{"id":383789,"date":"2020-11-18T07:33:10","date_gmt":"2020-11-18T12:33:10","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=383789"},"modified":"2020-11-18T07:33:10","modified_gmt":"2020-11-18T12:33:10","slug":"what-do-the-pfizer-vaccine-and-betterlife-pharma-have-in-common","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/what-do-the-pfizer-vaccine-and-betterlife-pharma-have-in-common\/","title":{"rendered":"What do the Pfizer Vaccine and BetterLife Pharma have in common?"},"content":{"rendered":"
\n

New York City, Nov. 18, 2020 (GLOBE NEWSWIRE) — BetterLife Pharma Inc. (\u201cBetterLife\u201d or the \u201cCompany\u201d) (CSE: BETR \/ OTCQB: BETRF \/ FRA: NPAT), an emerging biotech company focused on development and commercialization of interferon (IFN) based therapeutics, recently provided a clinical and regulatory update<\/u><\/a> for its AP-003 COVID-19 clinical trials using inhaled interferon alpha 2b. \u00a0While recent advancements in vaccines may seem to provide a glimmer of hope for bringing the pandemic to a close, it remains to be seen how safe and effective they will be, and for how long. The importance of life-saving COVID-19 therapeutics is as great ever, and the support for the Company\u2019s use of interferon as a therapeutic for COVID-19 is compelling.<\/p>\n

Recent research, summed up by an article<\/u><\/a> from NBC which stated \u2018\u2019COVID-19 patients with life-threatening illness have antibodies that disable key immune system proteins called interferons<\/em><\/strong>\u2019\u2019,<\/em> highlighted the latest findings on the importance of interferon and its role in fighting Covid-19 \u00a0and other viral infections:<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00b7Crucial Role of IFNs in Virus Infections <\/u><\/strong><\/p>\n

Type I IFNs are our natural first line of\u00a0defence against ANY and ALL viruses. The human body has a non-specific\u00a0surveillance system\u00a0in all its cells, since any cell can be infected – that detects virus and immediately triggers a response in that cell. \u00a0This is true whether it is a respiratory virus targeting the airways and lungs (flu and coronaviruses), a virus that targets the liver (hepatitis B or C), the heart (Coxsackie virus), the gut (many enteric viruses), the brain (Zika), or whether the virus enters the skin through a mosquito bite (dengue, West Nile virus).<\/p>\n

\n That\u00a0immediate sensing of a virus leads\u00a0immediately to the\u00a0production of interferons –\u00a0regardless of the virus.<\/strong> This is true for ALL viruses.\u00a0<\/p>\n

This IFN response is\u00a0highly important as some intelligent viruses have evolved to have specific genes that block this IFN response.\u00a0 because viruses have co-evolved to very\u00a0specifically have genes that will block this IFN\u00a0response.<\/strong> \u00a0\u00a0<\/p>\n

According to Dr. Eleanor Fish, an expert on IFNs and member of the Scientific board for BetterLife, SARS-COV-2 (the virus responsible for COVID-19) has within its viral genome a number of such trigger genes that are turned on immediately after the virus infects cells in the hosts airways which in turn produces factors that block IFN production.<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00b7Role of IFN (or lack thereof) in COVID-19<\/u><\/strong><\/p>\n

In the high profile publication referenced above, it was shown that not only does SARS CoV-2 blunt\/diminish an IFN response, thereby disabling an effective immune response to this infection, but that those individuals who become infected that have low blood levels of IFN tend to experience a more severe illness.\u00a0 Similarly,\u00a0those individuals who have any mutations in genes associated with the IFN response also tend to have a more severe response to COVID-19. \u00a0Individuals who, for whatever reason, have\u00a0antibodies to IFN, will also elicit a more\u00a0severe COVID.<\/strong> \u00a0<\/p>\n

\u00a0All this informs us of the\u00a0importance of the IFN\u00a0response in\u00a0resolving COVID.\u00a0<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00b7Pfizer Vaccine: an IFN Cell Modulator<\/u><\/strong><\/p>\n

The importance of IFN response has also been reflected in the development of the Pfizer vaccine.\u00a0 The vaccine stimulates the production of IFN gamma in T Cells (responsible for fighting infections).\u00a0 IFN gamma is Type II IFN.\u00a0 Both Type I (the Company\u2019s interferon alpha 2b) and type II interferons (are central to both combating virus infection and modulating the antiviral immune response.<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00b7An inhalation form of IFN based product can play an important role in fighting MOST infections beyond COVID-19.<\/u><\/strong>
\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/u><\/strong>
For every vaccine or drug that targets a specific aspect of a virus, viruses mutate and become drug resistant. Not so for IFNs: <\/strong>IFNs are produced by the immune system and are not virus-specific, thus there is no development of\u00a0resistance to IFNs.<\/p>\n

Notably, IFN targets many different stages of the virus life cycle – from blocking entry into cells, to\u00a0preventing\u00a0uncaring of enveloped viruses, to degrading the virus genome, to blocking the assembly of the virus particle and prevent virus form getting out of cells. When cells\u00a0have a huge number of virus particles, IFN will kill the cell – and the virus. IFN will also recruit\u00a0specific immune cells to a site of infection, and activate them to clear the infection.\u00a0<\/p>\n

The Company has always maintained that the best\u00a0approach to deal with virus infections are combination therapies, incorporating a cocktail of drugs that target different aspects of the virus. \u00a0<\/p>\n

Dr. Ahmad Doroudian, CEO BetterLife , has mentioned in recent interviews<\/u><\/a> that the best approach may well be combining IFN with remdesivir and\/or the monoclonal antibodies being evaluated now.<\/strong><\/p>\n

Affordable treatments will always be important.\u00a0 Remdesivir and monoclonal antibodies are very expensive and additionally are injected, not administered into the airways where the virus resides.<\/p>\n

Dr. Doroudian\u00a0 believes that that an inhaled IFN such as the Company\u2019s AP-003 therapeutic that directly targets the airways and that is also affordable will have widespread utility for COVID-19 and any other respiratory infection that might appear in the future.\u00a0<\/p>\n

While millions of people around the World may well have access to a vaccine eventually, there will be hundreds of thousands for whom the vaccine may well not work and will require effective treatment options.\u00a0\u00a0 AP-003 as both a treatment and preventative may well provide the solution for this unmet need, following conclusion of its imminent trials in Australia.<\/p>\n

\n About BDA International, Inc.:<\/strong>
\n
BDA International is an independent global firm offering a wide range of IR and PR related analysis, research and advisory services. In particular, we provide and are compensated for service packages that include strategic action plans and investor\/market perception studies to help entities improve communication with customers and investors, and to increase their visibility. BDA International has received no direct compensation related to this release but its principles hold shares of client companies in our personal portfolios, including BETRF. BDA International accepts sole responsibility for the content and distribution of the foregoing release, which does not contain any previously unpublished or non-public information. Parties interested in learning more about the relationship between BDA and BETRF may do so via the contact information at the bottom of this release.<\/p>\n

\n Disclaimer<\/strong>
\n
\n The information, opinions and analysis contained herein are based on sources believed to be reliable, but no representation, expressed or implied, is made as to its accuracy, completeness or correctness. The opinions contained in this analysis reflect our current judgment and are subject to change without notice. We do not accept any responsibility or liability for any losses, damages or costs arising from an investor\u2019s or other person\u2019s reliance on or use of this analysis. This analysis is for information purposes only, and is neither a solicitation to buy nor an offer to sell securities, nor a recommendation of any security, although members of the BDA may at times hold a position in the company covered within the article. BetterLife Pharma is a client of BDA International. Past gains are not a representative of future gains. The opinions herein contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements concerning manufacturing, marketing, growth, and expansion. When used herein, the words \u201canticipate,\u201d \u201cintend,\u201d \u201cestimate,\u201d \u201cbelieve,\u201d \u201cexpect,\u201d \u201cplans,\u201d \u201cshould,\u201d \u201cpotential,\u201d \u201cforecast,\u201d and variations of such words and similar expressions are intended to identify forward-looking statements. Such forward-looking information involves important risks and uncertainties that could affect actual results and cause them to differ materially from expectations expressed herein. A company\u2019s actual results could differ materially from those described in any forward-looking statements contained herein. BDA is not a licensed broker, broker dealer, market maker, investment advisor, analyst or underwriter. We recommend that you use the information found herein as an initial starting point for conducting your own research in order to determine your own personal opinion of the companies discussed herein before deciding whether or not to invest. You should seek such investment, tax, financial, accounting or legal advice appropriate for your particular circumstances. Information about many publicly traded companies and other investor resources can be found at www.sec.gov. Investing in securities is speculative and carries risk.<\/strong>\n <\/p>\n

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<\/div>\n","protected":false},"excerpt":{"rendered":"

New York City, Nov. 18, 2020 (GLOBE NEWSWIRE) — BetterLife Pharma Inc. (\u201cBetterLife\u201d or the \u201cCompany\u201d) (CSE: BETR \/ OTCQB: BETRF \/ FRA: NPAT), an emerging biotech company focused on development and commercialization of interferon (IFN) based therapeutics, recently provided a clinical and regulatory update for its AP-003 COVID-19 clinical trials using inhaled interferon alpha 2b. \u00a0While recent advancements in vaccines may seem to provide a glimmer of hope for bringing the pandemic to a close, it remains to be seen how safe and effective they will be, and for how long. The importance of life-saving COVID-19 therapeutics is as great ever, and the support for the Company\u2019s use of interferon as a therapeutic for COVID-19 is compelling. Recent research, … <\/p>\n

Continue reading “What do the Pfizer Vaccine and BetterLife Pharma have in common?”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-383789","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nWhat do the Pfizer Vaccine and BetterLife Pharma have in common? - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/what-do-the-pfizer-vaccine-and-betterlife-pharma-have-in-common\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What do the Pfizer Vaccine and BetterLife Pharma have in common? - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"New York City, Nov. 18, 2020 (GLOBE NEWSWIRE) — BetterLife Pharma Inc. (\u201cBetterLife\u201d or the \u201cCompany\u201d) (CSE: BETR \/ OTCQB: BETRF \/ FRA: NPAT), an emerging biotech company focused on development and commercialization of interferon (IFN) based therapeutics, recently provided a clinical and regulatory update for its AP-003 COVID-19 clinical trials using inhaled interferon alpha 2b. \u00a0While recent advancements in vaccines may seem to provide a glimmer of hope for bringing the pandemic to a close, it remains to be seen how safe and effective they will be, and for how long. The importance of life-saving COVID-19 therapeutics is as great ever, and the support for the Company\u2019s use of interferon as a therapeutic for COVID-19 is compelling. 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(\u201cBetterLife\u201d or the \u201cCompany\u201d) (CSE: BETR \/ OTCQB: BETRF \/ FRA: NPAT), an emerging biotech company focused on development and commercialization of interferon (IFN) based therapeutics, recently provided a clinical and regulatory update for its AP-003 COVID-19 clinical trials using inhaled interferon alpha 2b. \u00a0While recent advancements in vaccines may seem to provide a glimmer of hope for bringing the pandemic to a close, it remains to be seen how safe and effective they will be, and for how long. The importance of life-saving COVID-19 therapeutics is as great ever, and the support for the Company\u2019s use of interferon as a therapeutic for COVID-19 is compelling. 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