{"id":1020979,"date":"2026-11-13T11:33:06","date_gmt":"2026-11-13T16:33:06","guid":{"rendered":"https:\/\/www.marketnewsdesk.com\/index.php\/jama-network-open-publishes-quality-of-life-and-pain-outcomes-data-from-phase-3-panova-3-trial-of-novocures-tumor-treating-fields-for-pancreatic-cancer\/"},"modified":"2026-11-13T11:33:06","modified_gmt":"2026-11-13T16:33:06","slug":"jama-network-open-publishes-quality-of-life-and-pain-outcomes-data-from-phase-3-panova-3-trial-of-novocures-tumor-treating-fields-for-pancreatic-cancer","status":"publish","type":"post","link":"https:\/\/www.marketnewsdesk.com\/index.php\/jama-network-open-publishes-quality-of-life-and-pain-outcomes-data-from-phase-3-panova-3-trial-of-novocures-tumor-treating-fields-for-pancreatic-cancer\/","title":{"rendered":"JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer"},"content":{"rendered":"

<\/p>\n

JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer<\/b><\/p>\n

BAAR, Switzerland–(BUSINESS WIRE<\/a>)–
\nNovocure (Nasdaq: NVCR) announced today that JAMA Network Open<\/i> published the results of the prespecified secondary analysis of data from the Phase 3 PANOVA-3 trial of Tumor Treating Fields (TTFields) therapy concomitant with gemcitabine and nab-paclitaxel in patients with unresectable, locally advanced pancreatic adenocarcinoma.<\/p>\n

\nThe PANOVA-3 trial evaluated the use of TTFields therapy concomitantly with gemcitabine and nab-paclitaxel (GnP) as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma, compared to GnP alone. The trial met its primary endpoint, demonstrating a statistically significant improvement in median overall survival for patients treated with TTFields therapy.<\/p>\n

\n\u201cOne of the most debilitating complications of pancreatic cancer is pain. For clinicians, management of pain is a priority because it not only affects our patients\u2019 quality of life but it can reduce compliance with anticancer treatments, negatively impacting survival outcomes,\u201d said Teresa Macarulla, MD, PhD, Head of Medical Oncology Department at Hospital Cl\u00ednic Barcelona Comprehensive Cancer Centre. \u201cThe results from the PANOVA-3 trial found that in addition to improving overall survival, Tumor Treating Fields therapy provided clinically meaningful benefits on measures of pain outcomes and quality of life, which are important for clinical decision-making.\u201d<\/p>\n

\nSecondary endpoints included quality of life outcomes measured using the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) with the pancreatic cancer specific PAN26 addendum scales. The EORTC QLQ-C30 and the PAN26 measure global health status and function as well as symptoms including pain (irrespective of cause), pancreatic pain, and gastrointestinal symptoms.<\/p>\n

\nResults of the secondary endpoint measures demonstrated a statistically significant and clinically meaningful benefit across multiple measures of quality of life and pain outcomes. These results are detailed in the publication, Tumor Treating Fields and Quality of Life Among Patients With Locally Advanced Pancreatic Adenocarcinoma – A Secondary Analysis of a Randomized Clinical Trial<\/i>, https:\/\/jamanetwork.com\/journals\/jamanetworkopen\/fullarticle\/2856639<\/a>.<\/p>\n

\n\u201cThis publication in JAMA Network Open<\/i> is an important step in providing the results from PANOVA-3 to the oncology community through a peer-reviewed resource,\u201d said Uri Weinberg, MD, PhD, Chief Medical and Innovation Officer, Novocure. \u201cThe results from the PANOVA-3 trial demonstrated the efficacy of Tumor Treating Fields therapy in locally advanced pancreatic cancer. We also evaluated and saw a positive and clinically meaningful effect from treatment with Tumor Treating Fields on pain, which can significantly affect patients’ quality of life. We believe these results can help inform clinicians and patients as they make treatment decisions.\u201d<\/p>\n

\nTTFields therapy was well-tolerated in PANOVA-3, no new safety signals were observed, and device related safety outcomes were consistent with prior clinical studies using TTFields. Mild to moderate skin adverse events (AEs) were the most common device-related AEs.<\/p>\n

About Novocure<\/b><\/p>\n

\nNovocure is a global oncology company working to extend survival in some of the most aggressive forms of cancer through the development and commercialization of its innovative therapy, Tumor Treating Fields. Novocure\u2019s commercialized products are approved in certain countries for the treatment of adult patients with glioblastoma, pancreatic cancer, non-small cell lung cancer, malignant pleural mesothelioma and pleural mesothelioma. Novocure has several additional ongoing or completed clinical trials exploring the use of Tumor Treating Fields therapy in the treatment of glioblastoma, non-small cell lung cancer and pancreatic cancer.<\/p>\n

\nNovocure\u2019s global headquarters is located in Baar, Switzerland, with U.S. headquarters located in Portsmouth, New Hampshire and research and development facilities located in Haifa, Israel. For additional information about the company, please visit Novocure.com<\/a> and follow @Novocure on LinkedIn<\/a> and X<\/a>.<\/p>\n

Forward-Looking Statements<\/b><\/p>\n

\nIn addition to historical facts or statements of current condition, this press release may contain forward-looking statements. Forward-looking statements provide Novocure\u2019s current expectations or forecasts of future events. These may include statements regarding anticipated scientific progress on its research programs, clinical trial progress, development of potential products, interpretation of clinical results, prospects for regulatory approval, manufacturing development and capabilities, market prospects for its products, coverage, collections from third-party payers and other statements regarding matters that are not historical facts. You may identify some of these forward-looking statements by the use of words in the statements such as \u201canticipate,\u201d \u201cestimate,\u201d \u201cexpect,\u201d \u201cproject,\u201d \u201cintend,\u201d \u201cplan,\u201d \u201cbelieve\u201d or other words and terms of similar meaning. Novocure\u2019s performance and financial results could differ materially from those reflected in these forward-looking statements due to general financial, economic, environmental, regulatory and political conditions and other more specific risks and uncertainties facing Novocure such as those set forth in its Annual Report on Form 10-K filed on February 26, 2026, and subsequent filings with the U.S. Securities and Exchange Commission. Given these risks and uncertainties, any or all of these forward-looking statements may prove to be incorrect. Therefore, you should not rely on any such factors or forward-looking statements. Furthermore, Novocure does not intend to update publicly any forward-looking statement, except as required by law. Any forward-looking statements herein speak only as of the date hereof. The Private Securities Litigation Reform Act of 1995 permits this discussion.<\/p>\n

\"\"<\/p>\n

View source version on businesswire.com: <\/span>https:\/\/www.businesswire.com\/news\/home\/20261113972844\/en\/<\/a><\/span><\/p>\n

Investors:
\n<\/b>
Adam Daney
\n
investorinfo@novocure.com<\/a><\/p>\n

Media:
\n<\/b>
Catherine Falcetti
\n
media@novocure.com<\/a><\/p>\n

KEYWORDS:<\/b> Switzerland Europe<\/p>\n

INDUSTRY KEYWORDS:<\/b> Research Publishing Clinical Trials Communications Biotechnology Pharmaceutical Health Science Oncology Other Science<\/p>\n

MEDIA:<\/b><\/p>\n\n\n\n\n
Logo<\/b><\/font><\/td>\n<\/tr>\n
\"Logo\"<\/td>\n<\/tr>\n
<\/font><\/td>\n<\/tr>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer BAAR, Switzerland–(BUSINESS WIRE)– Novocure (Nasdaq: NVCR) announced today that JAMA Network Open published the results of the prespecified secondary analysis of data from the Phase 3 PANOVA-3 trial of Tumor Treating Fields (TTFields) therapy concomitant with gemcitabine and nab-paclitaxel in patients with unresectable, locally advanced pancreatic adenocarcinoma. The PANOVA-3 trial evaluated the use of TTFields therapy concomitantly with gemcitabine and nab-paclitaxel (GnP) as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma, compared to GnP alone. The trial met its primary endpoint, demonstrating a statistically significant improvement in median overall survival for patients treated with TTFields … <\/p>\n

Continue reading “JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer”<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-1020979","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"\nJAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer - Market Newsdesk<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.marketnewsdesk.com\/index.php\/jama-network-open-publishes-quality-of-life-and-pain-outcomes-data-from-phase-3-panova-3-trial-of-novocures-tumor-treating-fields-for-pancreatic-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer - Market Newsdesk\" \/>\n<meta property=\"og:description\" content=\"JAMA Network Open Publishes Quality of Life and Pain Outcomes Data from Phase 3 PANOVA-3 Trial of Novocure\u2019s Tumor Treating Fields for Pancreatic Cancer BAAR, Switzerland–(BUSINESS WIRE)– Novocure (Nasdaq: NVCR) announced today that JAMA Network Open published the results of the prespecified secondary analysis of data from the Phase 3 PANOVA-3 trial of Tumor Treating Fields (TTFields) therapy concomitant with gemcitabine and nab-paclitaxel in patients with unresectable, locally advanced pancreatic adenocarcinoma. The PANOVA-3 trial evaluated the use of TTFields therapy concomitantly with gemcitabine and nab-paclitaxel (GnP) as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma, compared to GnP alone. 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The PANOVA-3 trial evaluated the use of TTFields therapy concomitantly with gemcitabine and nab-paclitaxel (GnP) as a first-line treatment for unresectable, locally advanced pancreatic adenocarcinoma, compared to GnP alone. 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