{"id":404434,"date":"2020-12-22T08:33:28","date_gmt":"2020-12-22T13:33:28","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=404434"},"modified":"2020-12-22T08:33:28","modified_gmt":"2020-12-22T13:33:28","slug":"cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/","title":{"rendered":"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <em>CDI-45205 holds potential as a therapeutic and as a prophylactic to protect against coronavirus transmission, including SARS-CoV-2<\/em>\n      <\/p>\n<p align=\"justify\">\n        <strong>BOTHELL, Wash., Dec.  22, 2020  (GLOBE NEWSWIRE) &#8212;  <strong><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=TvQNUXefN9S9d50qqnafXkBFx3-YERtT7t0LZHLwr36nQ9KIKn-S-YZC5e414iP5csV8SSoVsZqTNTkQLZNnsZkryEidd6UQztLfcQPinmo=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Cocrystal Pharma, Inc.<\/a><\/strong>\u00a0<\/strong>(Nasdaq: COCP), (\u201cCocrystal\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics, announces the selection of C<em>DI-45205<\/em> as the lead compound for further development against coronaviruses including SARS-CoV-2, the virus that causes COVID-19.<\/p>\n<p align=\"justify\">\n        <em>CDI-45205<\/em> was one of the broad spectrum protease inhibitors that were obtained by an exclusive license from Kansas State University Research Foundation (KSURF) under an agreement announced in April 2020. That agreement provides Cocrystal with an exclusive, royalty-bearing license to develop and commercialize therapeutic, diagnostic and prophylactic products against coronaviruses, caliciviruses and picornaviruses based on antivirals discovered by KSURF. The Company believes these protease inhibitors have the ability to convert the inactive SARS-CoV-2 polymerase replication enzymes into an active form.<\/p>\n<p align=\"justify\">\u201cFollowing preclinical studies by Cocrystal, we have selected <em>CDI-45205<\/em> as having promising attributes in combatting a range of coronaviruses, including SARS-CoV-2,\u201d said Sam Lee, Ph.D., President of Cocrystal. \u201cWe see significant potential for delivering this compound either by injection or inhalation and for potential use as both a therapeutic and prophylactic, thereby providing protection to uninfected individuals who may become exposed. With this selection now made, we will initiate API synthesis and IND-enabling studies toward clinical development. In addition to identifying <em>CDI-45205<\/em>, we have also applied our proprietary platform technology for developing additional novel coronavirus inhibitors suitable for oral administration.\u201d<\/p>\n<p align=\"justify\">\u201cWe are particularly excited about the approach of using a protease inhibitor as the basis for a coronavirus antiviral,\u201d said Gary Wilcox, Ph.D., Chairman and Chief Executive Officer of Cocrystal. \u201c<em>CDI-45205<\/em> was selected from the broad spectrum protease inhibitors discovered by KSURF that demonstrated <em>in vitro <\/em>and<em> in vivo <\/em>activity in animal models against the viral pathogens MERS and SARS. Preclinical animal studies of these coronavirus compounds published in the prestigious medical journal, <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=i0jSQUbIZUd-SaFPKuxN4MquLTXPayEMQMZYabzqRAdniKO8y8CghC8Rnosh333CU7Ox7kHcJwkAwqjpeMrb6CTJt3Ql6WWg5_AnqrhA1ucc5pFelZhsxxIpEd95FMkny1qRqj89VToZX7yPX_yU6g==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>Science Translational Medicine<\/u><\/a> (August 19, 2020<u>)<\/u>, showed <em>in vivo<\/em> efficacy and an acceptable safety profile in the MERS-CoV mouse model. Our further testing allowed us to identify a promising candidate molecule among these compounds for our lead development program.<\/p>\n<p align=\"justify\">\u201cWe view our novel approach to developing antiviral therapeutics as highly complementary to new SARS-CoV-2 vaccines and as important weapons in the ongoing fight against coronaviruses,\u201d added Dr. Wilcox. \u201cWe plan to continue evaluating proprietary coronavirus antiviral compounds discovered through our technology platform, including those with potential for oral delivery.\u201d<\/p>\n<p align=\"justify\">Cocrystal\u2019s technology generates a 3-D structure of inhibitor complexes at near-atomic resolution, which provides the Company with the ability to identify novel binding sites and for the rapid turnaround of structural information through highly automated x-ray data processing and refinement. By utilizing this technology, Cocrystal is able to develop compounds that specifically target enzymes that are essential for viral replication. The Company is currently leveraging its unique structure-based technologies to develop antiviral drugs for seasonal and pandemic influenza, hepatitis C, coronaviruses and noroviruses.<\/p>\n<p align=\"justify\">\n        <strong>About Cocrystal Pharma, Inc.<\/strong><br \/>\n        <br \/>Cocrystal Pharma, Inc. is a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics that target the replication process of influenza viruses, hepatitis C viruses, coronaviruses and noroviruses. Cocrystal employs unique structure-based technologies and Nobel Prize-winning expertise to create first- and best-in-class antiviral drugs. For further information about Cocrystal, please visit\u00a0<strong><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=3JGMZOSkfA6LKWu1U8Hu101vQLkgsdg1x8sDlvc2McBR79w3u0TVR6uLqkyydVUkwaEajXveWW0oEGln0Dm-zjVYA1CMoz9po7d6tbo5BpY=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">www.cocrystalpharma.com<\/a><\/u><\/strong>.<\/p>\n<p align=\"justify\">\n        <strong>Cautionary Note Regarding Forward-Looking Statements<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the ability of <em>CDI-45205 <\/em>to combat coronaviruses, including SARS-CoV-2 and the expected delivery methods, our beliefs regarding the initiation of API synthesis and IND-enabling studies, and the expected potential of <em>CDI-45205<\/em> in light of recent development of SARS-CoV-2 vaccines. The words &#8220;believe,&#8221; &#8220;may,&#8221; &#8220;estimate,&#8221; &#8220;continue,&#8221; &#8220;anticipate,&#8221; &#8220;intend,&#8221; &#8220;should,&#8221; &#8220;plan,&#8221; &#8220;could,&#8221; &#8220;target,&#8221; &#8220;potential,&#8221; &#8220;is likely,&#8221; &#8220;will,&#8221; &#8220;expect&#8221; and similar expressions, as they relate to us, are intended to identify forward-looking statements. We have based these forward-looking statements largely on our current expectations and projections about future events. Some or all of the events anticipated by these forward-looking statements may not occur. Important factors that could cause actual results to differ from those in the forward-looking statements include, but are not limited to, risks arising from the impact of the COVID-19 pandemic on our ability to proceed with our programs, on third parties upon whom we rely, and on the national and global economy, the further development of effective treatments and\/or vaccines by competitors, our ability to find and enter into agreements with suitable collaboration partners the results of preclinical and clinical studies, and receipt of regulatory approvals. Further information on our risk factors is contained in our filings with the SEC, including our Prospectus Supplement dated August 26, 2020 and our Annual Report on Form 10-K for the year ended December 31, 2019. Any forward-looking statement made by us herein speaks only as of the date on which it is made. Factors or events that could cause our actual results to differ may emerge from time to time, and it is not possible for us to predict all of them. We undertake no obligation to publicly update any forward-looking statement, whether as a result of new information, future developments or otherwise, except as may be required by law.<\/p>\n<p>\n        <strong>Investor Contact:<\/strong><br \/>\n        <br \/>LHA Investor Relations<br \/>Jody Cain<br \/>310-691-7100<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=rSeNYjVTwyDNEfbyyU6qOVRjGO3Cn-TgAPSIa9YEJKZ0FQtIKfAP_OOANhLqVtVRSds8h6laRCapM_Y0ujcmuQ==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">jcain@lhai.com<\/a><\/u><\/p>\n<p align=\"center\"># # #<\/p>\n<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNjE4NyMzODkyNDc5IzIwODQyNzg=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/b958fdd0-f7d3-439e-b7fc-231a6c51f239\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CDI-45205 holds potential as a therapeutic and as a prophylactic to protect against coronavirus transmission, including SARS-CoV-2 BOTHELL, Wash., Dec. 22, 2020 (GLOBE NEWSWIRE) &#8212; Cocrystal Pharma, Inc.\u00a0(Nasdaq: COCP), (\u201cCocrystal\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics, announces the selection of CDI-45205 as the lead compound for further development against coronaviruses including SARS-CoV-2, the virus that causes COVID-19. CDI-45205 was one of the broad spectrum protease inhibitors that were obtained by an exclusive license from Kansas State University Research Foundation (KSURF) under an agreement announced in April 2020. That agreement provides Cocrystal with an exclusive, royalty-bearing license to develop and commercialize therapeutic, diagnostic and prophylactic products against coronaviruses, caliciviruses and picornaviruses based on antivirals &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-404434","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"CDI-45205 holds potential as a therapeutic and as a prophylactic to protect against coronavirus transmission, including SARS-CoV-2 BOTHELL, Wash., Dec. 22, 2020 (GLOBE NEWSWIRE) &#8212; Cocrystal Pharma, Inc.\u00a0(Nasdaq: COCP), (\u201cCocrystal\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics, announces the selection of CDI-45205 as the lead compound for further development against coronaviruses including SARS-CoV-2, the virus that causes COVID-19. CDI-45205 was one of the broad spectrum protease inhibitors that were obtained by an exclusive license from Kansas State University Research Foundation (KSURF) under an agreement announced in April 2020. That agreement provides Cocrystal with an exclusive, royalty-bearing license to develop and commercialize therapeutic, diagnostic and prophylactic products against coronaviruses, caliciviruses and picornaviruses based on antivirals &hellip; Continue reading &quot;Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-22T13:33:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNjE4NyMzODkyNDc5IzIwODQyNzg=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses\",\"datePublished\":\"2020-12-22T13:33:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/\"},\"wordCount\":886,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODExNjE4NyMzODkyNDc5IzIwODQyNzg=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\\\/\",\"name\":\"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/","og_locale":"en_US","og_type":"article","og_title":"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses - Market Newsdesk","og_description":"CDI-45205 holds potential as a therapeutic and as a prophylactic to protect against coronavirus transmission, including SARS-CoV-2 BOTHELL, Wash., Dec. 22, 2020 (GLOBE NEWSWIRE) &#8212; Cocrystal Pharma, Inc.\u00a0(Nasdaq: COCP), (\u201cCocrystal\u201d or the \u201cCompany\u201d), a clinical-stage biotechnology company discovering and developing novel antiviral therapeutics, announces the selection of CDI-45205 as the lead compound for further development against coronaviruses including SARS-CoV-2, the virus that causes COVID-19. CDI-45205 was one of the broad spectrum protease inhibitors that were obtained by an exclusive license from Kansas State University Research Foundation (KSURF) under an agreement announced in April 2020. That agreement provides Cocrystal with an exclusive, royalty-bearing license to develop and commercialize therapeutic, diagnostic and prophylactic products against coronaviruses, caliciviruses and picornaviruses based on antivirals &hellip; Continue reading \"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-22T13:33:28+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNjE4NyMzODkyNDc5IzIwODQyNzg=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses","datePublished":"2020-12-22T13:33:28+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/"},"wordCount":886,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNjE4NyMzODkyNDc5IzIwODQyNzg=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/cocrystal-pharma-selects-lead-compound-for-further-development-against-coronaviruses\/","name":"Cocrystal Pharma Selects Lead Compound for Further Development Against Coronaviruses - 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