{"id":394107,"date":"2020-12-07T07:33:10","date_gmt":"2020-12-07T12:33:10","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=394107"},"modified":"2020-12-07T07:33:10","modified_gmt":"2020-12-07T12:33:10","slug":"cytokinetics-announces-additional-results-from-galactic-hf-presented-at-the-17th-global-cardiovascular-clinical-trialists","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/cytokinetics-announces-additional-results-from-galactic-hf-presented-at-the-17th-global-cardiovascular-clinical-trialists\/","title":{"rendered":"Cytokinetics Announces Additional Results From GALACTIC-HF\u00a0Presented at the 17th Global Cardiovascular Clinical Trialists"},"content":{"rendered":"
\n

\n Supplemental <\/em>
\n Analyses of Primary Composite Endpoint <\/em>
\n Further Demonstrate Effect of Omecamtiv Mecarbil <\/em>
\n In Patie<\/em>
\n nts with Lower Ejection Fraction<\/em>
\n \n <\/p>\n

SOUTH SAN FRANCISCO, Calif., Dec. 07, 2020 (GLOBE NEWSWIRE) — Cytokinetics, Incorporated (Nasdaq: CYTK) today announced that additional results from GALACTIC-HF (G<\/strong>lobal A<\/strong>pproach to L<\/strong>owering A<\/strong>dverse C<\/strong>ardiac Outcomes T<\/strong>hrough I<\/strong>mproving C<\/strong>ontractility in H<\/strong>eart F<\/strong>ailure), the Phase 3 event-driven cardiovascular outcomes clinical trial of omecamtiv mecarbil<\/em>, <\/em>were presented by John Teerlink, M.D., Professor of Medicine, University of California San Francisco, Director of Heart Failure, San Francisco Veterans Affairs Medical Center and Executive Committee Chair, GALACTIC-HF, at the 17th<\/sup> Global Cardiovascular Clinical Trialists Forum (CVCT).<\/p>\n

\u201cThese results shed light on advanced heart failure patients who may benefit more from potential treatment with omecamtiv mecarbil<\/em>,\u201d said John Teerlink, M.D. \u201cThese sicker patients continue to have substantial persistent risk despite receiving standard of care therapy and, based on the progressive nature of their disease, are frequently unable to tolerate guideline-directed medical therapy as their disease worsens. These additional data from GALACTIC-HF suggest that omecamtiv mecarbil<\/em> may provide a new treatment option for this critical population of patients.\u201d<\/p>\n

\n GALACTIC-HF: Supplemental Analyses<\/strong>\n <\/p>\n

GALACTIC-HF enrolled 8,256 patients who were at risk of hospitalization and death, despite being well treated on standard of care therapy. As previously reported, after a median duration of follow-up of 21.8 months, the trial demonstrated a statistically significant effect of treatment with omecamtiv mecarbil <\/em>to reduce risk of the primary composite endpoint of heart failure events (heart failure hospitalization and other urgent treatment for heart failure) or cardiovascular (CV) death compared to placebo in patients treated with standard of care (hazard ratio, 0.92; 95% confidence interval [CI] 0.86, 0.99; p=0.025). No reduction in the secondary endpoint of time to CV death was observed in the overall population1<\/sup>.<\/p>\n

The effect of omecamtiv mecarbil<\/em> on the primary composite endpoint in GALACTIC-HF was consistent across most prespecified subgroups and with a potentially greater treatment effect suggested in patients with a lower left ventricular ejection fraction (LVEF \u226428%, n=4,456, hazard ratio, 0.84; 95% CI 0.77, 0.92; interaction p=0.003). Supplemental analyses of this lower ejection fraction subgroup in GALACTIC-HF presented at CVCT showed that this potentially greater treatment effect in patients who received omecamtiv<\/em>mecarbil<\/em> was consistently observed in patients with characteristics that may indicate advanced heart failure status, such as being hospitalized within the last 3 months (HR 0.83, 95% CI 0.74 \u2013 0.93, p=0.001), having New York Association Class III or IV heart failure (HR 0.80, 95% CI 0.71 \u2013 0.90, p<0.001), higher N-terminal-pro brain natriuretic peptide levels (HR 0.77, 95% CI 0.69 \u2013 0.87, p<0.001), and lower blood pressures (HR 0.81, 95% CI 0.70 \u2013 0.92, p=0.002). The absolute risk reductions (ARR) ranged from 5.2% to 8.1% in these subgroups as compared to the ARR of 2.1% observed in the overall population.<\/p>\n

Additionally, a supplemental analysis of the continuous relationship between ejection fraction and the hazard ratio for the primary composite endpoint in GALACTIC-HF suggested a potentially stronger treatment effect of omecamtiv mecarbil <\/em>in patients with increasingly lower ejection fractions.<\/em><\/p>\n

A photo accompanying this announcement is available at https:\/\/www.globenewswire.com\/NewsRoom\/AttachmentNg\/a6f54df3-faaf-4c79-9ab4-9297bf42fbff<\/a><\/p>\n

\u201cThese new data from GALACTIC-HF reinforce the relationship between the primary pharmacologic effect of omecamtiv mecarbil<\/em> to improve cardiac systolic function and its impact on heart failure outcomes, as it stands to reason that those with more impaired function may benefit most from this novel mechanism therapy,\u201d said Fady I. Malik, M.D., Ph.D., Cytokinetics\u2019 Executive Vice President of Research & Development. \u201cWe look forward to sharing additional analyses in upcoming publications and presentations which will elaborate further on these and other ongoing analyses of data arising from GALACTIC-HF.\u201d<\/p>\n

\n GALACTIC-HF: Trial Design<\/strong>
\n And Primary Results<\/strong>\n <\/p>\n

GALACTIC-HF,2<\/sup> (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure), one of the largest Phase 3 global cardiovascular outcomes studies in heart failure ever conducted, enrolled 8,256 patients in 35 countries across 945 sites with HFrEF, New York Heart Association (NYHA) class II-IV, left ventricular ejection fraction (LVEF) \u226435%, elevated natriuretic peptides and either current hospitalization for heart failure or history of hospitalization or emergency department visit for heart failure within a year. Patients were randomized to either oral placebo or a starting dose of 25 mg omecamtiv mecarbil <\/em>twice daily (maintenance dose of 50 mg, 37.5 mg, or 25 mg twice daily) guided by pharmacokinetic-guided dose selection. A blood test, the QMS Omecamtiv Mecarbil<\/em> Immunoassay (the OM Test) was used to measure plasma levels of omecamtiv mecarbil<\/em> in each patient in order to guide selection of the appropriate maintenance dose.<\/p>\n

The primary composite endpoint of this double-blind, placebo-controlled, event-driven trial was time to CV death or first heart failure event (heart failure hospitalization and other urgent treatment for heart failure). Secondary endpoints were: time to CV death, patient reported outcomes (measured by Kansas City Cardiomyopathy Questionnaire [KCCQ] Total Symptom Score [TSS]), time to first heart failure hospitalization and time to all-cause death. A first primary endpoint event occurred in 1,523 of 4,120 patients (37.0%) in the omecamtiv mecarbil<\/em> group and in 1,607 of 4,112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI] 0.86, 0.99; p=0.025). No reduction in the secondary endpoint of time to CV death was observed in the overall population. The effect on the primary endpoint was observed without evidence of an increase in the overall rates of myocardial ischemic events, ventricular arrhythmias or death from cardiovascular or all causes.<\/p>\n

\n About <\/strong>
\n
\n Omecamtiv Mecarbil<\/em>
\n <\/strong>
\n and the Phase 3 Clinical Trials Program<\/strong>\n <\/p>\n

\n Omecamtiv mecarbil<\/em> is an investigational selective cardiac myosin activator, the first of a novel class of myotropes3<\/sup> designed to directly target the contractile mechanisms of the heart, binding to and recruiting more cardiac myosin heads to interact with actin during systole. Preclinical research has shown that omecamtiv mecarbil<\/em> increases cardiac contractility without increasing intracellular myocyte calcium concentrations or myocardial oxygen consumption.4-6<\/sup> Cardiac myosin is the cytoskeletal motor protein in the cardiac muscle cell that is directly responsible for converting chemical energy into the mechanical force resulting in cardiac contraction.<\/p>\n

\n Omecamtiv mecarbil<\/em> is being developed for the potential treatment of heart failure with reduced ejection fraction (HFrEF) and is the subject of a comprehensive Phase 3 clinical trials program composed of GALACTIC-HF and METEORIC-HF (Multicenter Exercise Tolerance Evaluation of Omecamtiv Mecarbil<\/em> Related to Increased Contractility in Heart Failure), a Phase 3 clinical trial designed to evaluate the effect of treatment with omecamtiv mecarbil<\/em> compared to placebo on exercise capacity.<\/p>\n

\n About Heart Failure<\/strong>\n <\/p>\n

Heart failure is a grievous condition that affects more than 64 million people worldwide7<\/sup> about half of whom have reduced left ventricular function.8,9 <\/sup> It is the leading cause of hospitalization and readmission in people age 65 and older.10, 11<\/sup> Despite broad use of standard treatments and advances in care, the prognosis for patients with heart failure is poor.1<\/sup>2<\/sup> An estimated one in five people over the age of 40 are at risk of developing heart failure, and approximately 50 percent of people diagnosed with heart failure will die within five years of initial hospitalization.13<\/sup>,14<\/sup><\/p>\n

\n About Cytokinetics<\/strong>\n <\/p>\n

Cytokinetics is a late-stage biopharmaceutical company focused on discovering, developing and commercializing first-in-class muscle activators and next-in-class muscle inhibitors as potential treatments for debilitating diseases in which muscle performance is compromised and\/or declining. As a leader in muscle biology and the mechanics of muscle performance, the company is developing small molecule drug candidates specifically engineered to impact muscle function and contractility. Cytokinetics is preparing for regulatory interactions for omecamtiv mecarbil<\/em>, its novel cardiac muscle activator, following positive results from GALACTIC-HF, a large, international Phase 3 clinical trial in patients with heart failure. Cytokinetics is conducting METEORIC-HF, a second Phase 3 clinical trial of omecamtiv mecarbil<\/em>. Cytokinetics is also developing CK-274, a next- generation cardiac myosin inhibitor, for the potential treatment of hypertrophic cardiomyopathies (HCM). Cytokinetics is conducting REDWOOD-HCM, a Phase 2 clinical trial of CK-274 in patients with obstructive HCM. Cytokinetics is also developing reldesemtiv<\/em>, a fast skeletal muscle troponin activator for the potential treatment of ALS and other neuromuscular indications following conduct of FORTITUDE-ALS and other Phase 2 clinical trials. The company is considering potential advancement of reldesemtiv<\/em> to Phase 3 pending ongoing regulatory interactions. Cytokinetics continues its over 20-year history of pioneering innovation in muscle biology and related pharmacology focused to diseases of muscle dysfunction and conditions of muscle weakness.<\/p>\n

For additional information about\u00a0Cytokinetics, visit\u00a0www.cytokinetics.com<\/a> and follow us on Twitter<\/a>, LinkedIn<\/a>, Facebook<\/a> and YouTube<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

This press release contains forward-looking statements for purposes of the Private Securities Litigation Reform Act of 1995 (the “Act”).\u00a0Cytokinetics\u00a0disclaims any intent or obligation to update these forward-looking statements and claims the protection of the Act’s Safe Harbor for forward-looking statements. Examples of such statements include, but are not limited to, statements relating to the GALACTIC-HF clinical trial; statements relating to the METEORIC-HF clinical trial; the potential benefits of\u00a0omecamtiv mecarbil<\/em>, including its ability to represent a novel therapeutic strategy to increase cardiac muscle function and restore cardiac performance;\u00a0the potential approval of omecamtiv mecarbil<\/em> by the FDA or any other regulatory authority and the timing of such approvals; Cytokinetics’\u00a0and its partners’ research and development activities; the design, timing, results, significance and utility of preclinical and clinical results; and the properties and potential benefits of\u00a0Cytokinetics’\u00a0other drug candidates. Such statements are based on management’s current expectations, but actual results may differ materially due to various risks and uncertainties, including, but not limited to, potential difficulties or delays in the development, testing, regulatory approvals for trial commencement, progression or product sale or manufacturing, or production of\u00a0Cytokinetics’\u00a0drug candidates that could slow or prevent clinical development or product approval;\u00a0Cytokinetics’\u00a0drug candidates may have adverse side effects or inadequate therapeutic efficacy; the FDA or foreign regulatory agencies may delay or limit\u00a0Cytokinetics’\u00a0or its partners’ ability to conduct clinical trials;\u00a0Cytokinetics\u00a0may be unable to obtain or maintain patent or trade secret protection for its intellectual property; standards of care may change, rendering\u00a0Cytokinetics’\u00a0drug candidates obsolete; competitive products or alternative therapies may be developed by others for the treatment of indications\u00a0Cytokinetics’\u00a0drug candidates and potential drug candidates may target; and risks and uncertainties relating to the timing and receipt of payments from its partners, including milestones and royalties on future potential product sales under\u00a0Cytokinetics’\u00a0collaboration agreements with such partners. For further information regarding these and other risks related to\u00a0Cytokinetics’\u00a0business, investors should consult\u00a0Cytokinetics’\u00a0filings with the\u00a0Securities and Exchange Commission.<\/p>\n

Contact:
Cytokinetics
Diane Weiser
Senior Vice President, Corporate Communications, Investor Relations
(415) 290-7757<\/p>\n

\n References<\/strong>\n <\/p>\n

    \n
  1. Teerlink J et al. NEJM. 2020\n<\/li>\n
  2. Teerlink JR., Diaz R., Felker GM., et al. Omecamtiv Mecarbil in Chronic Heart\u00a0Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF.\u00a0JACC Heart Fail.\u00a0<\/em>2020 Apr; 8(4):329-340. doi: 10.1016\/j.jchf.2019.12.001.Epub 2020\u00a0Feb 6.\n<\/li>\n
  3. Psotka MA, Gottlieb SS, Francis GS et al. Cardiac Calcitropes, Myotropes, and Mitotropes.\u00a0JACC<\/em>. 2019; 73:2345-53.\n<\/li>\n
  4. Planelles-Herrero VJ, Hartman JJ,\u00a0Robert-Paganin J. et al. Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.\u00a0Nat Commun<\/em>. 2017;8:190.\n<\/li>\n
  5. Shen YT, Malik FI, Zhao X, et al. Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure.\u00a0Circ Heart Fail<\/em>. 2010; 3: 522-27.\n<\/li>\n
  6. Malik FI, Hartman JJ, Elias KA, Morgan BP, Rodriguez H, Brejc K, Anderson RL, Sueoka SH, Lee KH, Finer JT, Sakowicz R. Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.\u00a0Science<\/em>. 2011 Mar 18;331(6023):1439-43.\n<\/li>\n
  7. James et al. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators.\u00a0Lancet<\/em>\u00a02018; 392: 1789\u2013858.\n<\/li>\n
  8. Yancy CW, Jessup M, Bozkurt B, et al. 2013 ACCF\/AHA Guideline for the Management of Heart failure: A Report of the\u00a0American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines.\u00a0Circulation<\/em>. 2013;128:e240-e327.\u00a0\n<\/li>\n
  9. Ponikowski\u00a0 P, Voors\u00a0 AA, Anker\u00a0 SD, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the\u00a0European Society of Cardiology\u00a0(ESC). Developed with the special contribution of the Heart Failure Association\u00a0(HFA) of the ESC.\u00a0Eur Heart\u00a0J<\/em>. 2016;37:2129\u20132200.\n<\/li>\n
  10. Roger VL. Epidemiology of Heart Failure.\u00a0Circulation Research<\/em>. 2013;113:646-659, originally published\u00a0August 29, 2013. Doi: 10.1161\/CIRCRESAHA.113.300268.\n<\/li>\n
  11. Kilgore M, Patel HK, Kielhorn A et al. Economic burden of hospitalizations of\u00a0Medicare\u00a0beneficiaries with heart failure.\u00a0Risk Manag Healthc Policy<\/em>. 2017; 10: 63-70.\u00a0\n<\/li>\n
  12. Jhund PS, MacIntyre K, Simpson CR, et al. Long-Term Trends in First Hospitalization for Heart Failure and Subsequent Survival Between 1986 and 2003.\u00a0Circulation<\/em>. 2009;119:515-523.\n<\/li>\n
  13. Benjamin EJ, Virani SS, Callaway CW et al. Heart Disease and Stroke Statistics\u20142018 Update: A Report From the\u00a0American Heart Association.\u00a0Circulation<\/em>. 2018;137:e67-e492.\u00a0\n<\/li>\n
  14. Roger VL,\u00a0Weston SA, Redfield MM, et al. Trends in Heart Failure Incidence and Survival in a Community-Based Population.\u00a0JAMA<\/em>. 2004;292:344-350.\u00a0\u00a0<\/li>\n<\/ol>\n


    \n
    \n \n <\/div>\n

    <\/div>\n","protected":false},"excerpt":{"rendered":"

    Supplemental Analyses of Primary Composite Endpoint Further Demonstrate Effect of Omecamtiv Mecarbil In Patie nts with Lower Ejection Fraction SOUTH SAN FRANCISCO, Calif., Dec. 07, 2020 (GLOBE NEWSWIRE) — Cytokinetics, Incorporated (Nasdaq: CYTK) today announced that additional results from GALACTIC-HF (Global Approach to Lowering Adverse Cardiac Outcomes Through Improving Contractility in Heart Failure), the Phase 3 event-driven cardiovascular outcomes clinical trial of omecamtiv mecarbil, were presented by John Teerlink, M.D., Professor of Medicine, University of California San Francisco, Director of Heart Failure, San Francisco Veterans Affairs Medical Center and Executive Committee Chair, GALACTIC-HF, at the 17th Global Cardiovascular Clinical Trialists Forum (CVCT). \u201cThese results shed light on advanced heart failure patients who may benefit more from potential treatment with omecamtiv … <\/p>\n

    Continue reading “Cytokinetics Announces Additional Results From GALACTIC-HF\u00a0Presented at the 17th Global Cardiovascular Clinical Trialists”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-394107","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nCytokinetics Announces Additional Results From GALACTIC-HF\u00a0Presented at the 17th Global Cardiovascular Clinical Trialists - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/cytokinetics-announces-additional-results-from-galactic-hf-presented-at-the-17th-global-cardiovascular-clinical-trialists\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cytokinetics Announces Additional Results From GALACTIC-HF\u00a0Presented at the 17th Global Cardiovascular Clinical Trialists - 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