{"id":395982,"date":"2020-12-08T20:03:11","date_gmt":"2020-12-09T01:03:11","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=395982"},"modified":"2020-12-08T20:03:11","modified_gmt":"2020-12-09T01:03:11","slug":"applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/","title":{"rendered":"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology"},"content":{"rendered":"<div class=\"xn-newslines\">\n<p class=\"xn-distributor\">PR Newswire<\/p>\n<\/p><\/div>\n<div class=\"xn-content\">\n<p>\n        <span class=\"xn-location\">CONCORD, Mass.<\/span>, <span class=\"xn-chron\">Dec. 8, 2020<\/span> \/PRNewswire\/ &#8212;\u00a0Applied BioMath (<a href=\"http:\/\/www.appliedbiomath.com\" rel=\"nofollow\">www.appliedbiomath.com<\/a>), the industry-leader in applying systems pharmacology and mechanistic modeling, simulation, and analysis to de-risk drug research and development, today announced a collaboration with Antengene Corporation for the development of a systems pharmacology modeling in immuno-oncology. Applied BioMath will develop a systems pharmacology model for a PDL1\/41BB bispecific antibody, ATG-101, in immuno-oncology indications. The model will be used to predict clinical starting and efficacious doses for first-in-human studies. &#8220;Antengene Corporation is dedicated to developing first-in-class and\/or best-in-class therapies in oncology,&#8221; said <span class=\"xn-person\">Dirk Hoenemann<\/span>, M.D., VP, Head of Medical Affairs for Asia Pacific Region (APAC) and Early Clinical Development. &#8220;We decided to collaborate with Applied BioMath in an effort to provide ourselves the highest likelihood possible of predicting accurate starting and efficacious doses which is a critical part of our first-in-human studies.&#8221;<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<p>\n          <a href=\"https:\/\/mma.prnewswire.com\/media\/598885\/Applied_BioMath_Logo.html\" target=\"_blank\" rel=\"nofollow noopener noreferrer\"><br \/>\n            <img decoding=\"async\" src=\"https:\/\/mma.prnewswire.com\/media\/598885\/Applied_BioMath_Logo.jpg\" title=\"(PRNewsfoto\/Applied BioMath, LLC)\" alt=\"(PRNewsfoto\/Applied BioMath, LLC)\" \/><br \/>\n          <\/a>\n        <\/p>\n<\/p><\/div>\n<p>Applied BioMath employs a rigorous fit-for-purpose model development process which quantitatively integrates knowledge about therapeutics with an understanding of its mechanism of action in the context of human disease mechanisms. Their approach employs proprietary algorithms and software that were designed specifically for systems pharmacology model development, simulation, and analysis. &#8220;Predicting starting and efficacious doses for first-in-human studies is non-trivial for complex therapeutics such as Antengene&#8217;s bispecific therapeutic,&#8221; said Dr. <span class=\"xn-person\">John Burke<\/span>, Ph.D., Co-Founder, President, and CEO of Applied BioMath.\u00a0&#8220;We have developed algorithms and tools specifically for this purpose that have a proven track record of predicting such doses. We look forward to collaborating with Antengene to support them in this project.&#8221;<\/p>\n<p>About Applied BioMath<\/p>\n<p>Founded in 2013, Applied BioMath&#8217;s mission is to revolutionize drug invention. Applied BioMath uses mathematical modeling and simulation to provide quantitative and predictive guidance to biotechnology and pharmaceutical companies to help accelerate and de-risk drug research and development. Their approach employs proprietary algorithms and software to support groups worldwide in decision-making from early research through clinical trials. The Applied BioMath team leverages their decades of expertise in biology, mathematical modeling and analysis, high-performance computing, and industry experience to help groups better understand their candidate, its best-in-class parameters, competitive advantages, patients, and the best path forward into and in the clinic. For more information about Applied BioMath and its services, visit<a target=\"_blank\" href=\"https:\/\/c212.net\/c\/link\/?t=0&amp;l=en&amp;o=3005392-1&amp;h=2395258330&amp;u=https%3A%2F%2Fc212.net%2Fc%2Flink%2F%3Ft%3D0%26l%3Den%26o%3D2438189-1%26h%3D1251124301%26u%3Dhttp%253A%252F%252Fwww.appliedbiomath.com%252F%26a%3Dwww.appliedbiomath.com&amp;a=%C2%A0www.appliedbiomath.com\" rel=\"nofollow noopener noreferrer\">\u00a0www.appliedbiomath.com<\/a>.<\/p>\n<p>About Antengene<\/p>\n<p>Antengene Corporation Limited (&#8220;Antengene&#8221;, SEHK: 6996.HK) is a biopharmaceutical company with an integrated drug discovery and clinical development approach, anchored in <span class=\"xn-location\">Asia Pacific<\/span> with a global footprint. Antengene aims to provide the most advanced anti-cancer drugs to patients in <span class=\"xn-location\">China<\/span>, the Asia Pacific Region and around the world. Since official operation in <span class=\"xn-chron\">April 2017<\/span>, Antengene has built a pipeline of 12 clinical and pre-clinical stage assets, obtained 10 IND approvals and has 9 ongoing cross-regional clinical trials in <span class=\"xn-location\">Asia Pacific<\/span>. At Antengene, we focus on developing drug candidates with novel MoAs and first-in-class\/best-in-class potential to address significant unmet medical needs. The vision of Antengene is to &#8220;Treat Patients Beyond Borders&#8221; through discovery, development and commercialization of first-in-class\/best-in-class therapeutics.<\/p>\n<p>Contact: <span class=\"xn-person\">Kristen Zannella<\/span>, <a target=\"_blank\" href=\"mailto:kristen.zannella@appliedbiomath.com\" rel=\"nofollow noopener noreferrer\">kristen.zannella@appliedbiomath.com<\/a><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder2\"><\/div>\n<p id=\"PURL\">\n        <img loading=\"lazy\" decoding=\"async\" title=\"Cision\" width=\"12\" height=\"12\" alt=\"Cision\" src=\"https:\/\/c212.net\/c\/img\/favicon.png?sn=NE16251&amp;sd=2020-12-08\" \/> View original content to download multimedia:<a id=\"PRNURL\" rel=\"nofollow\" href=\"http:\/\/www.prnewswire.com\/news-releases\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology-301188861.html\">http:\/\/www.prnewswire.com\/news-releases\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology-301188861.html<\/a><\/p>\n<p>SOURCE  Applied BioMath, LLC<\/p>\n<\/p><\/div>\n<p>    <img decoding=\"async\" alt=\"\" src=\"https:\/\/rt.prnewswire.com\/rt.gif?NewsItemId=NE16251&amp;Transmission_Id=202012082000PR_NEWS_USPR_____NE16251&amp;DateId=20201208\" style=\"border:0px;width:1px;height:1px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PR Newswire CONCORD, Mass., Dec. 8, 2020 \/PRNewswire\/ &#8212;\u00a0Applied BioMath (www.appliedbiomath.com), the industry-leader in applying systems pharmacology and mechanistic modeling, simulation, and analysis to de-risk drug research and development, today announced a collaboration with Antengene Corporation for the development of a systems pharmacology modeling in immuno-oncology. Applied BioMath will develop a systems pharmacology model for a PDL1\/41BB bispecific antibody, ATG-101, in immuno-oncology indications. The model will be used to predict clinical starting and efficacious doses for first-in-human studies. &#8220;Antengene Corporation is dedicated to developing first-in-class and\/or best-in-class therapies in oncology,&#8221; said Dirk Hoenemann, M.D., VP, Head of Medical Affairs for Asia Pacific Region (APAC) and Early Clinical Development. &#8220;We decided to collaborate with Applied BioMath in an effort to provide &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-395982","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire CONCORD, Mass., Dec. 8, 2020 \/PRNewswire\/ &#8212;\u00a0Applied BioMath (www.appliedbiomath.com), the industry-leader in applying systems pharmacology and mechanistic modeling, simulation, and analysis to de-risk drug research and development, today announced a collaboration with Antengene Corporation for the development of a systems pharmacology modeling in immuno-oncology. Applied BioMath will develop a systems pharmacology model for a PDL1\/41BB bispecific antibody, ATG-101, in immuno-oncology indications. The model will be used to predict clinical starting and efficacious doses for first-in-human studies. &#8220;Antengene Corporation is dedicated to developing first-in-class and\/or best-in-class therapies in oncology,&#8221; said Dirk Hoenemann, M.D., VP, Head of Medical Affairs for Asia Pacific Region (APAC) and Early Clinical Development. &#8220;We decided to collaborate with Applied BioMath in an effort to provide &hellip; Continue reading &quot;Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-09T01:03:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnewswire.com\/media\/598885\/Applied_BioMath_Logo.jpg\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology\",\"datePublished\":\"2020-12-09T01:03:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/\"},\"wordCount\":528,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mma.prnewswire.com\\\/media\\\/598885\\\/Applied_BioMath_Logo.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\\\/\",\"name\":\"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology - 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Applied BioMath will develop a systems pharmacology model for a PDL1\/41BB bispecific antibody, ATG-101, in immuno-oncology indications. The model will be used to predict clinical starting and efficacious doses for first-in-human studies. &#8220;Antengene Corporation is dedicated to developing first-in-class and\/or best-in-class therapies in oncology,&#8221; said Dirk Hoenemann, M.D., VP, Head of Medical Affairs for Asia Pacific Region (APAC) and Early Clinical Development. &#8220;We decided to collaborate with Applied BioMath in an effort to provide &hellip; Continue reading \"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-09T01:03:11+00:00","og_image":[{"url":"https:\/\/mma.prnewswire.com\/media\/598885\/Applied_BioMath_Logo.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology","datePublished":"2020-12-09T01:03:11+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/"},"wordCount":528,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/#primaryimage"},"thumbnailUrl":"https:\/\/mma.prnewswire.com\/media\/598885\/Applied_BioMath_Logo.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/applied-biomath-llc-announces-collaboration-with-antengene-for-systems-pharmacology-modeling-in-oncology\/","name":"Applied BioMath, LLC Announces Collaboration with Antengene for Systems Pharmacology Modeling in Oncology - 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