{"id":417552,"date":"2021-01-20T06:03:15","date_gmt":"2021-01-20T11:03:15","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=417552"},"modified":"2021-01-20T06:03:15","modified_gmt":"2021-01-20T11:03:15","slug":"aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\/","title":{"rendered":"Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA)"},"content":{"rendered":"<p>        <!--body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p>\nAptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA)\n<\/p>\n<p>NEW YORK &amp; LONDON &amp; PARIS&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nAptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) ) (\u201cAptorum Group\u201d or \u201cAptorum\u201d), a biopharmaceutical company focused on novel technologies including the targeting of infectious diseases, announced that the company, through its wholly owned subsidiary, Aptorum International Limited, has received clearance from the Public Health Agency of Canada (Health Canada) regarding the Clinical Trial Application (CTA) to commence a Phase 1 study of ALS-4, an orally administered small molecule drug intended to treat infections caused by <i>Staphylococcus aureus<\/i> including MRSA.\n<\/p>\n<p>\nDr. Clark Cheng, Chief Medical Officer and Executive Director of Aptorum Group, commented, \u201cThe clearance of our CTA application for ALS-4 drug represents a significant milestone for the company and one of a number of targeted strategic goals for 2021. This milestone supports the transition of Aptorum Group to a clinical-stage company and reflects the potential of our scientific rigor and novel approach of our products. We are dedicated to delivering novel therapeutics in the field of growing unmet medical needs of infections starting with <i>Staphylococcus aureus<\/i>.\u201d\n<\/p>\n<p>\nThe Phase 1 clinical trial is planned to be conducted in Canada and targeted to recruit up to 48 and 24 healthy volunteers for the single-ascending dose (SAD) and multiple- ascending dose (MAD) cohorts, respectively. The primary objective of the trial is to evaluate the safety and tolerability of SAD and MAD of ALS-4 administered orally to healthy subjects. The secondary objective is to assess the pharmacokinetic profile of SAD and MAD of ALS-4 administered orally to healthy subjects.\n<\/p>\n<p><b>About ALS-4<\/b><\/p>\n<p>\nAs part of Aptorum Group\u2019s Acticule infectious disease platform, ALS-4 is a novel orally administered first-in-class small molecule that was developed based on an anti-virulence approach targeting <i>Staphylococcus aureus<\/i> including MRSA. ALS-4 can potentially lessen antimicrobial resistance via lowering selection pressure and render the bacteria to become highly susceptible to the host\u2019s immune clearance. ALS-4 is targeted for potential administration both on a standalone or a combined basis with other existing antibiotics such as vancomycin.\n<\/p>\n<p><b>About Aptorum Group<\/b><\/p>\n<p>\nAptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) is a pharmaceutical company dedicated to the discovery, development and commercializing of therapeutic assets to treat diseases with unmet medical needs, particularly infectious diseases and cancers (including orphan oncology indications). The pipeline of Aptorum is also enriched through the establishment of drug discovery platforms that enable the discovery of new therapeutics assets through programs such as the systematic screening of existing approved drug molecules and microbiome-based research platform for treatments of metabolic diseases. Aptorum also has projects focused on microbiome research and the commercialization of a natural supplement product targeted for women undergoing menopause and experiencing related symptoms.\n<\/p>\n<p>\nFor more information about Aptorum Group, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.aptorumgroup.com&amp;esheet=52364484&amp;newsitemid=20210120005304&amp;lan=en-US&amp;anchor=www.aptorumgroup.com&amp;index=1&amp;md5=771dd58bfe4c373b6ebe64e7fbd6f3f6\">www.aptorumgroup.com<\/a>.\n<\/p>\n<p><b>Disclaimer and Forward-Looking Statements<\/b><\/p>\n<p>\nThis press release does not constitute an offer to sell or a solicitation of offers to buy any securities of Aptorum Group.\n<\/p>\n<p>\nThis press release includes statements concerning Aptorum Group Limited and its future expectations, plans and prospects that constitute \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. In some cases, you can identify forward-looking statements by terms such as \u201cmay,\u201d \u201cshould,\u201d \u201cexpects,\u201d \u201cplans,\u201d \u201canticipates,\u201d \u201ccould,\u201d \u201cintends,\u201d \u201ctarget,\u201d \u201cprojects,\u201d \u201ccontemplates,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cpredicts,\u201d \u201cpotential,\u201d or \u201ccontinue,\u201d or the negative of these terms or other similar expressions. Aptorum Group has based these forward-looking statements, which include statements regarding projected timelines for application submissions and trials, largely on its current expectations and projections about future events and trends that it believes may affect its business, financial condition and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions including, without limitation, risks related to its announced management and organizational changes, the continued service and availability of key personnel, its ability to expand its product assortments by offering additional products for additional consumer segments, development results, the company\u2019s anticipated growth strategies, anticipated trends and challenges in its business, and its expectations regarding, and the stability of, its supply chain, and the risks more fully described in Aptorum Group\u2019s Form 20-F and other filings that Aptorum Group may make with the SEC in the future, as well as the prospectus that received the French Autorit\u00e9 des March\u00e9s Financiers visa n\u00b020-352 on 16 July 2020.\n<\/p>\n<p>\nAs a result, the projections included in such forward-looking statements are subject to change and actual results may differ materially from those described herein. Aptorum Group assumes no obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.\n<\/p>\n<p>\nThis announcement is not a prospectus within the meaning of the Regulation (EU) n\u00b02017\/1129 of 14 June 2017 as amended by Regulations Delegated (EU) n\u00b02019\/980 of 14 March 2019 and n\u00b02019\/979 of 14 March 2019.\n<\/p>\n<p>\nThis press release is provided \u201cas is\u201d without any representation or warranty of any kind.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210120005304r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20210120005304\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20210120005304\/en\/<\/a><\/span><\/p>\n<p>\nAptorum Group Limited<br \/>\n<br \/>Investor Relations Department:<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investor.relations@aptorumgroup.com\">investor.relations@aptorumgroup.com<br \/>\n<\/a><br \/>+44 20 80929299\n<\/p>\n<p>\nRedchip \u2013 Financial Communications United States<br \/>\n<br \/>Investor relations<br \/>\n<br \/>Dave Gentry<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:dave@redchip.com\">dave@redchip.com<br \/>\n<\/a><br \/>+1 407 491 4498\n<\/p>\n<p>\nActifin \u2013 Financial Communications Europe<br \/>\n<br \/>Investor relations<br \/>\n<br \/>Ghislaine Gasparetto<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ggasparetto@actifin.fr\">ggasparetto@actifin.fr<br \/>\n<\/a><br \/>+33 1 56 88 11 22\n<\/p>\n<p><b>KEYWORDS:<\/b> New York United States United Kingdom France Canada North America Europe<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Infectious Diseases Biotechnology Pharmaceutical Health<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20210120005304\/en\/694467\/3\/aptorum_hori_HQ.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA) NEW YORK &amp; LONDON &amp; PARIS&#8211;(BUSINESS WIRE)&#8211; Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) ) (\u201cAptorum Group\u201d or \u201cAptorum\u201d), a biopharmaceutical company focused on novel technologies including the targeting of infectious diseases, announced that the company, through its wholly owned subsidiary, Aptorum International Limited, has received clearance from the Public Health Agency of Canada (Health Canada) regarding the Clinical Trial Application (CTA) to commence a Phase 1 study of ALS-4, an orally administered small molecule drug intended to treat infections caused by Staphylococcus aureus including MRSA. Dr. Clark &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA)&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-417552","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA) - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA) - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA) NEW YORK &amp; LONDON &amp; PARIS&#8211;(BUSINESS WIRE)&#8211; Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) ) (\u201cAptorum Group\u201d or \u201cAptorum\u201d), a biopharmaceutical company focused on novel technologies including the targeting of infectious diseases, announced that the company, through its wholly owned subsidiary, Aptorum International Limited, has received clearance from the Public Health Agency of Canada (Health Canada) regarding the Clinical Trial Application (CTA) to commence a Phase 1 study of ALS-4, an orally administered small molecule drug intended to treat infections caused by Staphylococcus aureus including MRSA. Dr. Clark &hellip; Continue reading &quot;Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA)&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-20T11:03:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20210120005304r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA)\",\"datePublished\":\"2021-01-20T11:03:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/\"},\"wordCount\":957,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20210120005304r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/aptorum-group-receives-clearance-from-health-canada-to-initiate-a-phase-1-clinical-trial-for-als-4-a-small-molecule-drug-for-infections-caused-by-staphylococcus-aureus-including-methicillin-resistant\\\/\",\"name\":\"Aptorum Group Receives Clearance from Health Canada to Initiate a Phase 1 Clinical Trial for ALS-4, a Small Molecule Drug for Infections Caused by Staphylococcus aureus including Methicillin-resistant Staphylococcus aureus (MRSA) - 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