{"id":392962,"date":"2020-12-03T12:03:33","date_gmt":"2020-12-03T17:03:33","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=392962"},"modified":"2020-12-03T12:03:33","modified_gmt":"2020-12-03T17:03:33","slug":"new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\/","title":{"rendered":"New data supports development of colchicine for the prevention of acute respiratory distress syndrome"},"content":{"rendered":"<h2>\nThis syndrome can develop in patients with COVID-19\u00a0if the virus enters the respiratory tract and damages the lungs<br \/>\n<\/h2>\n<div class=\"mw_release\">\n<p align=\"left\">MONTREAL, Dec.  03, 2020  (GLOBE NEWSWIRE) &#8212; <strong>The<\/strong><strong>Montreal Heart Institute<\/strong><strong> (MHI)<\/strong> has announced that colchicine, a widely available low-cost drug, reduces acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and respiratory failure in pre-clinical models<sup>1<\/sup>. The article reporting these results was published yesterday by the Public Library of Science ONE (PLOS ONE)<sup> 1<\/sup>.<\/p>\n<p align=\"justify\">\u201cThis study was designed and executed in the wake of the COVID-19 pandemic as there were no effective therapies at that time to prevent SARS-CoV-2 related lung injury and ARDS,\u201d said Dr. Jean-Claude Tardif, Director of the MHI Research Center, Professor of Medicine at the University of Montreal, COLCORONA Principal Investigator and co-principal lead author of the study published in PLOS ONE. \u201cIn the context of COVID-19, there is an urgent need for effective therapies that can reduce intensive care unit admissions, mechanical ventilation and death, which is the reason why we initiated the international COLCORONA study to evaluate colchicine in treating at-home patients with COVID-19.\u201d<\/p>\n<p align=\"justify\">ARDS results from direct or indirect acute lung injury (ALI) leading to intense inflammation with fluid in the lungs resulting in respiratory failure. Currently, there are no effective pharmacologic therapies for ARDS. The preclinical data in this peer-reviewed publication show that colchicine reduced the area of lung injury by 61%, reduced lung edema, and markedly improved oxygenation<sup>1<\/sup>.<\/p>\n<p align=\"justify\">\u201cWhile there is a strong rationale to test colchicine in COVID-19, until today there was little pre-clinical data supporting its potential efficacy in ARDS,\u201d added Dr. Jocelyn Dupuis, Cardiologist at MHI, Professor at the Faculty of Medicine, University of Montreal, and co-principal lead author of the study. \u201cColchicine may also be effective for other causes of ARDS, which is responsible for 10% of intensive care units admissions and 24% of mechanically ventilated patients prior to COVID-19.\u201d<\/p>\n<p align=\"justify\">This pre-clinical proof-of-concept study was designed to evaluate colchicine\u2019s efficacy in a recognized model of acute lung injury and dysregulated inflammation leading to ARDS. The design, study conduct and analysis were completed in record time with the contribution of four research teams of the Montreal Heart Institute under the co-leaderships of Dr Jocelyn Dupuis and Dr Jean-Claude Tardif.<\/p>\n<p>\n        <strong>The full clinical trial manuscript can be found at <\/strong><br \/>\n        <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=jUx0ubEIWygasPDAM-bY0lGy22THGp4nIjDKOnZQ1-OTuM21DaZCh_oHhUKeQifBIgKcJkX-Dz0rj6A85spv3Nf0GM3LiLR1b46DtWwN85XtOxm0tfcKf4t3mPo9h-MUqtZE3x8O3e_59tsqy-bM7a7vWhZa_UNfibeSfXu4wrvDPu2Jwv2F6GTuV4tflXcilV_RmUG2jDdA9eYKMDC7rIBFpxmgPs1jqcxi3vJcTy0=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><br \/>\n          <strong>https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0242318<\/strong><br \/>\n        <\/a>\n      <\/p>\n<p align=\"justify\">\n        <strong>About the Montreal Heart Institute <\/strong>\n      <\/p>\n<p align=\"justify\">Founded in 1954, the Montreal Heart Institute constantly aims for the highest standards of excellence in the cardiovascular field through its leadership in clinical and basic research, ultra-specialized care, professional training, and prevention. It houses the largest research center in Canada, the largest cardiovascular prevention center in the country, and the largest cardiovascular genetics center in Canada. The Institute is affiliated with the University of Montreal and has more than 2000 employees, including 245 doctors and more than 85 researchers.<\/p>\n<p align=\"justify\">Media relations:<\/p>\n<p align=\"justify\">Camille Turbide<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=tLClbmQlwfhw0GqTDvRjWAGkIIzUs59ycVQAvs3VV1qpN3FiNqq3CCmbbUib2m73M1DyZHFfFmLDUdgIzaybmJi0wKe3I2uqWra9o5kWN-c=\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Camille.turbide@gmail.com<\/a><br \/>+ 1 514\u00a0755-5354<\/p>\n<p \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NjQyMCMzODU1MzU1IzUwMDA3MTQxMQ==\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/02e85aa9-8971-4900-87c2-3a233e40002b\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>This syndrome can develop in patients with COVID-19\u00a0if the virus enters the respiratory tract and damages the lungs MONTREAL, Dec. 03, 2020 (GLOBE NEWSWIRE) &#8212; TheMontreal Heart Institute (MHI) has announced that colchicine, a widely available low-cost drug, reduces acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and respiratory failure in pre-clinical models1. The article reporting these results was published yesterday by the Public Library of Science ONE (PLOS ONE) 1. \u201cThis study was designed and executed in the wake of the COVID-19 pandemic as there were no effective therapies at that time to prevent SARS-CoV-2 related lung injury and ARDS,\u201d said Dr. Jean-Claude Tardif, Director of the MHI Research Center, Professor of Medicine at the University of Montreal, &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;New data supports development of colchicine for the prevention of acute respiratory distress syndrome&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-392962","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New data supports development of colchicine for the prevention of acute respiratory distress syndrome - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New data supports development of colchicine for the prevention of acute respiratory distress syndrome - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"This syndrome can develop in patients with COVID-19\u00a0if the virus enters the respiratory tract and damages the lungs MONTREAL, Dec. 03, 2020 (GLOBE NEWSWIRE) &#8212; TheMontreal Heart Institute (MHI) has announced that colchicine, a widely available low-cost drug, reduces acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and respiratory failure in pre-clinical models1. The article reporting these results was published yesterday by the Public Library of Science ONE (PLOS ONE) 1. \u201cThis study was designed and executed in the wake of the COVID-19 pandemic as there were no effective therapies at that time to prevent SARS-CoV-2 related lung injury and ARDS,\u201d said Dr. Jean-Claude Tardif, Director of the MHI Research Center, Professor of Medicine at the University of Montreal, &hellip; Continue reading &quot;New data supports development of colchicine for the prevention of acute respiratory distress syndrome&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-03T17:03:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5NjQyMCMzODU1MzU1IzUwMDA3MTQxMQ==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"New data supports development of colchicine for the prevention of acute respiratory distress syndrome\",\"datePublished\":\"2020-12-03T17:03:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/\"},\"wordCount\":488,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODA5NjQyMCMzODU1MzU1IzUwMDA3MTQxMQ==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/new-data-supports-development-of-colchicine-for-the-prevention-of-acute-respiratory-distress-syndrome\\\/\",\"name\":\"New data supports development of colchicine for the prevention of acute respiratory distress syndrome - 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