{"id":394928,"date":"2020-12-07T20:42:18","date_gmt":"2020-12-08T01:42:18","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=394928"},"modified":"2020-12-07T20:42:18","modified_gmt":"2020-12-08T01:42:18","slug":"innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/","title":{"rendered":"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH"},"content":{"rendered":"<p>        <!--.bwalignc { text-align: center; list-style-position: inside }body {font:normal small Arial,Helvetica,sans-serif;color:#000;background-color:#fff;padding:24px;margin:0;} a img {border:0;} h3 {font-size:medium;color:#000;margin:0 0 1em 0; text-align:center;}-->  <\/p>\n<p class=\"bwalignc\"><b>InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH<\/b><\/p>\n<p>BEIJING&#8211;(<a href=\"http:\/\/www.businesswire.com\">BUSINESS WIRE<\/a>)&#8211;<br \/>\nInnoCare Pharma (HKEX: 09969), a leading biopharmaceutical company, announced today three presentations of the most recent clinical data with orelabrutinib, its BTK inhibitor, at the 62nd American Society of Hematology (ASH) Annual Meeting. These data, contained in the three poster sessions described below, highlight both favorable objective response rates (ORR) and complete response rates (CR) as demonstrated in patients with relapsed or refractory Mantle Cell Lymphoma (MCL) and patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) \/Small Cell Leukemia (SLL).\n<\/p>\n<p><b>Updated Results from the Phase II Study of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia\/Small Cell Leukemia<\/b><\/p>\n<p>\nAbstract Number\uff1a1320\n<\/p>\n<p>\nThis study was designed to evaluate safety and efficacy following oral daily administration. The primary endpoint was ORR. The duration of response (DOR), progression-free survival (PFS) and safety were chosen as secondary endpoints.\n<\/p>\n<p>\nA total of 80 patients were enrolled, most with advanced stage disease. The median follow-up time was 14.3 months. As evaluated by an independent review committee, the ORR was 91.3%, including 10.0% of patients with CR, 63.8% with partial response (PR) and 17.5% with PR-L. Median time to first response following treatment initiation was 1.87 months. The median DOR and PFS were not reached.\n<\/p>\n<p>\nMost adverse events were mild to moderate. Extended follow-up analysis did not reveal new safety concerns. The most frequent adverse events (AEs) include thrombocytopenia, neutropenia, anemia, upper respiratory tract infection, pneumonia and hypokalemia.\n<\/p>\n<p>\nDr. Wei Xu, Deputy Director of Department of Hematology, Jiangsu Province Hospital, said, \u201cThese updated data, based upon longer follow up periods, further confirm that orelabrutinib is active in treating r\/r CLL\/SLL patients with a higher CR rate, deeper response and improved safety profiles. As a highly selective BTK inhibitor with novel pharmacokinetic and pharmacodynamic properties, orelabrutinib provides a favorable therapeutic choice for patients with r\/r CLL\/SLL and a potential best candidate for combination therapy.\u201d\n<\/p>\n<p><b>Long-Term Safety and Efficacy of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Mantle Cell Lymphoma: A Multicenter, Open-Label, Phase II Study<\/b><\/p>\n<p>\nAbstract Number\uff1a2048\n<\/p>\n<p>\nThis study is aimed at evaluating its safety and efficacy. The primary endpoint was ORR assessed per Lugano criteria (2014). Safety and other efficacy (DOR, PFS) evaluations were chosen as secondary endpoints.\n<\/p>\n<p>\nA total of 106 patients, most with advanced stage disease, were enrolled in this study, with median follow up time of 16.4 months. As per protocol analysis, ORR was 87.9% and disease control rate was 93.9%.\n<\/p>\n<p>\nThe CR rate, by conventional CT method, reached 34.3%. The median DOR and PFS were not reached.\n<\/p>\n<p>\nOrelabrutinib demonstrated a good safety profile in r\/r MCL patients. Adverse events included thrombocytopenia, neutropenia, leukopenia, and hypertension.\n<\/p>\n<p>\nDr. Yuqin Song, deputy director of the Lymphoma Department at Peking University Cancer Hospital, Beijing, said, \u201cOrelabrutinib showed continued activity in treating patients with r\/r MCL over an extended period. In addition, orelabrutinib was observed to be safe, with no treatment related grade 3 or higher diarrhea, atrial fibrillation\/flutter or severe bleeding in this study. These results support orelabrutinib as a better selection for BTKi therapy for r\/r MCL patients.\u201d\n<\/p>\n<p><b>Pooled Analysis of Safety Data from Clinical Trials of Orelabrutinib Monotherapy in Hematologic Malignancies<\/b><\/p>\n<p>\nAbstract Number: 1140\n<\/p>\n<p>\nSafety data of 266 patients from the five ongoing orelabrutinib monotherapy studies were pooled and analyzed.\n<\/p>\n<p>\nOrelabrutinib was observed to have a lower frequency of BTK off-target related adverse events, such as atrial fibrillation\/flutter and diarrhea, compared with other BTK inhibitors. Among all 266 patients, one patient was reported with one episode of transient grade 1 atrial fibrillation, and no grade \u22653 atrial fibrillation was observed. One case (0.4%) was reported as grade 3 diarrhea. The second primary malignancies were reported in one patient (0.4%) with r\/r MCL. Most of the adverse events occurred early in treatment and the frequency of new event occurrence was significantly decreased during the later cycles.\n<\/p>\n<p>\nDr. Song said, \u201cOrelabrutinib shows good safety profile in long-term treatment. These data suggest that orelabrutinib may be a favorable treatment choice as a single agent for B-cell malignancies.\u201d\n<\/p>\n<p><b>About Orelabrutinib<\/b><\/p>\n<p>\nOrelabrutinib is a selective BTK inhibitor under development for the treatment of cancers and autoimmune diseases. Currently, multi-center, multi-indication clinical trials are underway in the US and China with orelabrutinib as monotherapy or in combination therapies. Current clinical data have demonstrated orelabrutinib\u2019s robust efficacy and safety profile. Orelabrutinib\u2019s two indications have been included in priority review by the NMPA.\n<\/p>\n<p><b>About InnoCare<\/b><\/p>\n<p>\nInnoCare is a leading biopharmaceutical company committed to discovering, developing, and commercializing first-in-class and\/or best-in-class drugs for the treatment of cancer and autoimmune diseases. We strategically focus on lymphoma, solid tumors, and autoimmune diseases with high unmet medical needs in China and worldwide. InnoCare has branches in Beijing, Nanjing, Shanghai, Guangzhou, New Jersey, and Boston.\n<\/p>\n<p><img decoding=\"async\" alt=\"\" src=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201207006002r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" style=\"width:0;height:0\" \/><span class=\"bwct31415\" \/><\/p>\n<p id=\"mmgallerylink\"><span id=\"mmgallerylink-phrase\">View source version on businesswire.com: <\/span><span id=\"mmgallerylink-link\"><a href=\"https:\/\/www.businesswire.com\/news\/home\/20201207006002\/en\/\" rel=\"nofollow\">https:\/\/www.businesswire.com\/news\/home\/20201207006002\/en\/<\/a><\/span><\/p>\n<p><b>Media<br \/>\n<\/b><br \/>Chunhua Lu<br \/>\n<br \/>86-10-66609879<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:chunhua.lu@innocarepharma.com\">chunhua.lu@innocarepharma.com<\/a><\/p>\n<p><b>Investors<br \/>\n<\/b><br \/>86-10-66609999<br \/>\n<br \/><a rel=\"nofollow\" href=\"mailto:ir@innocarepharma.com\">ir@innocarepharma.com<\/a><\/p>\n<p><b>KEYWORDS:<\/b> California China United States North America Asia Pacific<\/p>\n<p><b>INDUSTRY KEYWORDS:<\/b> Biotechnology Health Pharmaceutical Clinical Trials Oncology<\/p>\n<p><b>MEDIA:<\/b><\/p>\n<table cellpadding=\"3\" cellspacing=\"3\">\n<tr>\n<td><font face=\"Arial\" size=\"2\"><b>Logo<\/b><\/font><\/td>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" src=\"https:\/\/mms.businesswire.com\/media\/20201207006002\/en\/845073\/3\/ICP_Logo.jpg\" alt=\"Logo\" \/><\/td>\n<\/tr>\n<tr>\n<td><font face=\"Arial\" size=\"2\"><\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH BEIJING&#8211;(BUSINESS WIRE)&#8211; InnoCare Pharma (HKEX: 09969), a leading biopharmaceutical company, announced today three presentations of the most recent clinical data with orelabrutinib, its BTK inhibitor, at the 62nd American Society of Hematology (ASH) Annual Meeting. These data, contained in the three poster sessions described below, highlight both favorable objective response rates (ORR) and complete response rates (CR) as demonstrated in patients with relapsed or refractory Mantle Cell Lymphoma (MCL) and patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) \/Small Cell Leukemia (SLL). Updated Results from the Phase II Study of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia\/Small Cell Leukemia Abstract &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-394928","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH BEIJING&#8211;(BUSINESS WIRE)&#8211; InnoCare Pharma (HKEX: 09969), a leading biopharmaceutical company, announced today three presentations of the most recent clinical data with orelabrutinib, its BTK inhibitor, at the 62nd American Society of Hematology (ASH) Annual Meeting. These data, contained in the three poster sessions described below, highlight both favorable objective response rates (ORR) and complete response rates (CR) as demonstrated in patients with relapsed or refractory Mantle Cell Lymphoma (MCL) and patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) \/Small Cell Leukemia (SLL). Updated Results from the Phase II Study of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia\/Small Cell Leukemia Abstract &hellip; Continue reading &quot;InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-08T01:42:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201207006002r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH\",\"datePublished\":\"2020-12-08T01:42:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/\"},\"wordCount\":853,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/cts.businesswire.com\\\/ct\\\/CT?id=bwnews&amp;sty=20201207006002r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\\\/\",\"name\":\"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH - 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These data, contained in the three poster sessions described below, highlight both favorable objective response rates (ORR) and complete response rates (CR) as demonstrated in patients with relapsed or refractory Mantle Cell Lymphoma (MCL) and patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) \/Small Cell Leukemia (SLL). Updated Results from the Phase II Study of Orelabrutinib Monotherapy in Chinese Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia\/Small Cell Leukemia Abstract &hellip; Continue reading \"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-08T01:42:18+00:00","og_image":[{"url":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201207006002r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH","datePublished":"2020-12-08T01:42:18+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/"},"wordCount":853,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/#primaryimage"},"thumbnailUrl":"https:\/\/cts.businesswire.com\/ct\/CT?id=bwnews&amp;sty=20201207006002r1&amp;sid=flmnd&amp;distro=nx&amp;lang=en","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/innocare-presents-latest-clinical-data-of-orelabrutinib-at-the-62nd-annual-meeting-of-ash\/","name":"InnoCare Presents Latest Clinical Data of Orelabrutinib at the 62nd Annual Meeting of ASH - 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