a href=\"mailto:Sophie.santandrea@bpifrance.fr\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Sophie.santandrea@bpifrance.fr<\/a><br \/>+33 1 45 65 51 62<\/td>\n<td style=\"max-width:50%;width:50%;min-width:50%;text-align: left;vertical-align: middle;vertical-align: top\">\n            <strong>U.S. Media: LifeSci Communications<\/strong><br \/>\n            <br \/>Darren Opland, Ph.D.<br \/><a href=\"mailto:darren@lifescicomms.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">darren@lifescicomms.com<\/a><br \/>+1 646 627 8387<\/p>\n<p><strong>U.S. and European Investors<\/strong><br \/>Chris Maggos <br \/>chris@lifesciadvisors.com <br \/>+41 79 367 6254<\/td>\n<\/tr>\n<\/table>\n<p align=\"justify\">\n        <strong>ABOUT BPIFRANCE<\/strong><br \/>\n        <br \/>Bpifrance is the French national investment bank: it finances businesses \u2013 at every stage of their development \u2013 through loans, guarantees, equity investments and export insurances. Bpifrance also provides extra-financial services (training, consultancy.). to help entrepreneurs meet their challenges (innovation, export\u2026). <br \/>For more information, please visit: <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=fYMq3Yugm2G1AttO3U-KNXyVOoWE7yH7ShpeWUX5f-yoRW0VWSGHHdQ-hEGtSw_wZh00LZ4F4mrXdx-JV61MTg==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">www.bpifrance.fr<\/a> and presse.bpifrance.fr &#8211; Follow us on Twitter: @Bpifrance &#8211; @BpifrancePresse<\/p>\n<p align=\"justify\">\n        <strong>Forward-looking statements<\/strong><br \/>\n        <br \/>This press release contains express or implied information and statements that might be deemed forward-looking information and statements in respect of OSE Immunotherapeutics. They do not constitute historical facts. These information and statements include financial projections that are based upon certain assumptions and assessments made by OSE Immunotherapeutics\u2019 management in light of its experience and its perception of historical trends, current economic and industry conditions, expected future developments and other factors they believe to be appropriate.<br \/>These forward-looking statements include statements typically using conditional and containing verbs such as \u201cexpect\u201d, \u201canticipate\u201d, \u201cbelieve\u201d, \u201ctarget\u201d, \u201cplan\u201d, or \u201cestimate\u201d, their declensions and conjugations and words of similar import. Although the OSE Immunotherapeutics management believes that the forward-looking statements and information are reasonable, the OSE Immunotherapeutics\u2019 shareholders and other investors are cautioned that the completion of such expectations is by nature subject to various risks, known or not, and uncertainties which are difficult to predict and generally beyond the control of OSE Immunotherapeutics. These risks could cause actual results and developments to differ materially from those expressed in or implied or projected by the forward-looking statements. These risks include those discussed or identified in the public filings made by OSE Immunotherapeutics with the AMF. Such forward-looking statements are not guarantees of future performance. This press release includes only summary information and should be read with the OSE Immunotherapeutics Universal Registration Document filed with the AMF on 15 April 2020, including the annual financial report for the fiscal year 2019, available on the OSE Immunotherapeutics\u2019 website. Other than as required by applicable law, OSE Immunotherapeutics issues this press release at the date hereof and does not undertake any obligation to update or revise the forward-looking information or statements.<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE0MDI1OSMzOTQxMTIyIzIwODI5ODc=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/20f5d208-700f-4994-aacb-3738c0392b95\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Milestone as part of the collaborative program named EFFIMab marks continued clinical progress Interleukin-7 receptor antagonist (IL-7R) OSE-127\/S95011 is currently in a Phase 2 clinical trial in ulcerative colitis, sponsored by OSE NANTES, France, Jan. 25, 2021 (GLOBE NEWSWIRE) &#8212; OSE Immunotherapeutics (ISIN: FR0012127173; Mnemo: OSE) today announced it received a milestone payment of \u20ac1.3 million from Bpifrance related to the Company\u2019s collaborative program, EFFIMab, focused on evaluating interleukin-7 receptor antagonist OSE-127\/S95011, partnered with Servier1. This new milestone payment of \u20ac1.3 million was triggered by achieving several key steps in the development of OSE-127\/S95011 including reinforcement of preclinical and translational data in ulcerative colitis (UC), completion of the Phase 1 clinical trial, obtaining the Phase 2 regulatory authorization as well &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-419881","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Milestone as part of the collaborative program named EFFIMab marks continued clinical progress Interleukin-7 receptor antagonist (IL-7R) OSE-127\/S95011 is currently in a Phase 2 clinical trial in ulcerative colitis, sponsored by OSE NANTES, France, Jan. 25, 2021 (GLOBE NEWSWIRE) &#8212; OSE Immunotherapeutics (ISIN: FR0012127173; Mnemo: OSE) today announced it received a milestone payment of \u20ac1.3 million from Bpifrance related to the Company\u2019s collaborative program, EFFIMab, focused on evaluating interleukin-7 receptor antagonist OSE-127\/S95011, partnered with Servier1. This new milestone payment of \u20ac1.3 million was triggered by achieving several key steps in the development of OSE-127\/S95011 including reinforcement of preclinical and translational data in ulcerative colitis (UC), completion of the Phase 1 clinical trial, obtaining the Phase 2 regulatory authorization as well &hellip; Continue reading &quot;OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-25T06:33:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODE0MDI1OSMzOTQxMTIyIzIwODI5ODc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\\\/S95011\",\"datePublished\":\"2021-01-25T06:33:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/\"},\"wordCount\":1316,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODE0MDI1OSMzOTQxMTIyIzIwODI5ODc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\\\/\",\"name\":\"OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\\\/S95011 - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/ose-immunotherapeutics-receives-e1-3-million-milestone-payment-from-bpifrance-for-ose-127-s95011\/","og_locale":"en_US","og_type":"article","og_title":"OSE Immunotherapeutics Receives \u20ac1.3 Million Milestone Payment from Bpifrance for OSE-127\/S95011 - Market Newsdesk","og_description":"Milestone as part of the collaborative program named EFFIMab marks continued clinical progress Interleukin-7 receptor antagonist (IL-7R) OSE-127\/S95011 is currently in a Phase 2 clinical trial in ulcerative colitis, sponsored by OSE NANTES, France, Jan. 25, 2021 (GLOBE NEWSWIRE) &#8212; OSE Immunotherapeutics (ISIN: FR0012127173; Mnemo: OSE) today announced it received a milestone payment of \u20ac1.3 million from Bpifrance related to the Company\u2019s collaborative program, EFFIMab, focused on evaluating interleukin-7 receptor antagonist OSE-127\/S95011, partnered with Servier1. 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