{"id":396229,"date":"2020-12-09T08:03:23","date_gmt":"2020-12-09T13:03:23","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=396229"},"modified":"2020-12-09T08:03:23","modified_gmt":"2020-12-09T13:03:23","slug":"immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/","title":{"rendered":"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline"},"content":{"rendered":"<div class=\"mw_release\">\n<ul type=\"disc\">\n<li style=\"margin-top:5pt;margin-bottom:5pt;text-align:justify\">\n          <strong><br \/>\n            <em>ImmunoGenesis acquires rights to evofosfamide; Phase 2 clinical testing in combination with checkpoint blockade is planned for 2021<\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em>.<\/em><br \/>\n          <\/strong>\n        <\/li>\n<li style=\"margin-top:5pt;margin-bottom:5pt;text-align:justify\">\n          <strong><br \/>\n            <em>Evofosfamide\u00a0is <\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em>the <\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em>only <\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em>known <\/em><br \/>\n          <\/strong><br \/>\n          <strong><br \/>\n            <em>reducer of solid tumor hypoxia, a driver of therapeutic resistance in immunologically \u201ccold\u201d tumors such as pancreatic &amp; prostate cancer. <\/em><br \/>\n          <\/strong>\n        <\/li>\n<\/ul>\n<p align=\"justify\">HOUSTON, Dec.  09, 2020  (GLOBE NEWSWIRE) &#8212; ImmunoGenesis, Inc., a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically cold cancers such as prostate, colorectal and pancreatic cancer, today announced that it has acquired the rights to the hypoxia-reducing agent evofosfamide. The company plans to initiate a Phase 2 clinical trial in 2021 investigating evofosfamide in combination with both CTLA-4 and PD-1 blockade in patients with castration-resistant prostate cancer (CRPC), pancreatic ductal adenocarcinoma (PDAC) and HPV-negative head and neck cancer (HNSCC).<\/p>\n<p align=\"justify\">Evofosfamide, a 2-nitroimidazole prodrug of the\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=hERXV3vRkLYMbf-8_cjTrUTifjLCfDe1f5vXxYPgAOl-BQOmwIL7s0bmc_pDvWNI98ayO83QNQeIeevE5DHQeFdgTDhhF7ekw1u7Ht8zg94=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">cytotoxin<\/a>\u00a0bromo-isophosphoramide mustard (Br-IPM), was originally developed as a hypoxia-activated prodrug. Dr. Michael A. Curran, founder of ImmunoGenesis, discovered that evofosfamide can reduce hypoxia in solid tumors. Dr. Curran demonstrated in pre-clinical models that evofosfamide could restore T cell function and synergize with checkpoint inhibition.<\/p>\n<p align=\"justify\">Based on Dr. Curran\u2019s work as Associate Professor of Immunology at The University of Texas MD Anderson Cancer Center, ImmunoGenesis is developing evofosfamide as a hypoxia-reversal agent (HRA) which could synergize with checkpoint blockade to drive efficacy in tumor types where checkpoint blockade monotherapy is ineffective. Dr. Curran\u2019s financial relationship with ImmunoGenesis is managed and monitored by the MD Anderson Conflict of Interest Committee.<\/p>\n<p align=\"justify\">The planned Phase 2 trial is supported by data from a Phase 1 trial, both led by David S. Hong, M.D., Professor of Investigational Cancer Therapeutics at MD Anderson. The Phase 1 study investigated evofosfamide in combination with the CTLA-4 inhibitor, ipilimumab, in four tumor types where hypoxia is believed to be a major source of immune resistance. The combination treatment drove an overall response rate of 17 percent and a disease control rate of 83 percent across four different dose levels in 21 heavily pre-treated patients.<\/p>\n<p align=\"justify\">\u201cOvercoming resistance to immunotherapy in immunologically cold tumors will likely require a multi-faceted approach to address diverse mechanisms of host immune suppression,\u201d said Dr. Curran, \u201cEvofosfamide is the first drug to demonstrate success in reversing hostile tumor metabolism through reduction of hypoxia. Restoration of tumor oxygen supply facilitates T cell infiltration and persistence allowing these otherwise poorly immune checkpoint sensitive cancers to become therapeutically sensitized.\u201d<\/p>\n<p align=\"justify\">In addition to the clinical efficacy demonstrated in the Phase 1 trial, a clear biomarker picture has emerged. Pre-existing immune gene signatures predicted response to therapy, while hypermetabolic tumors predicted progression. Responders also showed improved cellular signatures of anti-tumor immunity.<\/p>\n<p align=\"justify\">\u201cOur vision at ImmunoGenesis is to develop a pipeline of drugs that synergize to address the critical ingredients necessary for effective immunity against the particularly difficult-to-treat cold tumors, including the generation of sufficient anti-tumor T cells, the protection and expansion of those cells in the tumor, and finally the reduction in hostile tumor metabolism,\u201d said James Barlow, ImmunoGenesis President and CEO. \u201cCoupled with the PD-L1\/PD-L2 dual specific antibody and STING agonist the company previously licensed from Dr. Curran\u2019s lab, the addition of evofosfamide creates an integrated suite of molecules with extraordinary potential to address the unmet therapeutic need in cold cancers.\u201d<\/p>\n<p align=\"justify\">\n        <strong>About ImmunoGenesis, Inc.<\/strong>\n      <\/p>\n<p align=\"justify\">ImmunoGenesis is a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically \u201ccold\u201d cancers such as prostate, colorectal, and pancreatic cancer. These tumor types represent more than half of all cancers, and current immunotherapies have shown limited to no efficacy here. As a result, there is a high unmet need for efficacious therapies.<\/p>\n<p align=\"justify\">www.immunogenesis.com<\/p>\n<p align=\"justify\">\n        <strong>Forward-Looking Statements<\/strong>\n      <\/p>\n<p align=\"justify\">This press release contains \u201cforward-looking statements\u201d within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release are forward-looking statements. These forward-looking statements may be identified by terms such as \u201cwill,\u201d \u201ccould,\u201d \u201cbelieve,\u201d \u201cplan,\u201d \u201cexpect,\u201d \u201ctarget,\u201d \u201ccontinue,\u201d \u201cto,\u201d and similar terms or expressions or the negative thereof. Examples of such statements include, but are not limited to, statements regarding the development and\/or effectiveness of evofosfamide and the ability of evofosfamide to achieve the desired results whether as a monotherapy or in combination with other therapies. We may not actually achieve the plans, carry out the intentions or meet the expectations or objectives disclosed in the forward-looking statements. You should not place undue reliance on these forward-looking statements. These statements are subject to risks and uncertainties which could cause actual results and performance to differ materially from those discussed in the forward-looking statements. The forward-looking statements contained in this press release speak only as of the date of this press release and are based on management\u2019s assumptions and estimates as of such date. We disclaim any intent or obligation to update these forward-looking statements to reflect events or circumstances that exist after the date on which they were made.<\/p>\n<p>\n        <strong>ImmunoGenesis Contact<\/strong>\n      <\/p>\n<p>Bill Tanner<br \/>Chief Financial Officer<br \/>203-517-8577<br \/>bill.tanner@immunogenesis.com<\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODk4NCMzODYyNDg4IzUwMDA3Mzc0NQ==\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/39ee9f25-dd8b-4d99-81d3-e33551380e64\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>ImmunoGenesis acquires rights to evofosfamide; Phase 2 clinical testing in combination with checkpoint blockade is planned for 2021 . Evofosfamide\u00a0is the only known reducer of solid tumor hypoxia, a driver of therapeutic resistance in immunologically \u201ccold\u201d tumors such as pancreatic &amp; prostate cancer. HOUSTON, Dec. 09, 2020 (GLOBE NEWSWIRE) &#8212; ImmunoGenesis, Inc., a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically cold cancers such as prostate, colorectal and pancreatic cancer, today announced that it has acquired the rights to the hypoxia-reducing agent evofosfamide. The company plans to initiate a Phase 2 clinical trial in 2021 investigating evofosfamide in combination with both CTLA-4 and PD-1 blockade in patients with castration-resistant prostate cancer (CRPC), pancreatic ductal adenocarcinoma (PDAC) &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-396229","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"ImmunoGenesis acquires rights to evofosfamide; Phase 2 clinical testing in combination with checkpoint blockade is planned for 2021 . Evofosfamide\u00a0is the only known reducer of solid tumor hypoxia, a driver of therapeutic resistance in immunologically \u201ccold\u201d tumors such as pancreatic &amp; prostate cancer. HOUSTON, Dec. 09, 2020 (GLOBE NEWSWIRE) &#8212; ImmunoGenesis, Inc., a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically cold cancers such as prostate, colorectal and pancreatic cancer, today announced that it has acquired the rights to the hypoxia-reducing agent evofosfamide. The company plans to initiate a Phase 2 clinical trial in 2021 investigating evofosfamide in combination with both CTLA-4 and PD-1 blockade in patients with castration-resistant prostate cancer (CRPC), pancreatic ductal adenocarcinoma (PDAC) &hellip; Continue reading &quot;ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T13:03:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODk4NCMzODYyNDg4IzUwMDA3Mzc0NQ==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline\",\"datePublished\":\"2020-12-09T13:03:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/\"},\"wordCount\":823,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODA5ODk4NCMzODYyNDg4IzUwMDA3Mzc0NQ==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\\\/\",\"name\":\"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline - 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Evofosfamide\u00a0is the only known reducer of solid tumor hypoxia, a driver of therapeutic resistance in immunologically \u201ccold\u201d tumors such as pancreatic &amp; prostate cancer. HOUSTON, Dec. 09, 2020 (GLOBE NEWSWIRE) &#8212; ImmunoGenesis, Inc., a clinical-stage biotechnology company developing therapeutics to catalyze effective immune responses in immunologically cold cancers such as prostate, colorectal and pancreatic cancer, today announced that it has acquired the rights to the hypoxia-reducing agent evofosfamide. The company plans to initiate a Phase 2 clinical trial in 2021 investigating evofosfamide in combination with both CTLA-4 and PD-1 blockade in patients with castration-resistant prostate cancer (CRPC), pancreatic ductal adenocarcinoma (PDAC) &hellip; Continue reading \"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-09T13:03:23+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODk4NCMzODYyNDg4IzUwMDA3Mzc0NQ==","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline","datePublished":"2020-12-09T13:03:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/"},"wordCount":823,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODk4NCMzODYyNDg4IzUwMDA3Mzc0NQ==","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/immunogenesis-acquisition-strengthens-cold-tumor-targeting-pipeline\/","name":"ImmunoGenesis: Acquisition Strengthens \u201cCold\u201d Tumor Targeting Pipeline - 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