{"id":400756,"date":"2020-12-16T07:33:36","date_gmt":"2020-12-16T12:33:36","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=400756"},"modified":"2020-12-16T07:33:36","modified_gmt":"2020-12-16T12:33:36","slug":"biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/","title":{"rendered":"Biohaven’s Rimegepant For Preventive Treatment Of Migraine Published In The Lancet"},"content":{"rendered":"
\n

– Rimegepant 75 mg, already approved for the acute treatment of migraine, demonstrated efficacy and safety for the preventive treatment of migraine in this pivotal Phase 3 trial in adults<\/h2>\n

– Rimegepant resulted in a -4.3 day reduction in the mean number of migraine days per month<\/h2>\n

– Approximately half of rimegepant-treated patients demonstrated a 50% or greater reduction in the number of moderate-to-severe migraine days per month<\/h2>\n

– Rimegepant is the first and only CGRP targeting medication in development to show dual efficacy for both the acute and preventive treatment of migraine<\/h2>\n

PR Newswire<\/p>\n<\/p><\/div>\n

\n

\n NEW HAVEN, Conn.<\/span>, Dec. 16, 2020<\/span> \/PRNewswire\/ — Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN) announced today that The Lancet <\/i>published the company’s\u00a0positive results from a Phase 3 clinical trial of rimegepant for the preventive treatment of migraine in adults. These data show rimegepant was superior to placebo in the reduction of monthly migraine days. Rimegepant was approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of migraine in February 2020<\/span>. \u00a0Rimegepant is marketed as NURTEC\u00ae ODT, and is the first and only calcitonin gene-related peptide (CGRP) receptor antagonist available in an orally disintegrating tablet (ODT) designed for rapid onset of action. <\/p>\n

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\n <\/a>\n <\/p>\n<\/p><\/div>\n

\n Peter J. Goadsby<\/span>, M.D., Ph.D., D.Sc., study co-author, Professor of Neurology at King’s College, London<\/span> and the University of California, Los Angeles<\/span>, commented, “These data demonstrate the continued innovation in migraine treatment aimed at CGRP mechanisms. This is the first time an oral CGRP migraine treatment has shown dual efficacy in both the acute and preventive treatment of migraine. With this flexibility, these therapies are truly disruptive and change the treatment paradigm for people living with migraine.”<\/p>\n

In the Phase 3 double-blind, randomized, placebo-controlled trial, 747 people with migraine were randomized.\u00a0Rimegepant was superior to placebo on the primary endpoint of change in mean number of migraine days per month during Weeks 9-12. Rimegepant showed a \u22124.3 day reduction in monthly migraine days during the prespecified treatment period. \u00a0Notably, the positive response to rimegepant was seen during the first four weeks of treatment and suggests an early onset of preventive effects. <\/p>\n

\n Richard B. Lipton<\/span>, M.D., study co-author, Professor and Vice Chair of Neurology at the Albert Einstein College of Medicine and Montefiore Health System, Director of the Montefiore Headache Center, stated, “Migraine is a prevalent and debilitating disease, affecting roughly 1 in 6 Americans, and many are not helped by current treatments. The results published in The Lancet<\/i> demonstrate the significant clinical benefits of rimegepant for the preventive treatment of migraine. These data show the promise of a new approach to preventive treatment with an oral CGRP antagonist.” <\/p>\n

Rimegepant was also superior to placebo on multiple secondary endpoints. Notably, 49% of the rimegepant group had at least a 50% reduction from baseline in mean number of moderate to severe migraine days per month compared to 41% in the placebo group in weeks 9 through 12. Additionally, the incidence\u00a0of adverse events was similar with rimegepant and placebo (36% vs 36%). <\/p>\n

\n Vlad Coric<\/span>, M.D., Chief Executive Officer of Biohaven, commented, “We are extremely excited by the publication of the rimegepant prevention of migraine data in The<\/i>Lancet<\/i>, one of the most influential scientific journals in medicine.\u00a0 For several years, leaders in the field such as Drs. Lipton and Goadsby hypothesized that CGRP antagonists could be effective as both an acute and preventive migraine therapy. The results of our pivotal prevention study show that “dual acting” efficacy \u2014 acute and preventive \u2014can be achieved in a single CGRP targeting drug such as rimegepant.”\u00a0 <\/p>\n

This is the fourth pivotal randomized placebo-controlled clinical trial that demonstrated the efficacy and safety of rimegepant in migraine. Nurtec ODT (rimegepant) is currently approved by the FDA for the acute treatment of migraine in adults. The FDA accepted Biohaven’s supplemental New Drug Application (sNDA) for NURTEC ODT for the preventive treatment of migraine in October 2020<\/span> and the Prescription Drug User Fee Act (PDUFA) goal date is in 2Q2021. <\/p>\n

Dr. Coric added, “Our strategic goal with the rimegepant development program is to offer patients a fast acting, quick-dissolve oral tablet with ‘dual-acting’ properties to treat migraine across the full spectrum from acute to preventive treatment.\u00a0 This publication in The Lancet<\/i> demonstrates that rimegepant has the potential to prevent migraine in addition to its previously established efficacy in the acute treatment of migraine. People with migraine deserve a simple to use, single oral medication that can help them take back their days when a migraine strikes and also prevent future attacks.” <\/p>\n

\n The Lancet <\/i>full article is available online<\/a>. Drs. Lipton and Goadsby have served as consultants to Biohaven and their full disclosures are listed in the referenced publication.<\/p>\n

\n About Nurtec ODT<\/b>\n <\/p>\n

NURTEC\u00ae ODT (rimegepant) is the first and only calcitonin gene-related peptide (CGRP) receptor antagonist available in a quick-dissolve ODT formulation that is approved by the U.S. Food and Drug Administration (FDA) for the acute treatment of migraine in adults. The activity of the neuropeptide CGRP is thought to play a causal role in migraine pathophysiology. NURTEC ODT is a CGRP receptor antagonist that works by reversibly blocking CGRP receptors, thereby inhibiting the biologic activity of the CGRP neuropeptide. The recommended dose of NURTEC ODT is 75 mg, taken as needed, up to once daily. The safety of treating up to 15 migraines in a 30-day period has been established. For more information about NURTEC ODT, visit\u00a0www.nurtec.com<\/a>.<\/p>\n

\n About CGRP Receptor Antagonism
<\/b>Small molecule CGRP receptor antagonists represent a novel class of drugs for the treatment of migraine. This unique mode of action potentially offers an alternative to current agents, particularly for patients who have contraindications to the use of triptans, or who have a poor response to triptans or are intolerant to them.<\/p>\n

\n Indication<\/b>
\n
NURTEC ODT is indicated for the acute treatment of migraine with or without aura in adults.<\/p>\n

\n Limitations of Use<\/b>
\n
NURTEC ODT is not indicated for the preventive treatment of migraine.<\/p>\n

\n Important Safety Information<\/b>
\n
\n Contraindications:\u00a0<\/b>Hypersensitivity to NURTEC ODT or any of its components.<\/p>\n

\n Warnings and Precautions:<\/b>\u00a0If a serious hypersensitivity reaction occurs, discontinue NURTEC ODT and initiate appropriate therapy.\u00a0 Serious hypersensitivity reactions have included dyspnea and rash, and can occur days after administration.<\/p>\n

\n Adverse Reactions:<\/b>\u00a0The most common adverse reaction was nausea (2% in patients who received NURTEC ODT compared to 0.4% in patients who received placebo).\u00a0 Hypersensitivity, including dyspnea and rash, occurred in less than 1% of patients treated with NURTEC ODT.<\/p>\n

\n Drug Interactions:<\/b>\u00a0Avoid concomitant administration of NURTEC ODT with strong inhibitors of CYP3A4, strong or moderate inducers of CYP3A or inhibitors of P-gp or BCRP.\u00a0 Avoid another dose of NURTEC ODT within 48 hours when it is administered with moderate inhibitors of CYP3A4.<\/p>\n

\n Use in Specific Populations:<\/b>\n <\/p>\n

    \n
  1. Pregnant\/breast feeding: It is not known if NURTEC ODT can harm an unborn baby or if it passes into breast milk.\n<\/li>\n
  2. Hepatic impairment: Avoid use of NURTEC ODT in persons with severe hepatic impairment.\n<\/li>\n
  3. Renal impairment: Avoid use in patients with end-stage renal disease.\u00a0<\/li>\n<\/ol>\n

    \n Please click here for full\u00a0<\/b>
    \n
    \n     Prescribing information<\/a>
    \n <\/b>
    \n .<\/b>\n <\/p>\n

    \n You are encouraged to report side effects of prescription drugs to the FDA.<\/b>\u00a0Visit\u00a0www.fda.gov\/medwatch<\/a>\u00a0or call 1-800-FDA-1088 or report side effects to Biohaven at 1-833-4NURTEC.<\/p>\n

    Please click here for full\u00a0Prescribing information<\/a>\u00a0and\u00a0Patient Information<\/a>.<\/p>\n

    \n About Biohaven
    <\/b>Biohaven is a commercial-stage biopharmaceutical company with a portfolio of innovative, best-in-class therapies to improve the lives of patients with debilitating neurological and neuropsychiatric diseases, including rare disorders. Biohaven’s neuroinnovation portfolio includes FDA-approved NURTEC\u2122 ODT (rimegepant) for the acute treatment of migraine and a broad pipeline of late-stage product candidates across three distinct mechanistic platforms: CGRP receptor antagonism for the acute and preventive treatment of migraine; glutamate modulation for obsessive-compulsive disorder, Alzheimer’s disease, and spinocerebellar ataxia; and myeloperoxidase (MPO) inhibition for multiple system atrophy and amyotrophic lateral sclerosis. More information about Biohaven is available at\u00a0    www.biohavenpharma.com<\/a>.<\/p>\n

    \n Forward-Looking Statements<\/b>
    \n
    This news release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements involve substantial risks and uncertainties, including statements that are based on the current expectations and assumptions of the Company’s management. All statements, other than statements of historical facts, included in this press release regarding the Company’s business and product candidate plans and objectives are forward-looking statements. Forward-looking statements include those related to: commercialization and sales of NURTEC ODT and the potential approval and commercialization of other product candidates, the effect of the ongoing COVID-19 pandemic on Biohaven, the expected timing, commencement and outcomes of Biohaven’s planned and ongoing clinical trials, the timing of planned interactions and filings with the FDA, the timing and outcome of expected regulatory filings,\u00a0 including the need for any REMS or Advisory Committee meetings, the potential for Biohaven’s product candidates to be first in class or best in class therapies and the effectiveness and safety of Biohaven’s product candidates. The use of certain words, including “believe”, “continue”, “may”, “on track”, “expects” and “will” and similar expressions, are intended to identify forward-looking statements. Various important factors could cause actual results or events to differ materially from those that may be expressed or implied by our forward-looking statements. Additional important factors to be considered in connection with forward-looking statements are described in the “Risk Factors” section of Biohaven’s Annual Report on Form 10-K filed with the Securities and Exchange Commission on\u00a0February 26, 2020\u00a0and Biohaven’s Quarterly Report on Form 10-Q for the quarter ended\u00a0September 30, 2020\u00a0filed with the Securities and Exchange Commission on\u00a0November 9, 2020. The forward-looking statements are made as of this date and Biohaven does not undertake any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.<\/p>\n

    \n Biohaven Contact<\/b>
    \n
    Dr.\u00a0Vlad Coric
    Chief Executive Officer
    Vlad.Coric@biohavenpharma.com<\/a><\/p>\n

    \n For Media
    <\/b>
    \n Mike Beyer<\/span>
    \n
    Sam Brown Inc.\u00a0
    mikebeyer@sambrown.com<\/a>
    312-961-2502<\/p>\n

    NURTEC is a registered trademark of Biohaven Pharmaceutical Ireland DAC.<\/p>\n

    \n

    \n
    \n \"(PRNewsfoto\/Biohaven
    \n <\/a>\n <\/p>\n<\/p><\/div>\n

    \n \"Cision\" View original content to download multimedia:http:\/\/www.prnewswire.com\/news-releases\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet-301193664.html<\/a><\/p>\n

    SOURCE Biohaven Pharmaceutical Holding Company Ltd.<\/p>\n<\/p><\/div>\n

    \"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

    – Rimegepant 75 mg, already approved for the acute treatment of migraine, demonstrated efficacy and safety for the preventive treatment of migraine in this pivotal Phase 3 trial in adults – Rimegepant resulted in a -4.3 day reduction in the mean number of migraine days per month – Approximately half of rimegepant-treated patients demonstrated a 50% or greater reduction in the number of moderate-to-severe migraine days per month – Rimegepant is the first and only CGRP targeting medication in development to show dual efficacy for both the acute and preventive treatment of migraine PR Newswire NEW HAVEN, Conn., Dec. 16, 2020 \/PRNewswire\/ — Biohaven Pharmaceutical Holding Company Ltd. (NYSE: BHVN) announced today that The Lancet published the company’s\u00a0positive results from … <\/p>\n

    Continue reading “Biohaven’s Rimegepant For Preventive Treatment Of Migraine Published In The Lancet”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-400756","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nBiohaven's Rimegepant For Preventive Treatment Of Migraine Published In The Lancet - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biohaven's Rimegepant For Preventive Treatment Of Migraine Published In The Lancet - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"– Rimegepant 75 mg, already approved for the acute treatment of migraine, demonstrated efficacy and safety for the preventive treatment of migraine in this pivotal Phase 3 trial in adults – Rimegepant resulted in a -4.3 day reduction in the mean number of migraine days per month – Approximately half of rimegepant-treated patients demonstrated a 50% or greater reduction in the number of moderate-to-severe migraine days per month – Rimegepant is the first and only CGRP targeting medication in development to show dual efficacy for both the acute and preventive treatment of migraine PR Newswire NEW HAVEN, Conn., Dec. 16, 2020 \/PRNewswire\/ — Biohaven Pharmaceutical Holding Company Ltd. 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(NYSE: BHVN) announced today that The Lancet published the company’s\u00a0positive results from … Continue reading \"Biohaven’s Rimegepant For Preventive Treatment Of Migraine Published In The Lancet\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-16T12:33:36+00:00","og_image":[{"url":"https:\/\/mma.prnewswire.com\/media\/1386410\/BIOHAVEN_Lancet.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"8 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Biohaven’s Rimegepant For Preventive Treatment Of Migraine Published In The Lancet","datePublished":"2020-12-16T12:33:36+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/"},"wordCount":1664,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/#primaryimage"},"thumbnailUrl":"https:\/\/mma.prnewswire.com\/media\/1386410\/BIOHAVEN_Lancet.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/biohavens-rimegepant-for-preventive-treatment-of-migraine-published-in-the-lancet\/","name":"Biohaven's Rimegepant For Preventive Treatment Of Migraine Published In The Lancet - 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