{"id":384300,"date":"2020-11-18T13:15:17","date_gmt":"2020-11-18T18:15:17","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=384300"},"modified":"2020-11-18T13:15:17","modified_gmt":"2020-11-18T18:15:17","slug":"european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\/","title":{"rendered":"European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older"},"content":{"rendered":"<div class=\"mw_release\">\n<p>\n        <strong>European Commission approves Supemtek<\/strong><br \/>\n        <strong><br \/>\n          <sup>\u00ae<\/sup><br \/>\n        <\/strong><br \/>\n        <strong> (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older<\/strong>\n      <\/p>\n<ul type=\"disc\">\n<li>First and only recombinant influenza vaccine approved in the European Union<\/li>\n<li>Contains three times more antigen than standard-dose vaccines <\/li>\n<li>Phase 3 efficacy trial demonstrated improved protection against influenza compared to standard-dose influenza vaccine, and reduced the risk of influenza by an additional 30% in adults aged 50 years and older<sup>1,2<\/sup><\/li>\n<\/ul>\n<p align=\"justify\">\n        <strong>PARIS \u2013 November 18, 2020<\/strong> \u2013 The European Commission has granted a marketing authorization for Supemtek<sup>\u00ae<\/sup>, a quadrivalent (four-strain) recombinant influenza vaccine, for the prevention of influenza in adults aged 18 years and older. Supemtek is the first and only recombinant influenza vaccine now approved in the European Union. <\/p>\n<p align=\"justify\">Supemtek is produced using recombinant technology, which allows an exact match to the key component of the influenza strains recommended by the World Health Organization, avoiding the risk of viral mutations. Supemtek also contains three times more antigen than both egg-based and cell-based standard-dose vaccines. This increased amount of antigen and the use of recombinant technology provide improved protection against influenza, particularly in those aged 50 and older. In comparison with a standard-dose egg-based quadrivalent influenza vaccine, Supemtek reduced the risk of influenza by an additional 30% for adults aged 50 years and older<sup>1,2<\/sup>.<\/p>\n<p align=\"justify\">The authorization is based on clinical data demonstrating safety, immunogenicity and efficacy of Supemtek in two Phase 3 randomized controlled trials<sup>1<\/sup><sup>,<\/sup><sup>2<\/sup> involving more than 10,000 patients in total. Specifically, the relative efficacy of Supemtek was demonstrated in a Phase 3 multicenter (40 outpatient centers in the US, involving more than 9,000 adults), randomized controlled efficacy trial<sup>1,2<\/sup>.<\/p>\n<p align=\"justify\">\n        <em>\u201cIn the context of the COVID-19 pandemic, preventing influenza remains a public health priority,\u201d <\/em>said Thomas Triomphe, Head of Sanofi Pasteur.<em> \u201cToday\u2019s approval of Supemtek supports our strong commitment in advancing influenza vaccine technology. With Supemtek, we provide European health authorities with an additional innovative solution that has demonstrated increased ability to prevent influenza and its potentially severe complications, as well as the burden this causes on healthcare systems.\u201d<\/em><\/p>\n<p align=\"justify\">Each year, influenza-associated deaths range from 290,000 to 650,000<sup>3<\/sup><sup>,<\/sup><sup>4<\/sup> globally, and the burden on hospitals is around 10 million of influenza-related hospitalizations<sup>5<\/sup>. Recent data also show that influenza can multiply the risk of heart attack by up to 10 times, and the risk of stroke by up to 8 times, in the week after influenza infection<sup>6<\/sup> \u2013 demonstrating that the burden of influenza goes beyond its well-known respiratory complications.<\/p>\n<p align=\"justify\">The first European launches are expected for the 2022\/2023 influenza season, with a possibility of accelerating the availability of doses as early as the 2021\/2022 season in certain countries. Outside of the EU, Supemtek is also approved in the U.S. under the tradename Flublok Quadrivalent<sup>\u00ae<\/sup>.<br \/><em><br \/><\/em><strong>About the recombinant technology<\/strong><\/p>\n<p align=\"justify\">The recombinant technology is a new way of producing influenza vaccines which differs significantly from the two other technologies currently in use (egg-based and cell-based technologies) as it avoids the risk of viral mutations that can lower vaccine efficacy. It ensures the exact match to the key component of the influenza strains recommended by the World Health Organization every year for producing influenza vaccines.<\/p>\n<p align=\"justify\">In an independent systematic review<sup>7<\/sup> published in October 2020, the European Center for Disease Prevention notes that \u201cthe recombinant haemagglutinin was found to provide a greater protective effect against overall influenza compared with no vaccination and with traditional influenza vaccination [\u2026] this effect may be attributable to either the restriction of mutations seen with egg-based vaccines or the higher dose of antigen seen in this type of influenza vaccine\u201d.<\/p>\n<p align=\"justify\">The recombinant technology is also used for the development of one of Sanofi\u2019s vaccines against COVID-19, developed in partnership with GSK and with the support of US Biomedical Advanced Research and Development Authority (BARDA). The Companies announced the start of the Phase 1\/2 clinical trial for their adjuvanted recombinant COVID-19 vaccine candidate in September and anticipate first results in December 2020, to support the initiation of a pivotal Phase 3 study before the end of the year. If these data are sufficient for licensure application, Sanofi and GSK plan to request regulatory approval in the first half of 2021. <\/p>\n<p align=\"justify\">\n        <strong>Increased production of seasonal influenza vaccines in the unique context of the COVID-19 pandemic <\/strong>\n      <\/p>\n<p align=\"justify\">As the leading manufacturer of influenza vaccines, Sanofi Pasteur, the vaccines global business unit of Sanofi, is supporting health authorities in their efforts to strengthen influenza vaccination campaigns in the unique context of COVID-19. For the 2020\/2021 influenza season, the Company is delivering globally 20% more doses of flu vaccines, reaching an unprecedented production level of 250 million doses, across its influenza vaccine portfolio which includes a wide range of vaccines (standard doses and differentiated vaccines) that are proven to protect people of all ages from the risks of influenza. <\/p>\n<table style=\"border-collapse: collapse;width:100%;border-collapse:collapse\">\n<tr>\n<td colspan=\"2\" style=\"width:100%;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top\"> \u00a0<\/p>\n<p><strong>About Sanofi<\/strong><\/p>\n<p> \u00a0<\/p>\n<p> Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions.<\/p>\n<p> \u00a0<\/p>\n<p> With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.<\/p>\n<p> \u00a0<\/p>\n<p> Sanofi, Empowering Life<\/p>\n<p> \u00a0 <\/td>\n<\/tr>\n<tr>\n<td style=\"width:50%;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: middle;text-align: left;padding-left: 20.0px;vertical-align: top\">\n            <br \/>\n            <strong>Media Relations Contact<\/strong><br \/>\n            <br \/> Nicolas Kressmann<br \/> Tel.: +1 (732) 532-5318<br \/><a href=\"mailto:Nicolas.Kressmann@sanofi.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>Nicolas.Kressmann@sanofi.com<\/u><br \/><\/a><\/p>\n<p> \u00a0 <\/td>\n<td style=\"width:50%;vertical-align: top\"> \u00a0<\/p>\n<p><strong>Investor Relations Contacts Paris<\/strong><br \/> Eva Schaefer-Jansen<br \/> Arnaud Delepine<br \/>Yvonne Naughton<\/p>\n<p>  \u00a0<\/p>\n<p><strong>Investor Relations Contacts North America<\/strong><br \/> Felix Lauscher<br \/>Fara Berkowitz<br \/>Suzanne Greco<\/p>\n<p>   \u00a0<\/p>\n<p> IR main line:<br \/>Tel.: +33 (0)1 53 77 45 45<br \/><a href=\"mailto:investor.relations@sanofi.com\" rel=\"nofollow noopener noreferrer\" target=\"_blank\"><u>investor.relations@sanofi.com<\/u><\/a><\/p>\n<p>  \u00a0<\/p>\n<p> \u00a0 <\/td>\n<\/tr>\n<tr>\n<td colspan=\"2\" style=\"width:100%;text-align: justify;vertical-align: middle;text-align: justify;vertical-align: middle;text-align: justify;vertical-align: middle;vertical-align: top;text-align: justify;vertical-align: middle\">\n            <strong><br \/>\n              <em>Sanofi Forward-Looking Statements<\/em><br \/>\n            <\/strong><br \/>\n            <br \/>\n            <em>This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements include projections and estimates regarding the marketing and other potential of the product, or regarding potential future revenues from the product. Forward-looking statements are generally identified by the words \u201cexpects\u201d, \u201canticipates\u201d, \u201cbelieves\u201d, \u201cintends\u201d, \u201cestimates\u201d, \u201cplans\u201d and similar expressions. Although Sanofi\u2019s management believes that the expectations reflected in such forward-looking statements are reasonable, investors are cautioned that forward-looking information and statements are subject to various risks and uncertainties, many of which are difficult to predict and generally beyond the control of Sanofi, that could cause actual results and developments to differ materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, unexpected regulatory actions or delays, or government regulation generally, that could affect the availability or commercial potential of the product, the fact that product may not be commercially successful, the uncertainties inherent in research and development, including future clinical data and analysis of existing clinical data relating to the product, including post marketing, unexpected safety, quality or manufacturing issues, competition in general, risks associated with intellectual property and any related future litigation and the ultimate outcome of such litigation, and volatile economic and market conditions, and the impact that COVID-19 will have on us, our customers, suppliers, vendors, and other business partners, and the financial condition of any one of them, as well as on our employees and on the global economy as a whole.\u00a0 Any material effect of COVID-19 on any of the foregoing could also adversely impact us. This situation is changing rapidly and additional impacts may arise of which we are not currently aware and may exacerbate other previously identified risks. The risks and uncertainties also include the uncertainties discussed or identified in the public filings with the SEC and the AMF made by Sanofi, including those listed under \u201cRisk Factors\u201d and \u201cCautionary Statement Regarding Forward-Looking Statements\u201d in Sanofi\u2019s annual report on Form 20-F for the year ended December 31, 2019. Other than as required by applicable law, Sanofi does not undertake any obligation to update or revise any forward-looking information or statements.<\/em><\/p>\n<p>  \u00a0 <\/td>\n<\/tr>\n<\/table>\n<p>\n        \n      <\/p>\n<hr \/>\n<p>\n        <br \/>\u00a0<\/p>\n<p>\n        <sup>1<\/sup><br \/>\n        <em><br \/>\n          <u><br \/>\n            <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28636855\/\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Dunkle LM, Izikson R, Patriarca P, et al. 2017<\/a><br \/>\n          <\/u><br \/>\n        <\/em><br \/>\n        <br \/>\n        <sup>2<\/sup><br \/>\n        <em><br \/>\n          <u><br \/>\n            <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28968871\/\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Dunkle LM, Izikson R, et al. 2017a<\/a><br \/>\n          <\/u><br \/>\n        <\/em><br \/>\n        <br \/>\n        <sup>3<\/sup><br \/>\n        <em><br \/>\n          <u><br \/>\n            <a href=\"https:\/\/www.cdc.gov\/flu\/about\/disease\/complications.htm\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Centers for Disease Control and Prevention. Flu symptoms and complications<\/a><br \/>\n          <\/u><br \/>\n        <\/em><br \/>\n        <br \/>\n        <sup>4<\/sup><br \/>\n        <em><br \/>\n          <u><br \/>\n            <a href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs211\/en\/\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">WHO factsheet<\/a><br \/>\n          <\/u><br \/>\n        <\/em><br \/>\n        <br \/>\n        <sup>5<\/sup><br \/>\n        <em> Lancet Respir Med 2019; 7: 69\u201389<\/em><br \/>\n        <br \/>\n        <sup>6<\/sup><br \/>\n        <em>Warren-Gash C, et al. Eur Respir J. 2018:51<\/em><br \/>\n        <br \/>\n        <sup>7<\/sup><br \/>\n        <em><br \/>\n          <u><br \/>\n            <a href=\"https:\/\/www.ecdc.europa.eu\/en\/publications-data\/seasonal-influenza-systematic-review-efficacy-vaccines\" rel=\"nofollow noopener noreferrer\" target=\"_blank\">Systematic review of the efficacy, effectiveness and safety of newer and enhanced seasonal influenza vaccines. ECDC. Oct 2020<\/a><br \/>\n          <\/u><br \/>\n        <\/em>\n      <\/p>\n<p>\u00a0<\/p>\n<p id=\"gnw_attachments_section-header\">\n        <strong>Attachment<\/strong>\n      <\/p>\n<ul id=\"gnw_attachments_section-items\">\n<li>\n          <a target=\"_blank\" href=\"https:\/\/ml-eu.globenewswire.com\/Resource\/Download\/13d27ec6-5488-4976-8628-cc543fde688a\" rel=\"noopener noreferrer\">PDF<\/a>\n        <\/li>\n<\/ul>\n<p>      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMDQzOTY2NCM0MDA4MjIwNDkjMTAxMTExMA==\" width=\"1\" height=\"1\" \/><br \/>\n      <br \/>\n      <img loading=\"lazy\" decoding=\"async\" class=\"__GNW8366DE3E__IMG\" src=\"https:\/\/ml-eu.globenewswire.com\/release\/track\/e9e627c0-5ebd-4d92-8725-a6e77465ec49\" width=\"1\" height=\"1\" \/>\n    <\/div>\n<div class=\"mw_contactinfo\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>European Commission approves Supemtek \u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older First and only recombinant influenza vaccine approved in the European Union Contains three times more antigen than standard-dose vaccines Phase 3 efficacy trial demonstrated improved protection against influenza compared to standard-dose influenza vaccine, and reduced the risk of influenza by an additional 30% in adults aged 50 years and older1,2 PARIS \u2013 November 18, 2020 \u2013 The European Commission has granted a marketing authorization for Supemtek\u00ae, a quadrivalent (four-strain) recombinant influenza vaccine, for the prevention of influenza in adults aged 18 years and older. Supemtek is the first and only recombinant influenza vaccine now approved in the European Union. &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.marketnewsdesk.com\/index.php\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older&#8221;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-384300","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"European Commission approves Supemtek \u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older First and only recombinant influenza vaccine approved in the European Union Contains three times more antigen than standard-dose vaccines Phase 3 efficacy trial demonstrated improved protection against influenza compared to standard-dose influenza vaccine, and reduced the risk of influenza by an additional 30% in adults aged 50 years and older1,2 PARIS \u2013 November 18, 2020 \u2013 The European Commission has granted a marketing authorization for Supemtek\u00ae, a quadrivalent (four-strain) recombinant influenza vaccine, for the prevention of influenza in adults aged 18 years and older. Supemtek is the first and only recombinant influenza vaccine now approved in the European Union. &hellip; Continue reading &quot;European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older&quot;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-18T18:15:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.globenewswire.com\/newsroom\/ti?nf=MTAwMDQzOTY2NCM0MDA4MjIwNDkjMTAxMTExMA==\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older\",\"datePublished\":\"2020-11-18T18:15:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/\"},\"wordCount\":1327,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.globenewswire.com\\\/newsroom\\\/ti?nf=MTAwMDQzOTY2NCM0MDA4MjIwNDkjMTAxMTExMA==\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\\\/\",\"name\":\"European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older - 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Market Newsdesk","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.marketnewsdesk.com\/index.php\/european-commission-approves-supemtek-quadrivalent-recombinant-influenza-vaccine-for-the-prevention-of-influenza-in-adults-aged-18-years-and-older\/","og_locale":"en_US","og_type":"article","og_title":"European Commission approves Supemtek\u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older - Market Newsdesk","og_description":"European Commission approves Supemtek \u00ae (quadrivalent recombinant influenza vaccine) for the prevention of influenza in adults aged 18 years and older First and only recombinant influenza vaccine approved in the European Union Contains three times more antigen than standard-dose vaccines Phase 3 efficacy trial demonstrated improved protection against influenza compared to standard-dose influenza vaccine, and reduced the risk of influenza by an additional 30% in adults aged 50 years and older1,2 PARIS \u2013 November 18, 2020 \u2013 The European Commission has granted a marketing authorization for Supemtek\u00ae, a quadrivalent (four-strain) recombinant influenza vaccine, for the prevention of influenza in adults aged 18 years and older. 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