{"id":395122,"date":"2020-12-08T07:33:29","date_gmt":"2020-12-08T12:33:29","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=395122"},"modified":"2020-12-08T07:33:29","modified_gmt":"2020-12-08T12:33:29","slug":"larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/","title":{"rendered":"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update"},"content":{"rendered":"
\n

\n – Preliminary <\/em>
\n data<\/em>
\n suggest <\/em>
\n that single subcutaneous injections of CTI-1601 <\/em>
\n were<\/em>
\n well tolerated at doses up to 100 mg<\/em>
\n \n <\/p>\n

\n – Company <\/em>
\n remains on track to report topline data from <\/em>
\n placebo<\/em>
\n –<\/em>
\n controlled <\/em>
\n single and multiple<\/em>
\n ascending dose <\/em>
\n clinical trials<\/em>
\n in Q2 2021<\/em>\n <\/p>\n

BALA CYNWYD, Pa., Dec. 08, 2020 (GLOBE NEWSWIRE) — Larimar Therapeutics, Inc. (\u201cLarimar\u201d) (Nasdaq: LRMR), a clinical-stage biotechnology company focused on developing treatments for complex rare diseases,\u00a0today announced the completion of dosing from the Company\u2019s Phase 1 single ascending dose (SAD) clinical trial (n=28) evaluating CTI-1601 as a treatment for Friedreich\u2019s ataxia (FA) and provided additional updates regarding the status of an ongoing multiple ascending dose (MAD) clinical trial, the timing of Phase 1 topline results, and future activities planned for 2021.<\/p>\n

A Safety Review Committee reviewed preliminary blinded data after each cohort of the placebo-controlled SAD clinical trial and recommended continuation of the trial. Dosing has been completed and based on preliminary data, single subcutaneous injections of CTI-1601 at doses up to 100 mg are thought to have been well tolerated. Injection site adverse events were mild and transient, and no serious adverse events were reported. Analysis of clinical trial results remains ongoing.<\/p>\n

\u201cAt all doses tested, the Phase 1 SAD data support further investigation of CTI-1601,\u201d said Nancy M. Ruiz, MD, Chief Medical Officer of Larimar. \u201cFA is a rare and progressive disease that has a devastating impact on patient quality of life and mortality. Current treatment options are limited to symptom management. These preliminary Phase 1 findings represent a critical step forward in developing CTI-1601 as a potential frataxin replacement therapy for patients with FA and we look forward to its continued advancement through the clinic.\u201d<\/p>\n

Eligible participants from the SAD trial may enroll in an ongoing double-blind, placebo-controlled, MAD clinical trial. To date, dosing of the first two MAD cohorts has been completed, with dosing of the third cohort expected to begin in the first quarter of 2021. Larimar expects to report unblinded topline data from both the SAD and MAD trials in the second quarter of 2021.<\/p>\n

Patients completing the SAD and\/or MAD clinical trials are eligible to screen for an open-label extension clinical trial, which is expected to initiate in the second half of 2021. Larimar also expects to initiate a MAD clinical trial in patients under 18 years of age in the second half of 2021.<\/p>\n

Carole Ben-Maimon, MD, President and Chief Executive Officer of Larimar, commented, \u201cThat our Phase 1 program remains on track for topline data in the second quarter of 2021 despite the industry-wide challenges posed by COVID-19 is a testament to the talent and unwavering commitment of our employees, partners, and investigators. Their hard work has allowed us to advance CTI-1601\u2019s clinical development without compromising the safety of our patients. These patients have shown a steadfast dedication to our clinical trials despite the pandemic, and for this we are extremely grateful. Looking forward, the safety of patients and employees will remain our top priority as we work to execute on clinical and corporate milestones in pursuit of our goal of developing this FA therapy.\u201d<\/p>\n

\n About the <\/strong>
\n Phase 1 <\/strong>
\n Single Ascending Dose<\/strong>
\n (SAD)<\/strong>
\n Clinical Trial<\/strong>
\n
The Phase 1 SAD clinical trial is a double-blind, placebo-controlled, randomized clinical trial to assess the safety of subcutaneously administered CTI-1601 versus placebo in adult subjects with Friedreich\u2019s ataxia (FA). Subjects receive either placebo or treatment consisting of 25 mg, 50 mg, 75 mg, or 100 mg of CTI-1601. The primary objective is to assess the safety and tolerability of single ascending doses of CTI-1601 in subjects with FA. Key secondary endpoints include pharmacokinetic and pharmacodynamic analyses following increasing single doses of subcutaneously administered CTI-1601. Patients from the SAD trial are eligible to screen for an ongoing MAD clinical trial and\/or an open-label extension trial that is expected to initiate in the second half of 2021.<\/p>\n

\n About the <\/strong>
\n Phase 1 M<\/strong>
\n ultiple <\/strong>
\n A<\/strong>
\n scending <\/strong>
\n D<\/strong>
\n ose (MAD)<\/strong>
\n Clinical Trial<\/strong>
\n
The Phase 1 MAD clinical trial is a double-blind, placebo-controlled, randomized clinical trial to assess the safety of subcutaneously administered CTI-1601 versus placebo in adult subjects with Friedreich\u2019s ataxia (FA). The primary objective is to assess the safety and tolerability of multiple ascending doses of CTI-1601 in subjects with FA. Key secondary endpoints include pharmacokinetic and pharmacodynamic analyses following increasing multiple doses of subcutaneously administered CTI-1601. Two cohorts of dosing have been completed and the third cohort is expected to begin dosing in the first quarter of 2021. Patients from the MAD trial are eligible to screen for an open-label extension trial that is expected to initiate in the second half of 2021.<\/p>\n

\n About CTI-1601<\/strong>
\n
CTI-1601 is a recombinant fusion protein intended to deliver human frataxin into the mitochondria of patients with Friedreich\u2019s ataxia who are unable to produce enough of this essential protein. Currently in Phase 1 clinical trials in the\u00a0U.S., CTI-1601 has been granted Rare Pediatric Disease designation, Fast Track designation and Orphan Drug designation by the\u00a0U.S. Food and Drug Administration\u00a0(FDA) and orphan drug designation by the\u00a0European Commission. Topline results from the Phase 1 clinical program are planned for the second quarter\u00a0of\u00a02021.<\/p>\n

\n About Larimar Therapeutics<\/strong>
\n
Larimar Therapeutics, Inc. (Nasdaq: LRMR), is a clinical-stage biotechnology company focused on developing treatments for complex rare diseases. The company\u2019s lead compound, CTI-1601, is currently being evaluated in a Phase 1 clinical program in the U.S. as a potential treatment for Friedreich\u2019s ataxia. Larimar also plans to use its intracellular delivery platform to design other fusion proteins to target additional rare diseases characterized by deficiencies in intracellular bioactive compounds. For more information, please visit: https:\/\/larimartx.com<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
This press release contains forward-looking statements that are based on Larimar\u2019s management\u2019s beliefs and assumptions and on information currently available to management. All statements contained in this release other than statements of historical fact are forward-looking statements, including but not limited to statements regarding Larimar\u2019s ability to develop and commercialize CTI-1601 and other planned product candidates, Larimar\u2019s planned research and development efforts, and other matters regarding Larimar\u2019s business strategies, use of capital, results of operations and financial position, and plans and objectives for future operations.<\/p>\n

In some cases, you can identify forward-looking statements by the words \u201cmay,\u201d \u201cwill,\u201d \u201ccould,\u201d \u201cwould,\u201d \u201cshould,\u201d \u201cexpect,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201canticipate,\u201d \u201cbelieve,\u201d \u201cestimate,\u201d \u201cpredict,\u201d \u201cproject,\u201d \u201cpotential,\u201d \u201ccontinue,\u201d \u201congoing\u201d or the negative of these terms or other comparable terminology, although not all forward-looking statements contain these words. These statements involve risks, uncertainties and other factors that may cause actual results, performance, or achievements to be materially different from the information expressed or implied by these forward-looking statements. These risks, uncertainties and other factors include, among others, the success, cost and timing of Larimar\u2019s product development activities, studies and clinical trials, including CTI-1601 clinical milestones, and risk that preliminary clinical data may not be indicative of final results or predict the results of later nonclinical or clinical trials; the ongoing impact of the COVID-19 pandemic on Larimar\u2019s clinical trial timelines, ability to raise additional capital and general economic conditions; Larimar\u2019s ability to optimize and scale CTI-1601\u2019s manufacturing process; Larimar\u2019s ability to obtain regulatory approval for CTI-1601 and future product candidates; Larimar\u2019s ability to develop sales and marketing capabilities, whether alone or with potential future collaborators, and successfully commercialize any approved product candidates; Larimar\u2019s ability to raise the necessary capital to conduct its product development activities; and other risks described in the filings made by the Company with the Securities and Exchange Commission (SEC), including but not limited to Larimar\u2019s periodic reports, including the annual report on Form 10-K, quarterly reports on Form 10-Q and current reports on Form 8-K, filed with or furnished to the Securities and Exchange Commission and available at www.sec.gov<\/a>. These forward-looking statements are based on a combination of facts and factors currently known by Larimar and its projections of the future, about which it cannot be certain. As a result, the forward-looking statements may not prove to be accurate. The forward-looking statements in this press release represent views as of the date hereof. Larimar undertakes no obligation to update any forward-looking statements for any reason, except as required by law.<\/p>\n

\n Investor Contact:<\/strong>
\n
Joyce Allaire
LifeSci Advisors
jallaire@lifesciadvisors.com
<\/a>(212) 915-2569<\/p>\n

\n Media Contact:<\/strong>
\n
Gina Cestari
6 Degrees
gcestari@6degreespr.com
<\/a>(917) 797-7904<\/p>\n

\u00a0<\/p>\n


\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

– Preliminary data suggest that single subcutaneous injections of CTI-1601 were well tolerated at doses up to 100 mg – Company remains on track to report topline data from placebo – controlled single and multiple ascending dose clinical trials in Q2 2021 BALA CYNWYD, Pa., Dec. 08, 2020 (GLOBE NEWSWIRE) — Larimar Therapeutics, Inc. (\u201cLarimar\u201d) (Nasdaq: LRMR), a clinical-stage biotechnology company focused on developing treatments for complex rare diseases,\u00a0today announced the completion of dosing from the Company\u2019s Phase 1 single ascending dose (SAD) clinical trial (n=28) evaluating CTI-1601 as a treatment for Friedreich\u2019s ataxia (FA) and provided additional updates regarding the status of an ongoing multiple ascending dose (MAD) clinical trial, the timing of Phase 1 topline results, and future … <\/p>\n

Continue reading “Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-395122","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nLarimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"– Preliminary data suggest that single subcutaneous injections of CTI-1601 were well tolerated at doses up to 100 mg – Company remains on track to report topline data from placebo – controlled single and multiple ascending dose clinical trials in Q2 2021 BALA CYNWYD, Pa., Dec. 08, 2020 (GLOBE NEWSWIRE) — Larimar Therapeutics, Inc. (\u201cLarimar\u201d) (Nasdaq: LRMR), a clinical-stage biotechnology company focused on developing treatments for complex rare diseases,\u00a0today announced the completion of dosing from the Company\u2019s Phase 1 single ascending dose (SAD) clinical trial (n=28) evaluating CTI-1601 as a treatment for Friedreich\u2019s ataxia (FA) and provided additional updates regarding the status of an ongoing multiple ascending dose (MAD) clinical trial, the timing of Phase 1 topline results, and future … Continue reading "Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-08T12:33:29+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODI5OCMzODYwNzMyIzIwMjM1MDY=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update\",\"datePublished\":\"2020-12-08T12:33:29+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/\"},\"wordCount\":1391,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODA5ODI5OCMzODYwNzMyIzIwMjM1MDY=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\\\/\",\"name\":\"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/","og_locale":"en_US","og_type":"article","og_title":"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update - Market Newsdesk","og_description":"– Preliminary data suggest that single subcutaneous injections of CTI-1601 were well tolerated at doses up to 100 mg – Company remains on track to report topline data from placebo – controlled single and multiple ascending dose clinical trials in Q2 2021 BALA CYNWYD, Pa., Dec. 08, 2020 (GLOBE NEWSWIRE) — Larimar Therapeutics, Inc. (\u201cLarimar\u201d) (Nasdaq: LRMR), a clinical-stage biotechnology company focused on developing treatments for complex rare diseases,\u00a0today announced the completion of dosing from the Company\u2019s Phase 1 single ascending dose (SAD) clinical trial (n=28) evaluating CTI-1601 as a treatment for Friedreich\u2019s ataxia (FA) and provided additional updates regarding the status of an ongoing multiple ascending dose (MAD) clinical trial, the timing of Phase 1 topline results, and future … Continue reading \"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-08T12:33:29+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODI5OCMzODYwNzMyIzIwMjM1MDY=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update","datePublished":"2020-12-08T12:33:29+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/"},"wordCount":1391,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5ODI5OCMzODYwNzMyIzIwMjM1MDY=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/larimar-therapeutics-announces-completion-of-dosing-of-the-single-ascending-dose-clinical-trial-in-friedreichs-ataxia-patients-and-provides-program-update\/","name":"Larimar Therapeutics Announces Completion of Dosing of the Single Ascending Dose Clinical Trial in Friedreich\u2019s Ataxia Patients and Provides Program Update - 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