{"id":386583,"date":"2020-11-23T07:33:33","date_gmt":"2020-11-23T12:33:33","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=386583"},"modified":"2020-11-23T07:33:33","modified_gmt":"2020-11-23T12:33:33","slug":"amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/","title":{"rendered":"Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics"},"content":{"rendered":"
\n

PR Newswire<\/p>\n<\/p><\/div>\n

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\n THOUSAND OAKS, Calif.<\/span>, Nov. 23, 2020<\/span> \/PRNewswire\/ — Amgen (NASDAQ:AMGN) today announced the Company has provided notice to Cytokinetics of termination of its collaboration and its intention to transition the development and commercialization rights for omecamtiv mecarbil and AMG 594. Omecamtiv mecarbil, an investigational selective cardiac myosin activator, was studied in GALACTIC-HF, a Phase 3\u00a0clinical trial in patients with chronic heart failure with reduced ejection fraction (HFrEF), and AMG 594, a novel mechanism selective cardiac troponin activator, is in Phase 1 development for HFrEF and other types of heart failure. <\/p>\n

Primary results of GALACTIC-HF were recently presented at\u00a0the American Heart Association Scientific Sessions and simultaneously published in the New England Journal of Medicine<\/i>. The trial demonstrated a statistically significant effect of treatment with omecamtiv mecarbil to reduce risk of the primary composite endpoint of cardiovascular (CV) death or heart failure events (heart failure hospitalization and other urgent treatment for heart failure) compared to placebo in patients treated with standard of care. No reduction in the secondary endpoint of time to CV death was observed. <\/p>\n

“Cardiovascular disease is one of the most significant public health issues in the world which means patients need more innovation, not less. Our commitment to cardiovascular disease remains steadfast, and we look forward to continuing to work closely with the cardiovascular community as we focus on advancing our innovative therapies, including our Lp(a) inhibitor olpasiran\u00a0(AMG 890), which is currently in Phase 2,” said David\u00a0M. Reese, M.D., executive vice president of Research and Development at\u00a0Amgen.\u00a0“We are grateful to the investigators and patients who participated in GALACTIC-HF. Unfortunately, the results of GALACTIC-HF did not meet the high bar we had set for the program.”<\/p>\n

Amgen thanks Cytokinetics and Servier for their productive collaboration over many years, and will work closely with them to facilitate a smooth transition of omecamtiv mecarbil. Servier provides funding and strategic support for the program. <\/p>\n

\n About Amgen<\/b>
\n \u00a0
<\/b>Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.\u00a0\u00a0<\/p>\n

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be\u00a0one of\u00a0the world’s\u00a0leading\u00a0independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.\u00a0\u00a0<\/p>\n

For more information, visit\u00a0www.amgen.com<\/a>\u00a0and follow us on\u00a0www.twitter.com\/amgen<\/a>.\u00a0\u00a0<\/p>\n

\n Amgen Forward-Looking Statements
<\/b>This news release contains forward-looking statements that are based on the current expectations and beliefs of\u00a0Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company, including BeiGene, Ltd. or any collaboration or potential collaboration in pursuit \u00a0of \u00a0therapeutic antibodies against COVID-19 (including statements regarding such collaboration’s, or\u00a0Amgen’s, ability to discover and develop fully-human neutralizing antibodies targeting SARS-CoV-2 or antibodies against targets other than the SARS-CoV-2 receptor binding domain, and\/or to produce any such antibodies to potentially prevent or treat COVID-19), or the Otezla\u00ae (apremilast) acquisition (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems such as the ongoing COVID-19 pandemic on\u00a0Amgen’s business, outcomes, progress, or effects relating to studies of Otezla as a potential \u00a0treatment \u00a0for \u00a0COVID-19, and \u00a0other \u00a0such \u00a0estimates \u00a0and \u00a0results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the\u00a0Securities and Exchange Commission\u00a0reports filed by\u00a0Amgen, including its most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted,\u00a0Amgen\u00a0is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise.<\/p>\n

No forward-looking statement can be guaranteed and actual results may differ materially from those\u00a0Amgen\u00a0projects. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. The complexity of the human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The length of time that it takes for\u00a0Amgen\u00a0to complete clinical trials and obtain regulatory approval for product marketing has in the past varied and\u00a0Amgen\u00a0expects similar variability in the future. Even when clinical trials are successful, regulatory authorities may question the sufficiency for approval of the trial endpoints\u00a0Amgen\u00a0has selected.\u00a0Amgen\u00a0develops product candidates internally and through licensing collaborations, partnerships and joint ventures. Product candidates that are derived from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as\u00a0Amgen\u00a0may have believed at the time of entering into such relationship. Also,\u00a0Amgen\u00a0or others could identify safety, side effects or manufacturing problems with its products, including its devices, after they are on the market.<\/p>\n

Amgen’s results may be affected by its ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing its products and global economic conditions. In addition, sales of\u00a0Amgen’s products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore,\u00a0Amgen’s research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities.\u00a0Amgen’s business may be impacted by government investigations, litigation and product liability claims. In addition,\u00a0Amgen’s business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If\u00a0Amgen\u00a0fails to meet the compliance obligations in the corporate integrity agreement between\u00a0Amgen\u00a0and the\u00a0U.S.\u00a0government,\u00a0Amgen\u00a0could become subject to significant sanctions. Further, while\u00a0Amgen\u00a0routinely obtains patents for its products and technology, the protection offered by its patents and patent applications may be challenged, invalidated or circumvented by its competitors, or\u00a0Amgen\u00a0may fail to prevail in present and future intellectual property litigation.\u00a0Amgen\u00a0performs a substantial amount of its commercial manufacturing activities at a few key facilities, including in\u00a0Puerto Rico, and also depends on third parties for a portion of its manufacturing activities, and limits on supply may constrain sales of certain of its current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials \u00a0for\u00a0Amgen’s manufacturing \u00a0activities, \u00a0the \u00a0distribution \u00a0of\u00a0Amgen’s products, \u00a0the commercialization of\u00a0Amgen’s product candidates, and\u00a0Amgen’s clinical trial operations, and any such events may have a material adverse effect on\u00a0Amgen’s product development, product sales, business and results of operations.\u00a0Amgen\u00a0relies on collaborations with third parties for the development of some of its product candidates and for the commercialization and sales of some of its commercial products. In addition,\u00a0Amgen\u00a0competes with other companies with respect to many of its marketed products as well as for the discovery and development of new products. Further, some raw materials, medical devices and component parts for\u00a0Amgen’s products are supplied by sole third-party suppliers. Certain of\u00a0Amgen’s distributors, customers and payers have substantial purchasing leverage in their dealings with\u00a0Amgen. The discovery of significant problems with a product similar to one of\u00a0Amgen’s products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on its business and results of operations.\u00a0Amgen’s efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology\u00a0Amgen\u00a0has acquired, may not be successful. A breakdown, cyberattack or information security breach could compromise the confidentiality, integrity and availability of\u00a0Amgen’s systems and\u00a0Amgen’s data.\u00a0Amgen’s stock price may be volatile and may be affected by a number of events.\u00a0Amgen’s business performance could affect or limit the ability of the\u00a0Amgen\u00a0Board of Directors to declare a dividend or its ability to pay a dividend or repurchase its common stock.\u00a0Amgen\u00a0may not be able to access the capital and credit markets on terms that are favorable to it, or at all.<\/p>\n

The scientific information discussed in this news release related to\u00a0Amgen’s product candidates is preliminary and investigative. Such product candidates are not approved by the\u00a0U.S. Food and Drug Administration, and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates.<\/p>\n

Further, any scientific information discussed in this news release relating to new indications for\u00a0Amgen’s products is preliminary and investigative and is not part of the labeling approved by the\u00a0U.S. Food and Drug Administration\u00a0for the products. The products are not approved for the investigational use(s) discussed in this news release, and no conclusions can or should be drawn regarding the safety or effectiveness of the products for these uses.\u00a0<\/p>\n

CONTACT: Amgen, Thousand Oaks\u00a0
Jessica Akopyan<\/span>, 805-447-0974 (media)
Trish Rowland<\/span>, 805-447-5631(media)\u00a0
Arvind Sood<\/span>, 805-447-1060 (investors)\u00a0<\/p>\n

\n

\n
\n \"Amgen
\n <\/a>\n <\/p>\n<\/p><\/div>\n

\u00a0<\/p>\n

<\/div>\n

\n \"Cision\" View original content to download multimedia:http:\/\/www.prnewswire.com\/news-releases\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics-301178604.html<\/a><\/p>\n

SOURCE Amgen<\/p>\n<\/p><\/div>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

PR Newswire THOUSAND OAKS, Calif., Nov. 23, 2020 \/PRNewswire\/ — Amgen (NASDAQ:AMGN) today announced the Company has provided notice to Cytokinetics of termination of its collaboration and its intention to transition the development and commercialization rights for omecamtiv mecarbil and AMG 594. Omecamtiv mecarbil, an investigational selective cardiac myosin activator, was studied in GALACTIC-HF, a Phase 3\u00a0clinical trial in patients with chronic heart failure with reduced ejection fraction (HFrEF), and AMG 594, a novel mechanism selective cardiac troponin activator, is in Phase 1 development for HFrEF and other types of heart failure. Primary results of GALACTIC-HF were recently presented at\u00a0the American Heart Association Scientific Sessions and simultaneously published in the New England Journal of Medicine. The trial demonstrated a statistically … <\/p>\n

Continue reading “Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-386583","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nAmgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"PR Newswire THOUSAND OAKS, Calif., Nov. 23, 2020 \/PRNewswire\/ — Amgen (NASDAQ:AMGN) today announced the Company has provided notice to Cytokinetics of termination of its collaboration and its intention to transition the development and commercialization rights for omecamtiv mecarbil and AMG 594. 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Omecamtiv mecarbil, an investigational selective cardiac myosin activator, was studied in GALACTIC-HF, a Phase 3\u00a0clinical trial in patients with chronic heart failure with reduced ejection fraction (HFrEF), and AMG 594, a novel mechanism selective cardiac troponin activator, is in Phase 1 development for HFrEF and other types of heart failure. Primary results of GALACTIC-HF were recently presented at\u00a0the American Heart Association Scientific Sessions and simultaneously published in the New England Journal of Medicine. The trial demonstrated a statistically … Continue reading \"Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/","og_site_name":"Market Newsdesk","article_published_time":"2020-11-23T12:33:33+00:00","og_image":[{"url":"https:\/\/mma.prnewswire.com\/media\/152881\/amgen_logo.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"9 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics","datePublished":"2020-11-23T12:33:33+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/"},"wordCount":1741,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/#primaryimage"},"thumbnailUrl":"https:\/\/mma.prnewswire.com\/media\/152881\/amgen_logo.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/amgen-to-transition-development-and-commercial-rights-for-omecamtiv-mecarbil-and-amg-594-to-cytokinetics\/","name":"Amgen To Transition Development And Commercial Rights For Omecamtiv Mecarbil And AMG 594 To Cytokinetics - 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