{"id":396571,"date":"2020-12-09T10:33:21","date_gmt":"2020-12-09T15:33:21","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=396571"},"modified":"2020-12-09T10:33:21","modified_gmt":"2020-12-09T15:33:21","slug":"top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/","title":{"rendered":"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals"},"content":{"rendered":"<div class=\"xn-newslines\">\n<p class=\"xn-distributor\">PR Newswire<\/p>\n<\/p><\/div>\n<div class=\"xn-content\">\n<p>\n        <span class=\"xn-location\">SYDNEY<\/span>, <span class=\"xn-chron\">Dec. 9, 2020<\/span> \/PRNewswire\/ &#8212; Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA), an Australian oncology-focused biotechnology company, is pleased to share top-line final data from its phase I study of Cantrixil (TRX-E-002-1) in patients with persistent or recurrent ovarian cancer (NCT02903771). <\/p>\n<p>\n        <b>Key Points<\/b>\n      <\/p>\n<ul type=\"disc\">\n<li>25 patients with advanced metastatic ovarian cancer received at least one dose of Cantrixil at six sites in <span class=\"xn-location\">the United States<\/span> and <span class=\"xn-location\">Australia<\/span>, comprising 11 patients in Part A (dose escalation) and 14 patients in Part B (dose expansion) <\/li>\n<li>Trial achieved its primary objective, determining the maximum tolerated dose (MTD) of Cantrixil to be 5 mg\/kg <\/li>\n<li>Overall, 16 patients were evaluable for efficacy. One patient demonstrated a complete response (CR) and two patients experienced a partial response (PR), according to industry-standard RECIST criteria, making an overall response rate (ORR) of 19% <\/li>\n<li>The patient who experienced a complete response remains in remission some three years after her last dose of Cantrixil <\/li>\n<li>The drug was generally well-tolerated, with primarily gastrointestinal toxicities observed (abdominal pain, vomiting, and nausea)<\/li>\n<\/ul>\n<p>Australian lead investigator, Associate Professor <span class=\"xn-person\">Jim Coward<\/span>, commented, &#8220;this was a heavily pre-treated population, comprising patients with very advanced disease. Existing treatment options for such patients are limited, and there remains an urgent need for new therapies. My colleagues and I are excited by the potential for Cantrixil to provide benefit here, and we look forward to seeing the drug move forward in its development.&#8221;<\/p>\n<p>Kazia expects the full data to be presented at a suitable academic conference and published in a peer-reviewed journal in 1H CY2021. In accordance with common practice, the full data will remain embargoed until they are formally published, in order not to prejudice the appropriate dissemination of the data, and only top-line data are discussed here. <\/p>\n<p>Kazia CEO, Dr <span class=\"xn-person\">James Garner<\/span>, commented, &#8220;we are very pleased to see the Cantrixil phase I study completed. The data unambiguously demonstrates the potential for Cantrixil to provide benefit in this very challenging patient population. With this positive data in hand, our focus now shifts to partnering activity, and we hope to transition Cantrixil to a company which both shares our belief in its potential and is able to apply the necessary resources and expertise to realise that potential over the next chapter of its development.&#8221; <\/p>\n<p>\n        <b>Background<\/b>\n      <\/p>\n<p>The phase I study of Cantrixil in ovarian cancer (NCT02903771) commenced recruitment in <span class=\"xn-chron\">December 2016<\/span>. It was designed in two parts. Part A (dose escalation component) was intended to determine the maximum tolerated dose (MTD) of Cantrixil in women with ovarian cancer. Part B (dose expansion cohort) was intended to seek preliminary evidence of clinical efficacy, as well as providing a deeper understanding of pharmacokinetics and safety of Cantrixil. All patients received two cycles of treatment with Cantrixil monotherapy, followed by up to six cycles in combination with other chemotherapy agents. <\/p>\n<p>Kazia announced completion of Part A in <span class=\"xn-chron\">October 2018<\/span>. At that stage, the study declared 5 mg\/kg to be the MTD, and this dose was used for all patients in Part B. The main dose-limiting toxicity (DLT) was abdominal pain. 11 patients received at least one dose of Cantrixil in Part A.<\/p>\n<p>Part B recruited an additional 14 patients, all of whom were treated at the MTD, with the goal of seeking exploratory signals of potential clinical efficacy. All 14 patients received at least one dose of Cantrixil in Part B. In total, 17 patients across Part A and Part B received Cantrixil at the MTD of 5 mg\/kg.<\/p>\n<p>The study completed recruitment in <span class=\"xn-chron\">August 2019<\/span>, and last patient last visit occurred in <span class=\"xn-chron\">March 2020<\/span>. Preliminary efficacy data was presented in <span class=\"xn-chron\">September 2019<\/span> at the European Society for Medical Oncology (ESMO) Annual Meeting in <span class=\"xn-location\">Barcelona, Spain<\/span>, and at the American Association of Cancer Research (AACR) Virtual Meeting in <span class=\"xn-chron\">June 2020<\/span>. <\/p>\n<p id=\"PURL\">\n        <img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=CN17756&amp;sd=2020-12-09\" \/> View original content:<a id=\"PRNURL\" rel=\"nofollow\" href=\"http:\/\/www.prnewswire.com\/news-releases\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals-301188916.html\">http:\/\/www.prnewswire.com\/news-releases\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals-301188916.html<\/a><\/p>\n<p>SOURCE  Kazia Therapeutics Ltd<\/p>\n<\/p><\/div>\n<p>    <img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=CN17756&amp;Transmission_Id=202012091030PR_NEWS_USPR_____CN17756&amp;DateId=20201209\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PR Newswire SYDNEY, Dec. 9, 2020 \/PRNewswire\/ &#8212; Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA), an Australian oncology-focused biotechnology company, is pleased to share top-line final data from its phase I study of Cantrixil (TRX-E-002-1) in patients with persistent or recurrent ovarian cancer (NCT02903771). Key Points 25 patients with advanced metastatic ovarian cancer received at least one dose of Cantrixil at six sites in the United States and Australia, comprising 11 patients in Part A (dose escalation) and 14 patients in Part B (dose expansion) Trial achieved its primary objective, determining the maximum tolerated dose (MTD) of Cantrixil to be 5 mg\/kg Overall, 16 patients were evaluable for efficacy. One patient demonstrated a complete response (CR) and two patients experienced &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-396571","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire SYDNEY, Dec. 9, 2020 \/PRNewswire\/ &#8212; Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA), an Australian oncology-focused biotechnology company, is pleased to share top-line final data from its phase I study of Cantrixil (TRX-E-002-1) in patients with persistent or recurrent ovarian cancer (NCT02903771). Key Points 25 patients with advanced metastatic ovarian cancer received at least one dose of Cantrixil at six sites in the United States and Australia, comprising 11 patients in Part A (dose escalation) and 14 patients in Part B (dose expansion) Trial achieved its primary objective, determining the maximum tolerated dose (MTD) of Cantrixil to be 5 mg\/kg Overall, 16 patients were evaluable for efficacy. 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/","og_locale":"en_US","og_type":"article","og_title":"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals - Market Newsdesk","og_description":"PR Newswire SYDNEY, Dec. 9, 2020 \/PRNewswire\/ &#8212; Kazia Therapeutics Limited (ASX: KZA; NASDAQ: KZIA), an Australian oncology-focused biotechnology company, is pleased to share top-line final data from its phase I study of Cantrixil (TRX-E-002-1) in patients with persistent or recurrent ovarian cancer (NCT02903771). Key Points 25 patients with advanced metastatic ovarian cancer received at least one dose of Cantrixil at six sites in the United States and Australia, comprising 11 patients in Part A (dose escalation) and 14 patients in Part B (dose expansion) Trial achieved its primary objective, determining the maximum tolerated dose (MTD) of Cantrixil to be 5 mg\/kg Overall, 16 patients were evaluable for efficacy. One patient demonstrated a complete response (CR) and two patients experienced &hellip; Continue reading \"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-09T15:33:21+00:00","og_image":[{"url":"https:\/\/c212.net\/c\/img\/favicon.png?sn=CN17756&amp;sd=2020-12-09","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals","datePublished":"2020-12-09T15:33:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/"},"wordCount":643,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/#primaryimage"},"thumbnailUrl":"https:\/\/c212.net\/c\/img\/favicon.png?sn=CN17756&amp;sd=2020-12-09","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/top-line-final-data-from-cantrixil-phase-i-study-confirms-prior-positive-efficacy-and-safety-signals\/","name":"Top-line Final Data from Cantrixil Phase I Study Confirms Prior Positive Efficacy and Safety Signals - 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