{"id":409462,"date":"2021-01-06T08:33:20","date_gmt":"2021-01-06T13:33:20","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=409462"},"modified":"2021-01-06T08:33:20","modified_gmt":"2021-01-06T13:33:20","slug":"sigyn-therapeutics-reports-results-of-pilot-study-to-address-inflammatory-cytovesicles","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/sigyn-therapeutics-reports-results-of-pilot-study-to-address-inflammatory-cytovesicles\/","title":{"rendered":"Sigyn Therapeutics\u2122 Reports Results of Pilot Study to Address Inflammatory CytoVesicles"},"content":{"rendered":"
\n

\n Sigyn Therapy\u2122 is a Candidate to Treat Life-Threatening Inflammatory Conditions<\/em>
\n That Are Not Addressed with Drug Therapies<\/em>
\n \n <\/p>\n

SAN DIEGO, Jan. 06, 2021 (GLOBE NEWSWIRE) — via NewMediaWire<\/u><\/a> — Sigyn Therapeutics, Inc. (OTCMarkets: SIGY), a medical technology company whose focus is the treatment of life-threatening inflammatory conditions precipitated by Cytokine Storm Syndrome (the Cytokine Storm), today announced the results of an\u00a0in vitro\u00a0<\/em>pilot study that successfully modeled the ability of Sigyn Therapy\u2122 to address CytoVesicles that transport inflammatory cytokine cargos in the bloodstream.\u00a0<\/p>\n

Cytokine Storm Syndrome is an excessive response of the immune system that is induced by infectious and non-infectious conditions. A hallmark indicator of Cytokine Storm Syndrome is the excessive or uncontrolled release of pro-inflammatory cytokines, which can lead to multiple organ failure and cause death. \u00a0The annual market opportunity to address Cytokine Storm related indications exceeds $20 billion and includes sepsis, the most common cause of hospital deaths worldwide.\u00a0 Virus-induced Cytokine Storm Syndrome is a leading cause of death resulting from severe SARS-CoV-2 (COVID-19) infections.<\/p>\n

Sigyn Therapy is a proprietary blood purification technology designed to overcome the limitations of previous drug and device candidates to treat acute inflammatory conditions.\u00a0 Incorporated within Sigyn Therapy is a cocktail of adsorbent components with unique binding and capture characteristics to optimize the broad-spectrum depletion of inflammatory targets from the bloodstream. These targets include pro-inflammatory cytokines, endotoxin and CytoVesicles (extracellular vesicles that transport inflammatory cytokine cargos) that participate in concert with freely circulating cytokines to further escalate the Cytokine Storm.\u00a0 \u00a0CytoVesicles are an important yet previously elusive target as they can be 20-60 times larger than cytokines themselves.\u00a0<\/p>\n

In the\u00a0in vitro\u00a0<\/em>pilot study, 104nm liposomes were utilized as a model system to assess the ability of Sigyn Therapy\u2019s adsorbent components to deplete CytoVesicles from human blood plasma. \u00a0After a two-hour interaction with Sigyn\u2019s adsorbent components, liposome concentrations in human blood plasma were reduced ~90%. \u00a0Previously published studies have validated liposomes as a model for the isolation of extracellular vesicles from blood based on the similarity of their size and structural characteristics.<\/p>\n

\u201cWhen we designed Sigyn Therapy, we envisioned a device that could be broadly deployed by the medical community, yet also have expansive first-in-industry capabilities that offer to improve patient outcomes,\u201d stated Jim Joyce, Chairman and CEO of Sigyn Therapeutics. \u201cWhen considering our previous report that Sigyn Therapy\u2122 clears both endotoxin and inflammatory cytokines from human blood plasma, the observation from our CytoVesicle pilot study further reinforces the potential for our vision to become a therapeutic reality.\u201d<\/p>\n

Sigyn Therapy is a single-use device designed for use on the established infrastructure of dialysis and CRRT machines already located in hospitals and clinics worldwide. On December 1, 2020, the Company reported the results of an\u00a0in vitro\u00a0<\/em>study that validated the ability of Sigyn Therapy to simultaneously reduce the presence of endotoxin and relevant pro-inflammatory cytokines, which included Interleukin-1 Beta (IL-1B), Interleukin-6 (IL-6) and Tumor Necrosis Factor alpha (TNF-a). Endotoxin (lipopolysaccharide or LPS) is a potent mediator implicated in the pathogenesis of sepsis and septic shock.\u00a0 The dysregulated over-production of IL-1B, IL-6 and TNF-a can lead to organ failure and cause death.<\/p>\n

An objective of the study was to rebalance elevated cytokine levels and optimize the elimination of endotoxin from human blood plasma. The study was conducted in triplicate over four-hour time periods with a pediatric version of Sigyn Therapy.\u00a0 Average reduction of endotoxin load peaked at 83% during the studies. The average reduction of IL-1B was 69%, IL-6 reduction was 59% and TNF-a reduction was 57% during the four-hour studies. \u00a0<\/p>\n

The resulting data from each of these studies will be incorporated into an Investigational Device Exemption (IDE) that Sigyn Therapeutics plans to submit to the United States Food and Drug Administration (FDA) in 2021.<\/p>\n

About Sigyn Therapeutics<\/p>\n

Sigyn Therapeutics\u2122 is a development-stage therapeutic technology company headquartered in San Diego, California USA. Our focus is directed toward a significant unmet need in global health; the treatment of life-threatening inflammatory conditions that are precipitated by Cytokine Storm Syndrome and not addressed with an approved therapy. Our mission is to save lives.<\/p>\n

Sigyn Therapy\u2122 is a novel blood purification technology designed to mitigate cytokine storm syndrome through the broad-spectrum depletion of inflammatory targets from the bloodstream. Cytokine storm syndrome is the hallmark of sepsis, which is the most common cause of in-hospital deaths and claims more lives each year than all forms of cancer combined. Virus induced cytokine storm (VICS) is associated with high mortality and is a leading cause of SARS-CoV-2 (COVID-19) deaths. Other therapeutic opportunities include, but are not limited to bacteria induced cytokine storm (BICS), acute respiratory distress syndrome (ARDS) and acute forms of liver failure, such as hepatic encephalopathy.<\/p>\n

To learn more, visit www.SigynTherapeutics.com or www.SigynTherapy.com<\/p>\n

Cautionary Note Regarding Forward-Looking Statements<\/p>\n

This press release contains forward-looking statements of Sigyn Therapeutics, Inc. (\u201cSigyn\u201d) that involve substantial risks and uncertainties. All statements contained in this press release are forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. The words \u201ccould,\u201d \u201cwill,\u201d \u201cplan,\u201d \u201cintend,\u201d \u201canticipate,\u201d \u201capproximate,\u201d \u201cexpect,\u201d \u201cpotential,\u201d or the negative of these terms or other similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. These forward-looking statements include, among others, statements about Sigyn\u2019s future financial performance, the impact of management changes, any proposed organizational restructuring, results of operations, capital resources to fund operations; statements about Sigyn\u2019s expectations regarding the capitalization, resources and ownership structure of the combined company; statements about the potential benefits of the transaction; the expected completion and timing of the transaction and other information relating to the transaction; and any other statements other than statements of historical fact. Actual results or events could differ materially from the plans, intentions and expectations disclosed in the forward-looking statements that Sigyn makes due to a number of important factors, including (i) the risk that the transaction may not be completed in a timely manner or at all, which may adversely affect Sigyn\u2019s business and the price of the common stock of Sigyn, (ii) the failure to satisfy of the conditions to the consummation of the transaction, (iii) the occurrence of any event, change or other circumstance that could give rise to the termination of the merger agreement, (iv) risks related to the ability to realize the anticipated benefits of the transaction, including the risk that the businesses will not be integrated successfully, (v) the effect of the announcement or pendency of the transaction on Sigyn\u2019s business relationships, operating results and business generally, (vi) risks that the proposed transaction disrupts current plans and operations, (vii) risks related to the combined entity\u2019s ability to up-list to a national securities exchange, (viii) risks related to the combined entity\u2019s access to existing capital and fundraising prospects to fund its ongoing operations, (ix) risks related to diverting management\u2019s attention from Sigyn\u2019s ongoing business operations, (x) other business effects, including the effects of industry, market, economic, political or regulatory conditions, future exchange and interest rates, and changes in tax and other laws, regulations, rates and policies, and (xi) risks related to an inability to manufacture Sigyn Therapy, risks related to the clinical advancement of Sigyn Therapy with regulatory agencies, and no assurance that Sigyn Therapy will be proven to be a safe and efficacious treatment for any condition. The forward-looking statements in this press release represent Sigyn\u2019s views as of the date of this press release. Sigyn anticipates that subsequent events and developments may cause its views to change. However, while it may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so. You should, therefore, not rely on these forward-looking statements as representing Sigyn\u2019s views as of any date subsequent to the date of this press release.<\/p>\n

Contact Sigyn Therapeutics, Inc.<\/p>\n

Jim Joyce<\/p>\n

Chairman, CEO<\/p>\n

(619) 368-2000<\/p>\n

jj@sigyntherapeutics.com<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Sigyn Therapy\u2122 is a Candidate to Treat Life-Threatening Inflammatory Conditions That Are Not Addressed with Drug Therapies SAN DIEGO, Jan. 06, 2021 (GLOBE NEWSWIRE) — via NewMediaWire — Sigyn Therapeutics, Inc. (OTCMarkets: SIGY), a medical technology company whose focus is the treatment of life-threatening inflammatory conditions precipitated by Cytokine Storm Syndrome (the Cytokine Storm), today announced the results of an\u00a0in vitro\u00a0pilot study that successfully modeled the ability of Sigyn Therapy\u2122 to address CytoVesicles that transport inflammatory cytokine cargos in the bloodstream.\u00a0 Cytokine Storm Syndrome is an excessive response of the immune system that is induced by infectious and non-infectious conditions. A hallmark indicator of Cytokine Storm Syndrome is the excessive or uncontrolled release of pro-inflammatory cytokines, which can lead to … <\/p>\n

Continue reading “Sigyn Therapeutics\u2122 Reports Results of Pilot Study to Address Inflammatory CytoVesicles”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-409462","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nSigyn Therapeutics\u2122 Reports Results of Pilot Study to Address Inflammatory CytoVesicles - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/sigyn-therapeutics-reports-results-of-pilot-study-to-address-inflammatory-cytovesicles\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sigyn Therapeutics\u2122 Reports Results of Pilot Study to Address Inflammatory CytoVesicles - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Sigyn Therapy\u2122 is a Candidate to Treat Life-Threatening Inflammatory Conditions That Are Not Addressed with Drug Therapies SAN DIEGO, Jan. 06, 2021 (GLOBE NEWSWIRE) — via NewMediaWire — Sigyn Therapeutics, Inc. 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(OTCMarkets: SIGY), a medical technology company whose focus is the treatment of life-threatening inflammatory conditions precipitated by Cytokine Storm Syndrome (the Cytokine Storm), today announced the results of an\u00a0in vitro\u00a0pilot study that successfully modeled the ability of Sigyn Therapy\u2122 to address CytoVesicles that transport inflammatory cytokine cargos in the bloodstream.\u00a0 Cytokine Storm Syndrome is an excessive response of the immune system that is induced by infectious and non-infectious conditions. 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