\nADC Therapeutics SA (NYSE: ADCT), a late clinical-stage oncology-focused biotechnology company pioneering the development and commercialization of highly potent and targeted antibody drug conjugates (ADCs) for patients with hematological malignancies and solid tumors, today reported financial results for the third quarter ended September 30, 2020 and provided recent business highlights.\n<\/p>\n
\n\u201cThe third quarter was one of tremendous execution as we prepare for the U.S. launch of our first drug, Lonca, for the treatment of relapsed or refractory diffuse large B-cell lymphoma,\u201d said Chris Martin, Chief Executive Officer of ADC Therapeutics. \u201cWe have submitted our Biologics License Application to the U.S. Food and Drug Administration and are now working diligently to prepare for a planned commercial launch in mid-2021, including U.S. organizational build-out, the establishment of U.S. operations to ensure distribution, access and reimbursement of Lonca, and significant appropriate physician engagement. In addition to our commercial preparations, we are expanding our Lonca development activities, having initiated our Phase 3 LOTIS 5 clinical trial evaluating Lonca in combination with rituximab as a second-line therapy in DLBCL and are preparing to initiate our Phase 2 trial of Lonca in follicular lymphoma next year.\u201d\n<\/p>\n
\nDr. Martin continued, \u201cAcross our Cami programs, we have now enrolled more than half of the 100-patient pivotal Phase 2 trial in Hodgkin lymphoma and continue to see promising preliminary data from our Phase 1b trial in solid tumors that show robust immune activity following treatment, as well as recently published preclinical data highlighting the anti-tumor activity of CD25-targeted antibody drug conjugates. With these promising data, we expanded our Phase 1b trial to evaluate Cami in combination with pembrolizumab to better understand its potential as both a monotherapy and in combination and have dosed the first patient in the combination arm. To support these exciting developments and ensure continued growth across our pipeline, we completed an upsized public offering in September. With these additional funds, we look forward to continuing to deliver on our vision to bring transformative therapies to cancer patients as quickly and effectively as possible.\u201d\n<\/p>\n
Recent Clinical and Business Highlights:<\/b><\/p>\n Anticipated Upcoming Milestones:<\/b><\/p>\n Third Quarter 2020 Financial Results<\/b><\/p>\n Cash and Cash Equivalents<\/b><\/p>\n \nCash and cash equivalents were $494.4 million as of September 30, 2020, compared to $115.6 million as of December 31, 2019.\n<\/p>\n Research and Development (R&D) Expenses<\/b><\/p>\n \nR&D expenses were $32.2 million for the quarter ended September 30, 2020, compared to $30.5 million for the same quarter in 2019. The increase was primarily due to increased share-based compensation expense.\n<\/p>\n General and Administrative (G&A) Expenses<\/b><\/p>\n \nG&A expenses were $20.3 million for the quarter ended September 30, 2020, compared to $2.3 million for the same quarter in 2019. The increase was primarily due to an increased number of Commercial employees, increased costs due to new commercial activities and increased share-based compensation expense.\n<\/p>\n Net Loss and Adjusted Net Loss<\/b><\/p>\n \nNet loss was $20.3 million, or a net loss of $0.29 per basic and diluted share, for the quarter ended September 30, 2020, compared to $31.3 million, or a net loss of $0.62 per basic and diluted share, for the same quarter in 2019. The net loss for the quarter ended September 30, 2020 includes a $33.9 million non-cash gain related to the changes in fair value of derivatives associated with the convertible loans under the Convertible Credit Facility with Deerfield. The decrease in fair value was driven by the decrease in the Company\u2019s share price from June 30, 2020. In addition, net loss included share-based compensation expense of $11.0 million for the quarter ended September 30, 2020, compared to $0.2 million for the same quarter in 2019.\n<\/p>\n \nAdjusted net loss was $41.3 million, or an adjusted net loss of $0.58 per basic and diluted share, for the quarter ended September 30, 2020, compared to $31.1 million, or an adjusted net loss of $0.62 per basic and diluted share, for the same quarter in 2019. The increase in adjusted net loss was primarily driven by higher employee headcount across the organization and costs associated with the build out of the Company\u2019s commercial organization in preparation for the anticipated launch of Lonca in 2021.\n<\/p>\n Conference Call Details<\/b><\/p>\n \nADC Therapeutics management will host a conference call and live audio webcast to discuss third quarter 2020 financial results and provide a company update today at 8:30 a.m. Eastern Time. To access the call, please dial +41 225 675632 (international) or (833) 249-8403 (U.S.). A live webcast of the presentation will be available on the Investors section of the ADC Therapeutics website at www.ir.adctherapeutics.com<\/a>. The archived webcast will be available after the completion of the event.\n<\/p>\n About ADC Therapeutics<\/b><\/p>\n \nADC Therapeutics SA (NYSE:ADCT) is a late clinical-stage oncology-focused biotechnology company pioneering the development and commercialization of highly potent and targeted antibody drug conjugates (ADCs) for patients with hematological malignancies and solid tumors. The Company develops ADCs by applying its decades of experience in this field and using next-generation pyrrolobenzodiazepine (PBD) technology to which ADC Therapeutics has proprietary rights for its targets. Strategic target selection for PBD-based ADCs and substantial investment in early clinical development have enabled ADC Therapeutics to build a deep clinical and research pipeline of therapies for the treatment of hematological and solid tumor cancers. The Company has multiple PBD-based ADCs in ongoing clinical trials, ranging from first in human to confirmatory Phase 3 clinical trials, in the USA and Europe, and numerous preclinical ADCs in development.\n<\/p>\n \nLoncastuximab tesirine (Lonca, formerly ADCT-402), the Company\u2019s lead product candidate, has been evaluated in a 145-patient pivotal Phase 2 clinical trial for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) that showed a 48.3% overall response rate (ORR), which exceeded the target primary endpoint. In September 2020, ADC Therapeutics submitted a Biologics License Application to the U.S. Food and Drug Administration seeking accelerated approval for Lonca for the treatment of patients with relapsed or refractory DLBCL. Camidanlumab tesirine (Cami, formerly ADCT-301), the Company\u2019s second lead product candidate, is being evaluated in a 100-patient pivotal Phase 2 clinical trial for the treatment of relapsed or refractory Hodgkin lymphoma (HL) after having shown in a Phase 1 clinical trial an 86.5% ORR in HL patients at the dose selected for Phase 2. The Company is also evaluating Cami as a novel immuno-oncology approach for the treatment of various advanced solid tumors.\n<\/p>\n \nADC Therapeutics is based in Lausanne (Biop\u00f4le), Switzerland and has operations in London, the San Francisco Bay Area and New Jersey. For more information, please visit https:\/\/adctherapeutics.com\/<\/a> and follow the Company on Twitter and LinkedIn.\n<\/p>\n Use of Non-IFRS Financial Measures<\/b><\/p>\n \nIn addition to financial information prepared in accordance with IFRS, this document also contains certain non-IFRS financial measures based on management\u2019s view of performance including:\n<\/p>\n \nManagement uses such measures internally when monitoring and evaluating our operational performance, generating future operating plans and making strategic decisions regarding the allocation of capital. We believe that these adjusted financial measures provide useful information to investors and others in understanding and evaluating our operating results in the same manner as our management and facilitate operating performance comparability across both past and future reporting periods. These non-IFRS measures have limitations as financial measures and should be considered in addition to, and not in isolation or as a substitute for, the information prepared in accordance with IFRS. When preparing these supplemental non-IFRS measures, management typically excludes certain IFRS items that management does not believe are indicative of our ongoing operating performance. Furthermore, management does not consider these IFRS items to be normal, recurring cash or non-cash operating expenses; however, these items may not meet the IFRS definition of unusual or non-recurring items. Since non-IFRS financial measures do not have standardized definitions and meanings, they may differ from the non-IFRS financial measures used by other companies, which reduces their usefulness as comparative financial measures. Because of these limitations, you should consider these adjusted financial measures alongside other IFRS financial measures.\n<\/p>\n \nThe following items are excluded from adjusted net loss and adjusted net loss per share:\n<\/p>\n Shared-Based Compensation Expense:<\/i> We exclude share-based compensation from our adjusted financial measures because share-based compensation expense, which is non-cash, fluctuates from period to period based on factors that are not within our control, such as our stock price on the dates share-based grants are issued. Share-based compensation has been, and will continue to be for the foreseeable future, a recurring expense in our business and an important part of our compensation strategy.\n<\/p>\n Certain Other Items:<\/i> We exclude certain other significant items that may occur occasionally and are not normal, recurring operating expenses, cash or non-cash, from our adjusted financial measures. Such items are evaluated by management on an individual basis based on both quantitative and qualitative aspects of their nature and generally represent items that, either as a result of their nature or significance, management would not anticipate occurring as part of our normal business on a regular basis. While not all-inclusive, examples of certain other significant items excluded from our adjusted financial measures would be: changes in the fair value of derivatives, and the effective interest expense, associated with the Convertible Credit Facility with Deerfield, as well as transaction costs associated with debt or equity issuances that are expensed pursuant to IFRS.\n<\/p>\n \nSee the attached Reconciliation of IFRS Measures to Non-IFRS Measures for explanations of the amounts excluded and included to arrive at the non-IFRS financial measures for the three- and nine-month periods ended September 30, 2020 and 2019.\n<\/p>\n Forward-Looking Statements<\/b><\/p>\n \nThis press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding our future results of operations and financial position, business strategy, product candidates, research pipeline, ongoing and planned preclinical studies and clinical trials, regulatory submissions and approvals, research and development costs, timing and likelihood of success, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on our management\u2019s beliefs and assumptions and on information currently available to our management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in our filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this document speak only as of the date of this press release. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in our expectations or any change in events, conditions, or circumstances on which such statements are based unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.\n<\/p>\n ADC Therapeutics SA<\/b><\/p>\n Condensed Consolidated Interim Statement of Operations (Unaudited)<\/b><\/p>\n (in KUSD<\/b>except for share and per share data)<\/b><\/p>\n<\/td>\n<\/tr>\n For the Three Months Ended \n\u00a0\n<\/p>\n<\/td>\n For the Nine Months Ended 2020<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2019<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2020<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2019<\/b><\/p>\n<\/td>\n<\/tr>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n2,340\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n(32,155\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(30,541\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(93,480\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(77,113\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n(20,273\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(2,302\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(47,782\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(8,894\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n(52,428\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(32,843\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(141,262\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(86,007\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n(52,428\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(32,843\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(141,262\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(83,667\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n145\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,433\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n423\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,433\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n33,868\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(45,393\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(1,571\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n163\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n729\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n732\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n2,035\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n(1,940\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(32\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(2,879\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(105\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n(139\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(360\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(210\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(428\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n32,097\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,770\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(48,898\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n2,935\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n(20,331\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(31,073\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(190,160\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(80,732\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n3\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n(268\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(201\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(467\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n (20,328<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (31,341<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (190,361<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (81,199<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n<\/tr>\n \n(20,328\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(31,341\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(190,361\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(81,199\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n(0.29\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(0.62\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(3.09\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(1.68\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n ADC Therapeutics SA<\/b><\/p>\n Condensed Consolidated Interim Balance Sheet (Unaudited)<\/b><\/p>\n (in KUSD)<\/b><\/p>\n<\/td>\n<\/tr>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n September 30,<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n December 31,<\/b><\/p>\n<\/td>\n<\/tr>\n \n\u00a0\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2020<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2019<\/b><\/p>\n<\/td>\n<\/tr>\n \n494,416\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n115,551\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n12,003\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n7,055\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n506,419\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n122,606\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n1,502\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,376\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n3,402\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n4,898\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n9,814\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n8,434\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n389\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n368\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n15,107\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n15,076\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n 521,526<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 137,682<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n6,146\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n3,329\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n22,633\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n15,430\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n1,051\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,132\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n91\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n52\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n2,642\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n32,563\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n19,943\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n33,788\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n73,190\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n2,605\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n3,899\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n3,113\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n2,684\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n208\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n112,904\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n6,583\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n 145,467<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 26,526<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n6,314\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n4,361\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n981,032\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n549,922\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n(4\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(100\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n27,642\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n5,473\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n5\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n69\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \n(638,930\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(448,569\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \n376,059\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n111,156\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n 521,526<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 137,682<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n ADC Therapeutics SA<\/b><\/p>\n Reconciliation of IFRS Measures to Non-IFRS Measures (Unaudited)<\/b><\/p>\n (in KUSD<\/b>except for share and per share data)<\/b><\/p>\n<\/td>\n<\/tr>\n Three months ended September 30,<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n Nine months ended September 30,<\/b><\/p>\n<\/td>\n<\/tr>\n in KUSD (except for share and per share data)<\/b><\/p>\n<\/td>\n 2020<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2019<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2020<\/b><\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n 2019<\/b><\/p>\n<\/td>\n<\/tr>\n Net loss<\/b><\/p>\n<\/td>\n \n(20,328\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(31,341\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(190,361\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(81,199\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n Adjustments:<\/b><\/p>\n<\/td>\n \nShare-based compensation expense (i)\n<\/p>\n<\/td>\n \n10,988\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n216\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n27,512\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n356\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \nConvertible loans, derivatives, change in fair value (income) expense (ii)\n<\/p>\n<\/td>\n \n(33,868\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n45,393\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \nConvertible loans, first tranche, derivative, transaction costs (iii)\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1,571\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \nEffective interest expense (iv)\n<\/p>\n<\/td>\n \n1,913\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n2,781\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n Adjusted net loss<\/b><\/p>\n<\/td>\n (41,295<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (31,125<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (113,104<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n (80,843<\/b><\/p>\n<\/td>\n )<\/b><\/p>\n<\/td>\n<\/tr>\n \n\u00a0\n<\/p>\n<\/td>\n \nNet loss per share, basic and diluted\n<\/p>\n<\/td>\n \n(0.29\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(0.62\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(3.09\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(1.68\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \nAdjustment to net loss per share, basic and diluted\n<\/p>\n<\/td>\n \n(0.29\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n–\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n1.25\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n0.01\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n \nAdjusted net loss per share, basic and diluted\n<\/p>\n<\/td>\n \n(0.58\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(0.62\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(1.84\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n \n(1.67\n<\/p>\n<\/td>\n \n)\n<\/p>\n<\/td>\n<\/tr>\n \nWeighted average shares outstanding, basic and diluted\n<\/p>\n<\/td>\n \n70,914,300\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n50,626,246\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n61,613,177\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n \n48,448,085\n<\/p>\n<\/td>\n \n\u00a0\n<\/p>\n<\/td>\n<\/tr>\n<\/table>\n \n(i) Share-based compensation expense represents the cost of equity awards issued to our directors, management and employees. The fair value of awards is computed at the time the award is granted and is recognized over the vesting period of the award by a charge to the income statement and a corresponding increase in other reserves within equity. These accounting entries have no cash impact.\n<\/p>\n \n(ii) Change in the fair value of the convertible loan derivatives results from the valuation at the end of each accounting period of the derivatives associated with the convertible loans, as explained in note 11 \u201cConvertible notes\u201d to the unaudited condensed consolidated interim financial statements. There are several inputs to these valuations, but those most likely to provoke significant changes in the valuations are changes in the value of the underlying instrument (i.e., changes in the price of our common shares) and changes in expected volatility in that price. Any change in the estimated probability of the regulatory approval of Lonca would directly affect the valuation related to the second tranche. These accounting entries have no cash impact.\n<\/p>\n \n(iii) The transaction costs allocated to the convertible loan first tranche derivative represent actual costs. These are not expected to recur on an ongoing basis.\n<\/p>\n \n(iv) Effective interest expense relates to the increase in the value of our convertible loan in accordance with the effective interest method. As the initial value of the loan is recorded net of the value of the embedded derivative, the increase in the loan value necessary to attain the amount necessary to fund the cash outflows of interest payments, repayment of capital and exit fee is considerably higher than the payments of interest at coupon rate and of the exit fee.\n<\/p>\n View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20201112005282\/en\/<\/a><\/span><\/p>\n Investors EU Media USA Media KEYWORDS:<\/b> Europe Switzerland United States North America<\/p>\n INDUSTRY KEYWORDS:<\/b> Biotechnology Health Pharmaceutical Clinical Trials Oncology<\/p>\n\n
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\n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n
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September 30,<\/b><\/p>\n<\/td>\n\n \n
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September 30,<\/b><\/p>\n<\/td>\n<\/tr>\n\n \n \n \n \n \n \n \n \n \n Contract revenue<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n Operating expense<\/td>\n \n \n \n \n \n \n <\/tr>\n \n Research and development<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n General and administrative<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Total operating expense<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Loss from operations<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n Other income (expense)<\/td>\n \n \n \n \n \n \n <\/tr>\n \n Other income<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Convertible loans, derivatives, change in fair value income (expense)<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Convertible loans, first tranche, derivative, transaction costs<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Financial income<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Financial expense<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Exchange differences<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Total other income (expense)<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Loss before taxes<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Income tax benefit (expense)<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n Net loss<\/b><\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n Net loss attributable to:<\/b><\/td>\n \n \n \n \n \n \n <\/tr>\n \n Owners of the parent<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n Net loss per share, basic and diluted<\/td>\n \n \n \n \n \n \n \n \n \n \n \n \n
\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n ASSETS<\/b><\/td>\n \n \n \n <\/tr>\n \n Current assets<\/td>\n \n \n \n <\/tr>\n \n Cash and cash equivalents<\/td>\n \n \n \n \n \n \n \n Other current assets<\/td>\n \n \n \n \n \n \n \n Total current assets<\/td>\n \n \n \n \n \n \n \n Non-current assets<\/td>\n \n \n \n <\/tr>\n \n Property, plant and equipment<\/td>\n \n \n \n \n \n \n \n Right-of-use assets<\/td>\n \n \n \n \n \n \n \n Intangible assets<\/td>\n \n \n \n \n \n \n \n Other long-term assets<\/td>\n \n \n \n \n \n \n \n Total non-current assets<\/td>\n \n \n \n \n \n \n \n Total assets<\/b><\/td>\n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n LIABILITIES AND SHAREHOLDERS’ EQUITY <\/b><\/td>\n \n \n \n <\/tr>\n \n Current liabilities<\/td>\n \n \n \n <\/tr>\n \n Accounts payable<\/td>\n \n \n \n \n \n \n \n Other current liabilities<\/td>\n \n \n \n \n \n \n \n Lease liabilities, short-term<\/td>\n \n \n \n \n \n \n \n Current income tax payable<\/td>\n \n \n \n \n \n \n \n Convertible loans, short-term<\/td>\n \n \n \n \n \n \n \n Total current liabilities<\/td>\n \n \n \n \n \n \n \n Non-current liabilities<\/td>\n \n \n \n <\/tr>\n \n Convertible loans, long-term<\/td>\n \n \n \n \n \n \n \n Convertible loans, derivatives<\/td>\n \n \n \n \n \n \n \n Lease liabilities, long-term<\/td>\n \n \n \n \n \n \n \n Defined benefit pension liabilities<\/td>\n \n \n \n \n \n \n \n Other non-current liabilities<\/td>\n \n \n \n \n \n \n \n Total non-current liabilities<\/td>\n \n \n \n \n \n \n \n Total liabilities<\/b><\/td>\n \n \n \n \n \n \n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n Equity attributable to owners of the parent<\/b><\/td>\n \n \n \n <\/tr>\n \n Share capital<\/td>\n \n \n \n \n \n \n \n Share premium<\/td>\n \n \n \n \n \n \n \n Treasury shares<\/td>\n \n \n \n \n \n \n \n Other reserves<\/td>\n \n \n \n \n \n \n \n Cumulative translation adjustment<\/td>\n \n \n \n \n \n \n \n Accumulated losses<\/td>\n \n \n \n \n \n \n \n Total equity attributable to owners of the parent<\/td>\n \n \n \n \n \n \n \n Total liabilities and equity<\/b><\/td>\n \n \n \n \n \n \n \n
\n \n \n \n \n \n \u00a0<\/td>\n<\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/tr>\n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n \n <\/p>\n
\n<\/b>
Amanda Hamilton
\n
ADC Therapeutics
\n
amanda.hamilton@adctherapeutics.com
\n<\/a>
Tel.: +1 917-288-7023\n<\/p>\n
\n<\/b>
Alexandre M\u00fcller
\n
Dynamics Group
\n
amu@dynamicsgroup.ch
\n<\/a>
Tel: +41 (0) 43 268 3231\n<\/p>\n
\n<\/b>
Annie Starr
\n
6 Degrees
\n
astarr@6degreespr.com
\n<\/a>
Tel.: +1 973-415-8838\n<\/p>\n
![\"Logo\"](\"https:\/\/mms.businesswire.com\/media\/20201112005282\/en\/797790\/3\/ADCT_Corporate_Final_4C.jpg\")
<\/td>\n<\/tr>\n