{"id":380246,"date":"2020-11-12T16:08:17","date_gmt":"2020-11-12T21:08:17","guid":{"rendered":"http:\/\/www.marketnewsdesk.com\/?p=380246"},"modified":"2020-11-12T16:08:17","modified_gmt":"2020-11-12T21:08:17","slug":"taysha-gene-therapies-reports-third-quarter-2020-financial-results-and-provides-business-update","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/taysha-gene-therapies-reports-third-quarter-2020-financial-results-and-provides-business-update\/","title":{"rendered":"Taysha Gene Therapies Reports Third Quarter 2020 Financial Results and Provides Business Update"},"content":{"rendered":"

<\/p>\n

Taysha Gene Therapies Reports Third Quarter 2020 Financial Results and Provides Business Update <\/b><\/p>\n

Successfully raised $96 million in Series B financing and completed $181 million IPO<\/i><\/p>\n

Established management team with successful track record of developing and commercializing AAV9-based gene therapies for monogenic diseases of the central nervous system<\/i><\/p>\n

Company on track to initiate a Phase 1\/2 clinical trial of TSHA-101 in GM2 gangliosidosis by the end of 2020 and plans to submit four INDs in 2021<\/i><\/p>\n

DALLAS–(BUSINESS WIRE<\/a>)–Taysha Gene Therapies, Inc.<\/a> (Nasdaq: TSHA), a patient-centric gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system in both rare and large patient populations, today reported its financial results for the third quarter of 2020 and provided a business update.\n<\/p>\n

\n\u201cJust over a year ago, we founded Taysha in partnership with UT Southwestern with a mission to develop gene therapies to address monogenic diseases of the central nervous system, and to that end we have made significant progress in building a talented team that can advance our broad portfolio,\u201d said RA Session, II, President, Founder and CEO of Taysha. \u201cDuring the third quarter, we raised over $275 million between our Series B financing and our IPO, providing the capital resources to support our industry-leading pipeline of 18 gene therapy programs. We have also bolstered our GMP manufacturing capabilities to ensure we have the capacity to support our development plans for multiple programs by utilizing the UTSW vector core, our internal Taysha manufacturing facility that is currently in development and our newly announced partnership with Catalent.\u201d\n<\/p>\n

Program Highlights<\/b><\/p>\n

TSHA-101 for GM2 gangliosidosis<\/b> \u2013 Taysha secured rare pediatric disease designation and orphan drug designation from the U.S. Food and Drug Administration (FDA) for TSHA-101, its bicistronic vector designed to treat GM2 gangliosidosis, also known as Tay-Sachs and Sandhoff disease. Taysha anticipates initiating a Phase 1\/2 clinical trial of TSHA-101 in Canada by end of 2020.\n<\/p>\n

TSHA-102 for Rett syndrome<\/b> \u2013Taysha announced that FDA has granted rare pediatric disease and orphan drug designation for TSHA-102, which is under development for the treatment of Rett syndrome, one of the most common genetic causes of severe intellectual disability. TSHA-102 utilizes the miRARE platform, which is designed to regulate the expression of therapeutic transgenes on a cellular basis. Taysha remains on track to file an Investigational New Drug (IND) application for the program in 2021.\n<\/p>\n

TSHA-118 for CLN1 <\/b>\u2013 Taysha announced the in-licensing of an AAV9-based gene therapy program for the treatment of CLN1. TSHA-118 was originally developed in the academic lab of Steven Gray, Ph.D., Taysha\u2019s Chief Scientific Advisor. CLN1 Batten disease is a rapidly progressive rare lysosomal storage disease with no approved treatments. The company intends to initiate a Phase 1\/2 clinical trial of TSHA-118 in 2021 under a currently open IND.\n<\/p>\n

Recent Business Highlights<\/b><\/p>\n

\nIn October, Taysha announced a partnership with Invitae to support two different screening programs to enable rapid identification of patients with genetic disorders. DETECT Lysosomal Storage Diseases provides genetic testing for lysosomal storage disorders, including GM2 gangliosidosis and CLN1. The Behind the Seizures\u00ae program supports the diagnosis of patients with genetic epilepsies.\n<\/p>\n

\nIn November, Taysha announced a development and manufacturing partnership with Catalent to support future preclinical and clinical supply for several of Taysha\u2019s gene therapy programs, including CLN1 and Rett syndrome.\n<\/p>\n

\nTaysha has also invested in building its internal management team to advance the development of its broad gene therapy pipeline. The company anticipates more than tripling its headcount from its IPO by the end of 2020 across all areas of the organization.\n<\/p>\n

Financial Results<\/b><\/p>\n

\nAs of September 30, 2020, cash and cash equivalents totaled $279 million, which includes gross proceeds of $181 million from Taysha\u2019s IPO and $96 million from its Series B financing. Taysha was incorporated in September of 2019 and thus has no previous nine-month results for comparison.\n<\/p>\n

\nTaysha reported R&D expenses for the nine months ended September 30, 2020 of $19.6 million. The $19.6 million was primarily attributable to $10.0 million of expenses recognized pursuant to the Queen\u2019s University Agreement and the Abeona CLN1 Agreement, $4.1 million related to the manufacture of clinical trial material and $3.9 million in other sponsored research agreements for the Company\u2019s various product candidates. Additionally, Taysha incurred regulatory and clinical consulting expenses of $0.8 million and employee compensation and benefits expenses of $0.8 million, which included $0.4 million of non-cash stock-based compensation.\n<\/p>\n

\nTaysha reported G&A expenses of $5.0 million for the nine months ended September 30, 2020. The $5.0 million was primarily attributable to $2.7 million of compensation and benefits related to new hires, which included $0.9 million of non-cash stock-based compensation, $1.7 million in consulting fees, $0.5 million of legal expenses related to general corporate matters and $0.1 million related to insurance and other administrative expenses.\n<\/p>\n

About Taysha Gene Therapies<\/b><\/p>\n

\nTaysha Gene Therapies (Nasdaq: TSHA) is on a mission to eradicate monogenic CNS disease. With a singular focus on developing curative medicines, we aim to rapidly translate our treatments from bench to bedside. We have combined our team\u2019s proven experience in gene therapy drug development and commercialization with the world-class UT Southwestern Gene Therapy Program to build an extensive, AAV gene therapy pipeline focused on both rare and large-market indications. Together, we leverage our fully integrated platform\u2014an engine for potential new cures\u2014with a goal of dramatically improving patients\u2019 lives. More information is available at www.tayshagtx.com<\/a>.\n<\/p>\n

Forward-Looking Statements <\/b><\/p>\n

\nThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as \u201canticipates,\u201d \u201cbelieves,\u201d \u201cexpects,\u201d \u201cintends,\u201d \u201cprojects,\u201d and \u201cfuture\u201d or similar expressions are intended to identify forward-looking statements. Forward-looking statements include statements concerning or implying the conduct or timing of our clinical trials and our research, development and regulatory plans for our product candidates, the potential of our product candidates to positively impact quality of life and alter the course of disease in the patients we seek to treat, our research, development and regulatory plans for our product candidates, the potential for these product candidates to receive regulatory approval from the FDA or equivalent foreign regulatory agencies, and whether, if approved, these product candidates will be successfully distributed and marketed and the success of our partnerships with Invitae and Catalent. Forward-looking statements are based on management’s current expectations and are subject to various risks and uncertainties that could cause actual results to differ materially and adversely from those expressed or implied by such forward-looking statements. Accordingly, these forward-looking statements do not constitute guarantees of future performance, and you are cautioned not to place undue reliance on these forward-looking statements. Risks regarding our business are described in detail in our Securities and Exchange Commission (\u201cSEC\u201d) filings, including in our Quarterly Report on Form 10-Q for the quarter ended September 30, 2020, which we intend to file shortly hereafter and will be available on the SEC\u2019s website at www.sec.gov<\/a>. Additional information will be made available in other filings that we make from time to time with the SEC. Such risks may be amplified by the impacts of the COVID-19 pandemic. These forward-looking statements speak only as of the date hereof, and we disclaim any obligation to update these statements except as may be required by law.\n<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Taysha Gene Therapies<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

Selected Condensed Consolidated Financial Information<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

(In thousands, except share and per share data)<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

(Unaudited)<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

\n

Statements of Operations<\/b><\/p>\n<\/td>\n<\/tr>\n

\n\n\n\n\n\u00a0<\/td>\n<\/tr>\n
\nFor the
Three Months Ended
September 30,
2020<\/b><\/td>\n		\nFor the
Nine Months Ended
September 30,
2020<\/b><\/td>\n		\nFor the
Period from
September 20, 2019
(date of inception)
to
September 30,
2019<\/b><\/td>\n<\/tr>\n
\n\n\n\n\n\u00a0<\/td>\n<\/tr>\n
Operating expenses: <\/b><\/td>\n\n\n\n\n<\/tr>\n
Research and development<\/td>\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n11,057\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n19,633\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n–\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

General and administrative<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n3,984\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n5,002\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n31\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

Total operating expenses<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n15,041\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n24,635\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n31\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

Loss from operations <\/b><\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(15,041\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(24,635\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(31\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n<\/tr>\n

Other expense: <\/b><\/td>\n\n\n\n\n<\/tr>\n
Change in fair value of preferred stock tranche liability<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n–\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(17,030\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n–\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

Interest expense<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(1\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(28\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n–\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

Total other expense<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(1\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n(17,058\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n–\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n

Net loss <\/b><\/td>\n\n

$<\/b><\/p>\n<\/td>\n

\n

(15,042<\/b><\/p>\n<\/td>\n

\n

)<\/b><\/p>\n<\/td>\n

\n\n

$<\/b><\/p>\n<\/td>\n

\n

(41,693<\/b><\/p>\n<\/td>\n

\n

)<\/b><\/p>\n<\/td>\n

\n\n

$<\/b><\/p>\n<\/td>\n

\n

(31<\/b><\/p>\n<\/td>\n

\n

)<\/b><\/p>\n<\/td>\n<\/tr>\n

\n\n\n\n\n\u00a0<\/td>\n<\/tr>\n
Net loss per common share, basic and diluted<\/td>\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n(1.28\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n(3.73\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n

\n\n

\n$\n<\/p>\n<\/td>\n

\n

\n(0.00\n<\/p>\n<\/td>\n

\n

\n)\n<\/p>\n<\/td>\n<\/tr>\n

Weighted average common shares outstanding, basic and diluted<\/td>\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n11,733,170\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n11,176,429\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n

\n\n

\n\u00a0\n<\/p>\n<\/td>\n

\n

\n8,715,999\n<\/p>\n<\/td>\n

\n

\n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Balance Sheet<\/b><\/p>\n<\/td>\n<\/tr>\n

\n\n\n\u00a0<\/td>\n<\/tr>\n
\nSeptember 30,
2020<\/b><\/td>\n		\nDecember 31,
2019<\/b><\/td>\n<\/tr>\n
\n\n\n\u00a0<\/td>\n<\/tr>\n
ASSETS<\/b><\/td>\n\n\n<\/tr>\n
Current assets:<\/td>\n\n\n<\/tr>\n
Cash and cash equivalents<\/td>\n\n

\n$ 278,634\n<\/p>\n<\/td>\n

\n\n

\n$ –\n<\/p>\n<\/td>\n<\/tr>\n

Prepaid expenses<\/td>\n\n

\n604\n<\/p>\n<\/td>\n

\n\n

\n–\n<\/p>\n<\/td>\n<\/tr>\n

Deferred offering costs<\/td>\n\n

\n–\n<\/p>\n<\/td>\n

\n\n

\n15\n<\/p>\n<\/td>\n<\/tr>\n

Total current assets<\/td>\n\n

\n279,238\n<\/p>\n<\/td>\n

\n\n

\n15\n<\/p>\n<\/td>\n<\/tr>\n

Property and equipment, net<\/td>\n\n

\n28\n<\/p>\n<\/td>\n

\n\n

\n–\n<\/p>\n<\/td>\n<\/tr>\n

Total assets<\/b><\/td>\n\n

$ 279,266<\/b><\/p>\n<\/td>\n

\n\n

$ 15<\/b><\/p>\n<\/td>\n<\/tr>\n

\n\n\n\u00a0<\/td>\n<\/tr>\n
LIABILITIES AND STOCKHOLDERS’ EQUITY (DEFICIT)<\/b><\/td>\n\n\n<\/tr>\n
Current liabilities<\/td>\n\n\n<\/tr>\n
Accounts payable<\/td>\n\n

\n$ 8,837\n<\/p>\n<\/td>\n

\n\n

\n$ –\n<\/p>\n<\/td>\n<\/tr>\n

Accrued expenses<\/td>\n\n

\n2,727\n<\/p>\n<\/td>\n

\n\n

\n150\n<\/p>\n<\/td>\n<\/tr>\n

Due to related party<\/td>\n\n

\n60\n<\/p>\n<\/td>\n

\n\n

\n–\n<\/p>\n<\/td>\n<\/tr>\n

Total current liabilities<\/td>\n\n

\n11,624\n<\/p>\n<\/td>\n

\n\n

\n150\n<\/p>\n<\/td>\n<\/tr>\n

Total liabilities<\/td>\n\n

\n11,624\n<\/p>\n<\/td>\n

\n\n

\n150\n<\/p>\n<\/td>\n<\/tr>\n

\n\n\n\u00a0<\/td>\n<\/tr>\n
\n\n\n\u00a0<\/td>\n<\/tr>\n
Stockholders’ equity (deficit)<\/b><\/td>\n\n\n<\/tr>\n
Preferred stock, $0.00001 par value per share; 10,000,000 shares authorized and no shares issued and outstanding as of September 30, 2020; no shares authorized, issued and outstanding as of December 31, 2019<\/td>\n\n

\n–\n<\/p>\n<\/td>\n

\n\n

\n–\n<\/p>\n<\/td>\n<\/tr>\n

Common stock, $0.00001 par value per share; 200,000,000 shares authorized and 37,761,435 issued and outstanding as of September 30, 2020; 10,895,000 shares authorized, 10,894,999 issued and outstanding as of December 31, 2019<\/td>\n\n

\n–\n<\/p>\n<\/td>\n

\n\n

\n–\n<\/p>\n<\/td>\n<\/tr>\n

Additional paid-in capital<\/td>\n\n

\n310,450\n<\/p>\n<\/td>\n

\n\n

\n980\n<\/p>\n<\/td>\n<\/tr>\n

Accumulated deficit<\/td>\n\n

\n(42,808)\n<\/p>\n<\/td>\n

\n\n

\n(1,115)\n<\/p>\n<\/td>\n<\/tr>\n

Total stockholders\u2019equity (deficit)<\/td>\n\n

\n267,642\n<\/p>\n<\/td>\n

\n\n

\n(135)\n<\/p>\n<\/td>\n<\/tr>\n

Total liabilities and stockholders’ equity (deficit)<\/b><\/td>\n\n

$ 279,266<\/b><\/p>\n<\/td>\n

\n\n

$ 15<\/b><\/p>\n<\/td>\n<\/tr>\n<\/table>\n

\n\u00a0\n<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20201112006028\/en\/<\/a><\/span><\/p>\n

Company Contact:
\n<\/b>
Niren Shah, PharmD, MBA
\n
Taysha Gene Therapies
\n
Nshah@tayshagtx.com<\/a><\/p>\n

Media Contact:
\n<\/b>
Carolyn Hawley
\n
Canale Communications
\n
carolyn.hawley@canalecomm.com<\/a><\/p>\n

KEYWORDS:<\/b> United States North America Texas<\/p>\n

INDUSTRY KEYWORDS:<\/b> Health Infectious Diseases Genetics Research Science Pharmaceutical Biotechnology<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Taysha Gene Therapies Reports Third Quarter 2020 Financial Results and Provides Business Update Successfully raised $96 million in Series B financing and completed $181 million IPO Established management team with successful track record of developing and commercializing AAV9-based gene therapies for monogenic diseases of the central nervous system Company on track to initiate a Phase 1\/2 clinical trial of TSHA-101 in GM2 gangliosidosis by the end of 2020 and plans to submit four INDs in 2021 DALLAS–(BUSINESS WIRE)–Taysha Gene Therapies, Inc. (Nasdaq: TSHA), a patient-centric gene therapy company focused on developing and commercializing AAV-based gene therapies for the treatment of monogenic diseases of the central nervous system in both rare and large patient populations, today reported its financial results for … <\/p>\n

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