{"id":401731,"date":"2020-12-17T08:03:31","date_gmt":"2020-12-17T13:03:31","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=401731"},"modified":"2020-12-17T08:03:31","modified_gmt":"2020-12-17T13:03:31","slug":"histogen-announces-filing-an-investigational-new-drug-application-for-hst-003","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\/","title":{"rendered":"Histogen Announces Filing an Investigational New Drug Application for HST-003"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"center\">\n        <strong>Phase 1\/2 Trial Initiation for Knee Cartilage Regeneration Anticipated in First Quarter 2021<\/strong>\n      <\/p>\n<p align=\"center\">\n        <strong>$2M Grant Awarded by the Department of Defense in September 2020 to Support Clinical Development<\/strong>\n      <\/p>\n<p>SAN DIEGO, Dec.  17, 2020  (GLOBE NEWSWIRE) &#8212; Histogen Inc. (NASDAQ: HSTO), a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the body\u2019s natural process to repair and maintain healthy biological function today announced that it has submitted an Investigational New Drug (\u201cIND\u201d) application with the U.S. Food and Drug Administration (\u201cFDA\u201d) for the initiation of a Phase 1\/2 clinical trial of HST-003 to evaluate the safety and efficacy of human extracellular matrix (hECM:HST-003) implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline cartilage in combination with a microfracture procedure. It is anticipated that clinical sites participating in the trial will include: OasisMD in San Diego, CA, The Steadman Clinic in Vail, CO and Walter Reed Medical Center in Bethesda, MD.<\/p>\n<p>\u201cThere is a significant need for improved acute knee injury treatments in both military and civilian populations. Approximately 900,000 Americans are affected by knee cartilage injuries annually, with 200,000 requiring surgical intervention<sup>1<\/sup>. Further, among US military personnel, musculoskeletal injuries are a leading cause of morbidity, lost training time and reduced operational readiness,\u201d said Richard W. Pascoe, Histogen\u2019s President and CEO. \u201cAssuming the HST-003 IND is approved, we anticipate initiating the Phase 1\/2 trial in the first quarter of 2021 utilizing funding provided by the $2M grant from the Department of Defense.\u201d<\/p>\n<p>The U.S. Army Medical Research Acquisition Activity, 820 Chandler Street, Fort Detrick, MD 21702, is the awarding and administering acquisition office. The views expressed in this press release are those of the author and may not reflect the official policy or position of the Department of the Army, Department of Defense, or the U.S. Government.<\/p>\n<p>\n        <strong>About HST-003<\/strong><br \/>\n        <br \/>Histogen\u2019s human extracellular matrix, or hECM, is intended for regenerating hyaline cartilage for the treatment of articular cartilage defects with a novel malleable scaffold that stimulates the body\u2019s own stem cells. In multiple preclinical models,\u00a0HST-003\u00a0has been shown to regenerate mature cartilage and well vascularized bone, indicating great therapeutic potential in the sports medicine, spinal disc repair, orthopedic, and dental areas. Studies conducted by outside experts have demonstrated that\u00a0HST-003\u00a0is anti-inflammatory, angiogenic, and can stimulate the growth of stem cells in damaged areas to induce tissue regeneration. The most extensive in vivo work in animals has focused on the regeneration of new hyaline cartilage and bone in full thickness knee injuries.<\/p>\n<p>\n        <strong>About Histogen<\/strong><br \/>\n        <br \/>Histogen Inc. is a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the body\u2019s natural process to repair and maintain healthy biological function. Histogen\u2019s innovative technology platform utilizes cell conditioned media and extracellular matrix materials produced by hypoxia-induced multipotent cells. Histogen\u2019s proprietary, reproducible manufacturing process provides targeted solutions across a broad range of therapeutic indications including hair growth, dermal rejuvenation, joint cartilage regeneration and spinal disk repair. For more information, please visit\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=ueJPSFKa7Cjw8eTQ-Nm63YNOSFUxTK71OQj4Do4D8aQEkldhhMONCW2deBbqKB0PR4JAxfwXU4rEOmoZZIrctg==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">www.histogen.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains forward-looking statements within the meaning of the \u201csafe harbor\u201d provisions of the Private Securities Litigation Reform Act of 1995 and other Federal securities laws. For example, we are using forward-looking statements when we discuss Histogen\u2019s ability future operations and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones and related timing, including those related to the approval of the HST-003 IND and planned Phase 1\/2 clinical trial of HST-003 for regeneration of cartilage in the knee; the nature, strategy and focus of Histogen\u2019s business; and the development and commercial potential and potential benefits of any of Histogen\u2019s product candidates, including HST-003. Histogen may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Because such statements deal with future events and are based on Histogen\u2019s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Histogen that could differ materially from those described in or implied by the statements in this press release, including: the uncertainties associated with the clinical development and regulatory approval of Histogen\u2019s product candidates, including potential delays in the approval of the HST-003 IND and commencement, enrollment and completion of clinical trials such as the planned Phase 1\/2 clinical trial of HST-003 for regeneration of cartilage in the knee; the potential that earlier clinical trials and studies of Histogen\u2019s product candidates may not be predictive of future results; risks related to business interruptions, including the outbreak of COVID-19 coronavirus, which could seriously harm Histogen\u2019s financial condition and increase its costs and expenses; and the requirement for additional capital to continue to advance these product candidates, which may not be available on favorable terms or at all. The foregoing review of important factors that could cause actual events to differ from expectations should not be construed as exhaustive and should be read in conjunction with statements that are included herein and elsewhere, including those risks discussed in Histogen\u2019s filings with the Securities and Exchange Commission. Except as otherwise required by law, Histogen disclaims any intention or obligation to update or revise any forward-looking statements, which speak only as of the date hereof, whether as a result of new information, future events, or circumstances or otherwise.<\/p>\n<p>\n        <strong>CONTACT:<\/strong>\n      <\/p>\n<p>Susan A. Knudson<br \/>Executive Vice President &amp; CFO <br \/>Histogen, Inc. <br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=kjUrDYJm7b8QMlz76mQS6PUTNav3i3w4XIm9eidbJ5ZI2yrIxljYuzJ7ffDX7H2NIdffusJ70vhhX8Mh3-RpDw==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">ir@histogen.com<\/a><\/p>\n<p>_______________<br \/><sup>1<\/sup> Merkely, G., Ackermann, J. &amp; Lattermann, C. Articular Cartilage Defects: Incidence, Diagnosis, and Natural History. Oper. Tech. Sports Med. 26, 156\u2013161 (2018).<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMzcyOCMzODg1Njg2IzIwODc4Mzc=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/588a1746-8706-4954-81b4-9f2b3edd3fea\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Phase 1\/2 Trial Initiation for Knee Cartilage Regeneration Anticipated in First Quarter 2021 $2M Grant Awarded by the Department of Defense in September 2020 to Support Clinical Development SAN DIEGO, Dec. 17, 2020 (GLOBE NEWSWIRE) &#8212; Histogen Inc. (NASDAQ: HSTO), a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the body\u2019s natural process to repair and maintain healthy biological function today announced that it has submitted an Investigational New Drug (\u201cIND\u201d) application with the U.S. Food and Drug Administration (\u201cFDA\u201d) for the initiation of a Phase 1\/2 clinical trial of HST-003 to evaluate the safety and efficacy of human extracellular matrix (hECM:HST-003) implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Histogen Announces Filing an Investigational New Drug Application for HST-003&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-401731","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Histogen Announces Filing an Investigational New Drug Application for HST-003 - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Histogen Announces Filing an Investigational New Drug Application for HST-003 - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Phase 1\/2 Trial Initiation for Knee Cartilage Regeneration Anticipated in First Quarter 2021 $2M Grant Awarded by the Department of Defense in September 2020 to Support Clinical Development SAN DIEGO, Dec. 17, 2020 (GLOBE NEWSWIRE) &#8212; Histogen Inc. (NASDAQ: HSTO), a clinical-stage therapeutics company focused on developing potential first-in-class restorative therapeutics that ignite the body\u2019s natural process to repair and maintain healthy biological function today announced that it has submitted an Investigational New Drug (\u201cIND\u201d) application with the U.S. Food and Drug Administration (\u201cFDA\u201d) for the initiation of a Phase 1\/2 clinical trial of HST-003 to evaluate the safety and efficacy of human extracellular matrix (hECM:HST-003) implanted within microfracture interstices and the cartilage defect in the knee to regenerate hyaline &hellip; Continue reading &quot;Histogen Announces Filing an Investigational New Drug Application for HST-003&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-17T13:03:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMzcyOCMzODg1Njg2IzIwODc4Mzc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Histogen Announces Filing an Investigational New Drug Application for HST-003\",\"datePublished\":\"2020-12-17T13:03:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/\"},\"wordCount\":942,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODExMzcyOCMzODg1Njg2IzIwODc4Mzc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/histogen-announces-filing-an-investigational-new-drug-application-for-hst-003\\\/\",\"name\":\"Histogen Announces Filing an Investigational New Drug Application for HST-003 - 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