{"id":385091,"date":"2020-11-19T09:03:14","date_gmt":"2020-11-19T14:03:14","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=385091"},"modified":"2020-11-19T09:03:14","modified_gmt":"2020-11-19T14:03:14","slug":"durable-responses-with-adp-a2m4-in-synovial-sarcoma-with-confirmed-responses-in-44-of-patients-and-disease-control-rate-of-94-presented-at-ctos","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/durable-responses-with-adp-a2m4-in-synovial-sarcoma-with-confirmed-responses-in-44-of-patients-and-disease-control-rate-of-94-presented-at-ctos\/","title":{"rendered":"Durable Responses with ADP-A2M4 in Synovial Sarcoma with Confirmed Responses in 44% of Patients and Disease Control Rate of 94% Presented at CTOS"},"content":{"rendered":"
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– Data support confidence in SPEARHEAD-1 as a registrational trial –<\/p>\n

– Projected to complete recruitment of all patients in Q1\u00a02021 –<\/p>\n

– Median duration of response was 28 weeks with ongoing responses beyond 72\u00a0weeks in two patients; median overall survival has not been reached \u2013<\/p>\n

PHILADELPHIA and OXFORDSHIRE, United Kingdom, Nov. 19, 2020 (GLOBE NEWSWIRE) — Adaptimmune Therapeutics plc (Nasdaq: ADAP), a leader in cell therapy to treat cancer, presented durability of response data from patients with synovial sarcoma from the Phase 1 ADP-A2M4 trial at the virtual Connective Tissue Oncology Society (CTOS) annual meeting. The oral presentation given by Dr. Brian Van Tine of the Washington University School of Medicine is available on-demand for congress attendees. Dr. Van Tine will also participate in a \u201clive stream\u201d session entitled – Immunotherapy in Sarcoma: Alveolar Soft Part Sarcoma, Clear Cell Sarcoma, Synovial Sarcoma (Proffered Papers Panel Discussion) scheduled for 9 AM EST today (November 19).<\/p>\n

\u201cThe impact on patients treated with ADP-A2M4 is transformative, as they benefit from a durable response from a single treatment. This leads to the highest quality of life I have been able to provide patients with synovial sarcoma after treatment,\u201d said Dr. Brian Van Tine, Associate Professor of Medicine, Division of Oncology, Section of Medical Oncology, Washington University School of Medicine.<\/p>\n

\u201cData from this trial have enabled rapid execution of our pivotal trial, SPEARHEAD-1, and support our aim to commercialize ADP-A2M4 as the first engineered TCR T-cell product in the US in 2022,\u201d said Adrian Rawcliffe, Adaptimmune\u2019s Chief Executive Officer. \u201cHowever, this is only the beginning of the tremendous potential of our products targeting MAGEA4. We will rapidly pursue additional indications, starting with the Phase 2 trial in gastroesophageal cancers with ADP-A2M4CD8 expected to initiate in the first half of 2021.\u201d<\/p>\n

Data presented at CTOS were updated durability of response and safety data from the 16\u00a0patients with synovial sarcoma who were treated in the Phase 1 ADP-A2M4 trial, presented earlier this year at ASCO. The data cut-off for this presentation was September 1, 2020 and results are summarized below:<\/p>\n