{"id":381392,"date":"2020-11-16T06:33:21","date_gmt":"2020-11-16T11:33:21","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=381392"},"modified":"2020-11-16T06:33:21","modified_gmt":"2020-11-16T11:33:21","slug":"mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/","title":{"rendered":"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience"},"content":{"rendered":"
\n

U.K. retrospective chart review examined potential predictors of treatment response including age, baseline AKI severity and concomitant use of albumin in patients with HRS-AKI<\/h2>\n

PR Newswire<\/p>\n<\/p><\/div>\n

\n

\n DUBLIN<\/span>, Nov. 16, 2020<\/span> \/PRNewswire\/ —\u00a0Mallinckrodt<\/span> plc<\/a>, a global biopharmaceutical company, today announced results from a post hoc analysis of a retrospective chart review study of terlipressin in patients with hepatorenal syndrome-acute kidney injury (HRS-AKI)\u00a0conducted in 26 hospitals in the United Kingdom<\/span>. HRS-AKI, also known as HRS-1, is an acute and life-threatening syndrome involving acute kidney failure in people with cirrhosis.1<\/sup>\u00a0Results were presented during a poster presentation at The Liver Meeting Digital Experience, the annual meeting of the\u00a0American Association for the Study of Liver Diseases\u00a0(AASLD). The poster can be accessed here<\/b><\/a>\u00a0on the company’s website.<\/p>\n

\n

\n
\n \"Mallinckrodt
\n <\/a>\n <\/p>\n<\/p><\/div>\n

Terlipressin is an investigational product and its safety and effectiveness have not yet been established by the U.S. Food and Drug Administration.<\/p>\n

The retrospective chart review study included 250 hospitalized adult patients from 26 centers in the\u00a0U.K. with a diagnosis of HRS-AKI who received terlipressin or other vasopressors.\u00a0The majority of patients were treated with terlipressin (n=203)\u00a0and were evenly distributed by baseline AKI severity: mild, 33 percent (SCr <2.25 mg\/dL); moderate, 36 percent (SCr \u22652.25 mg\/dL and <3.5 mg\/dL); severe, 31 percent (SCr \u22653.5 mg\/dL). The overall response rate among patients treated with terlipressin, including complete responses (SCr \u22641.5 mg\/dL) and partial responses (SCr reduction \u226520 percent but SCr >1.5 mg\/dL), was 73 percent and differed between the mild and moderate (79 percent and 78 percent) groups compared to the severe group (60 percent). The retrospective chart review study identified absence of a precipitating event, concomitant use of albumin and mild or moderate baseline AKI severity as predictors of overall response. Presence of encephalopathy was the only predictor of mortality (hazard ratio, 2.77; 95 percent confidence interval, 1.56 to 4.92) identified by the study.2<\/sup>\u00a0<\/p>\n

Other outcomes included need for dialysis, mortality, liver transplantation and adverse event rates. The limitations of this post hoc analysis of a retrospective chart review include a more heterogeneous HRS population than those in randomized clinical trials, sampling bias from conveniently selected enters, potential selection bias towards patients with known outcomes to the providers and under reporting of less severe adverse events. <\/p>\n

“As a physician treating patients with difficult to treat conditions like HRS-1, it’s important to continue to build on decades of research of investigational products like terlipressin that can advance our scientific understanding of potential treatment options for these very sick patients,” said Kevin Moore<\/span>, M.D.,\u00a0UCL Institute of Liver and Digestive Health,\u00a0Royal Free Hospital,\u00a0University College London<\/b>.<\/p>\n

Terlipressin is approved in many countries outside the United States<\/span>, where it has been a standard of care for decades in the treatment of patients with HRS-1.3,4<\/sup> Terlipressin, together with albumin, is currently the standard of care for HRS-1 in countries where it is available.5<\/sup>\u00a0<\/p>\n

HRS-1 has a median survival time of approximately two weeks and greater than 80 percent mortality within three months if left untreated.6,7<\/sup>\u00a0At present, there are no drug therapies approved for the treatment of HRS-1 in the U.S. or\u00a0Canada.8<\/sup>\u00a0HRS-1 is estimated to affect between 30,000 and 40,000 patients in the U.S.\u00a0annually.9,10\u00a0<\/sup><\/p>\n

“Mallinckrodt<\/span> remains committed to furthering our understanding of HRS-1 and the potential of terlipressin to address HRS-1, a disease that is often a challenge to effectively diagnose,” said Steven Romano<\/span>, M.D., Executive Vice President and Chief Scientific Officer at\u00a0Mallinckrodt<\/b>. “The results from this U.K. study add to the extensive knowledge and data of the investigational product in the U.S.”<\/p>\n

This study was funded by Mallinckrodt<\/span>.<\/p>\n

\n About Terlipressin<\/b>
\n
Terlipressin is a potent vasopressin analogue selective for V1 receptors being investigated for the treatment of HRS-1 in the U.S. and\u00a0Canada. It is an investigational product in these countries as the safety and efficacy have not been established with, nor has approval been granted by, regulatory authorities in either country. Terlipressin is approved for use outside the U.S. and\u00a0Canada.<\/p>\n

\n ABOUT\u00a0MALLINCKRODT\u00a0<\/b>
\n
Mallinckrodt\u00a0is a global business consisting of multiple wholly owned subsidiaries that develop, manufacture, market and distribute specialty pharmaceutical products and therapies. The company’s Specialty Brands reportable segment’s areas of focus include autoimmune and rare diseases in specialty areas like neurology, rheumatology, hepatology, nephrology, pulmonology and ophthalmology; immunotherapy and neonatal respiratory critical care therapies; analgesics and gastrointestinal products. Its Specialty Generics reportable segment includes specialty generic drugs and active pharmaceutical ingredients. To learn more about\u00a0Mallinckrodt, visit\u00a0www.mallinckrodt.com<\/a><\/u>. <\/p>\n

Mallinckrodt\u00a0uses its website as a channel of distribution of important company information, such as press releases, investor presentations and other financial information. It also uses its website to expedite public access to time-critical information regarding the company in advance of or in lieu of distributing a press release or a filing with the\u00a0U.S. Securities and Exchange Commission\u00a0(SEC) disclosing the same information. Therefore, investors should look to the Investor Relations page of the website for important and time-critical information. Visitors to the website can also register to receive automatic e-mail and other notifications alerting them when new information is made available on the Investor Relations page of the website.<\/p>\n

\n CAUTIONARY STATEMENTS RELATED TO FORWARD-LOOKING STATEMENTS
<\/b>This release includes forward-looking statements with regard to terlipressin, including its potential impact on patients. The statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those in the forward-looking statements: satisfaction of regulatory and other requirements; actions of regulatory bodies and other governmental authorities; changes in laws and regulations; issues with product quality, manufacturing or supply, or patient safety issues; and other risks identified and described in more detail in the “Risk Factors” section of\u00a0Mallinckrodt’s\u00a0most recent Annual Report on Form 10-K and other filings with the\u00a0SEC, all of which are available on its website. The forward-looking statements made herein speak only as of the date hereof and\u00a0Mallinckrodt\u00a0does not assume any obligation to update or revise any forward-looking statement, whether as a result of new information, future events and developments or otherwise, except as required by law.<\/p>\n

\n CONTACT<\/b>\n <\/p>\n

\n
\n Media Inquiries
<\/u>
\n <\/b>
\n Caren Begun<\/span>
\n
Green Room Communications
201-396-8551
caren@greenroompr.com<\/a><\/u><\/p>\n

\n
\n Investor Relations
<\/u>
\n <\/b>
\n Daniel J. Speciale<\/span>
\n
Vice President, Finance and Investor Relations Officer
314-654-3638
daniel.speciale@mnk.com<\/a><\/u><\/p>\n

\n Mallinckrodt<\/span>, the “M” brand mark and the\u00a0Mallinckrodt Pharmaceuticals\u00a0logo are trademarks of a\u00a0Mallinckrodt\u00a0company. Other brands are trademarks of a\u00a0Mallinckrodt\u00a0company or their respective owners. \u00a9 2020\u00a0Mallinckrodt.\u00a0US-2000454 11\/20<\/p>\n

\n
\n References<\/u>
\n <\/b>\n <\/p>\n

\n 1<\/sup>\u00a0National Organization for Rare Disorders. Hepatorenal Syndrome. Available at:\u00a0https:\/\/rarediseases.org\/rare-diseases\/hepatorenal-syndrome\/<\/a>. Accessed November 3, 2020<\/span>.
2<\/sup>\u00a0Moore K, Jamil K, Verleger K, Kelkar S, Kebede N et al. Predictors of response to terlipressin in patients with hepatorenal syndrome-acute kidney injury (HRS-AKI): A multicenter study. Poster presented at: The Liver Meeting Digital Experience; November 13-16, 2020<\/span>; Boston, MA.<\/span>
3<\/sup>\u00a0De Franchis R. Evolving Consensus in Portal Hypertension Report of the Baveno IV Consensus Workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol<\/i>. 2005;43:167-176.
4<\/sup>\u00a0Ioannou GN, Doust J, Rockey DC. Terlipressin for acute esophageal variceal hemorrhage. Cochrane Database of Systematic Reviews<\/i>. 2003;1. doi: 10.1002\/14651858.CD002147.
5<\/sup>\u00a0European Association for the Study of the Liver (EASL). Clinical practice guidelines for the management of patients with decompensated cirrhosis. J Hepatol<\/i>. 2018;69(2):406-460.
6<\/sup>\u00a0Colle I and Laterre PF. Hepatorenal syndrome: the clinical impact of vasoactive therapy. Expert Review of Gastroenterology & Hepatology<\/i>. (2018) 12:2, 173-188, DOI: 10.1080\/17474124.2018.1417034.\u00a0
7<\/sup>\u00a0Gines P, Sola E, Angeli P, et al. Hepatorenal syndrome. Nature Reviews<\/i>. (2018) 4:23.\u00a0
8<\/sup>\u00a0Boyer TD, Medicis JJ, Pappas SC, et al. A randomized, placebo-controlled, double-blind study to confirm the reversal of hepatorenal syndrome type 1 with terlipressin: the REVERSE trial design.\u00a0Open Access Journal of Clinical Trials\u00a02012:4.\u00a0https:\/\/www.dovepress.com\/a-randomized-placebo-controlled-double-blind-study-to-confirm-the-reve-peer-reviewed-article-OAJCT<\/a>.\u00a0
9<\/sup>\u00a0C Pant, B S Jani, M Desai, A Deshpande, Prashant Pandya<\/span>, Ryan Taylor<\/span>, R Gilroy, M Olyaee. Hepatorenal syndrome in hospitalized patients with chronic liver disease: results from the Nationwide Inpatient Sample 2002\u20132012. Journal of Investigative Medicine<\/i>. 2016;64:33\u201338.
10<\/sup>\u00a0United States Census Bureau: Quick Facts. Available at:\u00a0https:\/\/www.census.gov\/quickfacts\/fact\/table\/US\/PST045218<\/a>. Accessed\u00a0November 3, 2020.<\/p>\n

\u00a0<\/p>\n

<\/div>\n

\n \"Cision\" View original content to download multimedia:http:\/\/www.prnewswire.com\/news-releases\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience-301173285.html<\/a><\/p>\n

SOURCE Mallinckrodt<\/span> plc<\/p>\n<\/p><\/div>\n

\"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

U.K. retrospective chart review examined potential predictors of treatment response including age, baseline AKI severity and concomitant use of albumin in patients with HRS-AKI PR Newswire DUBLIN, Nov. 16, 2020 \/PRNewswire\/ —\u00a0Mallinckrodt plc, a global biopharmaceutical company, today announced results from a post hoc analysis of a retrospective chart review study of terlipressin in patients with hepatorenal syndrome-acute kidney injury (HRS-AKI)\u00a0conducted in 26 hospitals in the United Kingdom. HRS-AKI, also known as HRS-1, is an acute and life-threatening syndrome involving acute kidney failure in people with cirrhosis.1\u00a0Results were presented during a poster presentation at The Liver Meeting Digital Experience, the annual meeting of the\u00a0American Association for the Study of Liver Diseases\u00a0(AASLD). The poster can be accessed here\u00a0on the company’s website. … <\/p>\n

Continue reading “Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-381392","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nMallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"U.K. retrospective chart review examined potential predictors of treatment response including age, baseline AKI severity and concomitant use of albumin in patients with HRS-AKI PR Newswire DUBLIN, Nov. 16, 2020 \/PRNewswire\/ —\u00a0Mallinckrodt plc, a global biopharmaceutical company, today announced results from a post hoc analysis of a retrospective chart review study of terlipressin in patients with hepatorenal syndrome-acute kidney injury (HRS-AKI)\u00a0conducted in 26 hospitals in the United Kingdom. HRS-AKI, also known as HRS-1, is an acute and life-threatening syndrome involving acute kidney failure in people with cirrhosis.1\u00a0Results were presented during a poster presentation at The Liver Meeting Digital Experience, the annual meeting of the\u00a0American Association for the Study of Liver Diseases\u00a0(AASLD). The poster can be accessed here\u00a0on the company’s website. … Continue reading "Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience"\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/\" \/>\n<meta property=\"og:site_name\" content=\"Market Newsdesk\" \/>\n<meta property=\"article:published_time\" content=\"2020-11-16T11:33:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mma.prnewswire.com\/media\/167103\/mallinckrodt_plc_logo.jpg\" \/>\n<meta name=\"author\" content=\"Newsdesk\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Newsdesk\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/\"},\"author\":{\"name\":\"Newsdesk\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/#\\\/schema\\\/person\\\/482f27a394d4fda80ecb5499e519d979\"},\"headline\":\"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience\",\"datePublished\":\"2020-11-16T11:33:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/\"},\"wordCount\":1362,\"image\":{\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/mma.prnewswire.com\\\/media\\\/167103\\\/mallinckrodt_plc_logo.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/\",\"url\":\"https:\\\/\\\/www.marketnewsdesk.com\\\/index.php\\\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\\\/\",\"name\":\"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience - 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HRS-AKI, also known as HRS-1, is an acute and life-threatening syndrome involving acute kidney failure in people with cirrhosis.1\u00a0Results were presented during a poster presentation at The Liver Meeting Digital Experience, the annual meeting of the\u00a0American Association for the Study of Liver Diseases\u00a0(AASLD). The poster can be accessed here\u00a0on the company’s website. … Continue reading \"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience\"","og_url":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/","og_site_name":"Market Newsdesk","article_published_time":"2020-11-16T11:33:21+00:00","og_image":[{"url":"https:\/\/mma.prnewswire.com\/media\/167103\/mallinckrodt_plc_logo.jpg","type":"","width":"","height":""}],"author":"Newsdesk","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Newsdesk","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/#article","isPartOf":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/"},"author":{"name":"Newsdesk","@id":"https:\/\/www.marketnewsdesk.com\/#\/schema\/person\/482f27a394d4fda80ecb5499e519d979"},"headline":"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience","datePublished":"2020-11-16T11:33:21+00:00","mainEntityOfPage":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/"},"wordCount":1362,"image":{"@id":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/#primaryimage"},"thumbnailUrl":"https:\/\/mma.prnewswire.com\/media\/167103\/mallinckrodt_plc_logo.jpg","inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/","url":"https:\/\/www.marketnewsdesk.com\/index.php\/mallinckrodt-announces-data-from-a-multicenter-post-hoc-analysis-of-terlipressin-in-patients-with-hepatorenal-syndrome-acute-kidney-injury-hrs-aki-at-the-liver-meeting-digital-experience\/","name":"Mallinckrodt Announces Data from a Multicenter Post Hoc Analysis of Terlipressin in Patients with Hepatorenal Syndrome-Acute Kidney Injury (HRS-AKI) at The Liver Meeting Digital Experience - 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