{"id":393894,"date":"2020-12-06T10:03:23","date_gmt":"2020-12-06T15:03:23","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=393894"},"modified":"2020-12-06T10:03:23","modified_gmt":"2020-12-06T15:03:23","slug":"allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/","title":{"rendered":"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology"},"content":{"rendered":"<div class=\"mw_release\">\n<ul>\n<li>Results Demonstrate Ability of AlloCAR T\u2122 Therapy to Selectively Kill CD70 Expressing Leukemic Cells<\/li>\n<li style=\"margin-top:0.55pt\">Coupled with Previous Findings in Renal Cell Carcinoma (RCC), Results Highlight the Potential of ALLO-316 to Treat Both Hematologic Malignancies and Solid Tumors<\/li>\n<li style=\"margin-top:0.55pt\">Investigational New Drug (IND) Application for ALLO-316 Cleared by U.S. Food and Drug Administration (FDA); Phase 1 Trial in RCC to Start in 2021 <\/li>\n<\/ul>\n<p>SOUTH SAN FRANCISCO, Calif., Dec.  06, 2020  (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) therapies for cancer, today announced preclinical findings of ALLO-316, an AlloCAR T\u2122 therapy targeting CD70, in models of acute myeloid leukemia (AML). Data were presented in a poster session today at the 62<sup>nd<\/sup> Annual Meeting of the American Society of Hematology.<\/p>\n<p>The Company also announced that the U.S. Food and Drug Administration (FDA) has cleared an Investigational New Drug (IND) application for a Phase 1 trial of ALLO-316 for patients with advanced or metastatic clear cell renal cell carcinoma (RCC). The Company\u2019s first solid tumor trial is expected to begin enrolling patients in 2021.<\/p>\n<p>\u201cWe are very excited about the potential of ALLO-316, our fourth AlloCAR T investigational therapy, to treat patients with CD70 expressing malignancies across both hematologic and solid tumor indications,\u201d said Rafael Amado, M.D., Executive Vice President of Research &amp; Development and Chief Medical Officer of Allogene. \u201cThese preclinical results in AML, coupled with previous findings of ALLO-316 in RCC presented at the American Association for Cancer Research Annual Meeting in 2019, reinforce our belief that CD70 may become one of the more important targets across a broad spectrum of cancers.\u201d<\/p>\n<p>CD70 is expressed in a number of malignancies ranging from solid tumors such as RCC, lung cancer and glioblastoma to hematologic cancers including AML, diffuse large B-cell lymphoma, multiple myeloma, and chronic lymphocytic leukemia.<\/p>\n<p>In the preclinical studies presented at ASH, CD70 expression was detected on AML cell lines and primary AML samples from patients. No expression of CD70 was identified in hematopoietic stem cells. ALLO-316 demonstrated the ability to mediate efficient killing of leukemic cells in multiple models. This killing activity was specific to CD70 expression on the target cells as ALLO-316 did not kill AML cell lines in which CD70 was knocked out. The preclinical studies also showed that ALLO-316 can mask CD70 on the surface of CAR T cells thereby preventing fratercide and allowing scaled manufacturing of AlloCAR T cells.<\/p>\n<p>\n        <strong>About\u00a0Allogene Therapeutics<\/strong><br \/>\n        <br \/>Allogene Therapeutics, with headquarters in South San Francisco, is a clinical-stage biotechnology company pioneering the development of allogeneic chimeric antigen receptor T cell (AlloCAR T\u2122) therapies for cancer. Led by a management team with significant experience in cell therapy, Allogene is developing a pipeline of \u201coff-the-shelf\u201d CAR T cell therapy candidates with the goal of delivering readily available cell therapy on-demand, more reliably, and at greater scale to more patients. For more information, please visit www.allogene.com, and follow @AllogeneTx on Twitter and LinkedIn.<\/p>\n<p>\n        <strong>Cautionary Note on Forward-Looking Statements<\/strong><br \/>\n        <br \/>This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as &#8220;predicts,&#8221; &#8220;believes,&#8221; &#8220;potential,&#8221; &#8220;proposed,&#8221; &#8220;continue,&#8221; &#8220;estimates,&#8221; &#8220;anticipates,&#8221; &#8220;expects,&#8221; &#8220;plans,&#8221; &#8220;intends,&#8221; &#8220;may,&#8221; &#8220;could,&#8221; &#8220;might,&#8221; &#8220;will,&#8221; &#8220;should&#8221; or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: timing and ability to progress a clinical trial of ALLO-316 in RCC; ability to manufacture ALLO-316; and the potential benefits of ALLO-316 and AlloCAR T\u2122 therapy. Various factors may cause differences between Allogene\u2019s expectations and actual results as discussed in greater detail in Allogene\u2019s filings with the SEC, including without limitation in its Form 10-Q for the quarter ended September 30, 2020. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.<\/p>\n<p>AlloCAR T\u2122 is a trademark of\u00a0Allogene Therapeutics, Inc.<\/p>\n<p>ALLO-316 utilizes TALEN\u00ae gene-editing technology pioneered and owned by Cellectis. Allogene has an exclusive license to the Cellectis technology for allogeneic products directed at CD70 and holds all global development and commercial rights for this investigational candidate.<\/p>\n<p>\n        <strong>Allogene Media\/Investor Contact:<\/strong><br \/>\n        <br \/>Christine Cassiano<br \/>Chief Communications Officer<br \/>(714) 552-0326<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=FMHnysOkIBss48k3nPCgd8bcf6GLzYuH6vyB3VI7YWz2r5XxE3k5OyKLUL7KvDeMYknyhVQxYd-3lpbmchEFTsrCNHg2pq4Zdqts1uAgto8BLknMz5b0p6sHDeUHzCvx\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Christine.Cassiano@allogene.com<\/a><\/p>\n<p \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NzM0NCMzODU3NzE3IzIxMjQyNDc=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/c2332d40-a6ba-4194-9394-f11e939971e7\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Results Demonstrate Ability of AlloCAR T\u2122 Therapy to Selectively Kill CD70 Expressing Leukemic Cells Coupled with Previous Findings in Renal Cell Carcinoma (RCC), Results Highlight the Potential of ALLO-316 to Treat Both Hematologic Malignancies and Solid Tumors Investigational New Drug (IND) Application for ALLO-316 Cleared by U.S. Food and Drug Administration (FDA); Phase 1 Trial in RCC to Start in 2021 SOUTH SAN FRANCISCO, Calif., Dec. 06, 2020 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) therapies for cancer, today announced preclinical findings of ALLO-316, an AlloCAR T\u2122 therapy targeting CD70, in models of acute myeloid leukemia (AML). Data were presented in a poster session today at &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-393894","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Results Demonstrate Ability of AlloCAR T\u2122 Therapy to Selectively Kill CD70 Expressing Leukemic Cells Coupled with Previous Findings in Renal Cell Carcinoma (RCC), Results Highlight the Potential of ALLO-316 to Treat Both Hematologic Malignancies and Solid Tumors Investigational New Drug (IND) Application for ALLO-316 Cleared by U.S. Food and Drug Administration (FDA); Phase 1 Trial in RCC to Start in 2021 SOUTH SAN FRANCISCO, Calif., Dec. 06, 2020 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) therapies for cancer, today announced preclinical findings of ALLO-316, an AlloCAR T\u2122 therapy targeting CD70, in models of acute myeloid leukemia (AML). Data were presented in a poster session today at &hellip; Continue reading &quot;Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-06T15:03:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NzM0NCMzODU3NzE3IzIxMjQyNDc=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology\",\"datePublished\":\"2020-12-06T15:03:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/\"},\"wordCount\":765,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODA5NzM0NCMzODU3NzE3IzIxMjQyNDc=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\\\/\",\"name\":\"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/","og_locale":"en_US","og_type":"article","og_title":"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology - Market Newsdesk","og_description":"Results Demonstrate Ability of AlloCAR T\u2122 Therapy to Selectively Kill CD70 Expressing Leukemic Cells Coupled with Previous Findings in Renal Cell Carcinoma (RCC), Results Highlight the Potential of ALLO-316 to Treat Both Hematologic Malignancies and Solid Tumors Investigational New Drug (IND) Application for ALLO-316 Cleared by U.S. Food and Drug Administration (FDA); Phase 1 Trial in RCC to Start in 2021 SOUTH SAN FRANCISCO, Calif., Dec. 06, 2020 (GLOBE NEWSWIRE) &#8212; Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T\u2122) therapies for cancer, today announced preclinical findings of ALLO-316, an AlloCAR T\u2122 therapy targeting CD70, in models of acute myeloid leukemia (AML). Data were presented in a poster session today at &hellip; Continue reading \"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/","og_site_name":"Market Newsdesk","article_published_time":"2020-12-06T15:03:23+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NzM0NCMzODU3NzE3IzIxMjQyNDc=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology","datePublished":"2020-12-06T15:03:23+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/"},"wordCount":765,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NzM0NCMzODU3NzE3IzIxMjQyNDc=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/allogene-therapeutics-presents-preclinical-data-on-allo-316-in-acute-myeloid-leukemia-at-the-62nd-meeting-of-the-american-society-of-hematology\/","name":"Allogene Therapeutics Presents Preclinical Data on ALLO-316 in Acute Myeloid Leukemia at the 62nd Meeting of the American Society of Hematology - 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