{"id":387029,"date":"2020-11-23T13:03:03","date_gmt":"2020-11-23T18:03:03","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=387029"},"modified":"2020-11-23T13:03:03","modified_gmt":"2020-11-23T18:03:03","slug":"constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/","title":{"rendered":"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting"},"content":{"rendered":"<div class=\"mw_release\">\n<p>CAMBRIDGE, Mass., Nov.  23, 2020  (GLOBE NEWSWIRE) &#8212; <a href=\"https:\/\/www.globenewswire.com\/Tracker?data=usQoiJQ-z28H_d2gSaRRXzbrabKb4moVEajspIQX3_TFUvxFxfvamubGxuWTkBZR89ONFx5dd3M_WHlanXBJhYpqWsD4rFYbk9_yl0-9L3oOLmNes_jLMWVFqqh8EO-H3khI_WHEpn82sIBNDvICNi7cyzaq6yBxt-HuyxAdYqmTvmBpIHHcJ8N6cGzBVuvSqOZzvJJ15lhClLzVGHNHd9FfGWjkHlFJH2h7q7V9_bJdr2qPSVoWVRwBmj6vynyu\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>Constellation<\/u><\/a>\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=E-SJbSTxhWyLVrzsn0LDbdk_Znm23ZercqJ-548MR4R3QhnJHFSfHarsdaVRhqmpy9D9q5gGO--suBqTuZJi4Bp9S1t1eU9x8zRu8IH6WxTjOc9kKdev8OdlWfYC9huOHJ7KIxARVHLebhmyplbunJEhCSkLQ91ftAM5-Ke2P0LosCVFxOzQFOG0HwzPJJRWNCXk7Gw3qE1HT8whYkYdV_5NJcwGReOlvrsSLDsklQ5mrMZcfTueqIP8WrfwGXHJ\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>Pharmaceuticals<\/u><\/a><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=NkqK4lmnlmtLThnakasHIL5e7JsU1K2Wqnde_MpztZto17V51slBMugu2shyJLCPyMoWS1G7qvBUygI9mgOxgNowX7TGomSutm7NKp7NIAQLp2Uz3XyDCk8xpov67GCo1Ep8Nnky_DzpF9K1n0c1binGDR_-FK_A-4yBlJag4H9TUryapPgB_03yJ-L_kTO0q6iZbgnu_LMgtXSjLg3KMA==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>,<\/u><\/a>\u00a0Inc. (Nasdaq: CNST), a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, will host a virtual analyst\/investor event and conference call on\u00a0December 7 at 8:00 AM EDT\u00a0to discuss the data from two oral presentations and two posters on the MANIFEST clinical trial for CPI-0610 being presented at the\u00a062nd American Society of Hematology (ASH) Annual Meeting and Exposition.<\/p>\n<p>The event will include:<\/p>\n<ul type=\"disc\">\n<li style=\"margin-top:5pt;margin-bottom:5pt\">a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50 \u2013 60 first-line and 90 \u2013100 second-line myelofibrosis patients, and<\/li>\n<li style=\"margin-bottom:8pt\">a physician panel discussion and question-and-answer session with Dr. John\u00a0Mascarenhas, Associate Professor of Medicine\u202fat the Icahn School of Medicine at Mount Sinai- New York and Dr. Serge\u00a0Verstovsek,\u00a0Professor of Medicine\u00a0at\u00a0University of Texas MD Anderson Cancer Center.\u00a0<\/li>\n<\/ul>\n<p>This event will be webcast live and can be accessed on the Investor Relations section of Constellation\u2019s website at\u00a0<a href=\"https:\/\/www.globenewswire.com\/Tracker?data=2xaMHCc5DaWRsciHWWAgVkPjIxXQDgZRUGEoLGcpwM5n_Y3D3T0u7e1U3RkC7-DPwJQ0qD-aQNG0LKuv_LdNqOANysqq1_3ED-FPlQig22O56_LrxtXrYp1QJI7ozWGl0OvfdVQmlBpalS7_ztEUliPDUSFOF638oloP5mmw-ndfPe81srXlSU7UaUA8u07CL71596u7MN-JB5RUcSe2nSbv3JS8tazDKQ1R9tgydtGxJSCS5g6J37ZSPPVRAEQpoYCtRBJEpwUCQsFZfrpwriYSBiyKBOFf1QpHqLpujqM-JYs26CsTIGhg0Ar8FXzzWGYaI7Z_ukwRk4owtTP66xgKkK_4WY-zyZPf3Gg_hrUnBGPKlF7S6xC0YNdoi7tYKF6q9fMnCaWjKPAaZzuBRWd1mVcxSvU_l8IysrAuue_4RCAHvPuuqIaRB-iWUgaskL89X9XFDx-CkYjuvU8n3w==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>http:\/\/ir.constellationpharma.com\/events-and-presentations\/events<\/u><\/a>.\u00a0 To participate in the live question-and-answer session, please dial (877) 473-2077 (domestic) or (661) 378-9662 (international) and refer to conference ID 7164095.<\/p>\n<p>\n        <strong>About MANIFEST<\/strong>\n      <\/p>\n<p>MANIFEST is an open-label Phase 2 clinical trial of CPI-0610 in patients with myelofibrosis (MF), a rare cancer of the bone marrow that disrupts the body\u2019s normal production of blood cells. Constellation is evaluating CPI-0610 in combination with ruxolitinib in JAK-inhibitor-na\u00efve MF patients (Arm 3), with a primary endpoint of the proportion of patients with a \u226535% spleen volume reduction from baseline (SVR35) after 24 weeks of treatment. Constellation is also evaluating CPI-0610, either as a monotherapy in patients who are resistant to, intolerant of, or ineligible for ruxolitinib and no longer on the drug (Arm 1), or as add-on therapy in combination with ruxolitinib in patients with a sub-optimal response to ruxolitinib or MF progression (Arm 2). Patients in Arms 1 and 2 are being stratified based on Transfusion Dependence (TD) status. The primary endpoint for the patients in cohorts 1A and 2A, who were TD at baseline, is conversion to Transfusion Independence for 12 consecutive weeks. The primary endpoint for the patients in cohorts 1B and 2B, who were not TD at baseline, is the proportion of patients with a \u226535% spleen volume reduction from baseline after 24 weeks of treatment.<\/p>\n<p>\n        <strong>About\u00a0Constellation Pharmaceuticals<\/strong><br \/>\n        <br \/>Constellation Pharmaceuticals\u00a0is a clinical-stage biopharmaceutical company developing novel therapeutics that selectively modulate gene expression to address serious unmet medical needs in patients with cancer.\u00a0 The Company has a deep understanding of how epigenetic and chromatin modifications in cancer cells and in the tumor and immune microenvironment play a fundamental role in driving disease progression and drug resistance. Constellation is driving development of the\u00a0BET\u00a0inhibitor CPI-0610 for the treatment of myelofibrosis as well as the EZH2 inhibitor CPI-0209 for the treatment of solid tumors.\u00a0 The Company is also applying its broad research and development capabilities to explore other novel targets that directly and indirectly impact gene expression to fuel a sustainable pipeline of innovative small-molecule product candidates.\u00a0<\/p>\n<p>\n        <strong>Contact<\/strong><br \/>\n        <strong>s<\/strong>\n      <\/p>\n<p>Kia Khaleghpour, PhD<br \/>Vice President, Investor Relations and Communications<br \/>Constellation Pharmaceuticals<br \/>+1 617-844-6859<br \/><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=BaGK3gLTxOw6XSKvpEE1CG-PBQvRWo9YY2kv9JXbgbWTDBbYaTILdySxJFudi8AcW4YShh6yBNSooNf1B_lAA-M9u06Q3dwwMojj10z7XNf6CwS3Y_SsaoticIgh_pSh6z0LxSHByCNtqlG0vU0jVQt8k1Pm84wLLh9t0byG8WpS2M-I0kEr7nCgnaHH9J50Z7NpKRCa6JMOMMCRr0C-IwBQt3YdCOJzvFVOWgBhETD0Mi-ELgfG7NmO5_OaDgxwDUr6aHt67wSdjabm99OcuH0quP7Yn9sdadzRIuZULSvpVBaNH3mpmG66Ol-uSOKP3W1S5zG__ybysymoZH8BAg==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>kia.khaleghpour@constellationpharma.com<\/u><\/a><\/p>\n<p>Lauren Arnold<br \/>Media Relations<br \/>MacDougall Biomedical Communications<br \/>+1 781-235-3060<br \/><u><a href=\"https:\/\/www.globenewswire.com\/Tracker?data=eR96ff_Mz2R7qrq4e8dQKnmJCtsyTLnh4ANEA9cQh4PXUSS12Xut0liyjnab_3qtyOJ05nCJyK2E439ZO3jdh7s1qNlQGUjDEwuCwBYcKD4NlcB91oumfK9Um33mbf8u_07Dhj6bO0u9xQY2bD4Xa75oiOS19pwqtDxLFsF9WosYCTeYKemHKfwXz38zaEo8aRAIY_EzIX5PpqEpwW3kC6yaXrNdWDuPVkb_w8PlQZnRCsIvHWqBSoueeTyAKrWyBIuaIuqUibMJRYrQTl2zgQ==\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">larnold@macbiocom.com<\/a><\/u><\/p>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5MDkxMCMzODQwMzY2IzIxMjA4NjA=\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml.globenewswire.com\/release\/track\/90288b49-18ad-4ff4-a38f-20331cd9286d\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>CAMBRIDGE, Mass., Nov. 23, 2020 (GLOBE NEWSWIRE) &#8212; Constellation\u00a0Pharmaceuticals,\u00a0Inc. (Nasdaq: CNST), a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, will host a virtual analyst\/investor event and conference call on\u00a0December 7 at 8:00 AM EDT\u00a0to discuss the data from two oral presentations and two posters on the MANIFEST clinical trial for CPI-0610 being presented at the\u00a062nd American Society of Hematology (ASH) Annual Meeting and Exposition. The event will include: a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50 \u2013 60 first-line and 90 \u2013100 second-line myelofibrosis patients, and a physician panel discussion and question-and-answer session with Dr. John\u00a0Mascarenhas, Associate Professor of Medicine\u202fat the Icahn School &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-387029","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"CAMBRIDGE, Mass., Nov. 23, 2020 (GLOBE NEWSWIRE) &#8212; Constellation\u00a0Pharmaceuticals,\u00a0Inc. (Nasdaq: CNST), a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, will host a virtual analyst\/investor event and conference call on\u00a0December 7 at 8:00 AM EDT\u00a0to discuss the data from two oral presentations and two posters on the MANIFEST clinical trial for CPI-0610 being presented at the\u00a062nd American Society of Hematology (ASH) Annual Meeting and Exposition. The event will include: a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50 \u2013 60 first-line and 90 \u2013100 second-line myelofibrosis patients, and a physician panel discussion and question-and-answer session with Dr. John\u00a0Mascarenhas, Associate Professor of Medicine\u202fat the Icahn School &hellip; Continue reading &quot;Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-23T18:03:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5MDkxMCMzODQwMzY2IzIxMjA4NjA=\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Constellation Pharmaceuticals to Host Analyst \\\/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting\",\"datePublished\":\"2020-11-23T18:03:03+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/\"},\"wordCount\":540,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=ODA5MDkxMCMzODQwMzY2IzIxMjA4NjA=\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\\\/\",\"name\":\"Constellation Pharmaceuticals to Host Analyst \\\/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/","og_locale":"en_US","og_type":"article","og_title":"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting - Market Newsdesk","og_description":"CAMBRIDGE, Mass., Nov. 23, 2020 (GLOBE NEWSWIRE) &#8212; Constellation\u00a0Pharmaceuticals,\u00a0Inc. (Nasdaq: CNST), a clinical-stage biopharmaceutical company using its expertise in epigenetics to discover and develop novel therapeutics, will host a virtual analyst\/investor event and conference call on\u00a0December 7 at 8:00 AM EDT\u00a0to discuss the data from two oral presentations and two posters on the MANIFEST clinical trial for CPI-0610 being presented at the\u00a062nd American Society of Hematology (ASH) Annual Meeting and Exposition. The event will include: a review of the clinical and translational data from MANIFEST presented during ASH, including 24-week data from 50 \u2013 60 first-line and 90 \u2013100 second-line myelofibrosis patients, and a physician panel discussion and question-and-answer session with Dr. John\u00a0Mascarenhas, Associate Professor of Medicine\u202fat the Icahn School &hellip; Continue reading \"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/","og_site_name":"Market Newsdesk","article_published_time":"2020-11-23T18:03:03+00:00","og_image":[{"url":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5MDkxMCMzODQwMzY2IzIxMjA4NjA=","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting","datePublished":"2020-11-23T18:03:03+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/"},"wordCount":540,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/#primaryimage"},"thumbnailUrl":"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=ODA5MDkxMCMzODQwMzY2IzIxMjA4NjA=","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/constellation-pharmaceuticals-to-host-analyst-investor-event-to-discuss-update-of-manifest-clinical-trial-for-cpi-0610-presented-at-ash-meeting\/","name":"Constellation Pharmaceuticals to Host Analyst \/ Investor Event to Discuss Update of MANIFEST Clinical Trial for CPI-0610 Presented at ASH Meeting - 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