{"id":388164,"date":"2020-11-24T17:03:03","date_gmt":"2020-11-24T22:03:03","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=388164"},"modified":"2020-11-24T17:03:03","modified_gmt":"2020-11-24T22:03:03","slug":"reata-provides-update-on-omaveloxolone-program-for-patients-with-friedreichs-ataxia","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/reata-provides-update-on-omaveloxolone-program-for-patients-with-friedreichs-ataxia\/","title":{"rendered":"Reata Provides Update on Omaveloxolone Program for Patients with Friedreich\u2019s Ataxia"},"content":{"rendered":"
\n

PLANO, Texas, Nov. 24, 2020 (GLOBE NEWSWIRE) — Reata Pharmaceuticals, Inc. (Nasdaq: RETA) (\u201cReata,\u201d the \u201cCompany,\u201d or \u201cwe\u201d), a clinical-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration (\u201cFDA\u201d) completed its internal review of the Baseline-Controlled Study results of omaveloxolone for the treatment of patients with Friedreich\u2019s ataxia (\u201cFA\u201d) and concluded that the results do not strengthen the results of Part 2 of the MOXIe study. The FDA proposed some additional exploratory analyses using patients randomized to placebo during the MOXIe Part 2 study, but stated that the potential for these analyses to strengthen the study results was questionable due to the small number of patients available for analysis. The FDA stated that they remain interested in reviewing the results of the additional exploratory analyses as those may inform the future development program.<\/p>\n

The Company plans to submit to the FDA the analyses that they proposed and to request a meeting with the FDA to discuss the development program. In addition, based on the FDA\u2019s conclusion, the Company is considering the next steps for the development program, including whether to conduct a second pivotal study in patients with FA.<\/p>\n

\u201cOmaveloxolone improved motor function as measured by the modified Friedreich\u2019s Ataxia Rating Scale in both Part 2 of the MOXIe study and the Baseline-Controlled study. We are grateful to the families, physicians, investigators, and advocates who have supported this program to date,\u201d said Warren Huff, Reata\u2019s Chairman and Chief Executive Officer. \u201cThough we are disappointed in the FDA\u2019s feedback on this program, we will carefully consider the potential paths forward for making omaveloxolone available to patients with FA.\u201d<\/p>\n

\n About Friedreich’s Ataxia<\/strong>\n <\/p>\n

FA is a rare, inherited, life-shortening, debilitating, and degenerative neuromuscular disorder, which is normally diagnosed during adolescence. FA is typically caused by a trinucleotide repeat expansion in the first intron of the frataxin gene, which encodes the mitochondrial protein frataxin. Pathogenic repeat expansions can lead to impaired transcription and reduced frataxin expression, which can lead to mitochondrial iron overload and poor cellular iron regulation, increased sensitivity to oxidative stress, and impaired mitochondrial ATP production. Patients with FA experience initial symptoms in childhood, including progressive loss of coordination, muscle weakness, and fatigue, commonly resulting in motor incapacitation, with patients requiring a wheelchair by their teens or early 20s. FA patients may also experience visual impairment, hearing loss, diabetes, and cardiomyopathy. Based on literature and proprietary research, we believe FA affects approximately 5,000 children and adults in the United States and 22,000 individuals globally. There are currently no approved therapies for the treatment of FA.<\/p>\n

\n About Omaveloxolone<\/strong>\n <\/p>\n

Omaveloxolone is an investigational, oral, once-daily activator of Nrf2, a transcription factor that induces molecular pathways that promote the resolution of inflammation by restoring mitochondrial function, reducing oxidative stress, and inhibiting pro-inflammatory signaling. The FDA has granted Orphan Drug designation to omaveloxolone for the treatment of Friedreich\u2019s ataxia. The European Commission has granted Orphan Drug designation in Europe to omaveloxolone for the treatment of Friedreich\u2019s ataxia. \u00a0<\/p>\n

\n About Reata Pharmaceuticals, Inc.<\/strong>\n <\/p>\n

Reata is a clinical-stage biopharmaceutical company that develops novel therapeutics for patients with serious or life-threatening diseases by targeting molecular pathways involved in the regulation of cellular metabolism and inflammation. Reata\u2019s two most advanced clinical candidates, bardoxolone methyl (\u201cbardoxolone\u201d) and omaveloxolone, target the important transcription factor Nrf2 that promotes the resolution of inflammation by restoring mitochondrial function, reducing oxidative stress, and inhibiting pro-inflammatory signaling.\u00a0\u00a0 Bardoxolone and omaveloxolone are investigational drugs, and their safety and efficacy have not been established by any agency.<\/strong><\/p>\n

\n Contact:<\/strong>
\n
Reata Pharmaceuticals, Inc.
(972) 865-2219
http:\/\/reatapharma.com<\/a><\/p>\n

\n Investor Relations <\/strong>
\n
Vinny Jindal (469) 374-8721<\/p>\n

\n ir@reatapharma.com<\/a>
\n
\n http:\/\/reatapharma.com\/contact-us\/<\/a>\n <\/p>\n

\n Forward-Looking Statements<\/strong>\n <\/p>\n

\n This press release includes certain disclosures that contain \u201cforward-looking statements,\u201d including, without limitation, statements regarding the success, cost and timing of our product development activities and clinical trials, our plans to research, develop and commercialize our product candidates, our plans to submit regulatory filings, and our ability to obtain and retain regulatory approval of our product candidates.<\/em>
\n You can identify forward-looking statements because they contain words such as \u201cbelieves,\u201d \u201cwill,\u201d \u201cmay,\u201d \u201caims,\u201d \u201cplans,\u201d \u201cmodel,\u201d and \u201cexpects.\u201d<\/em>\u00a0\u00a0 Forward-looking statements are based on Reata\u2019s current expectations and assumptions.<\/em> Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks, and changes in circumstances that may differ materially from those contemplated by the forward-looking statements, which are neither statements of historical fact nor guarantees or assurances of future performance. <\/em>Important factors that could cause actual results to differ materially from those in the forward-looking statements include, but are not limited to, (<\/em>i<\/em>) the timing, costs, conduct, and outcome <\/em>of our clinical trials and future preclinical studies and clinical trials, including the timing of the initiation and availability of data from such trials; (ii) the timing and likelihood of regulatory filings and approvals for our product candidates; (iii) whether regulatory authorities determine that additional trials or data are necessary in order to obtain approval; (iv) the potential market size and the size of the patient populations for our product candidates, if approved for commercial use, and the market opportunities for our product candidates; and (v) other factors set forth in Reata\u2019s filings with the U.S. Securities and Exchange Commission, including the detailed factors discussed under the caption \u201cRisk Factors\u201d in its Annual Report on Form 10-K for the fiscal year ended December 31, 2019.<\/em> The forward-looking statements speak only as of the date made and, other than as required by law, we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.<\/em><\/p>\n

\n
\n
\n \n <\/div>\n

<\/div>\n","protected":false},"excerpt":{"rendered":"

PLANO, Texas, Nov. 24, 2020 (GLOBE NEWSWIRE) — Reata Pharmaceuticals, Inc. (Nasdaq: RETA) (\u201cReata,\u201d the \u201cCompany,\u201d or \u201cwe\u201d), a clinical-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration (\u201cFDA\u201d) completed its internal review of the Baseline-Controlled Study results of omaveloxolone for the treatment of patients with Friedreich\u2019s ataxia (\u201cFA\u201d) and concluded that the results do not strengthen the results of Part 2 of the MOXIe study. The FDA proposed some additional exploratory analyses using patients randomized to placebo during the MOXIe Part 2 study, but stated that the potential for these analyses to strengthen the study results was questionable due to the small number of patients available for analysis. The FDA stated that they remain interested in … <\/p>\n

Continue reading “Reata Provides Update on Omaveloxolone Program for Patients with Friedreich\u2019s Ataxia”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-388164","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nReata Provides Update on Omaveloxolone Program for Patients with Friedreich\u2019s Ataxia - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/reata-provides-update-on-omaveloxolone-program-for-patients-with-friedreichs-ataxia\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reata Provides Update on Omaveloxolone Program for Patients with Friedreich\u2019s Ataxia - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PLANO, Texas, Nov. 24, 2020 (GLOBE NEWSWIRE) — Reata Pharmaceuticals, Inc. (Nasdaq: RETA) (\u201cReata,\u201d the \u201cCompany,\u201d or \u201cwe\u201d), a clinical-stage biopharmaceutical company, today announced that the U.S. Food and Drug Administration (\u201cFDA\u201d) completed its internal review of the Baseline-Controlled Study results of omaveloxolone for the treatment of patients with Friedreich\u2019s ataxia (\u201cFA\u201d) and concluded that the results do not strengthen the results of Part 2 of the MOXIe study. The FDA proposed some additional exploratory analyses using patients randomized to placebo during the MOXIe Part 2 study, but stated that the potential for these analyses to strengthen the study results was questionable due to the small number of patients available for analysis. 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