{"id":401976,"date":"2020-12-17T09:10:21","date_gmt":"2020-12-17T14:10:21","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=401976"},"modified":"2020-12-17T09:10:21","modified_gmt":"2020-12-17T14:10:21","slug":"personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/","title":{"rendered":"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development"},"content":{"rendered":"<p>        <!--body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p><b>Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development<\/b><\/p>\n<p>MENLO PARK, Calif.&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nPersonalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced the launch of its Systematic HLA Epitope Ranking Pan Algorithm (SHERPA), the company\u2019s proprietary, machine learning-based tool for the comprehensive identification and characterization of cancer neoantigens. Integrated into the Personalis\u00ae NeXT Platform\u2122, SHERPA enables the development of new neoantigen-based diagnostic biomarkers, such as the company\u2019s proprietary Neoantigen Presentation Score (NEOPS\u2122), and novel personalized therapies.\n<\/p>\n<p>\nData presented at the SITC Annual Meeting in November 2020 showed SHERPA outperforming commonly used neoantigen binding prediction tools in clinical tumor samples. \u201cWith more accurate neoantigen presentation prediction, we are looking to enable a new generation of precision oncology applications,\u201d said Richard Chen, MD, Personalis CSO. \u201cTrained on a proprietary immunopeptidomics dataset derived from engineered cell lines, SHERPA improves neoantigen presentation prediction compared to other <i>in silico<\/i> methods. With this advancement, SHERPA can enable more predictive biomarkers for cancer therapy as well as facilitate the development of neoantigen-targeting, personalized cancer therapies. Our recently-launched NEOPS is one example of a SHERPA-derived composite biomarker that has shown promise in predicting immunotherapy response in cancer patients.\u201d\n<\/p>\n<p>\nWhile most conventional <i>in silico<\/i> methods generally only assess the potential MHC-binding affinity and stability of identified peptides, SHERPA goes a step further by incorporating features relating to the antigen processing machinery and RNA abundance to generate a presentation rank for each detected peptide. This serves to determine the relative likelihood of a given neoantigen being presented and undergoing immunosurveillance.\n<\/p>\n<p>\nThis launch represents the broader commercial release of SHERPA, which is currently being leveraged by Personalis\u2019 preferred partner, Sarepta Therapeutics, to characterize immune response to precision genetic therapeutics in patients with rare diseases, demonstrating the applicability of this machine learning tool in disease areas beyond cancer.\n<\/p>\n<p><b>About Personalis, Inc.<\/b><\/p>\n<p>\nPersonalis, Inc. is a leader in cancer genomics, with a focus on data, scale, efficiency and quality. Personalis operates one of the largest sequencing operations globally. In oncology, Personalis is transforming the development of next-generation therapies by providing more comprehensive molecular data about each patient\u2019s cancer and immune response. The Personalis <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.personalis.com%2Fimmunoid-next-platform%2F&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=NeXT+Platform&amp;index=1&amp;md5=8e5af3d477a87b83be5eb292cb4dcbae\">NeXT Platform<\/a> is designed to adapt to the complex and evolving understanding of cancer, providing its biopharmaceutical customers with information on all of the approximately 20,000 human genes, together with the immune system, from a single tissue sample. The Personalis <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.personalis.com%2Fabout%2Flaboratory%2F&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=Clinical+Laboratory&amp;index=2&amp;md5=4a598b258a4e4ff2197d1e82e7a39813\">Clinical Laboratory<\/a> is GxP aligned as well as CLIA\u201988-certified and CAP-accredited. For more information, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.personalis.com%2F&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=www.personalis.com&amp;index=3&amp;md5=58c99a18c894d014f5ee3cb2fe62eb68\">www.personalis.com<\/a> and follow Personalis on Twitter (<a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Ftwitter.com%2FPersonalisInc&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=%40PersonalisInc&amp;index=4&amp;md5=09a2ce7348d36e157c27f5466b53d98c\">@PersonalisInc<\/a>).\n<\/p>\n<p><b>Forward-Looking Statements<\/b><\/p>\n<p>\nAll statements in this press release that are not historical are \u201cforward-looking statements\u201d within the meaning of U.S. securities laws, including statements relating to attributes or advantages of SHERPA, NEOPS or the Personalis NeXT Platform, the company\u2019s business opportunities, leadership or growth, or other future events. Such forward-looking statements involve risks and uncertainties, including those related to the COVID-19 pandemic, that could cause actual results to differ materially from any anticipated results or expectations expressed or implied by such statements. Factors that could materially affect actual results can be found in Personalis\u2019 filings with the U.S. Securities and Exchange Commission, including the company\u2019s most recent reports on Forms 8-K, 10-K and 10-Q, and include those listed under the caption \u201cRisk Factors.\u201d Personalis disclaims any obligation to update such forward-looking statements.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201217005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20201217005355\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20201217005355\/en\/<\/a><\/span><\/p>\n<p>\nInvestor Relations Contact for Personalis:<br \/>\n<br \/>Caroline Corner<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:investors@personalis.com\">investors@personalis.com<br \/>\n<\/a><br \/><a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwestwicke.com%2F&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=www.westwicke.com&amp;index=5&amp;md5=dfed726401b35718f84aa2ed27c3c65f\">www.westwicke.com<br \/>\n<\/a><br \/>415-202-5678\n<\/p>\n<p>\nMedia Contact for Personalis:<br \/>\n<br \/>Jennifer Havlek<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:pr@personalis.com\">pr@personalis.com<br \/>\n<\/a><br \/><a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.personalis.com%2F&amp;esheet=52350300&amp;newsitemid=20201217005355&amp;lan=en-US&amp;anchor=www.personalis.com&amp;index=6&amp;md5=c55ae85d731750aff27e37e143ee96b2\">www.personalis.com<br \/>\n<\/a><br \/>650-752-1300\n<\/p>\n<p><b>KEYWORDS:<\/b> California United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Research Technology Genetics Software Biotechnology Pharmaceutical Health Science Oncology Other Science<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20201217005355\/en\/651797\/3\/Logo_Personalis_w-o_tag_correct.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development MENLO PARK, Calif.&#8211;(BUSINESS WIRE)&#8211; Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced the launch of its Systematic HLA Epitope Ranking Pan Algorithm (SHERPA), the company\u2019s proprietary, machine learning-based tool for the comprehensive identification and characterization of cancer neoantigens. Integrated into the Personalis\u00ae NeXT Platform\u2122, SHERPA enables the development of new neoantigen-based diagnostic biomarkers, such as the company\u2019s proprietary Neoantigen Presentation Score (NEOPS\u2122), and novel personalized therapies. Data presented at the SITC Annual Meeting in November 2020 showed SHERPA outperforming commonly used neoantigen binding prediction tools in clinical tumor samples. \u201cWith more accurate neoantigen presentation prediction, we are looking to enable &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-401976","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development MENLO PARK, Calif.&#8211;(BUSINESS WIRE)&#8211; Personalis, Inc. (Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced the launch of its Systematic HLA Epitope Ranking Pan Algorithm (SHERPA), the company\u2019s proprietary, machine learning-based tool for the comprehensive identification and characterization of cancer neoantigens. Integrated into the Personalis\u00ae NeXT Platform\u2122, SHERPA enables the development of new neoantigen-based diagnostic biomarkers, such as the company\u2019s proprietary Neoantigen Presentation Score (NEOPS\u2122), and novel personalized therapies. Data presented at the SITC Annual Meeting in November 2020 showed SHERPA outperforming commonly used neoantigen binding prediction tools in clinical tumor samples. \u201cWith more accurate neoantigen presentation prediction, we are looking to enable &hellip; Continue reading &quot;Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-17T14:10:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201217005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development\",\"datePublished\":\"2020-12-17T14:10:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/\"},\"wordCount\":644,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20201217005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\\\/\",\"name\":\"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development - 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(Nasdaq: PSNL), a leader in advanced genomics for cancer, today announced the launch of its Systematic HLA Epitope Ranking Pan Algorithm (SHERPA), the company\u2019s proprietary, machine learning-based tool for the comprehensive identification and characterization of cancer neoantigens. Integrated into the Personalis\u00ae NeXT Platform\u2122, SHERPA enables the development of new neoantigen-based diagnostic biomarkers, such as the company\u2019s proprietary Neoantigen Presentation Score (NEOPS\u2122), and novel personalized therapies. Data presented at the SITC Annual Meeting in November 2020 showed SHERPA outperforming commonly used neoantigen binding prediction tools in clinical tumor samples. \u201cWith more accurate neoantigen presentation prediction, we are looking to enable &hellip; Continue reading \"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-17T14:10:21+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201217005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development","datePublished":"2020-12-17T14:10:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/"},"wordCount":644,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201217005355r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/personalis-announces-the-launch-of-sherpa-for-high-accuracy-neoantigen-prediction-and-cancer-diagnostic-biomarker-development\/","name":"Personalis Announces the Launch of SHERPA\u2122 for High-Accuracy Neoantigen Prediction and Cancer Diagnostic Biomarker Development - 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