{"id":396089,"date":"2020-12-09T06:03:23","date_gmt":"2020-12-09T11:03:23","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=396089"},"modified":"2020-12-09T06:03:23","modified_gmt":"2020-12-09T11:03:23","slug":"nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/","title":{"rendered":"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in <i>Nature Communications<\/i><\/b><\/p>\n<p class=\"bwalignc\">\nMassachusetts General Hospital-led study uncovers that patient immune cell abundance and response are directly related to SARS-CoV-2 virus location\n<\/p>\n<p>SEATTLE&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nNanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today announced the publication of a new peer-reviewed study utilizing its GeoMx\u00ae Digital Spatial Profiler (DSP) platform to uncover new information in patients\u2019 responses to SARS-CoV-2 infection. The study published in Nature Communications titled, \u201cTemporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection,\u201d revealed the spatial heterogeneity of patients\u2019 immune responses based on GeoMx DSP profiling of active SARS-CoV-2 infection in the lungs. These learnings identifying the relationship between viral location and immune response have the potential to be applied towards future therapeutic and clinical applications.\n<\/p>\n<p id=\"news-body-cta\">This press release features multimedia. View the full release here: <a href=\"https:\/\/www.businesswire.com\/news\/home\/20201209005326\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20201209005326\/en\/<\/a><\/p>\n<div id=\"bwbodyimg\" style=\"width: 480px;float:left;padding-left:0px;padding-right:20px;padding-top:0px;padding-bottom:0px\"><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/845439\/4\/COIVD+tissue.jpg\" alt=\"Figure A: SARS Co-V2 is visualized in infected lung tissue from 6 different tissue samples with ACD RNAscope probe (pink), and corresponding virus-positive and virus-negative ROIs were selected from a serial section for GeoMx profiling with the Cancer Transcriptome Atlas. (Graphic: Business Wire)\" \/><\/p>\n<p style=\"font-size:85%\">Figure A: SARS Co-V2 is visualized in infected lung tissue from 6 different tissue samples with ACD RNAscope probe (pink), and corresponding virus-positive and virus-negative ROIs were selected from a serial section for GeoMx profiling with the Cancer Transcriptome Atlas. (Graphic: Business Wire)<\/p>\n<\/div>\n<p>\nCOVID-19 is still poorly understood within the scientific community, and outcomes vary greatly across individual patients. Research efforts have been challenged by the scarcity of patient-derived tissue samples, as well as the necessity of fixing such samples prior to analysis to reduce the risk of viral transmission. However, the ability of GeoMx DSP to perform high-plex, spatial profiling of formalin-fixed paraffin-embedded (FFPE) samples enables researchers to gather more information from each precious sample and rapidly evaluate the body\u2019s response to infection.\n<\/p>\n<p>\n\u201cWe now have the ability to better understand the diversity of SARS-CoV-2 infections in patient lung samples using the unprecedented spatial transcriptomic and proteomic analysis that the GeoMx Digital Spatial Profiler provides,\u201d said David Ting, Associate Clinical Director for Innovation at the Mass General Cancer Center and Assistant Professor of Medicine at Harvard Medical School. \u201cWe hope these findings, along with continued spatial analysis of infected tissue samples, will inform the design of prospective interventional trials.\u201d\n<\/p>\n<p>\nIn this study, FFPE autopsy samples from patients with SARS-CoV-2 infection were analyzed with the GeoMx DSP, using the &gt;1,800+ plex GeoMx COVID-19 Immune Response Atlas and a 79-plex GeoMx protein assay. GeoMx DSP revealed high intra- and inter-patient heterogeneity in the abundance and localization of immune markers. A critical step prior to quantitative profiling with GeoMX DSP is to determine the cells that contain the SAR-CoV-2 virus. Those cells are grouped into regions of interest with high and low viral loads using RNAscope SARs-CoV-2 probes from Advanced Cell Diagnostics (ACD), a Bio-techne brand. Immune cell types were classified in each region of interest, uncovering spatial relationships between the virus location and immune cell abundance, which may have therapeutic implications.\n<\/p>\n<p>\n\u201cThis study detected differences in immunoregulatory markers that were not identified using traditional immunohistochemical staining and whole slide analysis, illustrating the importance of high-plex spatial analysis,\u201d said Joe Beechem, chief scientific officer and SVP of R&amp;D for NanoString. \u201cThe ability of GeoMx DSP to perform robust, highly sensitive spatial profiling of FFPE samples was critical to enable researchers to gather more information from clinically relevant samples.\u201d\n<\/p>\n<p>\nData from this study has been uploaded to NCBI GEO and is accessible to the public for continued analysis. To learn more about the ways that NanoString\u2019s products enable COVID-19 research, and to access the GeoMx images and data from this study, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.nanostring.com%2FCOVID19&amp;esheet=52345262&amp;newsitemid=20201209005326&amp;lan=en-US&amp;anchor=www.nanostring.com%2FCOVID19&amp;index=1&amp;md5=52f3d338fef431905edb03f5f7fe73e3\">www.nanostring.com\/COVID19<\/a>.\n<\/p>\n<p>\nTo learn more about NanoString\u2019s GeoMx Digital Spatial Profiler, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.nanostring.com%2Fproducts%2Fgeomx-digital-spatial-profiler%2Fgeomx-dsp&amp;esheet=52345262&amp;newsitemid=20201209005326&amp;lan=en-US&amp;anchor=https%3A%2F%2Fwww.nanostring.com%2Fproducts%2Fgeomx-digital-spatial-profiler%2Fgeomx-dsp&amp;index=2&amp;md5=000c2d34a20a4e3957e3b8bef96647fc\">https:\/\/www.nanostring.com\/products\/geomx-digital-spatial-profiler\/geomx-dsp<\/a>.\n<\/p>\n<p><b>About NanoString Technologies, Inc. <\/b><\/p>\n<p>\nNanoString Technologies is a leading provider of life science tools for discovery and translational research. The company\u2019s nCounter\u00ae Analysis System is used in life sciences research and has been cited in more than 3,800 peer-reviewed publications. The nCounter Analysis System offers a cost-effective way to easily profile the expression of hundreds of genes, proteins, miRNAs, or copy number variations, simultaneously with high sensitivity and precision, facilitating a wide variety of basic research and translational medicine applications, including biomarker discovery and validation. The company\u2019s GeoMx\u00ae Digital Spatial Profiler enables highly-multiplexed spatial profiling of RNA and protein targets in a variety of sample types, including FFPE tissue sections.\n<\/p>\n<p>\nFor more information, please visit <a rel=\"nofollow\" href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.nanostring.com&amp;esheet=52345262&amp;newsitemid=20201209005326&amp;lan=en-US&amp;anchor=www.nanostring.com&amp;index=3&amp;md5=5ee2c431775d1865a3e3601c0ceeb1f6\">www.nanostring.com<\/a>.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201209005326r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20201209005326\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20201209005326\/en\/<\/a><\/span><\/p>\n<p><b>Doug Farrell, NanoString<br \/>\n<\/b><br \/>Vice President, Investor Relations &amp; Corporate Communications<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:dfarrell@nanostring.com\"><b>dfarrell@nanostring.com<br \/>\n<\/b><\/a><br \/><b>Phone: 206-602-1768<\/b><\/p>\n<p><b>KEYWORDS:<\/b> Washington United States North America<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Biotechnology Technology Health Medical Devices Research Infectious Diseases Software Nanotechnology Genetics Science Hardware<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/756482\/3\/NSTG_Logo_2020.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Photo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/845439\/3\/COIVD+tissue.jpg\" alt=\"Photo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\">Figure A: SARS Co-V2 is visualized in infected lung tissue from 6 different tissue samples with ACD RNAscope probe (pink), and corresponding virus-positive and virus-negative ROIs were selected from a serial section for GeoMx profiling with the Cancer Transcriptome Atlas. (Graphic: Business Wire)<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications Massachusetts General Hospital-led study uncovers that patient immune cell abundance and response are directly related to SARS-CoV-2 virus location SEATTLE&#8211;(BUSINESS WIRE)&#8211; NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today announced the publication of a new peer-reviewed study utilizing its GeoMx\u00ae Digital Spatial Profiler (DSP) platform to uncover new information in patients\u2019 responses to SARS-CoV-2 infection. The study published in Nature Communications titled, \u201cTemporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection,\u201d revealed the spatial heterogeneity of patients\u2019 immune responses based on GeoMx DSP profiling of active SARS-CoV-2 infection in the lungs. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-396089","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications Massachusetts General Hospital-led study uncovers that patient immune cell abundance and response are directly related to SARS-CoV-2 virus location SEATTLE&#8211;(BUSINESS WIRE)&#8211; NanoString Technologies, Inc. (NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today announced the publication of a new peer-reviewed study utilizing its GeoMx\u00ae Digital Spatial Profiler (DSP) platform to uncover new information in patients\u2019 responses to SARS-CoV-2 infection. The study published in Nature Communications titled, \u201cTemporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection,\u201d revealed the spatial heterogeneity of patients\u2019 immune responses based on GeoMx DSP profiling of active SARS-CoV-2 infection in the lungs. &hellip; Continue reading &quot;NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T11:03:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/845439\/4\/COIVD+tissue.jpg\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications\",\"datePublished\":\"2020-12-09T11:03:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/\"},\"wordCount\":853,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mms.businesswire.com\\\/media\\\/20201209005326\\\/en\\\/845439\\\/4\\\/COIVD+tissue.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\\\/\",\"name\":\"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications - 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(NASDAQ:NSTG), a leading provider of life science tools for discovery and translational research, today announced the publication of a new peer-reviewed study utilizing its GeoMx\u00ae Digital Spatial Profiler (DSP) platform to uncover new information in patients\u2019 responses to SARS-CoV-2 infection. The study published in Nature Communications titled, \u201cTemporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection,\u201d revealed the spatial heterogeneity of patients\u2019 immune responses based on GeoMx DSP profiling of active SARS-CoV-2 infection in the lungs. &hellip; Continue reading \"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-09T11:03:23+00:00","og_image":[{"url":"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/845439\/4\/COIVD+tissue.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications","datePublished":"2020-12-09T11:03:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/"},"wordCount":853,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/#primaryimage"},"thumbnailUrl":"https:\/\/mms.businesswire.com\/media\/20201209005326\/en\/845439\/4\/COIVD+tissue.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/nanostrings-geomx-digital-spatial-profiler-identifies-diverse-immune-responses-within-covid-19-patients-in-study-published-in-nature-communications\/","name":"NanoString\u2019s GeoMx Digital Spatial Profiler Identifies Diverse Immune Responses Within COVID-19 Patients in Study Published in Nature Communications - 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