{"id":414779,"date":"2021-01-14T08:03:31","date_gmt":"2021-01-14T13:03:31","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=414779"},"modified":"2021-01-14T08:03:31","modified_gmt":"2021-01-14T13:03:31","slug":"oncternal-therapeutics-inc-confirms-lentigen-technology-inc-to-manufacture-lentiviral-vectors-for-its-ror1-targeting-car-t-cell-therapy-program","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/oncternal-therapeutics-inc-confirms-lentigen-technology-inc-to-manufacture-lentiviral-vectors-for-its-ror1-targeting-car-t-cell-therapy-program\/","title":{"rendered":"Oncternal Therapeutics, Inc. Confirms Lentigen Technology, Inc. to Manufacture Lentiviral Vectors for Its ROR1-targeting CAR-T Cell Therapy Program"},"content":{"rendered":"
\n

SAN DIEGO, Jan. 14, 2021 (GLOBE NEWSWIRE) — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced an agreement with Lentigen Technology, Inc. (\u201cLentigen\u201d), a wholly-owned subsidiary of Miltenyi Biotec B.V. & Co. KG, to manufacture lentiviral vectors for Oncternal\u2019s investigational ROR1-targeting CAR-T cell therapy program.<\/p>\n

Lentigen is a leader in translating gene therapy products into the clinic, including design, construction and production of lentiviral vectors, from research through GMP manufacturing.<\/p>\n

As part of the agreement, Lentigen will reserve capacity in 2021 to manufacture, test and release GMP lentivirus to support and accelerate the development of Oncternal\u2019s CAR-T cell therapy program.\u00a0<\/p>\n

\u201cLentiviral vectors are an essential component in the CAR-T cell manufacturing process. Lentigen has successfully developed a large-scale, chemically-defined, serum-free lentiviral vector manufacturing process that ensures high quality and conformity with regulatory requirements,\u201d said Boro Dropulic, Ph.D., M.B.A., General Manager and Chief Science Officer of Lentigen Technology, Inc. \u201cWe are excited to support Oncternal by manufacturing lentiviral vectors for its ROR1-targeting CAR-T program and help bring these novel cell therapies to patients with cancer.\u201d<\/p>\n

\u201cOncternal is working on rapidly advancing its ROR1-targeting CAR-T cell immunotherapy program, and we are pleased to work with Lentigen that is widely recognized as a global leader in producing GMP lentiviral vectors for the biopharma industry,\u201d said James Breitmeyer, M.D., Ph.D., Oncternal\u2019s President and CEO. \u201cROR1 has emerged as an important target for cancer therapy, and we believe that our ROR1-targeting CAR-T program holds significant promise for patients with both hematologic cancers and solid tumors. Our goal is to achieve first-in-human dosing of the ROR1-targeting CAR-T therapy in the second half of 2021.\u201d<\/p>\n

\n
\n About Oncternal Therapeutics
<\/strong>
\n <\/strong>Oncternal Therapeutics is a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies for the treatment of cancers with critical unmet medical need. Oncternal focuses drug development on promising yet untapped biological pathways implicated in cancer generation or progression. The clinical pipeline includes cirmtuzumab<\/a>,<\/u> an investigational monoclonal antibody designed to inhibit the ROR1 pathway, a type I tyrosine kinase-like orphan receptor, that is being evaluated in a Phase 1\/2 clinical trial in combination with ibrutinib for the treatment of patients with mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) and in an investigator-sponsored, Phase 1b clinical trial in combination with paclitaxel for the treatment of women with HER2-negative metastatic or locally advanced, unresectable breast cancer. The clinical pipeline also includes TK216<\/a>,<\/u> an investigational targeted small-molecule inhibitor of the ETS family of oncoproteins, that is being evaluated in a Phase 1 clinical trial for patients with Ewing sarcoma alone and in combination with vincristine chemotherapy. In addition, Oncternal has a program utilizing the cirmtuzumab antibody backbone to develop a CAR-T<\/a>\u00a0therapy that targets ROR1, which is currently in preclinical development as a potential treatment for hematologic cancers and solid tumors. More information is available at www.oncternal.com<\/a><\/u>.<\/p>\n

\n
\n Forward-Looking Information
<\/strong>
\n <\/strong>Oncternal cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements. In some cases, you can identify forward-looking statements by terms such as \u201cmay,\u201d \u201cwill,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201ccould,\u201d \u201cintend,\u201d \u201ctarget,\u201d \u201cproject,\u201d \u201ccontemplates,\u201d \u201cbelieves,\u201d \u201cestimates,\u201d \u201cpredicts,\u201d \u201cpotential\u201d or \u201ccontinue\u201d or the negatives of these terms or other similar expressions. These statements are based on Oncternal\u2019s current beliefs and expectations. Forward looking statements include statements regarding Oncternal\u2019s beliefs, goals, intentions and expectations including, without limitation, the timing and ability of Lentigen to manufacture lentiviral vectors; Oncternal\u2019s belief that ROR1-targeting CAR-T therapies hold significant promise for patients with hematologic cancers and solid tumors; the timing of any human dosing of its ROR1-targeting CAR-T therapy; and other statements regarding Oncternal\u2019s development plans. Forward looking statements are subject to risks and uncertainties inherent in Oncternal\u2019s business, which include, but are not limited to: the parties must negotiate and execute a master services agreement and related agreements prior to Lentigen initiating manufacturing of the lentiviral vectors; Oncternal\u2019s dependence on Lentigen to manufacture the lentiviral vectors; the COVID-19 pandemic may disrupt Oncternal\u2019s or Lentigen\u2019s business operations; uncertainties associated with the preclinical and clinical development of the CAR-T cell therapy program; and other risks described in Oncternal\u2019s prior press releases as well as in public periodic filings with the U.S. Securities & Exchange Commission. All forward-looking statements in this press release are current only as of the date hereof and, except as required by applicable law, Oncternal undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise. All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995.<\/p>\n

\n
\n Oncternal Contacts:<\/strong>
\n <\/strong>\n <\/p>\n

\n Company Contact<\/strong>
\n
Richard Vincent
858-434-1113
rvincent@oncternal.com<\/a><\/u><\/p>\n

\n Investor Contact<\/strong>
\n
Corey Davis, Ph.D.
LifeSci Advisors
212-915-2577
cdavis@lifesciadvisors.com<\/a><\/u><\/p>\n

Source: Oncternal Therapeutics, Inc.<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

SAN DIEGO, Jan. 14, 2021 (GLOBE NEWSWIRE) — Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, today announced an agreement with Lentigen Technology, Inc. (\u201cLentigen\u201d), a wholly-owned subsidiary of Miltenyi Biotec B.V. & Co. KG, to manufacture lentiviral vectors for Oncternal\u2019s investigational ROR1-targeting CAR-T cell therapy program. Lentigen is a leader in translating gene therapy products into the clinic, including design, construction and production of lentiviral vectors, from research through GMP manufacturing. As part of the agreement, Lentigen will reserve capacity in 2021 to manufacture, test and release GMP lentivirus to support and accelerate the development of Oncternal\u2019s CAR-T cell therapy program.\u00a0 \u201cLentiviral vectors are an essential component in the CAR-T … <\/p>\n

Continue reading “Oncternal Therapeutics, Inc. Confirms Lentigen Technology, Inc. to Manufacture Lentiviral Vectors for Its ROR1-targeting CAR-T Cell Therapy Program”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-414779","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nOncternal Therapeutics, Inc. 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