{"id":403471,"date":"2020-12-21T07:33:07","date_gmt":"2020-12-21T12:33:07","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=403471"},"modified":"2020-12-21T07:33:07","modified_gmt":"2020-12-21T12:33:07","slug":"successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/","title":{"rendered":"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent"},"content":{"rendered":"<h2>\nData to be Published in a Peer-Reviewed Journal in First Half 2021<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"justify\">YAVNE, Israel, Dec.  21, 2020  (GLOBE NEWSWIRE) &#8212; MediWound Ltd. (Nasdaq: MDWD), a fully-integrated biopharmaceutical company bringing innovative therapies to address unmet needs in severe burn and wound management, today announced the successful completion of a pre-clinical study designed to evaluate the debridement efficacy of EscharEx<sup>\u00ae<\/sup>, a novel bromelain-based enzymatic debridement agent, in a porcine hard-to-heal wound model, and compare its efficacy with an FDA approved and commercially available collagenase enzymatic debridement agent. The study concluded that EscharEx treatment was more effective than the commercially available collagenase agent in removing eschars in this model. Results from the study will be published in a peer-reviewed journal in the first half of 2021.<\/p>\n<p align=\"justify\">\u201cWe are encouraged by the robust results of this in-vivo study comparing EscharEx to the commercially available enzymatic debriding agent,\u201d said Sharon Malka, Chief Executive Officer of MediWound. \u201cGiven the superior efficacy of EscharEx versus the comparator enzymatic debridement agent demonstrated in this study, as well as the positive safety and efficacy results generated in our previous phase 2 study, we believe EscharEx has the potential to become a game-changer in a sizeable market. EscharEx can have a meaningful impact on chronic wound management, offering significant benefits for patients, healthcare professionals and payers. We look forward to the publication of these study results in a peer-reviewed journal, and we continue to advance our U.S Phase 2 adaptive design study in venous leg ulcers.\u201d<\/p>\n<p align=\"justify\">The study, conducted in collaboration with a U.S. research center, was performed as part of MediWound\u2019s pharmacological evaluation of EscharEx\u2019s effect on chronic wounds, using a novel porcine eschar model designed to evaluate the efficacy of enzymatic debridement agents. The primary objective of the study was to compare the debridement efficacy of various concentrations of EscharEx, a novel bromelain-based enzymatic agent (second generation EscharEx formulation), with a commercially available collagenase debridement agent. Efficacy was evaluated based on the number of treatments of various concentrations of EscharEx and the collagenase agent needed to achieve complete eschar removal (greater than 95%), as assessed clinically.<\/p>\n<p align=\"justify\">With EscharEx treatment, complete eschar removal was achieved in all treated wounds, at all dose concentrations, within a maximum of ten 24-hour applications, and dose-dependency was observed in the time to complete debridement. After ten applications, the maximum number of applications needed to achieve complete eschar removal with EscharEx at its lower dose, none of the wounds treated with the collagenase enzymatic agent achieved complete eschar removal.<\/p>\n<p align=\"justify\">\n        <strong>About\u00a0EscharEx<br \/><\/strong>EscharEx\u00a0is a topical biological drug candidate for the debridement of chronic and other hard-to-heal wounds. In two phase 2 trials, EscharEx has demonstrated safety and efficacy in the debridement of various chronic and other hard-to-heal wounds, within a few daily applications.<\/p>\n<p align=\"justify\">EscharEx active substance (API) is a concentrate of proteolytic enzymes enriched in bromelain. The mechanism of action of EscharEx is mediated by the proteolytic enzymes that cleaves and removes the necrotic tissue and prepare the wound bed for healing. EscharEx is an investigational product, currently under a\u00a0U.S.\u00a0phase 2 adaptive design study.<\/p>\n<p align=\"justify\">\n        <strong>About\u00a0MediWound <\/strong><br \/>\n        <strong>Ltd.<\/strong><br \/>\n        <br \/>MediWound is a fully-integrated biopharmaceutical company focused on developing, manufacturing and commercializing novel therapeutics based on its patented proteolytic enzyme technology to address unmet needs in the fields of severe burns, chronic and other hard-to-heal wounds. MediWound\u2019s first innovative biopharmaceutical product, NexoBrid, non-surgically and rapidly removes burn eschar without harming viable tissue. The product has received marketing authorization from the European Medicines Agency as well as the Israeli, Argentinian, South Korean, Russian and Peruvian Ministries of Health for eschar removal (debridement) in adults with deep partial-thickness and\/or full-thickness thermal burns. On June 29, 2020, a biological license application (BLA) was submitted to the U.S. FDA and was assigned a Prescription Drug User Fee Act (PDUFA) target date of June 29, 2021. MediWound\u2019s second innovative product, EscharEx is a topical biological drug candidate for the debridement of chronic and other hard-to-heal wounds using the same proteolytic enzyme technology as NexoBrid. In two Phase 2 studies, EscharEx has demonstrated safety and efficacy in the debridement of various chronic and other hard-to-heal wounds, within a few daily applications. For more information, please visit <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=QwPlAtcJalHLguNcn9xcIyCl1LM19cFlvEmOPgzLWp37_GmD7psGAPnu1myFUl89OO8165dtDfDW7_opS7mWqA==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">www.mediwound.com<\/a>.<\/p>\n<p>\n        <strong><br \/>\n          <em>Cautionary Note Regarding Forward-Looking Statements<\/em><br \/>\n        <\/strong>\n      <\/p>\n<p align=\"justify\">\n        <em>MediWound\u00a0caution you that all statements other than statements of historical fact included in this press release that address activities, events, or developments that we expect, believe or anticipate will or may occur in the future are forward-looking statements. Although we believe that we have a reasonable basis for the forward-looking statements contained herein, they are based on current expectations about future events affecting us and are subject to risks, assumptions, uncertainties and factors, all of which are difficult to predict and many of which are beyond our control. Actual results may differ materially from those expressed or implied by the forward-looking statements in this press release. These statements are often, but are not always, made through the use of words or phrases such as \u201canticipates,\u201d \u201cintends,\u201d \u201cestimates,\u201d \u201cplans,\u201d \u201cexpects,\u201d \u201ccontinues,\u201d \u201cbelieve,\u201d \u201cguidance,\u201d \u201coutlook,\u201d \u201ctarget,\u201d \u201cfuture,\u201d \u201cpotential,\u201d \u201cgoals\u201d and similar words or phrases, or future or conditional verbs such as \u201cwill,\u201d \u201cwould,\u201d \u201cshould,\u201d \u201ccould,\u201d \u201cmay,\u201d or similar expressions.<\/em>\n      <\/p>\n<p align=\"justify\">\n        <em>Specifically, this press release contains forward-looking statements concerning the anticipated progress, development, objectives, expectations, and commercial potential of NexoBrid and EscharEx. Among the factors that may cause results to be materially different from those stated herein are the inherent uncertainties associated with the timing and conduct of pre-clinical and clinical trials and product development activities; the timing or likelihood of regulatory approvals; the ability to successfully develop and commercialize NexoBrid, including its commercial growth potential and the market demand for the product; competitive developments; whether FDA will provide marketing approval for NexoBrid in\u00a0the United States; the ability to successfully develop and commercialize EscharEx, the design of the Phase 2 study, the timing of the interim assessment, the impact of applicable laws and regulations; and the\u00a0uncertainties associated with the scope, scale and duration of the impact of the COVID-19 pandemic. For example, we are\u00a0unable to predict how the pandemic will affect the overall healthcare infrastructure, including the pace with which governmental agencies, such as the FDA, will review and approve regulatory submissions. Additional government-imposed quarantines and requirements to \u201cshelter at home\u201d or other incremental mitigation efforts also may impact our ability to source supplies for our operations or our ability or capacity to manufacture, sell and support the use of NexoBrid in the future.<\/em>\n      <\/p>\n<p align=\"justify\">\n        <em>These and other significant factors are discussed in greater detail in MediWound\u2019s annual report on Form 20-F for the year ended\u00a0December 31, 2019, filed with the\u00a0Securities and Exchange Commission\u00a0(\u201cSEC\u201d) on\u00a0February 25, 2020, Quarterly Reports on Form 6-K and other filings with the\u00a0SEC\u00a0from time-to-time. These forward-looking statements reflect MediWound\u2019s current views as of the date hereof and\u00a0MediWound\u00a0undertakes, and specifically disclaims, any obligation to update any of these forward-looking statements to reflect a change in their respective views or events or circumstances that occur after the date of this release except as required by law.\u00a0<\/em>\n      <\/p>\n<table style=\"border-collapse: collapse;width:70%;border-collapse:collapse\">\n<tr>\n<td style=\"max-width:30%;width:30%;min-width:30%\">\n            <strong>Contacts:<\/strong>\n          <\/td>\n<td style=\"max-width:70%;width:70%;min-width:70%\">\n            <strong>Jeremy Feffer<\/strong>\n          <\/td>\n<\/tr>\n<tr>\n<td>Boaz Gur-Lavie<\/td>\n<td>Jeremy Feffer<\/td>\n<\/tr>\n<tr>\n<td>Chief Financial Officer<\/td>\n<td>Managing Director, LifeSci Advisors<\/td>\n<\/tr>\n<tr>\n<td>MediWound Ltd.<\/td>\n<td>212-915-2568<\/td>\n<\/tr>\n<tr>\n<td>\n            <a href=\"mailto:ir@mediwound.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">ir@mediwound.com<\/a>\n          <\/td>\n<td>\n            <a href=\"mailto:jeremy@lifesciadvisors.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">jeremy@lifesciadvisors.com<\/a>\n          <\/td>\n<\/tr>\n<\/table>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNTQwNiMzODkwMzUxIzIwMTY4NjE=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/9e41f5a3-bd5f-4611-9500-78cf7942e17c\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Data to be Published in a Peer-Reviewed Journal in First Half 2021 YAVNE, Israel, Dec. 21, 2020 (GLOBE NEWSWIRE) &#8212; MediWound Ltd. (Nasdaq: MDWD), a fully-integrated biopharmaceutical company bringing innovative therapies to address unmet needs in severe burn and wound management, today announced the successful completion of a pre-clinical study designed to evaluate the debridement efficacy of EscharEx\u00ae, a novel bromelain-based enzymatic debridement agent, in a porcine hard-to-heal wound model, and compare its efficacy with an FDA approved and commercially available collagenase enzymatic debridement agent. The study concluded that EscharEx treatment was more effective than the commercially available collagenase agent in removing eschars in this model. Results from the study will be published in a peer-reviewed journal in the first &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-403471","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Data to be Published in a Peer-Reviewed Journal in First Half 2021 YAVNE, Israel, Dec. 21, 2020 (GLOBE NEWSWIRE) &#8212; MediWound Ltd. (Nasdaq: MDWD), a fully-integrated biopharmaceutical company bringing innovative therapies to address unmet needs in severe burn and wound management, today announced the successful completion of a pre-clinical study designed to evaluate the debridement efficacy of EscharEx\u00ae, a novel bromelain-based enzymatic debridement agent, in a porcine hard-to-heal wound model, and compare its efficacy with an FDA approved and commercially available collagenase enzymatic debridement agent. The study concluded that EscharEx treatment was more effective than the commercially available collagenase agent in removing eschars in this model. Results from the study will be published in a peer-reviewed journal in the first &hellip; Continue reading &quot;Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-21T12:33:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNTQwNiMzODkwMzUxIzIwMTY4NjE=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent\",\"datePublished\":\"2020-12-21T12:33:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/\"},\"wordCount\":1209,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODExNTQwNiMzODkwMzUxIzIwMTY4NjE=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\\\/\",\"name\":\"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/","og_locale":"en_US","og_type":"article","og_title":"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent - Market Newsdesk","og_description":"Data to be Published in a Peer-Reviewed Journal in First Half 2021 YAVNE, Israel, Dec. 21, 2020 (GLOBE NEWSWIRE) &#8212; MediWound Ltd. (Nasdaq: MDWD), a fully-integrated biopharmaceutical company bringing innovative therapies to address unmet needs in severe burn and wound management, today announced the successful completion of a pre-clinical study designed to evaluate the debridement efficacy of EscharEx\u00ae, a novel bromelain-based enzymatic debridement agent, in a porcine hard-to-heal wound model, and compare its efficacy with an FDA approved and commercially available collagenase enzymatic debridement agent. The study concluded that EscharEx treatment was more effective than the commercially available collagenase agent in removing eschars in this model. Results from the study will be published in a peer-reviewed journal in the first &hellip; Continue reading \"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-21T12:33:07+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNTQwNiMzODkwMzUxIzIwMTY4NjE=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent","datePublished":"2020-12-21T12:33:07+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/"},"wordCount":1209,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExNTQwNiMzODkwMzUxIzIwMTY4NjE=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/successful-completion-of-in-vivo-head-to-head-comparator-study-of-escharex-versus-a-commercial-enzymatic-debridement-agent\/","name":"Successful Completion of In-Vivo Head-to-Head Comparator Study of EscharEx versus a Commercial Enzymatic Debridement Agent - 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