{"id":410153,"date":"2021-01-07T07:03:12","date_gmt":"2021-01-07T12:03:12","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=410153"},"modified":"2021-01-07T07:03:12","modified_gmt":"2021-01-07T12:03:12","slug":"gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/","title":{"rendered":"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"margin-bottom:7.5pt\">\n          <strong>The VITAL study, published in The Lancet Oncology, demonstrates that Vigil first-line maintenance treatment resulted in improved RFS in <\/strong><br \/>\n          <strong><br \/>\n            <em>BRCA1\/2<\/em><br \/>\n          <\/strong><br \/>\n          <strong>-wt ovarian cancer when compared to placebo.<\/strong>\n        <\/li>\n<li style=\"margin-bottom:7.5pt\">\n          <strong>Importantly overall survival was also significantly longer for Vigil treated ovarian cancer patients with <\/strong><br \/>\n          <strong><br \/>\n            <em>BRCA1\/2<\/em><br \/>\n          <\/strong><br \/>\n          <strong>-wt disease compared to placebo.<\/strong>\n        <\/li>\n<\/ul>\n<p>DALLAS, Jan.  07, 2021  (GLOBE NEWSWIRE) &#8212; Gradalis, Inc., a clinical-stage immunotherapy company developing investigational treatments for individuals suffering from multiple cancer indications, today announced that\u00a0<em>The Lancet Oncology<\/em>\u00a0published data from the VITAL clinical trial showing Vigil front-line maintenance use was well tolerated with improved recurrence-free survival (RFS) and overall survival (OS) in patients with <em>BRCA1\/2<\/em>-wt advanced ovarian cancer. These results were published online in\u00a0<em>The Lancet Oncology<\/em>\u00a0on\u00a0December 1, 2020.<\/p>\n<p>\u201cAs ovarian cancer is becoming increasingly molecularly annotated for <em>BRCA<\/em> mutations, identifying effective treatment options for women whose tumors are <em>BRCA1\/2<\/em>-wt is a priority.\u201d said Robert L. Coleman, MD, FACOG, FACS and member of Gradalis Scientific Advisory Board. \u201cThe results from this study provide important context for the strategic development of Vigil in primary treatment algorithms. We are excited to bring a new approach to this setting.\u201d<\/p>\n<p>\u201cThe results of this study bring a new option to those least likely to benefit from PARP inhibitor maintenance, namely those without a <em>BRCA<\/em> mutation.\u201d said Bradley J. Monk, MD, FACS, FACOG and member of Gradalis Scientific Advisory Board. \u201cIn addition to the unprecedented efficacy of this cell-based immune maintenance therapy, the adverse event profile was favorable meaning that patients are not only likely to remain free of cancer progression, but also without maintenance treatment related adverse reactions. We look forward to continuing to study this novel intervention in future trials.\u201d<\/p>\n<p>\u201cResults published in The Lancet Oncology after years of intense investigation are very gratifying. We are encouraged now to pursue product registration advancement with FDA.\u201d According to John Nemunaitis, MD and Gradalis\u2019 Chief Scientific Officer.<\/p>\n<p>\n        <strong>Highlights from\u00a0<\/strong><br \/>\n        <strong><br \/>\n          <em>The<\/em><br \/>\n        <\/strong><br \/>\n        <strong>\u00a0<\/strong><br \/>\n        <strong><br \/>\n          <em>Lancet Oncology<\/em><br \/>\n        <\/strong><br \/>\n        <strong>\u00a0Publication Data<\/strong>\n      <\/p>\n<p>There are few options for advanced front-line ovarian cancer management. Despite primary care management of primary debulking surgery followed by adjuvant or neoadjuvant chemotherapy, delayed but persistent relapse occurs at a rate of almost 75% within the first 2 years of primary treatment. Consolidation or maintenance treatment including PARP and VEGF inhibitors have recently shown improvement in progression-free survival (niraparib PFS HR 0.62, 95% CI 0.50\u20130.76; p&lt;0.001), however, high proportions of grade 3 or 4 drug-related toxic effects and dose interruptions related to toxicity were concerning.<\/p>\n<p>We observed an advantage in recurrence-free survival (HR 0.51, 90% CI 0.30\u20130.88; p=0.020) and overall survival (HR 0.49, 90% CI 0.24\u20131.01; p=0.049) in the Vigil vaccine group in a planned sub-analysis of patients with <em>BRCA<\/em>-wt disease compared to placebo from randomization.<\/p>\n<p>In a post-hoc analysis, the 1-year overall survival rate from randomization was 100% (95% CI 100\u2013100) for patients with <em>BRCA<\/em>-wt disease in the Vigil group compared to 89% (95% CI 78\u2013100) in the placebo group (p=0.033). The 2-year overall survival rate was 90% (95% CI 79\u2013100) for patients with <em>BRCA<\/em>-wt disease in the Vigil group versus 67% (95% CI 51\u201389) in the placebo group (p=0.021). We observed no overall survival difference between patients in the Vigil group and patients in placebo group in those with <em>BRCA-<\/em>m disease.<\/p>\n<p>The primary endpoint of recurrence-free survival in all per-protocol (PP) patients some of whom had <em>BRCA<\/em>-m disease was not met (median RFS 11.5 months (95% CI 7.5\u2013not reached) in Vigil group versus 8.4 months (7.9\u201315.5) in placebo group (HR 0.69, 90% CI 0.44\u20131.07; one-sided p=0.078) but, Vigil clearly showed benefit as a front-line maintenance therapy in patients with ovarian cancer with <em>BRCA<\/em>-wt disease status.<\/p>\n<p>Commentary in the same issue of The Lancet Oncology by Peter G. Rose further supported Vigil results as evidence of a \u201clandmark study\u201d. Moreover, recent highlights of \u201cGemogenovatucel-T (Vigil) Maintenance in Stage III\/IV Ovarian Cancer\u201d covered by Matthew Stenger in The ASCO Post, December 22, 2020, further support relevance of Vigil in the BRCA-wt cancer population.<\/p>\n<p>\n        <strong>About Vigil<\/strong>\n      <\/p>\n<p>Vigil\u00ae is a novel triple function immunotherapy that combines bi-shRNA furin, which blocks immunosuppressive protein production, with DNA expressive human GM-CSF, which stimulates the immune system. By utilizing the patient&#8217;s own tumor as the antigen source, Vigil is designed to elicit an immune response that is specifically targeted and broadly relevant to each patient&#8217;s unique tumor neoantigens. Vigil is being studied in Ovarian cancer, Ewing\u2019s sarcoma as well as gynecological cancers and advanced women\u2019s cancer in combination with PD-L1 inhibitors.<\/p>\n<p>\n        <strong>About Ovarian Cancer<\/strong>\n      <\/p>\n<p>Ovarian cancer (OC) is a difficult and deadly disease that is typically diagnosed in advanced stages, and overall survival rates have held relatively steady over the past 20-30 years.<\/p>\n<p>Ovarian cancer is the 5th deadliest cancer among women with over 22,000 new cases are reported each year in the US, of which about 85% are BRCA-wt disease status. Approximately 80% of cases are diagnosed at late Stage III\/IV. There are 14,000 deaths per year due to Ovarian Cancer in the US.<\/p>\n<p>Debulking surgery and platinum-based chemotherapy is current initial standard of care for Stage III\/IV disease patients. Despite this aggressive front-line treatment, 60-75% of patients relapse within two years and median overall survival is less than 3 years. Even with increased diagnostic and treatment capabilities, there are not enough effective maintenance therapy options for all patients, particularly the BRCA-wt and homologous recombination proficient (HRP) population (about 50% of all ovarian cancer patients).<\/p>\n<p>\n        <strong>About Gradalis<\/strong>\n      <\/p>\n<p>Gradalis is a late stage biotechnology company focused on the development and commercialization of novel personalized therapeutics to treat cancer. We are focused on the development of the bi-shRNA platform that can be utilized to silence any gene or protein and applied to any cancer type. We utilized the bi-shRNA platform to develop Vigil, our proprietary personalized cancer in multiple advanced cancer indications with the lead program for the treatment of patients with Ovarian Cancer.<\/p>\n<p>For additional information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=Lmyp9E0Bi-CbE9FlPUKyOFsCW1lidAyhIYGlrQpOj8bZBGm1_3nilb0Dtmw_VERewOPYMfm2eL0yxE5UITjup6QSszvqMmGaHR_WsizG32k=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">http:\/\/www.gradalisinc.com<\/a><\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\u00a0<br \/>All forward-looking statements contained in this press release are expressly qualified by the cautionary statements contained or referred to herein.\u00a0Gradalis\u00a0cautions investors not to rely too heavily on the forward-looking statements\u00a0the company makes or that are made on its behalf. These forward-looking statements speak only as of the date of this press release (unless another date is indicated).\u00a0Gradalis\u00a0undertakes no obligation, and specifically declines any obligation, to publicly update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.<\/p>\n<p>Media Contact<br \/>Walter Chen<br \/>Gradalis, Inc.<br \/>Vice President \u2013 Finance &amp; Corporate Development<\/p>\n<p>+1 214 442 8170<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODEyMTgxNCMzOTA3ODI3IzIwMTg1MDE=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/f19fa444-591c-4537-a758-e84e72388c1c\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The VITAL study, published in The Lancet Oncology, demonstrates that Vigil first-line maintenance treatment resulted in improved RFS in BRCA1\/2 -wt ovarian cancer when compared to placebo. Importantly overall survival was also significantly longer for Vigil treated ovarian cancer patients with BRCA1\/2 -wt disease compared to placebo. DALLAS, Jan. 07, 2021 (GLOBE NEWSWIRE) &#8212; Gradalis, Inc., a clinical-stage immunotherapy company developing investigational treatments for individuals suffering from multiple cancer indications, today announced that\u00a0The Lancet Oncology\u00a0published data from the VITAL clinical trial showing Vigil front-line maintenance use was well tolerated with improved recurrence-free survival (RFS) and overall survival (OS) in patients with BRCA1\/2-wt advanced ovarian cancer. These results were published online in\u00a0The Lancet Oncology\u00a0on\u00a0December 1, 2020. \u201cAs ovarian cancer is becoming &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-410153","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"The VITAL study, published in The Lancet Oncology, demonstrates that Vigil first-line maintenance treatment resulted in improved RFS in BRCA1\/2 -wt ovarian cancer when compared to placebo. Importantly overall survival was also significantly longer for Vigil treated ovarian cancer patients with BRCA1\/2 -wt disease compared to placebo. DALLAS, Jan. 07, 2021 (GLOBE NEWSWIRE) &#8212; Gradalis, Inc., a clinical-stage immunotherapy company developing investigational treatments for individuals suffering from multiple cancer indications, today announced that\u00a0The Lancet Oncology\u00a0published data from the VITAL clinical trial showing Vigil front-line maintenance use was well tolerated with improved recurrence-free survival (RFS) and overall survival (OS) in patients with BRCA1\/2-wt advanced ovarian cancer. These results were published online in\u00a0The Lancet Oncology\u00a0on\u00a0December 1, 2020. \u201cAs ovarian cancer is becoming &hellip; Continue reading &quot;Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-07T12:03:12+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODEyMTgxNCMzOTA3ODI3IzIwMTg1MDE=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology\",\"datePublished\":\"2021-01-07T12:03:12+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/\"},\"wordCount\":1078,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODEyMTgxNCMzOTA3ODI3IzIwMTg1MDE=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\\\/\",\"name\":\"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology - Market Newsdesk","og_description":"The VITAL study, published in The Lancet Oncology, demonstrates that Vigil first-line maintenance treatment resulted in improved RFS in BRCA1\/2 -wt ovarian cancer when compared to placebo. Importantly overall survival was also significantly longer for Vigil treated ovarian cancer patients with BRCA1\/2 -wt disease compared to placebo. DALLAS, Jan. 07, 2021 (GLOBE NEWSWIRE) &#8212; Gradalis, Inc., a clinical-stage immunotherapy company developing investigational treatments for individuals suffering from multiple cancer indications, today announced that\u00a0The Lancet Oncology\u00a0published data from the VITAL clinical trial showing Vigil front-line maintenance use was well tolerated with improved recurrence-free survival (RFS) and overall survival (OS) in patients with BRCA1\/2-wt advanced ovarian cancer. These results were published online in\u00a0The Lancet Oncology\u00a0on\u00a0December 1, 2020. \u201cAs ovarian cancer is becoming &hellip; Continue reading \"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/","og_site_name":"Market Newsdesk","article_published_time":"2021-01-07T12:03:12+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODEyMTgxNCMzOTA3ODI3IzIwMTg1MDE=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"5 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology","datePublished":"2021-01-07T12:03:12+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/"},"wordCount":1078,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODEyMTgxNCMzOTA3ODI3IzIwMTg1MDE=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/gradalis-announces-publication-of-phase-2b-vital-trial-of-vigil-demonstrating-rfs-and-os-advantage-in-women-with-first-line-platinum-responsive-brca1-and-brca2-wild-type-advanced-ovarian-cancer\/","name":"Gradalis Announces Publication of Phase 2b VITAL trial of Vigil\u00ae demonstrating RFS and OS advantage in women with first-line platinum-responsive BRCA1 and BRCA2 wild-type advanced ovarian cancer in The Lancet Oncology - 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