{"id":398113,"date":"2020-12-11T07:12:57","date_gmt":"2020-12-11T12:12:57","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=398113"},"modified":"2020-12-11T07:12:57","modified_gmt":"2020-12-11T12:12:57","slug":"doptelet-avatrombopag-receives-positive-opinion-from-chmp-for-treatment-of-itp","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/doptelet-avatrombopag-receives-positive-opinion-from-chmp-for-treatment-of-itp\/","title":{"rendered":"Doptelet\u00ae (avatrombopag) receives positive opinion from CHMP for treatment of ITP"},"content":{"rendered":"
\n

PR Newswire<\/p>\n<\/p><\/div>\n

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\n STOCKHOLM<\/span>, Dec. 11, 2020<\/span> \/PRNewswire\/ — Swedish Orphan Biovitrum AB (publ)<\/a> (Sobi\u2122) (STO:SOBI) today announces that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion of Doptelet\u00ae (avatrombopag) for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins). The opinion is now referred to the European Commission for a decision. <\/p>\n

Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by low numbers of platelets, leading to bruising and an increased risk of bleeding. It is estimated that up to 100 per million people live with ITP, and the disorder is considered chronic when symptoms last more than 12 months. Currently, no cure is available, and these patients have usually relapsed after various treatments, yet still require treatment to reduce the risk of clinically significant bleeding. <\/p>\n

\n Ravi Rao<\/span>, Chief Medical Officer and Head of Research & Development at Sobi, said the news is an important step towards advancing treatment options for patients with ITP in Europe<\/span>. “Today’s positive opinion by the CHMP is a significant milestone for people living with ITP across Europe<\/span>. If approved by the European Commission, Doptelet will offer patients and specialists a new oral treatment option which does not have any food-type restrictions”, he said.<\/p>\n

\n Om Doptelet\u00ae (avatrombopag)<\/b>
\n
Doptelet is an orally administered thrombopoietin receptor agonist (TPO-RA) \u00a0that mimics the biologic effects of TPO in stimulating the development and maturation of megakaryocytes, resulting in increased platelet count. It is approved by both the US Food & Drug Administration (FDA) for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure and by the European Medicines Agency (EMA) for the treatment of severe thrombocytopenia in adult patients with chronic liver disease (CLD) who are scheduled to undergo an invasive procedure. In June 2019<\/span>, Doptelet was approved by the FDA for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Chronic ITP is a rare autoimmune bleeding disorder characterised by low number of platelets. The incidence of primary ITP in adults is 3.3\/100\u2009000 adults per year with a prevalence of 9.5 per 100\u2009000 adults1<\/sup>.<\/p>\n

\n About immune thrombocytopenia (ITP)<\/b>
\n
Immune thrombocytopenia is an autoimmune disorder characterised by low numbers of platelets, leading to bruising and an increased risk of bleeding. The incidence of primary ITP in adults is 3.3 per 100\u2009000 adults per year with a prevalence of 9.5 per 100\u2009000 adults1<\/sup>. The disorder is considered chronic when symptoms last more than 12 months. There is no cure for these patients, they have usually relapsed after various treatments, and does still require treatment to reduce the risk of clinically significant bleeding. <\/p>\n

\n About Sobi\u2122<\/b>
\n
Sobi is a specialised international biopharmaceutical company transforming the lives of people with rare diseases. Sobi is providing sustainable access to innovative therapies in the areas of haematology, immunology and specialty indications. Today, Sobi employs approximately 1,500 people across Europe<\/span>, North America<\/span>, the Middle East<\/span>, Russia<\/span> and North Africa<\/span>. In 2019, Sobi’s revenues amounted to SEK 14.2 billion<\/span>. Sobi’s share (STO:SOBI) is listed on Nasdaq Stockholm. You can find more information about Sobi at www.sobi.com<\/a>.<\/p>\n

\n Sobi<\/b>
\n
Paula Treutiger, Head of Communication & Investor Relations
+ 46 733 666 599
paula.treutiger@sobi.com<\/a><\/p>\n

\n 1<\/sup>\u00a0(Lambert et al. Blood 2017)<\/p>\n

This information was brought to you by Cision http:\/\/news.cision.com<\/a><\/p>\n

\n https:\/\/news.cision.com\/swedish-orphan-biovitrum-ab\/r\/doptelet—avatrombopag–receives-positive-opinion-from-chmp-for-treatment-of-itp,c3253249<\/a>\n <\/p>\n

The following files are available for download:<\/p>\n

\n\n\n
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\n https:\/\/mb.cision.com\/Main\/14266\/3253249\/1347365.pdf<\/a>
\n <\/span>\n <\/p>\n<\/td>\n

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\n Doptelet\u00ae (avatrombopag) receives positive opinion from CHMP for treatment of ITP<\/span>\n <\/p>\n<\/td>\n<\/tr>\n<\/table><\/div>\n

\u00a0<\/p>\n

\n \"Cision\" View original content:http:\/\/www.prnewswire.com\/news-releases\/doptelet-avatrombopag-receives-positive-opinion-from-chmp-for-treatment-of-itp-301191178.html<\/a><\/p>\n

SOURCE Swedish Orphan Biovitrum AB<\/p>\n<\/p><\/div>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

PR Newswire STOCKHOLM, Dec. 11, 2020 \/PRNewswire\/ — Swedish Orphan Biovitrum AB (publ) (Sobi\u2122) (STO:SOBI) today announces that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion of Doptelet\u00ae (avatrombopag) for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins). The opinion is now referred to the European Commission for a decision. Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by low numbers of platelets, leading to bruising and an increased risk of bleeding. It is estimated that up to 100 per million people live with ITP, and the disorder is considered chronic when symptoms last more than … <\/p>\n

Continue reading “Doptelet\u00ae (avatrombopag) receives positive opinion from CHMP for treatment of ITP”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-398113","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nDoptelet\u00ae (avatrombopag) receives positive opinion from CHMP for treatment of ITP - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/doptelet-avatrombopag-receives-positive-opinion-from-chmp-for-treatment-of-itp\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Doptelet\u00ae (avatrombopag) receives positive opinion from CHMP for treatment of ITP - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire STOCKHOLM, Dec. 11, 2020 \/PRNewswire\/ — Swedish Orphan Biovitrum AB (publ) (Sobi\u2122) (STO:SOBI) today announces that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion of Doptelet\u00ae (avatrombopag) for the treatment of primary chronic immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments (e.g. corticosteroids, immunoglobulins). The opinion is now referred to the European Commission for a decision. Immune thrombocytopenia (ITP) is an autoimmune disorder characterised by low numbers of platelets, leading to bruising and an increased risk of bleeding. 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