{"id":399616,"date":"2020-12-15T06:48:06","date_gmt":"2020-12-15T11:48:06","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=399616"},"modified":"2020-12-15T06:48:06","modified_gmt":"2020-12-15T11:48:06","slug":"annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/","title":{"rendered":"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences"},"content":{"rendered":"<div class=\"mw_release\">\n<p align=\"justify\">BERWYN, Pa., Dec.  15, 2020  (GLOBE NEWSWIRE) &#8212; Annovis Bio Inc. (NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and other neurodegenerative diseases, today announced its CEO, Maria Maccecchini, Ph.D., presented her paper, \u201cTargeting Increased Levels of Neurotoxic Proteins in Down Syndrome, Alzheimer\u2019s and Parkinson\u2019s Animals Normalized Axonal Transport, Cognition and Function,\u201d at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\u2019 Alzheimer&#8217;s Disease Therapeutics: Alternatives to Amyloid 2020 Virtual Conference on Friday, December 4, 2020.<\/p>\n<p align=\"justify\">Dr. Maccecchini\u2019s presentation highlighted the Company\u2019s data that demonstrates by lowering amyloid, tau, and alpha-synuclein, the Company\u2019s lead candidate, ANVS401, restores axonal transport and nerve cell health.<\/p>\n<p align=\"justify\">Hundreds of recent clinical trials individually targeting amyloid, tau, or alpha-synuclein in AD, PD or Down syndrome (DS) have failed. While these proteins at elevated levels turn toxic, just targeting one is not enough to protect the brain from neurodegeneration. Overexpression of neurotoxic proteins drives downstream events that dysregulate axonal transport, lead to inflammation, nerve cell death, and loss of function.<\/p>\n<p align=\"justify\">To test this hypothesis, trisomic DS mice were treated with ANVS401, an orally available small molecule shown to reduce amyloid precursor protein (APP), tau, and alpha-synuclein. ANVS401 lowered APP and phospho-tau, reversed Rab5 hyperactivation and restored retrograde transport. In transgenic APP-AD mice, ANVS401 lowered APP and its fragments in the brain and fully restored long-term potentiation, memory, and learning. In transgenic alpha-synuclein PD mice, it lowered alpha-synuclein in the gut and in the brain and fully restored affected functions.<\/p>\n<p align=\"justify\">\u201cLet me explain the science of axonal transport for non-scientists: If we think about it, it is obvious that the brain is our information processing, storage and distribution center. In order for us to function, our brain needs to direct everything we do, say, feel and think. To do so, the bodies of the nerve cells are located in the brain, they have long arms called axons that crisscross the body and at the end of the arms there are fingers, called synapses, that touch everything. The fingers need to communicate with the body and the body needs to communicate with the fingers, in order for the nerve cells, the brain and for us to function. That communication is done by sending packages of information up and down the arm. If that communication does not work, the information flow is blocked, the nerve cells get sick and the function associated with the sick nerve cells is lost. That is why in neurodegenerative diseases functions are lost. These functions can be in the brain: memory, learning, executive function; or in the body: speech, shaking, gate; or in the eye: sight,\u201d stated Dr. Maccecchini. \u201cOur approach to neurodegeneration is unique when compared to the long list of failed trials exclusively targeting amyloid. The NYAS conference, the first major event of its type dedicated to non-amyloid approaches to AD, provided a great opportunity to share our unique approach with the scientific community.\u201d<\/p>\n<p align=\"justify\">ANVS401 inhibits more than one neurotoxic protein and, thereby, improves axonal transport and reverses the toxic cascade leading to nerve cell death. The Company is presently in two ongoing double-blind, placebo-controlled Phase 2a studies that were designed to measure the toxic cascade that leads to nerve cell death and expects preliminary data in both AD and PD patients in the first quarter of 2021.<\/p>\n<p align=\"justify\">\n        <strong>About Annovis Bio<\/strong>\n      <\/p>\n<p align=\"justify\">Headquartered in Berwyn, Pennsylvania, Annovis Bio, Inc. (Annovis) is a clinical-stage, drug platform company addressing neurodegeneration, such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and Alzheimer\u2019s in Down Syndrome (AD-DS). We believe that we are the only company developing a drug for AD, PD and AD-DS that inhibits more than one neurotoxic protein and, thereby, improves the information highway of the nerve cell, known as axonal transport. When this information flow is impaired, the nerve cell gets sick and dies. We expect our treatment to improve memory loss and dementia associated with AD and AD-DS, as well as body and brain function in PD. We have an ongoing Phase 2a study in AD patients and have commenced a second Phase 2a study in AD and PD patients. For more information on Annovis, please visit the company\u2019s website:\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=uJ398O6PjMVWPZ1tbVPx5024LXYFPhR40mnZirSvTzdcYGw3Y5c9RgmWY9IAR8VnIRQXiUBqDCH7z1AYkWX486Zs-k3tSlmGoGvtaKRnT2I=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">www.annovisbio.com<\/a>.<\/p>\n<p>\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p align=\"justify\">Statements in this press release contain \u201cforward-looking statements\u201d that are subject to substantial risks and uncertainties. Forward-looking statements contained in this press release may be identified by the use of words such as \u201canticipate,\u201d \u201cexpect,\u201d \u201cbelieve,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201cshould,\u201d \u201cestimate,\u201d \u201cproject,\u201d \u201coutlook,\u201d \u201cforecast\u201d or other similar words, and include, without limitation, statements regarding the timing, effectiveness and anticipated results of ANVS401 clinical trials. Forward-looking statements are based on Annovis Bio, Inc.\u2019s current expectations and are subject to inherent uncertainties, risks and assumptions that are difficult to predict. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate, including that clinical trials may be delayed. These and other risks and uncertainties are described more fully in the section titled \u201cRisk Factors\u201d in the Annual Report on Form 10-K for the year ended December 31, 2019 filed with the Securities and Exchange Commission. Forward-looking statements contained in this announcement are made as of this date, and Annovis Bio, Inc. undertakes no duty to update such information except as required under applicable law.<\/p>\n<p>Investor Relations:<\/p>\n<p>Dave Gentry, CEO<br \/>RedChip Companies Inc.<br \/>407-491-4498<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=JMeDiUY3LgsdUWt7vDKEmwJa-_PvL1G8dq50yrMZODCWpdBF9b6mO1z3O2RX45vVmZXeg_e2-DP1dFeVp7qggA==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Dave@redchip.com<\/a><\/p>\n<p>SOURCE: Annovis Bio, Inc.<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMjQ4MSMzODgyMjEyIzIxOTQ4NTA=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/0069399a-aea0-45d4-866a-4fa5116938ff\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>BERWYN, Pa., Dec. 15, 2020 (GLOBE NEWSWIRE) &#8212; Annovis Bio Inc. (NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and other neurodegenerative diseases, today announced its CEO, Maria Maccecchini, Ph.D., presented her paper, \u201cTargeting Increased Levels of Neurotoxic Proteins in Down Syndrome, Alzheimer\u2019s and Parkinson\u2019s Animals Normalized Axonal Transport, Cognition and Function,\u201d at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\u2019 Alzheimer&#8217;s Disease Therapeutics: Alternatives to Amyloid 2020 Virtual Conference on Friday, December 4, 2020. Dr. Maccecchini\u2019s presentation highlighted the Company\u2019s data that demonstrates by lowering amyloid, tau, and alpha-synuclein, the Company\u2019s lead candidate, ANVS401, restores axonal transport and nerve cell health. Hundreds of recent clinical trials individually targeting amyloid, tau, or alpha-synuclein in AD, PD or Down syndrome &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-399616","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"BERWYN, Pa., Dec. 15, 2020 (GLOBE NEWSWIRE) &#8212; Annovis Bio Inc. (NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and other neurodegenerative diseases, today announced its CEO, Maria Maccecchini, Ph.D., presented her paper, \u201cTargeting Increased Levels of Neurotoxic Proteins in Down Syndrome, Alzheimer\u2019s and Parkinson\u2019s Animals Normalized Axonal Transport, Cognition and Function,\u201d at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\u2019 Alzheimer&#8217;s Disease Therapeutics: Alternatives to Amyloid 2020 Virtual Conference on Friday, December 4, 2020. Dr. Maccecchini\u2019s presentation highlighted the Company\u2019s data that demonstrates by lowering amyloid, tau, and alpha-synuclein, the Company\u2019s lead candidate, ANVS401, restores axonal transport and nerve cell health. Hundreds of recent clinical trials individually targeting amyloid, tau, or alpha-synuclein in AD, PD or Down syndrome &hellip; Continue reading &quot;Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-15T11:48:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMjQ4MSMzODgyMjEyIzIxOTQ4NTA=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\",\"datePublished\":\"2020-12-15T11:48:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/\"},\"wordCount\":911,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODExMjQ4MSMzODgyMjEyIzIxOTQ4NTA=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\\\/\",\"name\":\"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences - 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(NYSE American: ANVS), a clinical-stage drug platform company addressing Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD) and other neurodegenerative diseases, today announced its CEO, Maria Maccecchini, Ph.D., presented her paper, \u201cTargeting Increased Levels of Neurotoxic Proteins in Down Syndrome, Alzheimer\u2019s and Parkinson\u2019s Animals Normalized Axonal Transport, Cognition and Function,\u201d at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\u2019 Alzheimer&#8217;s Disease Therapeutics: Alternatives to Amyloid 2020 Virtual Conference on Friday, December 4, 2020. Dr. Maccecchini\u2019s presentation highlighted the Company\u2019s data that demonstrates by lowering amyloid, tau, and alpha-synuclein, the Company\u2019s lead candidate, ANVS401, restores axonal transport and nerve cell health. Hundreds of recent clinical trials individually targeting amyloid, tau, or alpha-synuclein in AD, PD or Down syndrome &hellip; Continue reading \"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-15T11:48:06+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMjQ4MSMzODgyMjEyIzIxOTQ4NTA=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences","datePublished":"2020-12-15T11:48:06+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/"},"wordCount":911,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODExMjQ4MSMzODgyMjEyIzIxOTQ4NTA=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/annovis-bio-showcases-its-unique-approach-to-alzheimers-at-the-new-york-academy-of-sciences\/","name":"Annovis Bio Showcases its Unique Approach to Alzheimer\u2019s at the New\u00a0York\u00a0Academy\u00a0of\u00a0Sciences - 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