{"id":389666,"date":"2020-11-30T09:43:30","date_gmt":"2020-11-30T14:43:30","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=389666"},"modified":"2020-11-30T09:43:30","modified_gmt":"2020-11-30T14:43:30","slug":"gain-therapeutics-and-university-of-maryland-school-of-medicine-announce-research-collaboration","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/gain-therapeutics-and-university-of-maryland-school-of-medicine-announce-research-collaboration\/","title":{"rendered":"Gain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration"},"content":{"rendered":"

\nPartnership to investigate Gain\u2019s structurally targeted allosteric regulator candidates (STARs) in cellular models of Gaucher disease and Parkinson\u2019s disease
\n<\/h2>\n
\n

BETHESDA, Md. and BALTIMORE, Nov. 30, 2020 (GLOBE NEWSWIRE) — Gain Therapeutics, Inc. (\u201cGain\u201d), today announced a research collaboration with the University of Maryland School of Medicine (UMSOM), to investigate Gain\u2019s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease (nGD) and Parkinson\u2019s disease (PD). STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes. These small molecule drug candidates are designed to cross the blood brain barrier and penetrate other hard to treat organs such as bone and cartilage, stabilize the effective enzyme to restore function and reduce toxic substrate. Research will be led by Ricardo A. Feldman, Ph.D., Associate Professor, of Microbiology and Immunology in UMSOM.<\/p>\n

Under the terms of the collaboration, UMSOM will investigate Gain\u2019s STAR candidates in macrophage and neuronal models of nGD and GBA<\/em>-associated PD. These diseases are characterized by mutations in the GBA<\/em> gene, where misfolding of the enzyme encoded by GBA<\/em> (beta-glucocerebrosidase (GCase)) interferes with its normal transport to the lysosome. The research program will aim to further elucidate the mechanism of action of Gain\u2019s STAR candidates by studying their effect on GCase, including GCase\u2019s enzyme activity and transport to the lysosome. Additionally, other effects such as prevention of alpha-synuclein aggregation in PD dopaminergic neurons will be evaluated.<\/p>\n

\u201cWe are exceedingly proud to be advancing our work in nGD and Parkinson\u2019s in close collaboration with the University of Maryland School of Medicine,\u201d said Eric Richman, Chief Executive Officer at Gain. \u201cThe expertise and experience of UMSOM and Dr. Feldman will be instrumental as we work to further validate the exciting potential of Gain\u2019s STAR candidate for these devastating diseases. I am confident these foundational studies will bring us closer to a potential new treatment option for those with these disorders.\u201d<\/p>\n

Dr. Feldman added, \u201cOur laboratory has used human induced pluripotent stem cell (iPSC) models of GD and GBA<\/em>-associated PD to uncover the molecular mechanisms leading to these diseases. We have also developed very sensitive assays to evaluate the therapeutic efficacy of small molecules in reversing the phenotypic abnormalities caused by mutant GBA in the cell types affected by these diseases, including macrophages and neuronal cells. I have been impressed by Gain\u2019s initial results evaluating the potential of STARs in correcting enzyme misfolding and restoring function, and look forward to working with Gain\u2019s team to further advance its program to treat these diseases.\u201d<\/p>\n

Gain and UMSOM intend to report initial data from the collaboration in the first half of 2021.<\/p>\n

\n Ab<\/strong>
\n out <\/strong>
\n Gain Therapeutics<\/strong>
\n , Inc.<\/strong>
\n
Gain Therapeutics is redefining drug discovery with its SEE-Tx\u2122 target identification platform. By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding. Gain was originally established in 2017 with the support of its founders and institutional investors such as TiVenture, 3B Future Health Fund (previously known as Helsinn Investment Fund) and VitaTech. It has been awarded funding support from The Michael J. Fox Foundation for Parkinson\u2019s Research (MJFF) and The Silverstein Foundation for Parkinson\u2019s with GBA, as well as from the Eurostars-2 joint program with co-funding from the European Union Horizon 2020 research and Innosuisse. In July 2020, Gain Therapeutics, Inc. completed a share exchange with Gain Therapeutics, SA., a Swiss corporation, whereby GT Gain Therapeutics SA became a wholly owned subsidiary of Gain Therapeutics, Inc. For more information, visit https:\/\/www.gaintherapeutics.com\/<\/a>.<\/p>\n

\n Forward-Looking Statements<\/strong>
\n
Any statements in this release that are not historical facts may be considered to be \u201cforward-looking statements.\u201d Forward-looking statements are based on management\u2019s current expectations and are subject to risks and uncertainties which may cause results to differ materially and adversely from the statements contained herein. Such statements include, but are not limited to, statements regarding Gain Therapeutics, Inc. (Gain) expected use of the proceeds from the Series B financing round; the market opportunity for Gain\u2019s product candidates; and the business strategies and development plans of Gain. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include Gain\u2019s ability to: make commercially available its products and technologies in a timely manner or at all; enter into other strategic alliances, including arrangements for the development and distribution of its products; obtain intellectual property protection for its assets; accurately estimate its expenses and cash burn and raise additional funds when necessary. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made. Except as required by law, Gain does not undertake any obligation to update any forward-looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.<\/p>\n

\n Gain Therapeutics <\/strong>
\n Investor Contact:<\/strong>
\n
Daniel Ferry
LifeSci Advisors
+1 617-430-7576
daniel@lifesciadvisors.com<\/a><\/p>\n

\n Gain Therapeutics <\/strong>
\n Media Contact:<\/strong>
\n
Cait Williamson, Ph.D.
LifeSci Communications
+1 646-751-4366
cait@lifescicomms.com<\/a><\/p>\n

\n
\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

Partnership to investigate Gain\u2019s structurally targeted allosteric regulator candidates (STARs) in cellular models of Gaucher disease and Parkinson\u2019s disease BETHESDA, Md. and BALTIMORE, Nov. 30, 2020 (GLOBE NEWSWIRE) — Gain Therapeutics, Inc. (\u201cGain\u201d), today announced a research collaboration with the University of Maryland School of Medicine (UMSOM), to investigate Gain\u2019s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease (nGD) and Parkinson\u2019s disease (PD). STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes. These small molecule drug candidates are designed to cross the blood brain barrier and penetrate other hard to treat organs such as bone and cartilage, stabilize the effective enzyme to restore function and reduce toxic substrate. Research will be led by … <\/p>\n

Continue reading “Gain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-389666","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nGain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/gain-therapeutics-and-university-of-maryland-school-of-medicine-announce-research-collaboration\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"Partnership to investigate Gain\u2019s structurally targeted allosteric regulator candidates (STARs) in cellular models of Gaucher disease and Parkinson\u2019s disease BETHESDA, Md. and BALTIMORE, Nov. 30, 2020 (GLOBE NEWSWIRE) — Gain Therapeutics, Inc. (\u201cGain\u201d), today announced a research collaboration with the University of Maryland School of Medicine (UMSOM), to investigate Gain\u2019s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease (nGD) and Parkinson\u2019s disease (PD). STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes. These small molecule drug candidates are designed to cross the blood brain barrier and penetrate other hard to treat organs such as bone and cartilage, stabilize the effective enzyme to restore function and reduce toxic substrate. 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